BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0025.0022.p         (109 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

PA2025 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex...   114   4e-26
AGc2967 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase comple...   101   4e-22
BMEI0972 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase compl...   100   9e-22
SMc00154 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase compl...    90   1e-18
all4968 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase comple...    89   3e-18

>PA2025 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex,
           dihydrolipoamide dehydrogenase (E3) component, and
           related enzymes Pae Pseudomonas aeruginosa
          Length = 451

 Score =  114 bits (286), Expect = 4e-26,   Method: Compositional matrix adjust.
 Identities = 51/93 (54%), Positives = 68/93 (73%)

Query: 1   MSYGAHFHQDFADAAGFGWTVGETSFDWAALIAAKDKEIARLNGIYRKILEGAKVDIVEG 60
           + YGAHF +DF  A  +GW+ GE  FDWA LI  K++EI RLNGIYR +L  + V ++EG
Sbjct: 53  LVYGAHFSEDFEQARAYGWSAGEAQFDWATLIGNKNREIQRLNGIYRNLLVNSGVTLLEG 112

Query: 61  HAAVEDAHTVSVNGKRYTAAHILVATGGQXRRP 93
           HA + DAH+V V+G+R++A HILVATGG  + P
Sbjct: 113 HARLLDAHSVEVDGQRFSAKHILVATGGWPQVP 145


>AGc2967 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex,
           dihydrolipoamide dehydrogenase (E3) component, and
           related enzymes Atu Agrobacterium tumefaciens strain C58
           (Cereon)
          Length = 464

 Score =  101 bits (252), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 50/88 (56%), Positives = 60/88 (68%), Gaps = 2/88 (2%)

Query: 3   YGAHFHQDFADAAGFGWTVGETSFDWAALIAAKDKEIARLNGIYRKILEGAKVDIVEGHA 62
           Y + F + F DA GFGW+VGE  FDW  LIAAKDKEI RL G+YRK LE AK DI +  A
Sbjct: 58  YASQFPEYFEDAEGFGWSVGERRFDWKKLIAAKDKEITRLEGLYRKGLENAKADIFDSRA 117

Query: 63  AVEDAHTVSV--NGKRYTAAHILVATGG 88
            + DAHTV +   G+ YTA  I++A GG
Sbjct: 118 ELVDAHTVKLTKTGETYTAERIVIAVGG 145


>BMEI0972 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex,
           dihydrolipoamide dehydrogenase (E3) component, and
           related enzymes Bme Brucella melitensis
          Length = 483

 Score =  100 bits (248), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 47/89 (52%), Positives = 64/89 (71%), Gaps = 2/89 (2%)

Query: 3   YGAHFHQDFADAAGFGWTVGETSFDWAALIAAKDKEIARLNGIYRKILEGAKVDIVEGHA 62
           Y + F + F D+AG+GW++GE +FDW  LIAAKDKEI+RL G+YRK LE + VDI    A
Sbjct: 75  YASQFPEHFEDSAGYGWSMGEAAFDWKKLIAAKDKEISRLEGLYRKGLENSHVDIFASRA 134

Query: 63  AVEDAHTVSV--NGKRYTAAHILVATGGQ 89
            + D HT+ +  +G+R TA  IL+ATGG+
Sbjct: 135 ELIDEHTIELKADGRRVTADKILIATGGR 163


>SMc00154 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex,
           dihydrolipoamide dehydrogenase (E3) component, and
           related enzymes Sme Sinorhizobium meliloti
          Length = 463

 Score = 90.1 bits (222), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 45/88 (51%), Positives = 61/88 (69%), Gaps = 2/88 (2%)

Query: 3   YGAHFHQDFADAAGFGWTVGETSFDWAALIAAKDKEIARLNGIYRKILEGAKVDIVEGHA 62
           Y + F + F DAAGFGWTVGE+ FDWA L+AAK++EIARL G+YRK L  A  +I++  A
Sbjct: 56  YASQFAEHFEDAAGFGWTVGESRFDWAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRA 115

Query: 63  AVEDAHTVSV--NGKRYTAAHILVATGG 88
            +   +TV +  +GK  TA  I++A GG
Sbjct: 116 ELAGPNTVKLLASGKTVTAERIVIAVGG 143


>all4968 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex,
           dihydrolipoamide dehydrogenase (E3) component, and
           related enzymes Nos Nostoc sp. PCC 7120
          Length = 459

 Score = 88.6 bits (218), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 40/93 (43%), Positives = 59/93 (63%)

Query: 1   MSYGAHFHQDFADAAGFGWTVGETSFDWAALIAAKDKEIARLNGIYRKILEGAKVDIVEG 60
           M YG+HF   F DAAG+GW VG+   +W   I + DKE+ RL+ ++   LE A V+++ G
Sbjct: 53  MVYGSHFPALFEDAAGYGWQVGKAELNWEHFITSIDKEVRRLSQLHISFLEKAGVELISG 112

Query: 61  HAAVEDAHTVSVNGKRYTAAHILVATGGQXRRP 93
            A + D HTV V  +++TA  IL+A GG+  +P
Sbjct: 113 RATLVDNHTVEVGERKFTADKILIAVGGRPIKP 145