BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0023.0026.p (302 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2225 [GER] COG0697 Permeases of the drug/metabolite transport... 254 2e-67 NMA1785 [GER] COG0697 Permeases of the drug/metabolite transport... 156 6e-38 NMB1593 [GER] COG0697 Permeases of the drug/metabolite transport... 156 7e-38 YPO1348 [GER] COG0697 Permeases of the drug/metabolite transport... 103 7e-22 PA2628 [GER] COG0697 Permeases of the drug/metabolite transporte... 97 4e-20 >RSc2225 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 324 Score = 254 bits (648), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 143/300 (47%), Positives = 193/300 (64%), Gaps = 5/300 (1%) Query: 1 MLVASFLFSIMGVCVKLSSDYYSTAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDHLI 60 M++A+F FS MGVCVKL+S +YST E+V R ++GVA + ++ G +RTP+ H+ Sbjct: 23 MVLAAFAFSAMGVCVKLASAHYSTGEIVFYRSLIGVALMGAVLYHTGAGVRTPHFASHIK 82 Query: 61 RGGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKK-RFEWGLAGTV 119 R GV SL LWF S LLP+ATA TLNYMS +WIA ++ A GK + + + Sbjct: 83 RSVFGVTSLLLWFSSISLLPLATAMTLNYMSPVWIALIIGAGATLAGKAGGADRKMVTAI 142 Query: 120 LLSFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSFT 179 L+SFVGV LL+PS+ Q+ GG+I L SGV +AL Y++VR+LG LGE E R+VFYFS Sbjct: 143 LMSFVGVICLLQPSVGPSQMTGGMIGLVSGVFTALAYVEVRQLGDLGENEARIVFYFSLV 202 Query: 180 GLLAGLAGSVVIGRIPFWHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTANLQY 239 +AG A ++ G HAH+ + LLV +GL ATL Q AMTRAY+ GNTL+TANLQY Sbjct: 203 SSIAGGAWMLIAGA----HAHTWQSAWLLVAVGLLATLGQTAMTRAYKRGNTLLTANLQY 258 Query: 240 TGIVFASLWGLFIWNDAPGWMGWTGIAIILMSGVVSTFYNQRSQQQSRQSRNLPAIDPIA 299 TGIVFAS WG+ +W+D + W G+A+I+ SG+V+T R + + P A Sbjct: 259 TGIVFASGWGMLLWHDHLNALSWMGMALIIGSGIVTTVMRARQSGVAHPTPQTAVSGPEA 318 >NMA1785 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily NmA Neisseria meningitidis Z2491 Length = 300 Score = 156 bits (394), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 110/294 (37%), Positives = 160/294 (54%), Gaps = 14/294 (4%) Query: 1 MLVASFLFSIMGVCVKLSSDYYS--TAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDH 58 MLVA+ F+IM V +K +S ++ + E+V R + + +R T RTP+ ++H Sbjct: 14 MLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKNH 73 Query: 59 LIRGGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGT 118 L R VG ++ L FY+ LP+AT TL+Y SSI++A F + K+R Sbjct: 74 LNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQAV 129 Query: 119 VLLSFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSF 178 +LL F GV +LL PS S Q L L G +S YL+VR+L L GEP +RVVFY S Sbjct: 130 LLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLSV 189 Query: 179 TGLLAGLAGSVVIGRIPFWHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTANLQ 238 TG+ A S V + WH S L IG++A +AQ++MTRAY++G+ A+L Sbjct: 190 TGV----AMSSVWATLTGWHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASLS 245 Query: 239 YTGIVFASLWGLFIWNDAPGWMGWTGIAIILMSGVVS----TFYNQRSQQQSRQ 288 Y +VF++L F + W G+ II++SG++S T + QR Q RQ Sbjct: 246 YMTVVFSALSAAFFLAEELFWQEILGMCIIILSGILSSIRPTAFKQRLQSLFRQ 299 >NMB1593 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Nme Neisseria meningitidis MC58 Length = 287 Score = 156 bits (394), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 110/294 (37%), Positives = 160/294 (54%), Gaps = 14/294 (4%) Query: 1 MLVASFLFSIMGVCVKLSSDYYS--TAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDH 58 MLVA+ F+IM V +K +S ++ + E+V R + + +R T RTP+ ++H Sbjct: 1 MLVAAACFTIMNVLIKEASAKFALGSGELVFWRMLFSTVALGAAAVLRRDTFRTPHWKNH 60 Query: 59 LIRGGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGT 118 L R VG ++ L FY+ LP+AT TL+Y SSI++A F + K+R Sbjct: 61 LNRSMVGTGAMLLLFYAVTHLPLATGVTLSYTSSIFLAVFSFLIL----KERISVYTQAV 116 Query: 119 VLLSFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSF 178 +LL F GV +LL PS S Q L L G +S YL+VR+L L GEP +RVVFY S Sbjct: 117 LLLGFAGVVLLLNPSFRSGQETAALAGLAGGAMSGWAYLKVRELSLAGEPGWRVVFYLSV 176 Query: 179 TGLLAGLAGSVVIGRIPFWHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTANLQ 238 TG+ A S V + WH S L IG++A +AQ++MTRAY++G+ A+L Sbjct: 177 TGV----AMSSVWATLTGWHTLSFPSAVYLSCIGVSALIAQLSMTRAYKVGDKFTVASLS 232 Query: 239 YTGIVFASLWGLFIWNDAPGWMGWTGIAIILMSGVVS----TFYNQRSQQQSRQ 288 Y +VF++L F + W G+ II++SG++S T + QR Q RQ Sbjct: 233 YMTVVFSALSAAFFLGEELFWQEILGMCIIILSGILSSIRPTAFKQRLQSLFRQ 286 >YPO1348 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ype Yersinia pestis Length = 281 Score = 103 bits (256), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 83/277 (29%), Positives = 135/277 (48%), Gaps = 20/277 (7%) Query: 2 LVASFLFSIMGVCVKLSSDYYSTAEVVLCRGIVGVAFIYGLVKIRGGTLRTPYPRDHLI- 60 ++AS +FS+M V VK +D T E+V R +G I GL+ + G + R L+ Sbjct: 9 ILASLIFSVMNVLVKTIADEIPTGEIVFFRSSIGCLLI-GLLMYQRGIAFSREDRPLLVL 67 Query: 61 RGGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGTVL 120 RG +G + L +FYS L +A A+ L Y+S + + V ++R +A ++ Sbjct: 68 RGTMGALYLICYFYSIAHLTLADASMLAYLSPFFSIVLSLLVL----RERVNATMAFWLV 123 Query: 121 LSFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSFTG 180 + +G +L+RP S L L+ + S V +A+ YL V KL Y +VFYF F Sbjct: 124 MVIIGAIILIRPWNFSTYTLASLVGVMSAVFAAIAYLSVNKLTK-RHHNYEIVFYFLFIT 182 Query: 181 LLAGLAGSVVIGRIPF-WHAH---SAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTAN 236 L IP WH S +L+ I L + L Q+ +T+A+ N +V + Sbjct: 183 TLIS---------IPLMWHNFVWPSGYQFGILIAIALVSLLGQVVLTQAFSSDNLIVVSV 233 Query: 237 LQYTGIVFASLWGLFIWNDAPGWMGWTGIAIILMSGV 273 ++Y GIVF WG W++ P + G ++++S + Sbjct: 234 VRYIGIVFNITWGWLFWDEVPLMLSLMGGGLVVVSCI 270 >PA2628 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Pae Pseudomonas aeruginosa Length = 296 Score = 97.1 bits (240), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 79/286 (27%), Positives = 140/286 (48%), Gaps = 18/286 (6%) Query: 3 VASFLFSIMGVCVKLSSDYYSTAEVVLCRGIVGVAFIYGLVKIRG-GTLRTPYPRDHLIR 61 +++ F++MG ++ +S + VV R +VGV F L RG G LRT P HL+R Sbjct: 23 LSALFFALMGGLIREASSTVNNETVVFFRNLVGVLFFLPLALTRGIGPLRTRRPLSHLLR 82 Query: 62 GGVGVISLWLWFYSFGLLPVATATTLNYMSSIWIAAMLFGVAWWQGKKRFEWGLAGTVLL 121 G+ ++ +FY+ LP+ A +Y + ++ L W K+ + L+ Sbjct: 83 TTYGLGGMYCYFYALAHLPLTDAMLFSYAAPVFTP--LIAHLWI--KEPLTRRMMVATLV 138 Query: 122 SFVGVAMLLRPSIDSDQLLGGLIALFSGVLSALVYLQVRKLGLLGEPEYRVVFYFSFTGL 181 F+GV ++ RPS + L+ + S +++A ++ +R++ EP YR+VFYF+ G Sbjct: 139 GFLGVLLVARPSGAVVAPIA-LVGIASSLMAACAFVSIREMSD-SEPAYRIVFYFALFGT 196 Query: 182 LAGLAGSVVIGRIPF---WHAHSAKGLALLVTIGLTATLAQIAMTRAYRLGNTLVTANLQ 238 L +P W + + L LL+ GL A+L Q+ M++AY L + V + Sbjct: 197 L--------FSAVPLAWAWQPLNGQELLLLLGAGLFASLGQLTMSQAYALASPGVIGPIA 248 Query: 239 YTGIVFASLWGLFIWNDAPGWMGWTGIAIILMSGVVSTFYNQRSQQ 284 Y IVFA + W++ P G A+I + ++ N+ +++ Sbjct: 249 YMAIVFAGVIAWLRWDELPSHTSLLGAALIFAASLIPLLGNRPAER 294