BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0013.0083.p (260 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMc01635 [IQR] COG1028 Dehydrogenases with different specificiti... 112 6e-25 PAE0797 [IQR] COG1028 Dehydrogenases with different specificitie... 108 1e-23 mll6713 [IQR] COG1028 Dehydrogenases with different specificitie... 105 1e-22 PH1901 [IQR] COG1028 Dehydrogenases with different specificities... 105 1e-22 SSO2276 [IQR] COG1028 Dehydrogenases with different specificitie... 103 3e-22 >SMc01635 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 253 Score = 112 bits (281), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 94/256 (36%), Positives = 126/256 (49%), Gaps = 9/256 (3%) Query: 3 LALTNKKILITGASQGIGEGLAHAFAQEGCAVYLTARSEE----KLQGIAAALRSQYDVA 58 + L N+ ++TGA GIG A A+EG V + RS E + IAA S +A Sbjct: 1 MILNNRIAIVTGAGSGIGRAGAAIMAREGAHVVVVDRSVEAAGDTVAAIAAGGGSAEALA 60 Query: 59 AHVLAADMTAPGAIECLCDFAGDADVLVNNAGAIEGGDLWEIDDARWRGSWELKVFGYIN 118 V D A G + L G D+L N+AGA GDL E++ A + SW L V + Sbjct: 61 VDVTDDDALADGIADILYRH-GRIDILHNHAGAQVAGDLEEVEVAGFDRSWNLNVRAHFM 119 Query: 119 LTRALYGRMKTRKSGVILNNIGNGGENFDFNYIAGTTGNAALMAFTRAMGGKSLEDGIRV 178 R + MK GVI+N + G +D IA TT A++A TR M G + G+RV Sbjct: 120 AARLVMPSMKKAGRGVIVNTSSSSGVLYDREMIAYTTTKHAVIAMTRQMAGDYAKYGVRV 179 Query: 179 VGVNPGPVDTDRIRRVLKKRAGSRLGDENRYEELLKGYPLGRAAHVREIADMFVFLASER 238 + PG VDT + G R E E + PLGR A V EIA+ +FL S+R Sbjct: 180 NALCPGWVDTP-FNEPFIDQMGGREAIEAYIRERV---PLGRWASVDEIAESILFLVSDR 235 Query: 239 SGYTSGNIITIDGGIT 254 S Y +G I+ +DGG T Sbjct: 236 SSYMTGQILVVDGGET 251 >PAE0797 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pya Pyrobaculum aerophilum Length = 260 Score = 108 bits (270), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 129/259 (49%), Gaps = 9/259 (3%) Query: 3 LALTNKKILITGASQGIGEGLAHAFAQEGCAVYLTARSEEKLQGIAAALRSQYDVAAHVL 62 + L ++ ++T AS+GIG G+A A+EG + + AR+ E+L+G+A L SQY V+ + Sbjct: 1 MLLKDRVSIVTAASRGIGAGVATVLAREGSNLVIAARNLERLEGLAKQLSSQYGVSVVPV 60 Query: 63 AADMTAPGAIECLCDFA----GDADVLVNNAGAIEGGDLWEIDDARWRGSWELKVFGYIN 118 AD+T + + D A G D+L N G + G E+ + W L + + Sbjct: 61 QADLTRREDVRKIVDEALRHFGKVDILAYNTGPPKPGTFLELTEDDWDYGVRLLLMSAVW 120 Query: 119 LTRALYGRMKTRKSGVILNNIGNGGENFDFNYIAGTTGNAALMAFTRAMGGKSLEDGIRV 178 +T+ + M R+ G ++ + + +L + + + + I V Sbjct: 121 ITKDVLPYMIERRWGRLIYITSSTLKQPIPTLTLSNVIRISLAGLVKTLAYQLGKYNILV 180 Query: 179 VGVNPGPVDTDRIRRVLK---KRAGSRLGDENRYEELLKGYPLGRAAHVREIADMFVFLA 235 G+ G +DT+R+R V + KR G L + R EL + PLGR EI ++ FLA Sbjct: 181 NGIMQGYIDTERVREVAEARAKREGRSLDEILR--ELEREIPLGRIGKPEEIGELVAFLA 238 Query: 236 SERSGYTSGNIITIDGGIT 254 SE++ Y +G++I IDGG T Sbjct: 239 SEKASYITGSLILIDGGRT 257 >mll6713 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 253 Score = 105 bits (262), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 92/259 (35%), Positives = 122/259 (47%), Gaps = 15/259 (5%) Query: 3 LALTNKKILITGASQGIGEGLAHAFAQEGCAVYLTARSEEKLQGIAAALRSQYDVA---A 59 + L ++ ++TGA GIG A A+EG V + RS + A A Q A A Sbjct: 1 MILKDRTAIVTGAGSGIGRAAALIIAREGAMVGVADRSADG----ANATVDQILAAGGRA 56 Query: 60 HVLAADMTAPGAIEC-LCDF---AGDADVLVNNAGAIEGGDLWEIDDARWRGSWELKVFG 115 L D+T A+E DF G D+L N+AG GD+ + + SW L V Sbjct: 57 KALVFDLTDDQALEAGFHDFIHTQGRIDILHNHAGVQVEGDVLGVSVKGFDTSWTLNVRA 116 Query: 116 YINLTRALYGRMKTRKSGVILNNIGNGGENFDFNYIAGTTGNAALMAFTRAMGGKSLEDG 175 + R + MK GVILN + G +D IA TT A++A TR M G G Sbjct: 117 HFLGARIVMPFMKKAGRGVILNTSSSSGVLYDREMIAYTTTKHAVIAMTRQMAGDYGRFG 176 Query: 176 IRVVGVNPGPVDTDRIRRVLKKRAGSRLGDENRYEELLKGYPLGRAAHVREIADMFVFLA 235 IRV + PG VDT + G R E E + PLGR A V EIA+ +FL Sbjct: 177 IRVNALCPGWVDTP-FNAPFIAQMGGREAIEAYIRERV---PLGRWATVEEIAEAVLFLV 232 Query: 236 SERSGYTSGNIITIDGGIT 254 S+RS Y +G I+ +DGG T Sbjct: 233 SDRSSYMTGQILVVDGGET 251 >PH1901 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Pho Pyrococcus horikoshii Length = 282 Score = 105 bits (261), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 77/254 (30%), Positives = 122/254 (48%), Gaps = 8/254 (3%) Query: 5 LTNKKILITGASQGIGEGLAHAFAQEGCAVYLTARSEEKLQGIAAALRSQYDVAAHVLAA 64 L+ K T +S+GIG G+A A+ G V + +R+EE L+ ++S+ +V H + A Sbjct: 25 LSGKLAFTTASSKGIGFGVARVLARAGADVIILSRNEENLKRAKEKIKSESNVEVHYIVA 84 Query: 65 DMTA----PGAIECLCDFAGDADVLVNNAGAIEGGDLWEIDDARWRGSWELKVFGYINLT 120 D+T I+ L D GD D+ + G + G E+ W G+ +L ++ + LT Sbjct: 85 DLTKMEDLERTIKELKDI-GDPDIFFFSTGGPKPGYFMEMSMEDWEGAVKLLLYPAVYLT 143 Query: 121 RALYGRMKTRKSGVILNNIGNGGENFDFNYIAGTTGNAALMAFTRAMGGKSLEDGIRVVG 180 +AL M+ + G I+ + + N A+ R + + GI V G Sbjct: 144 KALVPGMERKGFGRIVYSTSVAIKEPIPNIALSNVVRIAMAGLVRTLAKELGPKGITVNG 203 Query: 181 VNPGPVDTDRIRRVLKKRAGSRLGD--ENRYEELLKGYPLGRAAHVREIADMFVFLASER 238 + PG + TDR+ ++ + RA R G E +E K PLGR EI + FLASE Sbjct: 204 IMPGIIRTDRVIQLAQDRA-KREGKSVEEALKEYAKPIPLGRLGEPEEIGYLVAFLASEL 262 Query: 239 SGYTSGNIITIDGG 252 Y +G +I +DGG Sbjct: 263 GSYINGAMIPVDGG 276 >SSO2276 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sso Sulfolobus solfataricus Length = 261 Score = 103 bits (258), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 73/260 (28%), Positives = 126/260 (48%), Gaps = 13/260 (5%) Query: 1 MDLALTNKKILITGASQGIGEGLAHAFAQEGCAVYLTARSEEKLQGIAAALRSQYDVAAH 60 MDL + KK+++T AS+GIG +A F +EG V +++ E L L+ + Sbjct: 1 MDLGIKGKKVIVTAASKGIGLAIAKRFLEEGAKVIISSNDESNLMKAYNKLKEIHSENVS 60 Query: 61 VLAADMTAPGAIECLCD----FAGDADVLVNNAGAIEGGDLWEIDDARWRGSWELKVFGY 116 + AD+ P ++ L G DVL G+ + G+L+ + D W ++ L + Sbjct: 61 YIKADLMNPHEVKSLVHEGYRKLGGLDVLAYVTGSPKPGNLFSLSDKDWMDAFNLLLLSA 120 Query: 117 INLTRALYGRMKTRKSGVILN---NIGNGGENFDFNYIAGTTGNAALMAFTRAMGGKSLE 173 + R G++ +IL+ + +N D + + + + +R +G K Sbjct: 121 VVAVRE-AGQLMQSGGRIILSTSTTLRQPIDNLDLSNVVRLSLAGLIKVASRELGPK--- 176 Query: 174 DGIRVVGVNPGPVDTDRIRRVLKKRAGSRLGDENR-YEELLKGYPLGRAAHVREIADMFV 232 GI V GV PG T+R+ ++++ RA E+ + ++ PLGRA EIA++ + Sbjct: 177 -GILVNGVMPGWTKTERLLQIIRDRAIREGKSEDEVLKSIVADVPLGRAGEPEEIANVVL 235 Query: 233 FLASERSGYTSGNIITIDGG 252 FLAS S Y +G +I +DGG Sbjct: 236 FLASNLSTYVTGALIPVDGG 255