BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0182.p (286 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value MTH1726 [C] COG0372 Citrate synthase Mth Methanothermobacter the... 142 8e-34 MTH962 [C] COG0372 Citrate synthase Mth Methanothermobacter ther... 141 2e-33 aq_150 [C] COG0372 Citrate synthase Aae Aquifex aeolicus 112 1e-24 BS_mmgD [C] COG0372 Citrate synthase Bsu Bacillus subtilis 65 2e-10 NMB0431 [C] COG0372 Citrate synthase Nme Neisseria meningitidis ... 65 2e-10 >MTH1726 [C] COG0372 Citrate synthase Mth Methanothermobacter thermautotrophicus Length = 312 Score = 142 bits (358), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 81/243 (33%), Positives = 133/243 (54%), Gaps = 8/243 (3%) Query: 19 DLVAKAKAWWSTSIIDIQPGIIRIKGEPIENMIGNVGYVHMVWRMLRDDIPSAGQLHLLE 78 D++ W TSI ++P I +G E++IG V + MV+ ++R ++P +LE Sbjct: 29 DILRVKNPRWRTSITRVEPNRIVTRGYSQEDLIGGVSFSEMVYLLIRGELPPQNVARMLE 88 Query: 79 AALVSAVDHGPQAPSIAIARMSVTCGLPLNGAMSSAINMLDDIHGGAGEQCLLLFNQLLD 138 A LVS DHG PS ARM + G P++ ++ + H GA E+ + LF + + Sbjct: 89 AVLVSFCDHGVTPPSTQAARMIASAGSPVHACIAGGLLAFGKNHAGAIERSMKLFQETVS 148 Query: 139 AAEASAGEPESVLEQVMAAHAKAHGRIVPGYGHRFHPIDPRAVKLLAMVDEAAAAGVVKG 198 + E+ P++ L +++ H +A+ RI PG+GHR+H DPRAV+LL + ++ G Sbjct: 149 SCESEDEIPDAAL-RLVDDHLQANRRI-PGFGHRYHNADPRAVRLLELAEDYGCVGP--- 203 Query: 199 LHAKAGRLIEAHLAGRSSKPVPMNIDGATAVIYGELGFDAALARGLFILSRSVGILAHAW 258 H ++ L R K V MN+DGA A I ++GFD G+F++ R G+++H + Sbjct: 204 -HTSLALEVQEILLER--KGVRMNVDGANAGILSDMGFDWRTGAGVFMIGRLPGLISHVY 260 Query: 259 EQK 261 E+K Sbjct: 261 EEK 263 >MTH962 [C] COG0372 Citrate synthase Mth Methanothermobacter thermautotrophicus Length = 280 Score = 141 bits (356), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 80/234 (34%), Positives = 130/234 (55%), Gaps = 8/234 (3%) Query: 28 WSTSIIDIQPGIIRIKGEPIENMIGNVGYVHMVWRMLRDDIPSAGQLHLLEAALVSAVDH 87 W TSI ++P I +G E++IG V + MV+ ++R ++P +LEA LVS DH Sbjct: 19 WRTSITRVEPNRIVTRGYSQEDLIGGVSFSEMVYLLIRGELPPQNVARMLEAVLVSFCDH 78 Query: 88 GPQAPSIAIARMSVTCGLPLNGAMSSAINMLDDIHGGAGEQCLLLFNQLLDAAEASAGEP 147 G PS ARM + G P++ ++ + H GA E+ + LF + + + E+ P Sbjct: 79 GVTPPSTQAARMIASAGSPVHACIAGGLLAFGKNHAGAIERSMKLFQETVSSCESEDEIP 138 Query: 148 ESVLEQVMAAHAKAHGRIVPGYGHRFHPIDPRAVKLLAMVDEAAAAGVVKGLHAKAGRLI 207 ++ L +++ H +A+ RI PG+GHR+H DPRAV+LL + ++ G H + Sbjct: 139 DAAL-RLVDDHLQANRRI-PGFGHRYHNADPRAVRLLELAEDYGCVGP----HTSLALEV 192 Query: 208 EAHLAGRSSKPVPMNIDGATAVIYGELGFDAALARGLFILSRSVGILAHAWEQK 261 + L R K V MN+DGA A I ++GFD G+F++ R G+++H +E+K Sbjct: 193 QEILLER--KGVRMNVDGANAGILSDMGFDWRTGAGVFMIGRLPGLISHVYEEK 244 >aq_150 [C] COG0372 Citrate synthase Aae Aquifex aeolicus Length = 259 Score = 112 bits (279), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 69/266 (25%), Positives = 132/266 (49%), Gaps = 27/266 (10%) Query: 28 WSTSI---IDIQPGIIRIKGEPIENMIGNVGYVHMVWRMLRDDIPSAGQLHLLEAALVSA 84 W T+I ++ +P ++G + +++GN+ + ++ +L+ ++PS + +++A VS Sbjct: 6 WKTAISTHVNHEP---YVRGYRLLDLVGNLTFSEAIYLLLKGELPSEAEAKMMDAIFVSV 62 Query: 85 VDHGPQAPSIAIARMSVTCGLPLNGAMSSAINMLDDIHGGAGEQCLLLFNQLLDAAEASA 144 ++H PS+ R ++ G LN + + + HGGA E + + + S Sbjct: 63 IEHSIAPPSVIATRAVISGGNSLNVGVGAGVLAFGSAHGGALEDAM----KFMQEGVKSN 118 Query: 145 GEPESVLEQVMAAHAKAHGRIVPGYGHRFHP-IDPRAVKLLAMVDEAAAAGVVKGLHAKA 203 E ++++ ++ + +PGYGHR++ DPR +L + A G K H + Sbjct: 119 RPVEEIVKEYLS-----QKKPIPGYGHRYYKEFDPRTKRLFEL---AEKYGFCKE-HCEF 169 Query: 204 GRLIEAHLAGRSSKPVPMNIDGATAVIYGELGFDAALARGLFILSRSVGILAHAWEQKKQ 263 + +E + + K + +N+DGA A I ++GFD L +G FI+ R G++AHA+E+ Q Sbjct: 170 AKKVEEEIYKQKGKRIVLNVDGAIAAITSDMGFDWRLGKGFFIIGRVPGLVAHAYEELTQ 229 Query: 264 GGRIKGPMPPSMG---YTYTGPAANE 286 + P + Y YTG E Sbjct: 230 ----EKPFSKRLSEEEYEYTGVEPRE 251 >BS_mmgD [C] COG0372 Citrate synthase Bsu Bacillus subtilis Length = 372 Score = 65.1 bits (157), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 83/286 (29%), Positives = 127/286 (44%), Gaps = 38/286 (13%) Query: 4 QQVDAIQPS-EADRNADLVAKAKAWWSTSIIDIQPGIIRIKGEPIENMIGNVGYVHMVWR 62 +Q+D PS +R L+ K A + S I K EPI + + Y Sbjct: 111 RQIDDRSPSANKERAYQLLGKMPALTAASYRIIN------KKEPILP-LQTLSYSANFLY 163 Query: 63 MLRDDIPSAGQLHLLEAALVSAVDHGPQAPSIAIARMSVTCGLPLNGAMSSAINMLD-DI 121 M+ +PS+ + + + +LV +H + A AR+ + L GA++ A+ L ++ Sbjct: 164 MMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFA-ARVIASTHSDLYGALTGAVASLKGNL 222 Query: 122 HGGAGEQCLLLFNQLLDAAEASAGEPESVLEQVMAAHAKAHGRIVPGYGHRFH--PIDPR 179 HGGA E + L LL+A S EQ++ K +I+ G+GHR + +DPR Sbjct: 223 HGGANEAVMYL---LLEAKTTSD------FEQLLQTKLKRKEKIM-GFGHRVYMKKMDPR 272 Query: 180 AVKLLAMVDEAAAAGVVKGLHAKAG--RLIEAHLAGR----SSKPVPMNIDGATAVIYGE 233 A+ M+ EA ++ L KAG RL E AG K + N+D A +Y Sbjct: 273 AL----MMKEA-----LQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWM 323 Query: 234 LGFDAALARGLFILSRSVGILAHAWEQKKQGGRIKGPMPPSMGYTY 279 LG L +F +R+ G+ AH EQ R+ P MG Y Sbjct: 324 LGIPIPLYTPIFFSARTSGLCAHVIEQHA-NNRLFRPRVSYMGPRY 368 >NMB0431 [C] COG0372 Citrate synthase Nme Neisseria meningitidis MC58 Length = 384 Score = 65.1 bits (157), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 71/246 (28%), Positives = 108/246 (43%), Gaps = 37/246 (15%) Query: 41 RIKGEPIENMIGNVGYVHMVWRMLRDDIPSAGQLHLLEAALVSAVDHGPQAPSIAIARMS 100 RI+ E E IG H + ++L PS + + +L+ +H A + AR+ Sbjct: 155 RIEVESDEETIGG----HFL-QLLHGKRPSESHIKAMHVSLILYAEHEFNASTFT-ARVI 208 Query: 101 VTCGLPLNGAMSSAINMLDD-IHGGAGEQCLLLFNQLLDAAEASAGEPESVLEQVMAAHA 159 G + +++ AI L HGGA E + + +A EA A E + Sbjct: 209 AGTGSDMYSSITGAIGALKGPKHGGANEVAYDIQKRYRNADEAEADIRERI--------- 259 Query: 160 KAHGRIVPGYGHRFHPI-DPRAVKLLAMVDEAAAAGVVKGLHAKAGRLIEAHLAGR---- 214 IV G+GH + I DPR V ++ E A +GL + G + +A R Sbjct: 260 -GRKEIVIGFGHPVYTISDPRNV----VIKEVA-----RGLSKETGDMRLFDIAERLESV 309 Query: 215 --SSKPVPMNIDGATAVIYGELGFDAALARGLFILSRSVGILAHAWEQKKQGGRIKGPMP 272 K + N+D +AV Y +LG A+ LF++SR+ G AH EQ+K G I+ Sbjct: 310 MWEEKKMFPNLDWFSAVSYQKLGVPTAMFTPLFVISRTTGWSAHVLEQRKDGKIIR---- 365 Query: 273 PSMGYT 278 PS YT Sbjct: 366 PSANYT 371