BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0017.0048.p (455 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1278 [GEPR] COG0477 Permeases of the major facilitator superf... 395 e-109 STM3887 [GEPR] COG0477 Permeases of the major facilitator superf... 371 e-102 STM2129 [GEPR] COG0477 Permeases of the major facilitator superf... 362 1e-99 yieO [GEPR] COG0477 Permeases of the major facilitator superfami... 359 8e-99 ZyieO [GEPR] COG0477 Permeases of the major facilitator superfam... 358 1e-98 >RSp1278 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 476 Score = 395 bits (1014), Expect = e-109, Method: Compositional matrix adjust. Identities = 223/454 (49%), Positives = 312/454 (68%), Gaps = 12/454 (2%) Query: 6 SRSQKALLWIVASGFFMQTLDTTIVNTALPSMAASLGEPVLAMHPVVVSYTLAMASLTPA 65 +S + LLW+VA G FMQTLD TIVNTALP+MA SL E L M V+++YTL A L PA Sbjct: 8 DKSLQPLLWLVAVGLFMQTLDATIVNTALPAMARSLSESPLQMQSVIIAYTLTTAMLMPA 67 Query: 66 SGWLADRFGTRRVYFLAILIFVLGSLLCANAHSLSQLLLARVVQGVGGSMLLPIGRLAVL 125 SGWLADRFGTRR++F AI +F +GSLLCA + +L+ L++ARVVQGVGG++L+P+GRL VL Sbjct: 68 SGWLADRFGTRRMFFAAIFLFSVGSLLCAESRTLTMLIVARVVQGVGGALLMPVGRLTVL 127 Query: 126 RSVPGAQYISALAFISIAGQLGPVVGPVTGGWLSQTIGWHWIFLINVPVGVIGMFAVHRF 185 R VP Q++ A++F++I G +GP++GP GGWL + + WHWIFLIN+PVGV+G + Sbjct: 128 RVVPREQFLPAMSFVTIPGLIGPLIGPTLGGWLVEAVSWHWIFLINLPVGVVGALVTLKV 187 Query: 186 LP---AEEIVSPPRFDMLGCALLSTCMVAFSLALD--VPMEEHRAWWSAGL-FGISVLTV 239 +P + + FD G +L+ M + S +LD + RA L FG++ LT Sbjct: 188 MPDVRGDAADAADAFDWAGYLMLAFGMASVSFSLDGLSDLGFRRATVLVLLMFGLAALTA 247 Query: 240 WWYVVHARRDEQPLFRLGLFNEPNFSVGLIGNLICRIGSSAVPFLLPLLLQVKLGFSPLH 299 +W +HA R +Q LF LF P+FSVG++GNL RIG+ +PFL+PLLLQV LG+SP+ Sbjct: 248 YW--LHAGRAKQALFPRALFAIPSFSVGILGNLFARIGAGGMPFLIPLLLQVGLGYSPMQ 305 Query: 300 AGLVLLPAAVAGTIAKPWIAPLVRRYGYENFLLVNTVMVGAAIVSFALITPAWPIWIGIV 359 AGL+++P AVAG AKP LV+R+GY + L NT+++G IVSFAL +P P+W+ IV Sbjct: 306 AGLMMVPVAVAGMAAKPLGTWLVKRHGYRHMLFGNTLLLGLMIVSFALSSPQEPLWLRIV 365 Query: 360 QLAVFGVCNSMQFAAMNSVTLKGLNSKDAGSGNSLFSMVQMLALGLGVTIAGSMLSGIDG 419 QLA FG NSMQF +MN++TL+ L+ A +GNS+ SMV ML++ LGV AG++L+G Sbjct: 366 QLAAFGTFNSMQFTSMNALTLRDLSGAQASAGNSMLSMVMMLSMSLGVAAAGALLNGFSE 425 Query: 420 VAWARD----WSFTLTFVCVGLVTLLSALVFRRM 449 A + +F ++C+GL+T + +F ++ Sbjct: 426 YAGGQPADTLGAFHKAYICLGLITTAAGWIFAQL 459 >STM3887 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 475 Score = 371 bits (953), Expect = e-102, Method: Compositional matrix adjust. Identities = 200/458 (43%), Positives = 291/458 (63%), Gaps = 5/458 (1%) Query: 1 MSLNSSRSQKALLWIVASGFFMQTLDTTIVNTALPSMAASLGEPVLAMHPVVVSYTLAMA 60 M+ +RS L WI A FFMQ LD TI+NTALP++A SL LAM ++SYTL +A Sbjct: 1 MTSKKARSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVA 60 Query: 61 SLTPASGWLADRFGTRRVYFLAILIFVLGSLLCANAHSLSQLLLARVVQGVGGSMLLPIG 120 L P SGWLADRFGTRRV+ +A+ +F LGSL CA + SLS+L++ RVVQGVGG+M++P+ Sbjct: 61 MLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVA 120 Query: 121 RLAVLRSVPGAQYISALAFISIAGQLGPVVGPVTGGWLSQTIGWHWIFLINVPVGVIGMF 180 RLA+LR+ P ++ + L F+++ G +GP++GPV GG L WHWIFLIN+P+GV G+ Sbjct: 121 RLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGIL 180 Query: 181 AVHRFLPAEEIVSPPR-FDMLGCALLSTCMVAFSLALDVPMEEHRAWW-SAGLFGISVLT 238 +++P +P R FDM G L +V FS +++ E+ A W ++ + S++ Sbjct: 181 YARKYMP--NFTTPRRKFDMTGFFLFGLSLVLFSSGMELFGEKIVATWIASAIIFCSIVL 238 Query: 239 VWWYVVHARRDEQPLFRLGLFNEPNFSVGLIGNLICRIGSSAVPFLLPLLLQVKLGFSPL 298 + Y+ HARR PL L LF FSVG+ GNL R+G+ VPFL+PL+LQV G+ L Sbjct: 239 LLAYIRHARRHPTPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPAL 298 Query: 299 HAGLVLLPAAVAGTIAKPWIAPLVRRYGYENFLLVNTVMVGAAIVSFALITPAWPIWIGI 358 AG ++ P A+ IAK + ++RR GY L+ TV +G I F+ +PA PIW+ + Sbjct: 299 IAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFQSPAMPIWMLV 358 Query: 359 VQLAVFGVCNSMQFAAMNSVTLKGLNSKDAGSGNSLFSMVQMLALGLGVTIAGSMLSGID 418 + L + G+ S QF AMN++TL L +A SGNS+ ++ Q L++ LGV I+ ++L + Sbjct: 359 LPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIYE 418 Query: 419 GVAWARD-WSFTLTFVCVGLVTLLSALVFRRMDARYFN 455 G A F TF+ +G +T++SAL+F + A+ N Sbjct: 419 GFAGTSTVEQFHYTFITMGAITIVSALMFMLLRAKDGN 456 >STM2129 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 470 Score = 362 bits (928), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 206/446 (46%), Positives = 291/446 (65%), Gaps = 15/446 (3%) Query: 13 LWIVASGFFMQTLDTTIVNTALPSMAASLGEPVLAMHPVVVSYTLAMASLTPASGWLADR 72 LWIVA GFFMQ+LDTTIVNTALPSMA SLGE L MH VVVSY L +A + PASGWLAD+ Sbjct: 12 LWIVAFGFFMQSLDTTIVNTALPSMAKSLGESPLHMHMVVVSYVLTVAVMLPASGWLADK 71 Query: 73 FGTRRVYFLAILIFVLGSLLCANAHSLSQLLLARVVQGVGGSMLLPIGRLAVLRSVPGAQ 132 G R ++F AI++F LGSL CA + +L+QL+LARV+QGVGG+M++P+GRL V++ VP AQ Sbjct: 72 IGVRNIFFAAIVLFTLGSLFCALSGTLNQLVLARVLQGVGGAMMVPVGRLTVMKIVPRAQ 131 Query: 133 YISALAFISIAGQLGPVVGPVTGGWLSQTIGWHWIFLINVPVGVIGMFAVHRFLPAEEIV 192 Y++A+ F+++ GQ+GP++GP GG L + WHWIFLIN+PVG++G A +P I+ Sbjct: 132 YMAAMTFVTLPGQIGPLLGPALGGVLVEYASWHWIFLINIPVGIVGAMATFMLMP-NYII 190 Query: 193 SPPRFDMLGCALLSTCMVAFSLALDVPMEEHRAWWS-AGLFGISVLTVWWYVVHARRDEQ 251 RFD+ G LL+ M +LALD + W+ AGL + Y+ HA+++ Sbjct: 191 ETRRFDLPGFLLLAIGMAVLTLALDGSKSMGISPWTLAGLAAGGAAAILLYLFHAKKNSG 250 Query: 252 PLFRLGLFNEPNFSVGLIGNLICRIGSSAVPFLLPLLLQVKLGFSPLHAGLVLLPAAVAG 311 LF L LF P FS+GL+G+ RIGS +PF+ P+ LQ+ LGFSP HAGL+++P + Sbjct: 251 ALFSLRLFRTPTFSLGLLGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGS 310 Query: 312 TIAKPWIAPLVRRYGYENFLLVNTVMVGAAIVSFALITPAWPIWIGIVQLAVF--GVCNS 369 K + +V R+GY L+ T +G A+VS ++ A W ++ L + G+ NS Sbjct: 311 MGMKRIVVQIVNRFGYRRVLVATT--LGLALVSLLFMSVALLGWYYLLPLVLLLQGMVNS 368 Query: 370 MQFAAMNSVTLKGLNSKDAGSGNSLFSMVQMLALGLGVTIAGSMLS-------GIDGVAW 422 +F++MN++TLK L A SGNSL SM+ L++ +GVTIAG +L GID + Sbjct: 369 ARFSSMNTLTLKDLPDTLASSGNSLLSMIMQLSMSIGVTIAGMLLGMFGQQHIGID--SS 426 Query: 423 ARDWSFTLTFVCVGLVTLLSALVFRR 448 A F T++C+ ++ L A++F R Sbjct: 427 ATHHVFMYTWLCMAVIIALPAIIFAR 452 >yieO [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 475 Score = 359 bits (921), Expect = 8e-99, Method: Compositional matrix adjust. Identities = 190/450 (42%), Positives = 285/450 (63%), Gaps = 7/450 (1%) Query: 1 MSLNSSRSQKALLWIVASGFFMQTLDTTIVNTALPSMAASLGEPVLAMHPVVVSYTLAMA 60 MS RS L WI A FFMQ LD TI+NTALP++A SL LAM ++SYTL +A Sbjct: 1 MSDKKKRSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVA 60 Query: 61 SLTPASGWLADRFGTRRVYFLAILIFVLGSLLCANAHSLSQLLLARVVQGVGGSMLLPIG 120 L P SGWLADRFGTRR++ LA+ +F LGSL CA ++SL QL++ RV+QG+GG+M++P+ Sbjct: 61 MLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVA 120 Query: 121 RLAVLRSVPGAQYISALAFISIAGQLGPVVGPVTGGWLSQTIGWHWIFLINVPVGVIGMF 180 RLA+LR+ P + + L F+++ G +GP++GPV GG L WHWIFLIN+P+G+ G+ Sbjct: 121 RLALLRAYPRNELLPVLNFVAMPGLVGPILGPVLGGVLVTWATWHWIFLINIPIGIAGLL 180 Query: 181 AVHRFLPAEEIVSPPRFDMLGCALLSTCMVAFSLALDVPMEEHRAWWSA-GLFGISVLTV 239 + +P + RFD+ G L +V FS +++ E+ A W A + S+ + Sbjct: 181 YARKHMP-NFTTARRRFDITGFLLFGLSLVLFSSGIELFGEKIVASWIALTVIVTSIGLL 239 Query: 240 WWYVVHARRDEQPLFRLGLFNEPNFSVGLIGNLICRIGSSAVPFLLPLLLQVKLGFSPLH 299 Y++HARR PL L LF FS+G++GN+ R+G+ VPFL+PL+LQV G+ Sbjct: 240 LLYILHARRTPNPLISLDLFKTRTFSIGIVGNIATRLGTGCVPFLMPLMLQVGFGYQAFI 299 Query: 300 AGLVLLPAAVAGTIAKPWIAPLVRRYGYENFLLVNTVMVGAAIVSFALITPAWPIWIGIV 359 AG ++ P A+ IAK + ++RR GY + L+ TV++G I F+L +PA IW+ I+ Sbjct: 300 AGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITVIIGLMIAQFSLQSPAMAIWMLIL 359 Query: 360 QLAVFGVCNSMQFAAMNSVTLKGLNSKDAGSGNSLFSMVQMLALGLGVTIAGSML---SG 416 L + G+ S QF AMN++TL L +A SGNS+ ++ Q L++ LGV ++ ++L G Sbjct: 360 PLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAVLRVYEG 419 Query: 417 IDGVAWARDWSFTLTFVCVGLVTLLSALVF 446 ++G + + TF+ +G++T+ SA +F Sbjct: 420 MEGTTTVEQFHY--TFITMGIITVASAAMF 447 >ZyieO [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 475 Score = 358 bits (919), Expect = 1e-98, Method: Compositional matrix adjust. Identities = 189/450 (42%), Positives = 285/450 (63%), Gaps = 7/450 (1%) Query: 1 MSLNSSRSQKALLWIVASGFFMQTLDTTIVNTALPSMAASLGEPVLAMHPVVVSYTLAMA 60 MS RS L WI A FFMQ LD TI+NTALP++A SL LAM ++SYTL +A Sbjct: 1 MSDKKKRSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVA 60 Query: 61 SLTPASGWLADRFGTRRVYFLAILIFVLGSLLCANAHSLSQLLLARVVQGVGGSMLLPIG 120 L P SGWLADRFGTRR++ LA+ +F LGSL CA ++SL QL++ RV+QG+GG+M++P+ Sbjct: 61 MLIPVSGWLADRFGTRRIFTLAVSLFTLGSLACALSNSLPQLVVFRVIQGIGGAMMMPVA 120 Query: 121 RLAVLRSVPGAQYISALAFISIAGQLGPVVGPVTGGWLSQTIGWHWIFLINVPVGVIGMF 180 RLA+LR+ P + + L F+++ G +GP++GP+ GG L WHWIFLIN+P+G+ G+ Sbjct: 121 RLALLRAYPRNELLPVLNFVAMPGLVGPILGPILGGVLVTWATWHWIFLINIPIGIAGLL 180 Query: 181 AVHRFLPAEEIVSPPRFDMLGCALLSTCMVAFSLALDVPMEEHRAWWSA-GLFGISVLTV 239 + +P + RFD+ G L +V FS +++ E+ A W A + S+ + Sbjct: 181 YARKHMP-NFTTARRRFDITGFLLFGLSLVLFSSGIELFGEKIVASWIALTVIVTSIGLL 239 Query: 240 WWYVVHARRDEQPLFRLGLFNEPNFSVGLIGNLICRIGSSAVPFLLPLLLQVKLGFSPLH 299 Y++HARR PL L LF FS+G++GN+ R+G+ VPFL+PL+LQV G+ Sbjct: 240 LLYILHARRTPNPLISLDLFKTRTFSIGIVGNIATRLGTGCVPFLMPLMLQVGFGYQAFI 299 Query: 300 AGLVLLPAAVAGTIAKPWIAPLVRRYGYENFLLVNTVMVGAAIVSFALITPAWPIWIGIV 359 AG ++ P A+ IAK + ++RR GY + L+ TV++G I F+L +PA IW+ I+ Sbjct: 300 AGCMMAPTALGSIIAKSMVTQVLRRLGYRHTLVGITVIIGLMIAQFSLQSPAMAIWMLIL 359 Query: 360 QLAVFGVCNSMQFAAMNSVTLKGLNSKDAGSGNSLFSMVQMLALGLGVTIAGSML---SG 416 L + G+ S QF AMN++TL L +A SGNS+ ++ Q L++ LGV ++ ++L G Sbjct: 360 PLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAVSAAVLRVYEG 419 Query: 417 IDGVAWARDWSFTLTFVCVGLVTLLSALVF 446 ++G + + TF+ +G++T+ SA +F Sbjct: 420 MEGTTTVEQFHY--TFITMGIITVASAAMF 447