BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0003.p (308 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value yfhK [T] COG0642 Signal transduction histidine kinase Eco Escher... 191 2e-48 ZyfhK [T] COG0642 Signal transduction histidine kinase EcZ Esche... 191 2e-48 ECs3422 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 191 2e-48 YPO2916 [T] COG0642 Signal transduction histidine kinase Ype Yer... 188 1e-47 STM2564 [T] COG0642 Signal transduction histidine kinase Sty Sal... 182 7e-46 >yfhK [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 496 Score = 191 bits (485), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 115/308 (37%), Positives = 174/308 (56%), Gaps = 3/308 (0%) Query: 1 LSNDLEQQRQMLTFQVIGAIVLAVLLAFWFGLWLSRPLARIELAINRLGENR-FDQPIIV 59 L ++ ++ Q +Q + ++++++ F + P+ IE INRLGE R + Sbjct: 185 LQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSF 244 Query: 60 KGPADLRRLGQQLDWLRQRLADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDEVAGKL 119 GP++LR +GQ++ WL +RL+ LE+++ +FLRH+SHELKTPLA++ EG LL D+V G L Sbjct: 245 SGPSELRSVGQRILWLSERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPL 304 Query: 120 TDSQREISRILRQNTQALQNQIEDLLRYNEVAFDAQHINRLPVDLRALLYKVIDDQRLQW 179 T Q+E+ IL +++ LQ IE LL YN D+ + V+L L+ V+ L Sbjct: 305 TPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADSA-VELENVELAPLVETVVSAHSLPA 363 Query: 180 TARDLKVEVEGGARTAVLDPDKFAIVLANLLSNAVRFSPRGGTIRFVLSGHEGRVRIDCI 239 A+ + +V+ A + +P VL NL SNAV + G I S H RV ID I Sbjct: 364 RAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVI 423 Query: 240 DQGPGVAATDTVRIFDPFYQGLNQPQGARHGNGIGLSIVREYVLAHNGEVQLVAGPG-GA 298 + G + + IF+PF+QG +Q +GA G+G+GLSI R+ + GE+ LV G Sbjct: 424 NTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDV 483 Query: 299 HFRIELPD 306 FRIELP Sbjct: 484 CFRIELPS 491 >ZyfhK [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 496 Score = 191 bits (484), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 115/308 (37%), Positives = 174/308 (56%), Gaps = 3/308 (0%) Query: 1 LSNDLEQQRQMLTFQVIGAIVLAVLLAFWFGLWLSRPLARIELAINRLGENR-FDQPIIV 59 L ++ ++ Q +Q + ++++++ F + P+ IE INRLGE R + Sbjct: 185 LQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSF 244 Query: 60 KGPADLRRLGQQLDWLRQRLADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDEVAGKL 119 GP++LR +GQ++ WL +RL+ LE+++ +FLRH+SHELKTPLA++ EG LL D+V G L Sbjct: 245 SGPSELRSVGQRILWLSERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPL 304 Query: 120 TDSQREISRILRQNTQALQNQIEDLLRYNEVAFDAQHINRLPVDLRALLYKVIDDQRLQW 179 T Q+E+ IL +++ LQ IE LL YN D+ + V+L L+ V+ L Sbjct: 305 TPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADSA-VELDNVELAPLVETVVSAHSLPA 363 Query: 180 TARDLKVEVEGGARTAVLDPDKFAIVLANLLSNAVRFSPRGGTIRFVLSGHEGRVRIDCI 239 A+ + +V+ A + +P VL NL SNAV + G I S H RV ID I Sbjct: 364 RAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVI 423 Query: 240 DQGPGVAATDTVRIFDPFYQGLNQPQGARHGNGIGLSIVREYVLAHNGEVQLVAGPG-GA 298 + G + + IF+PF+QG +Q +GA G+G+GLSI R+ + GE+ LV G Sbjct: 424 NTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDV 483 Query: 299 HFRIELPD 306 FRIELP Sbjct: 484 CFRIELPS 491 >ECs3422 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 496 Score = 191 bits (484), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 115/308 (37%), Positives = 174/308 (56%), Gaps = 3/308 (0%) Query: 1 LSNDLEQQRQMLTFQVIGAIVLAVLLAFWFGLWLSRPLARIELAINRLGENR-FDQPIIV 59 L ++ ++ Q +Q + ++++++ F + P+ IE INRLGE R + Sbjct: 185 LQREIAERGQYFGWQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSF 244 Query: 60 KGPADLRRLGQQLDWLRQRLADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDEVAGKL 119 GP++LR +GQ++ WL +RL+ LE+++ +FLRH+SHELKTPLA++ EG LL D+V G L Sbjct: 245 SGPSELRSVGQRILWLSERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPL 304 Query: 120 TDSQREISRILRQNTQALQNQIEDLLRYNEVAFDAQHINRLPVDLRALLYKVIDDQRLQW 179 T Q+E+ IL +++ LQ IE LL YN D+ + V+L L+ V+ L Sbjct: 305 TPEQKEVVSILDSSSRNLQKLIEQLLDYNRKQADSA-VELDNVELAPLVETVVSAHSLPA 363 Query: 180 TARDLKVEVEGGARTAVLDPDKFAIVLANLLSNAVRFSPRGGTIRFVLSGHEGRVRIDCI 239 A+ + +V+ A + +P VL NL SNAV + G I S H RV ID I Sbjct: 364 RAKMMHTDVDLKATACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVI 423 Query: 240 DQGPGVAATDTVRIFDPFYQGLNQPQGARHGNGIGLSIVREYVLAHNGEVQLVAGPG-GA 298 + G + + IF+PF+QG +Q +GA G+G+GLSI R+ + GE+ LV G Sbjct: 424 NTGTPIPQEERAMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDV 483 Query: 299 HFRIELPD 306 FRIELP Sbjct: 484 CFRIELPS 491 >YPO2916 [T] COG0642 Signal transduction histidine kinase Ype Yersinia pestis Length = 483 Score = 188 bits (478), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 116/275 (42%), Positives = 158/275 (57%), Gaps = 11/275 (4%) Query: 37 PLARIELAINRLGENR-FDQPIIVKGPADLRRLGQQLDWLRQRLADLEAEKSRFLRHVSH 95 P+ IE INRLGE R + KGP +LR L Q++ WL +RLA LE+++ FLRH+SH Sbjct: 208 PVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRIIWLSERLAWLESQRHEFLRHISH 267 Query: 96 ELKTPLAALCEGAALLDDEVAGKLTDSQREISRILRQNTQALQNQIEDLLRYNEVAFDA- 154 ELKTPLA++ EG LL DEVAG LT Q+E+ IL +++ LQ IE LL YN D Sbjct: 268 ELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHSSRHLQQLIEQLLDYNRKLADGP 327 Query: 155 ---QHINRLPVDLRALLYKVIDDQRLQWTARDLKVEVEGGARTAVLDPDKFAIVLANLLS 211 +H VDL ++ VI L A+ ++ E E AR +P VL NL S Sbjct: 328 GEPEH-----VDLAEMVGNVISAHSLPARAKMIRTETELDARICWAEPTLLMRVLDNLYS 382 Query: 212 NAVRFSPRGGTIRFVLSGHEGRVRIDCIDQGPGVAATDTVRIFDPFYQGLNQPQGARHGN 271 NAV + GTI RV+ID + G + ++ + IF+PF+QG +Q +GA G+ Sbjct: 383 NAVHYGEESGTIWICSRQVNDRVQIDVANTGAPIPTSEEIMIFEPFFQGSHQRKGAVKGS 442 Query: 272 GIGLSIVREYVLAHNGEVQLVAGPGGA-HFRIELP 305 G+GLSI ++ + G++QLV A FRIELP Sbjct: 443 GLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELP 477 >STM2564 [T] COG0642 Signal transduction histidine kinase Sty Salmonella typhimurium LT2 Length = 480 Score = 182 bits (463), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 112/307 (36%), Positives = 168/307 (54%), Gaps = 3/307 (0%) Query: 1 LSNDLEQQRQMLTFQVIGAIVLAVLLAFWFGLWLSRPLARIELAINRLGENR-FDQPIIV 59 L ++ ++ Q +Q + ++++ + F + P+ IE INRLGE R + Sbjct: 168 LQQEIAERGQFFGWQALVLFLVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTF 227 Query: 60 KGPADLRRLGQQLDWLRQRLADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDEVAGKL 119 GP +LR +GQ++ WL +RLA LE+++ +FLRH+SHELKTPLA++ EG LL D+V G L Sbjct: 228 TGPRELRSVGQRIIWLSERLAWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPL 287 Query: 120 TDSQREISRILRQNTQALQNQIEDLLRYNEVAFDAQHINRLPVDLRALLYKVIDDQRLQW 179 T Q+E+ IL +++ LQ IE LL YN D+ VD+ L+ V+ L Sbjct: 288 TPEQKEVVDILDDSSRNLQKLIEQLLDYNRKLVDSA-TELEAVDIAPLVDMVVSAHSLPA 346 Query: 180 TARDLKVEVEGGARTAVLDPDKFAIVLANLLSNAVRFSPRGGTIRFVLSGHEGRVRIDCI 239 A+ + +V+ A + +P VL NL SNAV + G I V ID + Sbjct: 347 RAKMMHTDVDLEAERCIAEPMLLMSVLDNLYSNAVHYGAESGNICIRSRSQGSTVYIDVV 406 Query: 240 DQGPGVAATDTVRIFDPFYQGLNQPQGARHGNGIGLSIVREYVLAHNGEVQLVAGPGG-A 298 + G + T+ IF+PF+QG +Q +GA G+G+GLSI R+ + GE+QLV Sbjct: 407 NSGEPIPQTEREMIFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEV 466 Query: 299 HFRIELP 305 FRI LP Sbjct: 467 CFRISLP 473