BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0018.p (547 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1047 [GEPR] COG0477 Permeases of the major facilitator superf... 731 0.0 AGl343 [GEPR] COG0477 Permeases of the major facilitator superfa... 640 0.0 NMA1574 [GEPR] COG0477 Permeases of the major facilitator superf... 488 e-137 NMB1362 [GEPR] COG0477 Permeases of the major facilitator superf... 484 e-136 BH2528 [GEPR] COG0477 Permeases of the major facilitator superfa... 272 2e-72 >RSp1047 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 549 Score = 731 bits (1888), Expect = 0.0, Method: Compositional matrix adjust. Identities = 374/543 (68%), Positives = 444/543 (81%), Gaps = 4/543 (0%) Query: 5 FLQKEHTIAKPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSRALGIKESIACAPDTGF 64 F +E T+A GFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSRALGI +S C D Sbjct: 9 FFSRERTVAAVGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSRALGITQSHTCGADVSL 68 Query: 65 FAQVFSTTCDWKISMLGWMYTMFFVLLGISAAIWGGWLERAGPRKAGVVSALCWCGGLLI 124 A++F+T+CDW+IS LGWMYT+FFV LG SAA+WGGWLER GPRKAGVVSA+CWCGGLLI Sbjct: 69 IAELFTTSCDWRISSLGWMYTLFFVFLGASAALWGGWLERVGPRKAGVVSAVCWCGGLLI 128 Query: 125 SALGVYTHQIWLMWLGSGVIGGIGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGAL 184 SA GV THQ+W++W+GSGVIGGIGLGLGYISPVSTLIKWFPD+RGMATGMAIMGFGGGA+ Sbjct: 129 SAFGVQTHQLWMLWIGSGVIGGIGLGLGYISPVSTLIKWFPDKRGMATGMAIMGFGGGAM 188 Query: 185 VGSPLADKLMKHFATPTSVGVWETFVAMAVIYFVFMMAGALGYRVPPSGWKPAGWTP-PA 243 +G+PLAD+LMK FA+ SVGV +TF+ +A IYFVFMMAGALGYRVPP+GWKPAGW P PA Sbjct: 189 IGAPLADRLMKLFASADSVGVSQTFIVLAAIYFVFMMAGALGYRVPPAGWKPAGWKPSPA 248 Query: 244 TTNSTMITQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGISSPMLQEVFGGHLLGVN 303 N TM+TQ HVHVS+ PQFWL+W VLCLNVSAGIGV+G++SP+LQEVFGG LLGV Sbjct: 249 KANDTMVTQRHVHVSQAVKTPQFWLIWAVLCLNVSAGIGVLGMASPLLQEVFGGKLLGVT 308 Query: 304 VGFSDLSIEQKAAIAAIAAGFTGLISLFNIGGRFVWASCSDFFGRKMTYVIFFVLGFILY 363 F++L+ QK IAAIAAGFTGL+SLFNIGGRF WAS SD GRK+TY +FF LGF+LY Sbjct: 309 TAFTELTAAQKGQIAAIAAGFTGLLSLFNIGGRFFWASLSDRLGRKLTYAVFFALGFVLY 368 Query: 364 VSLPWSAKAGSIALFVGAVCIILSMYGGGFSTVPAYLADLFGTQMVGAIHGRLLTAWATA 423 ++PW++ +IALF A C+ILSMYGGGF+TVPAYLAD+FGTQMVGAIHGRLLTAW+TA Sbjct: 369 AAIPWTSHTSNIALFSLAFCVILSMYGGGFATVPAYLADMFGTQMVGAIHGRLLTAWSTA 428 Query: 424 GILGPVVVNYMREYQLSLGMPREQVYNTTMYILAGMLVVGLICNLLVRPVAAKHFMTPEE 483 GILGPV+VNY+REYQ++ G+ R VY+ TM +LAG+LV+G ICNLLVRPV KHFMT + Sbjct: 429 GILGPVLVNYLREYQIAHGVARAAVYDITMMVLAGLLVLGFICNLLVRPVDPKHFMTEAQ 488 Query: 484 LAREKQLAHEKSSSDNTTSLSPTDMALVGRGGNPALIGAAWLAVGIPLIWGISLTLQKTA 543 L ++ H +++ + T + G+ + AW AVG+PL WG+ +TLQK A Sbjct: 489 LDEQR---HAATAATPQANAPETSLEWQAHPGSAVAVVLAWAAVGLPLGWGVWITLQKAA 545 Query: 544 VLF 546 VLF Sbjct: 546 VLF 548 >AGl343 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 552 Score = 640 bits (1652), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/544 (65%), Positives = 423/544 (77%), Gaps = 12/544 (2%) Query: 5 FLQKEHTIAKPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSRALGIKESIACAPDTGF 64 FL +E IA+PGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLS+AL + +C+ T Sbjct: 18 FLDRERIIARPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSKALPATDP-SCSSLT-L 75 Query: 65 FAQVFSTTCDWKISMLGWMYTMFFVLLGISAAIWGGWLERAGPRKAGVVSALCWCGGLLI 124 +F+T C+W+++ LGW+YT+FFVLLG SAAIWGGWLER GPRKAG VSA CWCGG+L+ Sbjct: 76 MGALFTTECNWRVADLGWIYTLFFVLLGCSAAIWGGWLERVGPRKAGFVSACCWCGGILV 135 Query: 125 SALGVYTHQIWLMWLGSGVIGGIGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGAL 184 +A+GV THQ+WLMWLG+GVIGG+GLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGA+ Sbjct: 136 AAIGVATHQLWLMWLGAGVIGGVGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGAM 195 Query: 185 VGSPLADKLMKHFATPTSVGVWETFVAMAVIYFVFMMAGALGYRVPPSGWKPAGWTPPAT 244 +G+PLA+ LM F T S+GVW+TFV MA++YF FMMAGA GYR+PP+GW+P GWT PA Sbjct: 196 IGAPLANLLMNTFKTEASIGVWQTFVVMALVYFAFMMAGAFGYRIPPAGWRPEGWTAPA- 254 Query: 245 TNSTMITQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGISSPMLQEVFGGHLLGV-N 303 S MIT HVH+ PQFWL+W VLCLNVSAGIGVIG++SPMLQE+F G L+G+ Sbjct: 255 AKSAMITTRHVHLRDAHKTPQFWLIWAVLCLNVSAGIGVIGMASPMLQEIFAGSLIGLPG 314 Query: 304 VGFSDLSIEQKAAIAAIAAGFTGLISLFNIGGRFVWASCSDFFGRKMTYVIFFVLGFILY 363 VGF+DL QKA IAAIAAGFTGL+SLFNIGGRF WAS SD GRK TY FFVLG ILY Sbjct: 315 VGFADLDAGQKAQIAAIAAGFTGLLSLFNIGGRFFWASMSDKIGRKNTYFCFFVLGIILY 374 Query: 364 VSLPWSAKAGSIALFVGAVCIILSMYGGGFSTVPAYLADLFGTQMVGAIHGRLLTAWATA 423 P A G+ ALFV A IILSMYGGGF+T+PAYLAD+FGTQ VGAIHGRLLTAWATA Sbjct: 375 ALAPTLATMGNKALFVLAFGIILSMYGGGFATIPAYLADIFGTQFVGAIHGRLLTAWATA 434 Query: 424 GILGPVVVNYMREYQLSLGM-PREQVYNTTMYILAGMLVVGLICNLLVRPVAAKHFMTPE 482 GI GPVVVNY+RE Q++ G+ P +Y +TMYILAGML +GLI N VRP+A K FM+ Sbjct: 435 GIAGPVVVNYIREAQIAAGVAPGPALYTSTMYILAGMLAIGLIANAFVRPLADKWFMSDA 494 Query: 483 ELAREKQLAHEKSSSDNTTSLSPTDMALVGRGGNPALIGAAWLAVGIPLIWGISLTLQKT 542 E+A + ++ PT +GRGG A AW AVGIPL+WG+ +T++ + Sbjct: 495 EVAALQAKTAAANA-------GPTGSFGIGRGGLDAKAALAWAAVGIPLLWGVWVTVRSS 547 Query: 543 AVLF 546 LF Sbjct: 548 LALF 551 >NMA1574 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 513 Score = 488 bits (1257), Expect = e-137, Method: Compositional matrix adjust. Identities = 278/546 (50%), Positives = 369/546 (67%), Gaps = 38/546 (6%) Query: 4 DFLQKEHTIAKPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSRALGIKESIACAPDTG 63 FL +E +IAKPGFNRWLVPPAALA+HL IG Y +SVF PL++ +GI ES A Sbjct: 2 KFLDREASIAKPGFNRWLVPPAALAVHLAIGQIYAYSVFNAPLTKLIGITESAAG----- 56 Query: 64 FFAQVFSTTCDWKISMLGWMYTMFFVLLGISAAIWGGWLERAGPRKAGVVSALCWCGGLL 123 DWK++ +GW++++ +LG SAA++G W+ER GPRKA +A C+ G Sbjct: 57 ----------DWKLTTVGWIFSIALAMLGASAALFGTWMERVGPRKAIFAAACCFSLGFF 106 Query: 124 ISALGVYTHQIWLMWLGSGVIGGIGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGA 183 +SA GV TH ++L++LG+GVIGG+GLGLGYI PVSTL+KWFPD+ GMATG+AIMGFGGGA Sbjct: 107 VSAFGVRTHNLFLLYLGNGVIGGVGLGLGYIGPVSTLMKWFPDKPGMATGLAIMGFGGGA 166 Query: 184 LVGSPLADKLMKHFATPTSVGVWETFVAMAVIYFVFMMAGALGYRVPPSGWKPAGWTPPA 243 ++ SPL+ LM F+ TSVGV ETF + ++Y MM GA RVP GWKP G+T P Sbjct: 167 MLASPLSVSLMNTFSNATSVGVAETFAVLGLLYLALMMFGAFTIRVPADGWKPEGYTAPK 226 Query: 244 TTNSTMITQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGISSPMLQEVFGGHLLGVN 303 T N +++ NHV+VS+ PQFWL++ VLCLNV+AGIGV+G +S M+QE+F +G Sbjct: 227 TQNK-LVSSNHVNVSQAMKTPQFWLLFWVLCLNVTAGIGVLGQASVMIQELFSETSIG-- 283 Query: 304 VGFSDLSIEQKAAIAAIAAGFTGLISLFNIGGRFVWASCSDFFGRKMTYVIFFVLGFILY 363 Q A A AAGF L+SLFN+GGRF+W+S SD GRK TY IFFVLG +LY Sbjct: 284 --------RQAAVGAGAAAGFVSLLSLFNMGGRFLWSSVSDKIGRKNTYTIFFVLGSLLY 335 Query: 364 VSLPWSAKAGSIALFVGAVCIILSMYGGGFSTVPAYLADLFGTQMVGAIHGRLLTAWATA 423 ++P + GS ALF+ C+I+SMYGGGF+ +PAYL DLFGT VGAIHGR+L AW+TA Sbjct: 336 FAVPSIGEGGSKALFIIGFCVIISMYGGGFAAIPAYLKDLFGTYQVGAIHGRILLAWSTA 395 Query: 424 GILGPVVVNYMREYQLSLGMPREQVYNTTMYILAGMLVVGLICNLLVRPVAAKHFMTPEE 483 ++GPV+VNY+R+ Q+ G+P Q Y+ TMYI+AG+L++GL+CNL V+ V KH Sbjct: 396 AVIGPVLVNYIRQSQIDSGIPAAQAYSVTMYIMAGLLIIGLLCNLAVKSVHEKHH----- 450 Query: 484 LAREKQLAHEKSSSDNTTSLSPTDMALVGRGGNPALIGAAW---LAVGIPLIWGISLTLQ 540 ++ + A + D+ T++S D LVG + I W LAV IPL +G+ + Sbjct: 451 -EKDIKTAAHSGNPDDETAIS--DAYLVGEKVSGGGISVWWRWALAV-IPLAYGVVMIFV 506 Query: 541 KTAVLF 546 K LF Sbjct: 507 KALDLF 512 >NMB1362 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 513 Score = 484 bits (1245), Expect = e-136, Method: Compositional matrix adjust. Identities = 276/546 (50%), Positives = 367/546 (67%), Gaps = 38/546 (6%) Query: 4 DFLQKEHTIAKPGFNRWLVPPAALAIHLCIGMAYGFSVFWLPLSRALGIKESIACAPDTG 63 FL +E +IAKPGFNRWLVPPAALA+HL IG Y +SVF PL++ +GI ES A Sbjct: 2 KFLDREASIAKPGFNRWLVPPAALAVHLAIGQIYAYSVFNAPLTKLIGITESAAG----- 56 Query: 64 FFAQVFSTTCDWKISMLGWMYTMFFVLLGISAAIWGGWLERAGPRKAGVVSALCWCGGLL 123 DWK++ +GW++++ +LG SAA++G W+ER GPRKA +A C+ G Sbjct: 57 ----------DWKLTTVGWIFSIALAMLGASAALFGTWMERVGPRKAIFAAACCFSLGFF 106 Query: 124 ISALGVYTHQIWLMWLGSGVIGGIGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGA 183 +SA GV TH ++L++LG+GVIGG+GLGLGYI PVSTL+KWFPD+ GMATG+AIMGFGGGA Sbjct: 107 VSAFGVRTHNLFLLYLGNGVIGGVGLGLGYIGPVSTLMKWFPDKPGMATGLAIMGFGGGA 166 Query: 184 LVGSPLADKLMKHFATPTSVGVWETFVAMAVIYFVFMMAGALGYRVPPSGWKPAGWTPPA 243 ++ SPL+ LM F+ SVGV ETF + ++Y MM GA RVP GWKP G+T P Sbjct: 167 MLASPLSVSLMNTFSNAASVGVAETFAVLGLLYLALMMFGAFTIRVPADGWKPEGYTAPK 226 Query: 244 TTNSTMITQNHVHVSKVWGIPQFWLVWLVLCLNVSAGIGVIGISSPMLQEVFGGHLLGVN 303 T N +++ NHV+VS+ PQFWL++ VLCLNV+AGIGV+G +S M+QE+F +G Sbjct: 227 TQNK-LVSSNHVNVSQAMKTPQFWLLFWVLCLNVTAGIGVLGQASVMIQELFSETSIG-- 283 Query: 304 VGFSDLSIEQKAAIAAIAAGFTGLISLFNIGGRFVWASCSDFFGRKMTYVIFFVLGFILY 363 Q A A AAGF L+SLFN+GGRF+W+S SD GRK TY IFFVLG +LY Sbjct: 284 --------RQAAVGAGAAAGFVSLLSLFNMGGRFLWSSVSDKIGRKNTYTIFFVLGSLLY 335 Query: 364 VSLPWSAKAGSIALFVGAVCIILSMYGGGFSTVPAYLADLFGTQMVGAIHGRLLTAWATA 423 ++P + GS ALF+ C+I+SMYGGGF+ +PAYL DLFGT VGAIHGR+L AW+TA Sbjct: 336 FAVPSIGEGGSKALFIIGFCVIISMYGGGFAAIPAYLKDLFGTYQVGAIHGRILLAWSTA 395 Query: 424 GILGPVVVNYMREYQLSLGMPREQVYNTTMYILAGMLVVGLICNLLVRPVAAKHFMTPEE 483 ++GPV+VNY+R+ Q+ G+P Q Y+ TMYI+A +L++GL+CNL V+ V KH Sbjct: 396 AVIGPVLVNYIRQSQIDSGIPAAQAYSVTMYIMACLLIIGLLCNLAVKSVHEKHH----- 450 Query: 484 LAREKQLAHEKSSSDNTTSLSPTDMALVGRGGNPALIGAAW---LAVGIPLIWGISLTLQ 540 ++ + A + D+ T++S D LVG + I W LAV IPL +G+ + Sbjct: 451 -EKDIKTAAHSGNPDDETAIS--DAYLVGEKVSGGGISVWWRWALAV-IPLAYGVVMVFV 506 Query: 541 KTAVLF 546 K LF Sbjct: 507 KALDLF 512 >BH2528 [GEPR] COG0477 Permeases of the major facilitator superfamily Bha Bacillus halodurans Length = 419 Score = 272 bits (695), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 175/456 (38%), Positives = 253/456 (55%), Gaps = 61/456 (13%) Query: 18 NRWLVPPAALAIHLCIGMAYGFSVFWLPLSRALGIKESIACAPDTGFFAQVFSTTCDWKI 77 NRWL+ AA+ IH+ IG Y +SVF PL G W + Sbjct: 6 NRWLIALAAVGIHISIGSVYAWSVFTNPLIEQFG-----------------------WGL 42 Query: 78 SMLGWMYTMFFVLLGISAAIWGGWLERAGPRKAGVVSALCWCGGLLISALGVYTHQIWLM 137 + +++ LG+SAA G ++E+ GPRK+G+V+A + G L + L V +WL+ Sbjct: 43 GEVSLTFSIAIAFLGVSAAFMGHFVEKHGPRKSGMVAASFFGLGTLGAGLAVSLESLWLL 102 Query: 138 WLGSGVIGGIGLGLGYISPVSTLIKWFPDRRGMATGMAIMGFGGGALVGSPLADKLMKHF 197 + GV+GG GLG+GYI+PVSTL+KWFPDRRG+ATG+AIMGFG +LV SP+ + + Sbjct: 103 YFSYGVLGGFGLGVGYITPVSTLVKWFPDRRGLATGLAIMGFGFASLVFSPIMNAFI--- 159 Query: 198 ATPTSVGVWETFVAMAVIYFVFMMAGALGYRVPPSGWKPAGWTPPATTNSTMITQN--HV 255 TSVG+ TF + +Y + M AL PP GW PAG+ T N + Q+ + Sbjct: 160 ---TSVGIAATFFILGGLYMIIMFTAALYLEPPPQGWVPAGFKEAKTENGRLQKQDLSQL 216 Query: 256 HVSKVWGIPQFWLVWLVLCLNVSAGIGVIGISSPMLQEVFGGHLLGVNVGFSDLSIEQKA 315 ++ +FW +W +L +NV+ GI ++ ++SPM QE+ Sbjct: 217 TANEAVKTKRFWFLWTMLFINVTCGIAILAVASPMAQEI-------------------TG 257 Query: 316 AIAAIAAGFTGLISLFNIGGRFVWASCSDFFGRKMTYVIFFVLGFILYVSLPWSAKAGSI 375 AA AA GL+ LFN GR WAS SD+ GR Y FF++ + +V LP + Sbjct: 258 MTAATAATMVGLMGLFNGLGRIGWASISDYIGRPNVYTAFFLIQIVAFVMLP---SITHV 314 Query: 376 ALFVGAVCIILSMYGGGFSTVPAYLADLFGTQMVGAIHGRLLTAWATAGILGPVVVNYMR 435 LF + I++ YGGGF+++PAY+ DLFGT+ +GAIHG +LTAWA AG++GP++ +Y+R Sbjct: 315 LLFQVVLFFIMTCYGGGFASIPAYIGDLFGTKQLGAIHGYILTAWALAGLVGPMIASYIR 374 Query: 436 EYQLSLGMPREQVYNTTMYILAGMLVVGLICNLLVR 471 E S Y T+YI GM +V L +L +R Sbjct: 375 ETTNS--------YAGTLYIFTGMFIVALAVSLFIR 402