BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0015.0073.p (422 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1370 [GEPR] COG0477 Permeases of the major facilitator superf... 544 e-154 YPO0792 [GEPR] COG0477 Permeases of the major facilitator superf... 263 8e-70 ygeD [GEPR] COG0477 Permeases of the major facilitator superfami... 253 8e-67 ZygeD [GEPR] COG0477 Permeases of the major facilitator superfam... 252 1e-66 ECs3692 [GEPR] COG0477 Permeases of the major facilitator superf... 252 1e-66 >RSc1370 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 438 Score = 544 bits (1401), Expect = e-154, Method: Compositional matrix adjust. Identities = 296/438 (67%), Positives = 356/438 (81%), Gaps = 19/438 (4%) Query: 1 MNRGFYTIMAAQFFSSLADNALLIAAIALLSEMHSPAWMTPLLKLFFVLSYVLLAAFVGA 60 M +GFYTIMAAQFFSSLADNALLIAAIALL+EMHSP WMTPLLKLFFVLSYVLLAAFVGA Sbjct: 1 MKKGFYTIMAAQFFSSLADNALLIAAIALLTEMHSPQWMTPLLKLFFVLSYVLLAAFVGA 60 Query: 61 FADAFPKGKVMFITNLIKVVGCALMFFTVHPLIAYAVVGFGAAAYSPAKYGILTELLPPE 120 FAD+ PKG+VM ITN IK+ GC +M +HPL+AY VVGFGAAAYSPAKYG+LTELLPPE Sbjct: 61 FADSMPKGRVMLITNAIKLAGCGVMLTGLHPLLAYGVVGFGAAAYSPAKYGLLTELLPPE 120 Query: 121 KLVAANGWIEGLTVGSIIFGTVLGGALVNPHIASALLNFDFPVFDFGINTPTEAALCIIT 180 KLVAANGWIEGLTVGSII GTVLGGAL++ HI++ LL+ D P + I+TP EAA+ +I Sbjct: 121 KLVAANGWIEGLTVGSIILGTVLGGALISKHISTWLLSIDVPGLE-AIDTPAEAAMIVIM 179 Query: 181 VIYVAAAIFNLNIPDTGARYAHQQRNPIKLIADFGNCFSTLWKDKLGQISLAVTTLFWGA 240 VIY+ AA+FNL IPDTGARY Q++NP++LIA+F +CF+ LW+DKLGQISLAVTTLFWGA Sbjct: 180 VIYLVAALFNLRIPDTGARYPQQEKNPVRLIAEFADCFNALWRDKLGQISLAVTTLFWGA 239 Query: 241 GATLQFIVLKWAEKSLHMPLDKAAILQGVVALGVALGAVGAARFVPLKKSLSVMPLGIVM 300 GATLQFIVLKWAE+SL + L + AILQ VVA+GVA GA+ AA VPL++SL V+P+G+ M Sbjct: 240 GATLQFIVLKWAERSLELNLSQGAILQAVVAVGVAAGAMAAAVKVPLRRSLDVLPVGVAM 299 Query: 301 GLVVMAMTMVTS------------------VWVAYPLLIIIGALSGYFVVPMNALLQHRG 342 G +VM M T + +AY L+++GA+SG+FVVPMNALLQHRG Sbjct: 300 GALVMLMAFYTKHTIPDVTFHIGHMKLPLYMLIAYLFLMMVGAMSGFFVVPMNALLQHRG 359 Query: 343 HVLMSAGHSIAVQNFNENLSVLTMLVLYAVMVRLNLDVNIVILIFGVFVASIMYLIMRRH 402 HVL+SAGHSIAVQNFNEN+SVL ML LYA++++L++ V +VI+ FGVFV M L+MRRH Sbjct: 360 HVLLSAGHSIAVQNFNENVSVLLMLCLYALLIKLDVPVGVVIVAFGVFVCVTMALVMRRH 419 Query: 403 AANQREHDSLALIGEHKH 420 N+R + + ALIGE KH Sbjct: 420 RRNERVYHTAALIGEDKH 437 >YPO0792 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 406 Score = 263 bits (671), Expect = 8e-70, Method: Compositional matrix adjust. Identities = 158/379 (41%), Positives = 232/379 (61%), Gaps = 23/379 (6%) Query: 1 MNRGFYTIMAAQFFSSLADNALLIAAIALLSEMHSPAWMTPLLKLFFVLSYVLLAAFVGA 60 ++R ++ AQFFS+ DNALL A +AL+ + P W P+L++ FV +Y++LA FVG Sbjct: 12 LSRSMVAVLCAQFFSAFGDNALLFATLALIKQQLYPDWSQPILQMAFVATYIVLAPFVGQ 71 Query: 61 FADAFPKGKVMFITNLIKVVGCALMFFTVHPLIAYAVVGFGAAAYSPAKYGILTELLPPE 120 AD F KG+VM + N +K+ G ++ F ++P + Y++VG GAAAYSPAKYGIL E+ E Sbjct: 72 IADGFAKGRVMMVANGLKLAGALVICFGLNPFLGYSLVGVGAAAYSPAKYGILGEITSGE 131 Query: 121 KLVAANGWIEGLTVGSIIFGTVLGGALVNPHIASALLNFDFPVFDFGINTPTEAALCIIT 180 +LV ANG +E T+ +I+ G+V GG L + H+ AAL + Sbjct: 132 QLVKANGMMEASTIAAILLGSVAGGILADWHL--------------------MAALGVCA 171 Query: 181 VIYVAAAIFNLNIPDTGARYAHQQRNPIKLIADFGNCFSTLWKDKLGQISLAVTTLFWGA 240 ++Y A I NL IP A + P + F LW+D + SLA T+LFWGA Sbjct: 172 LVYAIAVIANLFIPRLAAARSGASWRPRAMTGSFFTACRLLWQDSETRFSLAGTSLFWGA 231 Query: 241 GATLQFIVLKWAEKSLHMPLDKA--AILQGVVALGVALGAVGAARFVPLKKSLSVMPLGI 298 G TL+F+++ W +L + D A +L +VA+G+ +GA AARFV LK +P G+ Sbjct: 232 GVTLRFLLVLWVPVALGIA-DNATPTLLNAMVAIGIVVGAGAAARFVTLKTVKRCLPAGV 290 Query: 299 VMGLVVMAMTMVTSVWVAYPLLIIIGALSGYFVVPMNALLQHRGHVLMSAGHSIAVQNFN 358 ++G++V ++ S+ +AY LLIIIG L G+FVVP+NALLQ RG + AG++IAVQN Sbjct: 291 LIGVMVTIFSLQNSMPMAYLLLIIIGILGGFFVVPLNALLQERGKHSVGAGNAIAVQNLG 350 Query: 359 ENLSVLTMLVLYAVMVRLN 377 EN ++L ML LY+++V+L Sbjct: 351 ENTAMLFMLGLYSLVVKLG 369 >ygeD [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 397 Score = 253 bits (645), Expect = 8e-67, Method: Compositional matrix adjust. Identities = 159/406 (39%), Positives = 236/406 (58%), Gaps = 26/406 (6%) Query: 2 NRGFYTIMAAQFFSSLADNALLIAAIALLSEMHSPAWMTPLLKLFFVLSYVLLAAFVGAF 61 ++G ++ AQF S+ DNALL A +ALL P W P+L++ FV +Y+L A FVG Sbjct: 13 SKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQV 72 Query: 62 ADAFPKGKVMFITNLIKVVGCALMFFTVHPLIAYAVVGFGAAAYSPAKYGILTELLPPEK 121 AD+F KG+VM N +K++G A + F ++P + Y +VG GAAAYSPAKYGIL EL K Sbjct: 73 ADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSK 132 Query: 122 LVAANGWIEGLTVGSIIFGTVLGGALVNPHIASALLNFDFPVFDFGINTPTEAALCIITV 181 LV ANG +E T+ +I+ G+V GG L + H AL + Sbjct: 133 LVKANGLMEASTIAAILLGSVAGGVLADWH--------------------VLVALAACAL 172 Query: 182 IYVAAAIFNLNIPDTGARYAHQQRNPIKLIADFGNCFSTLWKDKLGQISLAVTTLFWGAG 241 Y A + N+ IP A Q N I + F N ++LW++ + SL T+LFWGAG Sbjct: 173 AYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAG 232 Query: 242 ATLQFIVLKWAEKSLHMPLDKA--AILQGVVALGVALGAVGAARFVPLKKSLSVMPLGIV 299 TL+F+++ W +L + D A L +VA+G+ +GA AA+ V L+ MP GI+ Sbjct: 233 VTLRFLLVLWVPVALGIT-DNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGIL 291 Query: 300 MGLVVMAMTMVTSVWVAYPLLIIIGALSGYFVVPMNALLQHRGHVLMSAGHSIAVQNFNE 359 +G+VV+ ++ + AY LL++IG + G+FVVP+NALLQ RG + AG++IAVQN E Sbjct: 292 IGVVVLIFSLQHELLPAYALLMLIGVMGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGE 351 Query: 360 NLSVLTMLVLYAVMVRLNLDVNIVILIFGVFVA---SIMYLIMRRH 402 N ++L ML +Y++ V + + V + + FG A + +++ RRH Sbjct: 352 NSAMLLMLGIYSLAVMIGIPVVPIGIGFGALFALAITALWIWQRRH 397 >ZygeD [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 397 Score = 252 bits (644), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 160/406 (39%), Positives = 235/406 (57%), Gaps = 26/406 (6%) Query: 2 NRGFYTIMAAQFFSSLADNALLIAAIALLSEMHSPAWMTPLLKLFFVLSYVLLAAFVGAF 61 ++G ++ AQF S+ DNALL A +ALL P W P+L++ FV +Y+L A FVG Sbjct: 13 SKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQV 72 Query: 62 ADAFPKGKVMFITNLIKVVGCALMFFTVHPLIAYAVVGFGAAAYSPAKYGILTELLPPEK 121 AD+F KG+VM N +K++G A + F ++P + Y +VG GAAAYSPAKYGIL EL K Sbjct: 73 ADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSK 132 Query: 122 LVAANGWIEGLTVGSIIFGTVLGGALVNPHIASALLNFDFPVFDFGINTPTEAALCIITV 181 LV ANG +E T+ +I+ G+V GG L + H AL + Sbjct: 133 LVKANGLMEASTIAAILLGSVAGGVLADWH--------------------VLVALAACAL 172 Query: 182 IYVAAAIFNLNIPDTGARYAHQQRNPIKLIADFGNCFSTLWKDKLGQISLAVTTLFWGAG 241 Y A + N+ IP A Q N I + F N ++LW++ + SL T+LFWGAG Sbjct: 173 AYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAG 232 Query: 242 ATLQFIVLKWAEKSLHMPLDKA--AILQGVVALGVALGAVGAARFVPLKKSLSVMPLGIV 299 TL+F+++ W +L + D A L +VA+G+ +GA AA+ V L+ MP GI+ Sbjct: 233 VTLRFLLVLWVPVALGIT-DNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGIL 291 Query: 300 MGLVVMAMTMVTSVWVAYPLLIIIGALSGYFVVPMNALLQHRGHVLMSAGHSIAVQNFNE 359 +G+VV+ ++ AY LL++IG L G+FVVP+NALLQ RG + AG++IAVQN E Sbjct: 292 IGVVVLIFSLQHEQLPAYALLMLIGVLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGE 351 Query: 360 NLSVLTMLVLYAVMVRLNLDVNIVILIFGVFVA---SIMYLIMRRH 402 N ++L ML +Y++ V + + V + + FG A + +++ RRH Sbjct: 352 NSAMLLMLGIYSLAVMVGIPVVPIGIGFGALFALAITALWIWQRRH 397 >ECs3692 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 397 Score = 252 bits (644), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 160/406 (39%), Positives = 235/406 (57%), Gaps = 26/406 (6%) Query: 2 NRGFYTIMAAQFFSSLADNALLIAAIALLSEMHSPAWMTPLLKLFFVLSYVLLAAFVGAF 61 ++G ++ AQF S+ DNALL A +ALL P W P+L++ FV +Y+L A FVG Sbjct: 13 SKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQV 72 Query: 62 ADAFPKGKVMFITNLIKVVGCALMFFTVHPLIAYAVVGFGAAAYSPAKYGILTELLPPEK 121 AD+F KG+VM N +K++G A + F ++P + Y +VG GAAAYSPAKYGIL EL K Sbjct: 73 ADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSK 132 Query: 122 LVAANGWIEGLTVGSIIFGTVLGGALVNPHIASALLNFDFPVFDFGINTPTEAALCIITV 181 LV ANG +E T+ +I+ G+V GG L + H AL + Sbjct: 133 LVKANGLMEASTIAAILLGSVAGGVLADWH--------------------VLVALAACAL 172 Query: 182 IYVAAAIFNLNIPDTGARYAHQQRNPIKLIADFGNCFSTLWKDKLGQISLAVTTLFWGAG 241 Y A + N+ IP A Q N I + F N ++LW++ + SL T+LFWGAG Sbjct: 173 AYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAG 232 Query: 242 ATLQFIVLKWAEKSLHMPLDKA--AILQGVVALGVALGAVGAARFVPLKKSLSVMPLGIV 299 TL+F+++ W +L + D A L +VA+G+ +GA AA+ V L+ MP GI+ Sbjct: 233 VTLRFLLVLWVPVALGIT-DNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGIL 291 Query: 300 MGLVVMAMTMVTSVWVAYPLLIIIGALSGYFVVPMNALLQHRGHVLMSAGHSIAVQNFNE 359 +G+VV+ ++ AY LL++IG L G+FVVP+NALLQ RG + AG++IAVQN E Sbjct: 292 IGVVVLIFSLQHEQLPAYALLMLIGVLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGE 351 Query: 360 NLSVLTMLVLYAVMVRLNLDVNIVILIFGVFVA---SIMYLIMRRH 402 N ++L ML +Y++ V + + V + + FG A + +++ RRH Sbjct: 352 NSAMLLMLGIYSLAVMVGIPVVPIGIGFGALFALAITALWIWQRRH 397