BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0100.p (824 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3079 [R] COG1033 Predicted exporters of the RND superfamily Pa... 770 0.0 BB0252 Non COG 77 2e-13 PAB1101 [R] COG1033 Predicted exporters of the RND superfamily P... 75 8e-13 PH0287 [R] COG1033 Predicted exporters of the RND superfamily Ph... 74 1e-12 AF1229 [R] COG1033 Predicted exporters of the RND superfamily Af... 68 9e-11 >PA3079 [R] COG1033 Predicted exporters of the RND superfamily Pae Pseudomonas aeruginosa Length = 793 Score = 770 bits (1988), Expect = 0.0, Method: Compositional matrix adjust. Identities = 397/792 (50%), Positives = 547/792 (69%), Gaps = 17/792 (2%) Query: 18 LKDFDRQSGTRVERLLFNHRAIVLLICLLVTLVLGTQIPNLSLNANFEKMIPTSHPYVVN 77 + + + +ERL+FN+R +V+ +C+LV++ L Q + + +FEKMIP HP++ Sbjct: 4 MNQHQQNKASLLERLIFNNRPVVIFLCVLVSVFLFYQATQVRPSTSFEKMIPLEHPFIQK 63 Query: 78 FLKYKSDLAGLGNAVRIAVATKKGTIYSPEYLETLQKINDEVFLLPGVERTNMRSLWTPS 137 L++++DLA LGN VRI+V G I++ EY+ETL++I+DEVF +PGV+R+ ++SLW+PS Sbjct: 64 MLEHRNDLANLGNTVRISVEAVNGDIFTKEYMETLRQIHDEVFYIPGVDRSGLKSLWSPS 123 Query: 138 TQWVGVTEDGMEGGPVIPNNYNGSPQSLTQVQLNIERSGEIGQLVALDAKSSIIYVPLLD 197 +W VTE+G GG VIP Y+GSP++L +++ N+ +SG+IG+LVA + KSSI+ VPLL+ Sbjct: 124 VRWTEVTEEGFAGGEVIPQTYDGSPRALEELRNNVLKSGQIGRLVANNFKSSIVDVPLLE 183 Query: 198 ------NDSATGKPLDYAEFSGRLEE-LRAKYE--TSDITLHITGFAQVVGNLISGLQQM 248 N S K LDY +FS LEE +R KY+ ++ +HI GFA+ VG+LI GL + Sbjct: 184 MYPNPKNQSELIK-LDYRQFSHELEEKIRDKYQLQNPNVKVHIVGFAKKVGDLIDGLVMV 242 Query: 249 LFFFVFAILVTALMLYWYTRCLRSTLLVVVSSMVAVVWQLGILPLAGFQLDPYSILVPFL 308 + FF +L+T ++LYW+T+C+RST+ V+++++VAV+WQLG+L L GF LDPYS+LVPFL Sbjct: 243 VGFFGICLLITLVLLYWFTKCIRSTIAVLITTLVAVLWQLGLLNLVGFGLDPYSMLVPFL 302 Query: 309 VFAIGMSHGAQKMNGILQDIGRGTHRVVAARYTFRRLFLAGLTALLCDAVGFAVLKVIEI 368 +FAIG+SHG QK+NGI + ++AAR TFR+LFL G+ A+L DAVGF L VI+I Sbjct: 303 IFAIGISHGVQKINGIALQSSGADNALMAARLTFRQLFLPGMIAILADAVGFITLLVIDI 362 Query: 369 KVIQDLAAIASIGVAVLVFTNLIMLPIFLSYVGVGQKAARRSIAGELEYSSPAEKHPAWR 428 VI++LA ASIGVAV+VFTNLI+LP+ +SY+G+ +KA +RS +HP WR Sbjct: 363 GVIRELAIGASIGVAVIVFTNLILLPVAISYIGISKKAVQRS------KDDAVREHPFWR 416 Query: 429 FFDLFTRRKWASITVVAATLMAVGGFIVSLDLQVGDLDPGAPELRAESRYNKDNAFINRY 488 F+ K A +++ A LM GG L++GDLD GAPELR +SRYN DN FI R Sbjct: 417 LLSNFSSPKVAPVSIAIALLMLGGGLWYGKHLKIGDLDQGAPELRPDSRYNLDNDFIIRN 476 Query: 489 YAAGSDVYAVMVKTPDAECASYDTLMKVDALEWKLRQLNGVDSTVSLAGLNRRVLVGLNE 548 Y+ SDV VMVKT C+++ L +D L WKL GV S +S+ ++++V+ G+NE Sbjct: 477 YSTSSDVLVVMVKTSPEGCSTHQALAAMDELAWKLENTEGVQSAISMVTVSKQVIKGMNE 536 Query: 549 GNPKWFDLVKSQATLNMVTSGAPRGLYNGSCNLLTVYAFLRDHKAETLTRVNDAVNEFSA 608 GN KW L ++Q LN + A GLYN C+L + FL DHKAETL R AV F+A Sbjct: 537 GNLKWETLSRNQDVLNNSIARAD-GLYNTDCSLAPLLVFLNDHKAETLDRAVAAVQAFAA 595 Query: 609 ANNSERAQFLLAAGPAGIEAATNIVVKKASHEMLLWVYGAVIILCLLTFRSWRAVVCAVL 668 N+ + QF LAAG AGIEAATN V+K++ +L+ VY V +C++TFRS+ A +C VL Sbjct: 596 ENDKDDLQFQLAAGNAGIEAATNEVIKQSELIILVLVYICVAAMCMITFRSFAATLCIVL 655 Query: 669 PLVLTSILCEALMVKLNMGVKVATLPVIALGVGIGIDYALYVMSITLTKMREGKSLSEAY 728 PL+LTS+L ALM L +GVKVATLPVIALGVGIG+DY +Y+ + + +R G L EAY Sbjct: 656 PLILTSVLGNALMAALGIGVKVATLPVIALGVGIGVDYGIYIYTRLESFLRMGLPLQEAY 715 Query: 729 YDALTFTGKVVMLTGVTLAAGVATWAFSPIKFQADMGILLAFMFLWNMLGALILLPALAY 788 Y+ L TGK V+ TG+ LA GVATW FS IKFQADMG++L FM LWNM GAL LLPALA Sbjct: 716 YETLRSTGKAVLFTGLCLAIGVATWIFSAIKFQADMGLMLTFMLLWNMFGALWLLPALAR 775 Query: 789 FLLPPTAFKNGK 800 FL+ P + K Sbjct: 776 FLINPAKLQARK 787 >BB0252 Non COG Length = 767 Score = 76.6 bits (187), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 141/768 (18%), Positives = 307/768 (39%), Gaps = 106/768 (13%) Query: 52 GTQIPNLSLNANFEKMIPTSHPY--VVNFLKYKSDLAGLGNAVRIAVATKKGTIYSPEYL 109 G + NL +AN K+IP + +++ K S L+ I + K I++ + Sbjct: 26 GFFLKNLKFDANILKLIPKTKETESLIDIDKSNSLLS------TIVIFQDKKNIFNKKNF 79 Query: 110 ETLQKINDEVFLLPGVERTNMRSLWTPSTQW---------VGVTEDGMEGGPVIPNNYNG 160 ET+ + E+ + V + S+++ Q+ + + ++ P + N + G Sbjct: 80 ETINSVISEITKILKVSPNAVTSIFSYFPQFKKEIYTDKDIEEIKSKIKSTPFVKNTFLG 139 Query: 161 SPQSLTQVQLNIERSGEIGQLVALDAKSSIIYVPLLDNDSATGKPLDYAEFSGRL----- 215 + ++L IY ++ ++S D FS L Sbjct: 140 NSENL-------------------------IYFIIIPSES------DQINFSRNLKTELD 168 Query: 216 --EELRAKYETSDITLHITGFAQVVGNLISGL-QQMLFFFVFAILVTALMLYWYTRCLRS 272 E+ KYET D+ L++TG V +++ + + A V + LY + L Sbjct: 169 EMEKTIKKYETDDLKLYLTGDLIVREKILNYMVEDFKILGPLATFVVIISLYLIIKNLIG 228 Query: 273 TLLVVVSSMVAVVWQLGILPLAGFQLDPYSILVP-----FLVFAIGMSHGAQKMNGILQD 327 L+ + ++++++W GI G P I VP L+ +IG ++ +N I + Sbjct: 229 ALIPIFIALLSLIWTFGI---KGLVQSP--ITVPETSMIVLLISIGCANAVHIINEIFKL 283 Query: 328 IGRGTHRVVAARYTFRRLFLAGLTALLCDAVGFAVLKVIEIKVIQDLAAIASIGVAVLVF 387 I + + + T ++L L A GF L I + + SIGV + + Sbjct: 284 IKKEQLSKESIKATIKKLKTPILLTSFTTAFGFLSLTTSSINAYKTMGIFMSIGVIISMI 343 Query: 388 TNLIMLPIFLSYVGVGQKAARRSIA----GELEYSSPAEKHPAWRFFDLFTRRKWASITV 443 +L +LP ++ + +K + ++ + K + R+ +SI V Sbjct: 344 ISLTVLPGIITLIPFAKKKSFEKEKENKLNKISFLERLAKLNTQITKSILKRKYTSSIMV 403 Query: 444 VAATLMAVGGFIVSLDLQVGDLDPGAPELRAESRYNKDNAFINRYYAAGSDVYAVMVKTP 503 L+ +G V L L++ +++ + ES K + + G ++ + ++ Sbjct: 404 ----LIILGISFVGL-LKI-EINFDEKDYFKESTSVKKTLNLMQKEMGGISIFKIEIEGR 457 Query: 504 DAECASYDTLMKVDALEWKLRQLNGVDSTVSLAGLNRRVLVGLNEGNPKWFDLVKSQATL 563 E + + +D + KL + + S+ G+ + + + +P + L +++ L Sbjct: 458 PGEFKNAKAMQILDLITDKLDAFSAKTQSSSINGILKFTNFKIKKESPLEYKLPENKIIL 517 Query: 564 NMV---------TSGAPRGLYNGSCNLLTVYAFLRDHKAETLTRVND-AVNEFSAANNSE 613 N + T R N +L+++ + D+ E + + A+N + + Sbjct: 518 NKLINLIDKSDWTKDNKRMYINDDWSLISIIVRIEDNSTEGIKKFEKYAINTINEYMKNN 577 Query: 614 RAQF------LLAAGPAGIEAATNIVVKKASHEMLLWVYGAVIILCLLTFRSWRAVVCAV 667 + F +L A E NI+ G++ +L + F+S + + Sbjct: 578 KYHFSGVYDKVLIAKTMVKEQVINIIT----------TLGSITLLLMFFFKSIKTGIIIA 627 Query: 668 LPLVLTSILCEALMVKLNMGVKVATLPVIALGVGIGIDYALYVMSITLTKMREGKSLSEA 727 +P+ + L A+M + + AT + ++ +G+G+DY+++ + + + ++ + A Sbjct: 628 IPVAWSVFLNFAVMRLFGITLNPATATIASVSMGVGVDYSIHFFNTFILQYQKNQIYKTA 687 Query: 728 YYDAL--TFTGKVVMLTGVTLAAGVATWAFSPIKFQADMGILLAFMFL 773 +++ F G + +++ G T FS K + +G ++AF L Sbjct: 688 LLESIPNVFNG--IFANSISVGIGFLTLTFSSYKIISTLGAIIAFTML 733 >PAB1101 [R] COG1033 Predicted exporters of the RND superfamily Pab Pyrococcus abyssi Length = 746 Score = 74.7 bits (182), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 101/361 (27%), Positives = 166/361 (45%), Gaps = 24/361 (6%) Query: 435 RRKWASITVVAATLMAVGGFIVSLDLQVGDLDPGAPE-LRAESRYNKDNAFINRYYAAGS 493 R A +T+ L A G I L + DL PE L A Y N + +GS Sbjct: 13 RHSLAVVTMFLLILSAYG--ITQLRFET-DLSKQLPEDLEAVKSYF---TLQNEFGGSGS 66 Query: 494 DVYAVMVKTPDAECASYD--TLMKVDALEWKLRQLNGVDSTVSLAGLNRRVLVGLNEGNP 551 + V +K D D + + +LE +LR+ V T S+A L ++L L P Sbjct: 67 ALIYVKIKNNDNVVDIRDPKIIEAMYSLEQRLREKEYVTDTFSIADLMVQILGRL----P 122 Query: 552 KWFDLVKSQATLNMVTSGAPRGLYNGS-CNLLTVYAFLRDHKAETLTRV-NDAVNEFSAA 609 K D VK LNM+ A GL +G + + + R+ + L RV ND E Sbjct: 123 KNMDEVK--FVLNMLPPEARNGLISGDYSSTIIIVNLNREKNQKALVRVYNDIEREIERT 180 Query: 610 NNSERAQFLLAAGPAGIEAATNIVVKKASHEM--LLWVYGAVIILCLLTF-RSWRAVVCA 666 N + + +L G GI T +++ ++M + + G +++L LL F +S ++ Sbjct: 181 NFPQGVEVVLT-GDLGI---TYKILEMLQNDMNRTMAISGIIVVLILLYFYKSPIRMLVP 236 Query: 667 VLPLVLTSILCEALMVKLNMGVKVATLPVIALGVGIGIDYALYVMSITLTKMREGKSLSE 726 ++PL+ ++ M L + + +AT V A+ +G+GIDY ++V + + +GKSL E Sbjct: 237 LVPLIFGVVMTLGFMGLLGIPLDIATTTVGAMIIGMGIDYGVHVTNRYYEERGKGKSLEE 296 Query: 727 AYYDALTFTGKVVMLTGVTLAAGVATWAFSPIKFQADMGILLAFMFLWNMLGALILLPAL 786 A +A+ TGK ++ +T AG + S + + + L L A+I+ PAL Sbjct: 297 AAEEAIAETGKALLGAALTTIAGFLALSISILPSLKRLSVSLVMGLGLAALNAVIVTPAL 356 Query: 787 A 787 A Sbjct: 357 A 357 >PH0287 [R] COG1033 Predicted exporters of the RND superfamily Pho Pyrococcus horikoshii Length = 787 Score = 73.9 bits (180), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 102/384 (26%), Positives = 177/384 (46%), Gaps = 29/384 (7%) Query: 440 SITVVAATLMAVGGF-IVSLDLQVGDLDPGAPE-LRAESRYNKDNAFINRYYAAGSDVYA 497 S+ V+ L+ + G+ I L + DL PE L A Y N + +GS + Sbjct: 56 SLAVITIFLLILSGYGITKLKFE-SDLSKQLPEDLEAVKNYF---TLQNEFGGSGSALIY 111 Query: 498 VMVKTPD--AECASYDTLMKVDALEWKLRQLNGVDSTVSLAGLNRRVLVGLNEGNPKWFD 555 V +K+PD A+ + + +LE +L+ V T S+A L ++L L P + Sbjct: 112 VKIKSPDKVADIRDPTVIKAMYSLEQRLKDKEYVTDTFSIADLAVQILGRL----PNNIE 167 Query: 556 LVKSQATLNMVTSGAPRGLYNGS-CNLLTVYAFLRDHKAETLTRV-NDAVNEFSAANNSE 613 VK LNM+ A GL + + + + + R+ L RV N+ NE +N E Sbjct: 168 EVK--FVLNMLPEDARNGLVSRDYSSTIIIVSLNREKNQRALVRVYNEIKNEIEKSNFPE 225 Query: 614 RAQFLLAAGPAGIEAATNIVVKKASHEM--LLWVYGAVIILCLLTF-RSWRAVVCAVLPL 670 + +L G GI T +++ ++M + V G ++I+ LL F +S ++ ++PL Sbjct: 226 GVEVVLT-GDLGI---TYKILEMLQNDMNRTMAVAGIIVIILLLYFYKSPIRMLVPLIPL 281 Query: 671 VLTSILCEALMVKLNMGVKVATLPVIALGVGIGIDYALYVMSITLTKMREGKSLSEAYYD 730 + + M L + + +AT V A+ +G+GIDY ++V + + +G+S EA + Sbjct: 282 IFGVTMTLGFMGLLGIPLDIATSTVGAMIIGMGIDYGVHVTNRYYEERNKGRSPEEAAEE 341 Query: 731 ALTFTGKVVMLTGVTLAAGVATWAFSPIKFQADMGILLAFMFLWNMLGALILLPALAYFL 790 A++ TGK ++ +T AG + S + + I L + A+I+ PALA Sbjct: 342 AISETGKALLGAALTTIAGFLALSLSILPSLKRLSISLVMGLGLAAVNAVIVTPALAIL- 400 Query: 791 LPPTAFKN---GKLDTVKSLSGSE 811 F+ GK + S+ G E Sbjct: 401 --EEEFRTKILGKKGEIISIGGEE 422 >AF1229 [R] COG1033 Predicted exporters of the RND superfamily Afu Archaeoglobus fulgidus Length = 750 Score = 68.2 bits (165), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 124/560 (22%), Positives = 227/560 (40%), Gaps = 70/560 (12%) Query: 256 ILVTALMLYWYTRCLR---STLLVVVSSMVAVVWQLGILPLAGFQLDPYSILVPFLVFAI 312 IL+ L+ ++ +R + L +V S+++V G++P+ G L ++ ++ + Sbjct: 210 ILMVLLLFLTFSGAVRKKYTAFLPLVISVMSVTVVYGLMPILGIPLSEHTNGALPMLIGL 269 Query: 313 GMSHGAQKMNGILQDIGRGTHRVVAARYTFRRLFLAGLTALLCDAVGFAVLKVIEIKVIQ 372 + +GAQ N ++ G A + R LA + AL+ +GF + + + Sbjct: 270 AIEYGAQLQNRYEEERREGRDVDDAVVISITRTGLAIVMALITTVIGFMSMLAPGMPAMA 329 Query: 373 DLAAIASIGVAVLVFTNLIMLPIFLSYV-----GVGQKAARRSIAGELEYSSPAEKHPAW 427 I+S+G+ V L LP L + QK G LE S A Sbjct: 330 QFGIISSLGLIVAYLLTLTFLPAVLKLIDHWNDAKEQKREEEKSVGTLERSLSA------ 383 Query: 428 RFFDLFTRRKWASITVVAATLMAVGGFIVSLDLQVGDLDPGAPELRAESRYNK----DNA 483 T + I V A+ ++ G + AP++ E+ YNK D Sbjct: 384 --ISTLTATRPVGILVAASIIVLFGLY-------------AAPQIGLETNYNKYVPQDLT 428 Query: 484 FINRY-----YAAGSDVYAVMVKTPDAECASYDTLMKVDALE----WKLRQLNGVDSTVS 534 + R+ G Y ++++ + +TL ++D L K + S Sbjct: 429 AMQRFKEIERLVGGQATYTLVLEVDELNA---ETLKEIDELSKYIVEKEELIYDYSSITK 485 Query: 535 LAGLNRRV--LVGLNEGNPKWFDLVKS--QATLNMVTSGAPRGLYNGSCNLLTVYAFLRD 590 L R+ GL E + + ++ + Q ++ SG ++ S N + ++ Sbjct: 486 LISEVRKAYGFEGLPESDAELMQILSALPQEEVSRYISGGQIAVHF-SSNADSQDEYIST 544 Query: 591 HKAETLTRVNDAVNEFSAANNSERAQFLLAAGPAGIEAATNIVVKKASHEMLLWVYGAVI 650 HK + V D EF + + + GP I ++ M + Y +I Sbjct: 545 HK----SIVRDV--EFFGWSGG----YYVTGGPV-IYGEMGRLMTSGQTTMTVVAYALII 593 Query: 651 ILCLLTFRSWRAVVCAVLPLV-LTSILCEALMVKLNMGVKVATLPVIALG---VGIGIDY 706 +L L +RS R AV+PL+ +TS++ + G K T+ IAL +G+GID+ Sbjct: 594 MLLLAVYRSIRK---AVVPLIAITSVIGAMNTIMFLTGTK-QTMISIALNSITLGLGIDF 649 Query: 707 ALYVMSITLTKMREGKSLSEAYYDALTFTGKVVMLTGVTLAAGVATWAFSPIKFQADMGI 766 +++V+ + R S EA + TGK + + +T+A G + FS + G Sbjct: 650 SIHVLERYFEE-RAAFSPVEAVRRTIERTGKAITTSALTMAGGFGSLMFSTFPIMQNFGF 708 Query: 767 LLAFMFLWNMLGALILLPAL 786 + L+++L AL ++PA Sbjct: 709 IALVAILFSLLAALTVVPAF 728