BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0017.0081.p (454 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0945 [R] COG0312 Predicted Zn-dependent proteases and their i... 643 0.0 NMA1048 [R] COG0312 Predicted Zn-dependent proteases and their i... 427 e-119 NMB0839 [R] COG0312 Predicted Zn-dependent proteases and their i... 426 e-119 pmbA [R] COG0312 Predicted Zn-dependent proteases and their inac... 419 e-117 ZpmbA [R] COG0312 Predicted Zn-dependent proteases and their ina... 419 e-117 >RSc0945 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs Rso Ralstonia solanacearum Length = 457 Score = 643 bits (1658), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/453 (74%), Positives = 384/453 (84%), Gaps = 4/453 (0%) Query: 2 SDTVFTHSQDQLKQLAQDVLRYAKEKGASDAAVDISEGSGLSVAVRKGQIETIEQNKDKG 61 +D+VF + +++L+++A+DVLR A+E GA+DAA +ISEG GLSV VRKG+IETIEQN+DK Sbjct: 9 TDSVFAYRRERLEEMARDVLRIARELGATDAATEISEGQGLSVTVRKGEIETIEQNRDKV 68 Query: 62 IGVTVYLGEGRNVRRGNASTSDFSQQALKETVEAAYNIARFTAIDDCAGLPDEENLEFNP 121 +GVTV LG+ +RGNASTSDFS AL+ TVEAAYNIARFTA DDCAGL +EE LE P Sbjct: 69 VGVTVMLGK----KRGNASTSDFSPAALRSTVEAAYNIARFTADDDCAGLAEEELLERQP 124 Query: 122 RDLKLCTPWLITAEEAVELAQRCEAAALSVDKRITNSEGASVYAQQSHFVAANSRGFIGG 181 RDL L PW + AE AVE+A+ EAAA +V +I NS+GASV AQ SHFV A SRGF+GG Sbjct: 125 RDLSLYHPWTLDAEAAVEIARAAEAAAFAVSPKIRNSDGASVSAQHSHFVLATSRGFLGG 184 Query: 182 YPFSRHTISVAPIAGKGSNMQRDDWYSSMRDPKKLAKPEAIGRYAAERALARLNACKLST 241 YP+SRH IS APIAG G MQRDDWYSS R PK LA PEAIG+YAAERALARL A +LST Sbjct: 185 YPYSRHFISCAPIAGSGQQMQRDDWYSSKRSPKDLAAPEAIGQYAAERALARLAARRLST 244 Query: 242 RKCPVLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGKQVLPGHIQILEDPHVIGGV 301 RKCPVLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGK + H+QI EDPHV G+ Sbjct: 245 RKCPVLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGKAIFAPHVQIKEDPHVPSGM 304 Query: 302 GSAPFDDEGVKTHRREVVKDGVVQGYFLSTYSARKLGMQTTGNSGGSHNLSITSSLTTAS 361 GSAPFD+EGV+T RR+VV+DGVV+GYFLSTYSARKLGMQTTGN+GGSHNL++ S T Sbjct: 305 GSAPFDEEGVRTQRRDVVRDGVVEGYFLSTYSARKLGMQTTGNAGGSHNLTLFSDRTQPG 364 Query: 362 DNFKGMLKKLDTGLLVTELMGQGVNYVTGDYSRGASGYWVEKGVIQYPVEEITIAGNMRD 421 D+F GML+++ TGLLVTELMGQGVNYVTGDYSRGASGYWVE GVIQYPVEEITIAGN+RD Sbjct: 365 DDFAGMLRRMGTGLLVTELMGQGVNYVTGDYSRGASGYWVENGVIQYPVEEITIAGNLRD 424 Query: 422 MLRQIVAIGNDTLIRGTKETGSILLESMTIAGD 454 M RQIVAIG D LIRGTKETGSIL+E MTIAG+ Sbjct: 425 MFRQIVAIGADALIRGTKETGSILIEQMTIAGE 457 >NMA1048 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs NmA Neisseria meningitidis Z2491 Length = 443 Score = 427 bits (1098), Expect = e-119, Method: Compositional matrix adjust. Identities = 223/449 (49%), Positives = 300/449 (66%), Gaps = 8/449 (1%) Query: 5 VFTHSQDQLKQLAQDVLRYAKEKGASDAAVDISEGSGLSVAVRKGQIETIEQNKDKGIGV 64 +F H+ +L L + L AK GA+ A D SE G SV+VR G+IE IE +DK + + Sbjct: 2 LFNHTASELLDLCRRTLDLAKATGATAAEADFSESLGQSVSVRLGEIEQIEFQQDKSLDI 61 Query: 65 TVYLGEGRNVRRGNASTSDFSQQALKETVEAAYNIARFTAIDDCAGLPDEENLEFNPRDL 124 TVY+G+ R+G A T+DFS+QAL++TV AA +IAR TA D CAGL D E + + D Sbjct: 62 TVYVGK----RKGRAGTADFSEQALRDTVRAAADIARHTAEDGCAGLADPELMAQHIGDP 117 Query: 125 KLCTPWLITAEEAVELAQRCEAAALSVDKRITNSEGASVYAQQSHFVAANSRGFIGGYPF 184 L W + E AV LA++CE AAL+ D+RI NSEGA+V +V N+ GF Sbjct: 118 DLYHEWDLDTEAAVGLAKQCEQAALNEDERIENSEGAAVQTGHYQYVYGNTYGFAAHRQS 177 Query: 185 SRHTISVAPIAGKGSNMQRDDWYSSMRDPKKLAKPEAIGRYAAERALARLNACKLSTRKC 244 + H+IS + +A + MQRD WY S + PE IG+ AA R L RL + + T Sbjct: 178 THHSISCSVVAADENGMQRDYWYDSACRHPDMDSPETIGQTAARRTLRRLGSRSIPTGNY 237 Query: 245 PVLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGKQVLPGHIQILEDPHVIGGVGSA 304 PVLF+ ++ GL+G V A+SGGALYR+S+FL+DS+GK+VLP + + E+PH+ S+ Sbjct: 238 PVLFDTTVSGGLIGHLVGALSGGALYRQSSFLIDSIGKKVLPDFLNLREEPHIPRSFRSS 297 Query: 305 PFDDEGVKTHRREVVKDGVVQGYFLSTYSARKLGMQTTGNSGGSHNLSITSSLTTASDNF 364 FD EGV T R V+++G+V+GYFLS+YSARKLGMQTTGN+GG+HNL + + T SD Sbjct: 298 YFDAEGVATAPRFVIQNGIVEGYFLSSYSARKLGMQTTGNAGGAHNLYLNHTHETQSD-- 355 Query: 365 KGMLKKLDTGLLVTELMGQGVNYVTGDYSRGASGYWVEKGVIQYPVEEITIAGNMRDMLR 424 +LK++ TGLLVTELMGQG N +TGDYSRGA+G+WVE GVI YPV EIT+AG ++DM R Sbjct: 356 --LLKEMGTGLLVTELMGQGANTITGDYSRGAAGFWVENGVIAYPVHEITVAGRLQDMYR 413 Query: 425 QIVAIGNDTLIRGTKETGSILLESMTIAG 453 IV + +D L R + + GSIL+ MT+AG Sbjct: 414 DIVGVADDALRRSSNKIGSILIAGMTVAG 442 >NMB0839 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs Nme Neisseria meningitidis MC58 Length = 443 Score = 426 bits (1094), Expect = e-119, Method: Compositional matrix adjust. Identities = 222/449 (49%), Positives = 301/449 (67%), Gaps = 8/449 (1%) Query: 5 VFTHSQDQLKQLAQDVLRYAKEKGASDAAVDISEGSGLSVAVRKGQIETIEQNKDKGIGV 64 +F H+ +L L + L AK GA+ A D SE G SV+VR G+IE IE +DK + + Sbjct: 2 LFNHTASELLDLCRRTLDLAKATGATAAEADFSESLGQSVSVRLGEIEQIEFQQDKSLDI 61 Query: 65 TVYLGEGRNVRRGNASTSDFSQQALKETVEAAYNIARFTAIDDCAGLPDEENLEFNPRDL 124 TVY+G+ R+G AST+DFS++AL++TV+AA +IAR TA D CAGL D + + D Sbjct: 62 TVYVGK----RKGRASTADFSEKALQDTVKAAIDIARHTAEDGCAGLADACLMAKHIGDP 117 Query: 125 KLCTPWLITAEEAVELAQRCEAAALSVDKRITNSEGASVYAQQSHFVAANSRGFIGGYPF 184 L W + E AV LA++CE AAL+ D+RI NSEGA+V +V N+ GF Sbjct: 118 DLYHEWDLDTEAAVGLAKQCEQAALNEDERIENSEGAAVQTGHYQYVYGNTHGFAAHRQG 177 Query: 185 SRHTISVAPIAGKGSNMQRDDWYSSMRDPKKLAKPEAIGRYAAERALARLNACKLSTRKC 244 + H+IS + +A + MQRD WY S + PE IG+ AA R L RL + + T Sbjct: 178 THHSISCSVVAADENGMQRDYWYDSACRHPDMDSPETIGQTAARRTLRRLGSRSIPTGSY 237 Query: 245 PVLFEAPLAAGLLGAFVQAVSGGALYRKSTFLLDSLGKQVLPGHIQILEDPHVIGGVGSA 304 PVLF+ ++ GL+G V A+SGGALYR+S+FL+DS+GK+VLP + + E+PH+ S+ Sbjct: 238 PVLFDTTVSGGLIGHLVGALSGGALYRQSSFLIDSIGKKVLPDFLNLREEPHIPRSFRSS 297 Query: 305 PFDDEGVKTHRREVVKDGVVQGYFLSTYSARKLGMQTTGNSGGSHNLSITSSLTTASDNF 364 FD EGV T R V+++G+V+GYFLS+YSARKLGMQTTGN+GG+HNL + + T SD Sbjct: 298 YFDAEGVATAPRFVIQNGIVEGYFLSSYSARKLGMQTTGNAGGAHNLYLNHTHETQSD-- 355 Query: 365 KGMLKKLDTGLLVTELMGQGVNYVTGDYSRGASGYWVEKGVIQYPVEEITIAGNMRDMLR 424 +LK++ TGLLVTELMGQG N +TGDYSRGA+G+WVE GVI YPV EIT+AG ++DM R Sbjct: 356 --LLKEMGTGLLVTELMGQGANTITGDYSRGAAGFWVENGVIAYPVHEITVAGRLQDMYR 413 Query: 425 QIVAIGNDTLIRGTKETGSILLESMTIAG 453 IV + +D L R + + GSIL+ MT+AG Sbjct: 414 DIVGVADDALRRSSNKIGSILIAGMTVAG 442 >pmbA [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs Eco Escherichia coli K12 Length = 450 Score = 419 bits (1076), Expect = e-117, Method: Compositional matrix adjust. Identities = 214/427 (50%), Positives = 292/427 (68%), Gaps = 9/427 (2%) Query: 28 GASDAA-VDISEGSGLSVAVRKGQIETIEQNKDKGIGVTVYLGEGRNVRRGNASTSDFSQ 86 G SD A V +S+ +G+SV+ R G++E +E N D +G+TVY R+G+AS++D S Sbjct: 31 GKSDGAEVAVSKTTGISVSTRYGEVENVEFNSDGALGITVY----HQNRKGSASSTDLSP 86 Query: 87 QALKETVEAAYNIARFTAIDDCAGLPDEENLEFNPRDLKLCTPWLITAEEAVELAQRCEA 146 QA+ TV+AA +IAR+T+ D CAG+ D+E L F+ DL L P ++ +EA+ELA R E Sbjct: 87 QAIARTVQAALDIARYTSPDPCAGVADKELLAFDAPDLDLFHPAEVSPDEAIELAARAEQ 146 Query: 147 AALSVDKRITNSEGASVYAQQSHFVAANSRGFIGGYPFSRHTISVAPIAGKGSNMQRDDW 206 AAL DKRITN+EG S + V NS G + GY +RH++S IA + +M+RD Sbjct: 147 AALQADKRITNTEGGSFNSHYGVKVFGNSHGMLQGYCSTRHSLSSCVIAEENGDMERDYA 206 Query: 207 YSSMRDPKKLAKPEAIGRYAAERALARLNACKLSTRKCPVLFEAPLAAGLLGAFVQAVSG 266 Y+ R L PE +G A R L+RL+ KLST K PV+F +A GL G V A++G Sbjct: 207 YTIGRAMSDLQTPEWVGADCARRTLSRLSPRKLSTMKAPVIFANEVATGLFGHLVGAIAG 266 Query: 267 GALYRKSTFLLDSLGKQVLPGHIQILEDPHVIGGVGSAPFDDEGVKTHRREVVKDGVVQG 326 G++YRKSTFLLDSLGKQ+LP + I E PH++ G+ S PFD EGV+T RR+++KDG++ Sbjct: 267 GSVYRKSTFLLDSLGKQILPDWLTIEEHPHLLKGLASTPFDSEGVRTERRDIIKDGILTQ 326 Query: 327 YFLSTYSARKLGMQTTGNSGGSHNLSITSSLTTASDNFKGMLKKLDTGLLVTELMGQGVN 386 + L++YSARKLG+++TG++GG HN I +F+ MLK++ TGL+VTELMGQGV+ Sbjct: 327 WLLTSYSARKLGLKSTGHAGGIHNWRIAGQ----GLSFEQMLKEMGTGLVVTELMGQGVS 382 Query: 387 YVTGDYSRGASGYWVEKGVIQYPVEEITIAGNMRDMLRQIVAIGNDTLIRGTKETGSILL 446 +TGDYSRGA+G+WVE G IQYPV EITIAGN++DM R IV +GND R + GS+LL Sbjct: 383 AITGDYSRGAAGFWVENGEIQYPVSEITIAGNLKDMWRNIVTVGNDIETRSNIQCGSVLL 442 Query: 447 ESMTIAG 453 M IAG Sbjct: 443 PEMKIAG 449 >ZpmbA [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs EcZ Escherichia coli O157:H7 EDL933 Length = 450 Score = 419 bits (1076), Expect = e-117, Method: Compositional matrix adjust. Identities = 214/427 (50%), Positives = 292/427 (68%), Gaps = 9/427 (2%) Query: 28 GASDAA-VDISEGSGLSVAVRKGQIETIEQNKDKGIGVTVYLGEGRNVRRGNASTSDFSQ 86 G SD A V +S+ +G+SV+ R G++E +E N D +G+TVY R+G+AS++D S Sbjct: 31 GKSDGAEVAVSKTTGISVSTRYGEVENVEFNSDGALGITVY----HQNRKGSASSTDLSP 86 Query: 87 QALKETVEAAYNIARFTAIDDCAGLPDEENLEFNPRDLKLCTPWLITAEEAVELAQRCEA 146 QA+ TV+AA +IAR+T+ D CAG+ D+E L F+ DL L P ++ +EA+ELA R E Sbjct: 87 QAIARTVQAALDIARYTSPDPCAGVADKELLAFDAPDLDLFHPAEVSPDEAIELAARAEQ 146 Query: 147 AALSVDKRITNSEGASVYAQQSHFVAANSRGFIGGYPFSRHTISVAPIAGKGSNMQRDDW 206 AAL DKRITN+EG S + V NS G + GY +RH++S IA + +M+RD Sbjct: 147 AALQADKRITNTEGGSFNSHYGVKVFGNSHGMLQGYCSTRHSLSSCVIAEENGDMERDYA 206 Query: 207 YSSMRDPKKLAKPEAIGRYAAERALARLNACKLSTRKCPVLFEAPLAAGLLGAFVQAVSG 266 Y+ R L PE +G A R L+RL+ KLST K PV+F +A GL G V A++G Sbjct: 207 YTIGRAMSDLQTPEWVGADCARRTLSRLSPRKLSTMKAPVIFANEVATGLFGHLVGAIAG 266 Query: 267 GALYRKSTFLLDSLGKQVLPGHIQILEDPHVIGGVGSAPFDDEGVKTHRREVVKDGVVQG 326 G++YRKSTFLLDSLGKQ+LP + I E PH++ G+ S PFD EGV+T RR+++KDG++ Sbjct: 267 GSVYRKSTFLLDSLGKQILPDWLTIEEHPHLLKGLASTPFDSEGVRTERRDIIKDGILTQ 326 Query: 327 YFLSTYSARKLGMQTTGNSGGSHNLSITSSLTTASDNFKGMLKKLDTGLLVTELMGQGVN 386 + L++YSARKLG+++TG++GG HN I +F+ MLK++ TGL+VTELMGQGV+ Sbjct: 327 WLLTSYSARKLGLKSTGHAGGIHNWRIAGQ----GLSFEQMLKEMGTGLVVTELMGQGVS 382 Query: 387 YVTGDYSRGASGYWVEKGVIQYPVEEITIAGNMRDMLRQIVAIGNDTLIRGTKETGSILL 446 +TGDYSRGA+G+WVE G IQYPV EITIAGN++DM R IV +GND R + GS+LL Sbjct: 383 AITGDYSRGAAGFWVENGEIQYPVSEITIAGNLKDMWRNIVTVGNDIETRSNIQCGSVLL 442 Query: 447 ESMTIAG 453 M IAG Sbjct: 443 PEMKIAG 449