BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0074.p (457 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2099 [FR] COG0402 Cytosine deaminase and related metal-depend... 330 4e-90 PA1521 [FR] COG0402 Cytosine deaminase and related metal-depende... 294 2e-79 ygfP [FR] COG0402 Cytosine deaminase and related metal-dependent... 287 4e-77 ZygfP [FR] COG0402 Cytosine deaminase and related metal-dependen... 286 5e-77 ECs3756 [FR] COG0402 Cytosine deaminase and related metal-depend... 286 6e-77 >RSc2099 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Rso Ralstonia solanacearum Length = 445 Score = 330 bits (846), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 158/266 (59%), Positives = 200/266 (75%), Gaps = 4/266 (1%) Query: 2 NSHVQAYRASLLHFRNDPAFDEH-ATQWHSDGLLIVADGKIVAAGDYSKLAATLPAASSD 60 ++ + AYR +LHF +DP + EH A Q+ DGLL++ GK+V AGD++ L TLPA + Sbjct: 9 DATLHAYRGRVLHFLHDPQYREHDAYQYWEDGLLVIGAGKVVRAGDHAALKGTLPAGAQ- 67 Query: 61 YVLFDYRGKIITPGFIDTHVHYPQTDIIGSPAPGLLPWLNTYTFPAERRFESGEHASEVA 120 + DY GK+I PGFIDTH+H+PQTDII SP+PGLL WL TYTFP ERRFES ++A+ VA Sbjct: 68 --VHDYSGKLIVPGFIDTHIHFPQTDIIASPSPGLLHWLETYTFPEERRFESPQYAAGVA 125 Query: 121 DFFLAELLRNGTTTAAVYCTVHPQSVDAFFTRSSELNLRMVAGKCLMDRNAPDFLRDTAE 180 FFL ELLRNGTT+A V+ TVH S + F ++ +R++ GK +MDRN P++LRDTAE Sbjct: 126 SFFLDELLRNGTTSAMVWSTVHRGSAETLFEQARARGMRLITGKVMMDRNCPEYLRDTAE 185 Query: 181 SGVRESEELIQRWHNKGRQHYAITVRFAPTSTPQQLKLAGELATQYPDTYIQTHVAENTD 240 G R++ +LI RWH K R YAIT RFAPTS+ QL GELA Q+PD +IQTHVAEN D Sbjct: 186 RGARDAADLIARWHGKDRLAYAITPRFAPTSSEAQLAACGELARQHPDVFIQTHVAENPD 245 Query: 241 EVKWVKELFPDSRSYLDVYDQYGLMR 266 EVKWV ELFP++RSYLDVYD+YGL+R Sbjct: 246 EVKWVAELFPNARSYLDVYDRYGLLR 271 >PA1521 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Pae Pseudomonas aeruginosa Length = 434 Score = 294 bits (753), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 146/276 (52%), Positives = 192/276 (69%), Gaps = 7/276 (2%) Query: 1 MNSHVQAYRASLLHFRNDPAFD--EHATQWHSDGLLIVADGKIVAAGDYSKLAATLPAAS 58 M + +AYRA++LH DPA E + ++ DGLL+V DGK+ GD A TL Sbjct: 1 MTRNAKAYRAAILHSIADPAEVGVERSYEYFEDGLLLVEDGKVARLGD----AETLLGEI 56 Query: 59 SDYVLFDYRGKIITPGFIDTHVHYPQTDIIGSPAPGLLPWLNTYTFPAERRFESGEHASE 118 + +F+YR +ITPGFIDTH+H+PQT +I S LL WLNTYTFP ER+F HA + Sbjct: 57 GEVEVFEYRDALITPGFIDTHIHFPQTGMIASYGEQLLDWLNTYTFPTERQFGDQAHADQ 116 Query: 119 VADFFLAELLRNGTTTAAVYCTVHPQSVDAFFTRSSELNLRMVAGKCLMDRNAPDFLRDT 178 VA+ FL ELLRNGTTTA V+ +VH QSV++ F + L+LR++AGK +MDRNAPD+L DT Sbjct: 117 VAEIFLQELLRNGTTTALVFGSVHRQSVESLFEAARRLDLRLIAGKVMMDRNAPDYLTDT 176 Query: 179 AESGVRESEELIQRWHNKGRQHYAITVRFAPTSTPQQLKLAGELATQYPDTYIQTHVAEN 238 AES R+S+ LI+RWH +GR YA+T RFAPTST +QL +A L ++P Y+ TH++EN Sbjct: 177 AESSYRDSKALIERWHGQGRLLYAVTPRFAPTSTAEQLDMAARLLREHPGVYLHTHLSEN 236 Query: 239 TDEVKWVKELFPDSRSYLDVYDQYGLMRARXR-AHG 273 E++WVKELFP+ YLDVYD +GL+ R AHG Sbjct: 237 LKEIEWVKELFPERSGYLDVYDHHGLLGPRSVFAHG 272 >ygfP [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Eco Escherichia coli K12 Length = 439 Score = 287 bits (734), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 135/263 (51%), Positives = 184/263 (69%), Gaps = 6/263 (2%) Query: 5 VQAYRASLLHFR---NDPAFDEHATQWHSDGLLIVADGKIVAAGDYSKLAATLPAASSDY 61 ++A R S + ++P A ++ DGLL++ GK+ G++ +P Sbjct: 8 LKAVRGSFIDVTRTIDNPEEIASALRFIEDGLLLIKQGKVEWFGEWENGKHQIPDTIR-- 65 Query: 62 VLFDYRGKIITPGFIDTHVHYPQTDIIGSPAPGLLPWLNTYTFPAERRFESGEHASEVAD 121 + DYRGK+I PGF+DTH+HYPQ++++G+ LL WLN +TFP ERR+E E+A E++ Sbjct: 66 -VRDYRGKLIVPGFVDTHIHYPQSEMVGAYGEQLLEWLNKHTFPTERRYEDLEYAREMSA 124 Query: 122 FFLAELLRNGTTTAAVYCTVHPQSVDAFFTRSSELNLRMVAGKCLMDRNAPDFLRDTAES 181 FF+ +LLRNGTTTA V+ TVHPQSVDA F +S +N+RM+AGK +MDRNAPD+L DTAES Sbjct: 125 FFIKQLLRNGTTTALVFGTVHPQSVDALFEAASHINMRMIAGKVMMDRNAPDYLLDTAES 184 Query: 182 GVRESEELIQRWHNKGRQHYAITVRFAPTSTPQQLKLAGELATQYPDTYIQTHVAENTDE 241 +S+ELI+RWH GR YAIT RFAPTS+P+Q+ +A L +YPDT++ TH+ EN DE Sbjct: 185 SYHQSKELIERWHKNGRLLYAITPRFAPTSSPEQMAMAQRLKEEYPDTWVHTHLCENKDE 244 Query: 242 VKWVKELFPDSRSYLDVYDQYGL 264 + WVK L+PD YLDVY QYGL Sbjct: 245 IAWVKSLYPDHDGYLDVYHQYGL 267 >ZygfP [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases EcZ Escherichia coli O157:H7 EDL933 Length = 439 Score = 286 bits (733), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 135/263 (51%), Positives = 184/263 (69%), Gaps = 6/263 (2%) Query: 5 VQAYRASLLHFR---NDPAFDEHATQWHSDGLLIVADGKIVAAGDYSKLAATLPAASSDY 61 ++A R S + ++P A ++ DGLL++ GK+ G++ +P Sbjct: 8 LKAVRGSFIDVTRTVDNPEEIASALRFIEDGLLLIKQGKVEWFGEWEDGKHQIPDTIR-- 65 Query: 62 VLFDYRGKIITPGFIDTHVHYPQTDIIGSPAPGLLPWLNTYTFPAERRFESGEHASEVAD 121 + DYRGK+I PGF+DTH+HYPQ++++G+ LL WLN +TFP ERR+E E+A E++ Sbjct: 66 -VRDYRGKLIVPGFVDTHIHYPQSEMVGAYGEQLLEWLNKHTFPTERRYEDLEYAREMSA 124 Query: 122 FFLAELLRNGTTTAAVYCTVHPQSVDAFFTRSSELNLRMVAGKCLMDRNAPDFLRDTAES 181 FF+ +LLRNGTTTA V+ TVHPQSVDA F +S +N+RM+AGK +MDRNAPD+L DTAES Sbjct: 125 FFIKQLLRNGTTTALVFGTVHPQSVDALFEAASHINMRMIAGKVMMDRNAPDYLLDTAES 184 Query: 182 GVRESEELIQRWHNKGRQHYAITVRFAPTSTPQQLKLAGELATQYPDTYIQTHVAENTDE 241 +S+ELI+RWH GR YAIT RFAPTS+P+Q+ +A L +YPDT++ TH+ EN DE Sbjct: 185 SYHQSKELIERWHKNGRLLYAITPRFAPTSSPEQMAMAQRLKEEYPDTWVHTHLCENKDE 244 Query: 242 VKWVKELFPDSRSYLDVYDQYGL 264 + WVK L+PD YLDVY QYGL Sbjct: 245 IAWVKSLYPDHDGYLDVYHQYGL 267 >ECs3756 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Ecs Escherichia coli O157:H7 Length = 439 Score = 286 bits (733), Expect = 6e-77, Method: Compositional matrix adjust. Identities = 135/263 (51%), Positives = 184/263 (69%), Gaps = 6/263 (2%) Query: 5 VQAYRASLLHFR---NDPAFDEHATQWHSDGLLIVADGKIVAAGDYSKLAATLPAASSDY 61 ++A R S + ++P A ++ DGLL++ GK+ G++ +P Sbjct: 8 LKAVRGSFIDVTRTVDNPEEIASALRFIEDGLLLIKQGKVEWFGEWEDGKHQIPDTIR-- 65 Query: 62 VLFDYRGKIITPGFIDTHVHYPQTDIIGSPAPGLLPWLNTYTFPAERRFESGEHASEVAD 121 + DYRGK+I PGF+DTH+HYPQ++++G+ LL WLN +TFP ERR+E E+A E++ Sbjct: 66 -VRDYRGKLIVPGFVDTHIHYPQSEMVGAYGEQLLEWLNKHTFPTERRYEDLEYAREMSA 124 Query: 122 FFLAELLRNGTTTAAVYCTVHPQSVDAFFTRSSELNLRMVAGKCLMDRNAPDFLRDTAES 181 FF+ +LLRNGTTTA V+ TVHPQSVDA F +S +N+RM+AGK +MDRNAPD+L DTAES Sbjct: 125 FFIKQLLRNGTTTALVFGTVHPQSVDALFEAASHINMRMIAGKVMMDRNAPDYLLDTAES 184 Query: 182 GVRESEELIQRWHNKGRQHYAITVRFAPTSTPQQLKLAGELATQYPDTYIQTHVAENTDE 241 +S+ELI+RWH GR YAIT RFAPTS+P+Q+ +A L +YPDT++ TH+ EN DE Sbjct: 185 SYHQSKELIERWHKNGRLLYAITPRFAPTSSPEQMAMAQRLKEEYPDTWVHTHLCENKDE 244 Query: 242 VKWVKELFPDSRSYLDVYDQYGL 264 + WVK L+PD YLDVY QYGL Sbjct: 245 IAWVKSLYPDHDGYLDVYHQYGL 267