BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0013.0019.p (462 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM0367 [KT] COG1221 Transcriptional regulators containing an AA... 291 2e-78 prpR [KT] COG1221 Transcriptional regulators containing an AAA-t... 284 4e-76 ZprpR [KT] COG1221 Transcriptional regulators containing an AAA-... 283 4e-76 ECs0384 [KT] COG1221 Transcriptional regulators containing an AA... 283 4e-76 CAC0459 [KT] COG3829 Transcriptional regulator containing PAS, A... 188 3e-47 >STM0367 [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Sty Salmonella typhimurium LT2 Length = 541 Score = 291 bits (745), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 144/220 (65%), Positives = 177/220 (80%), Gaps = 5/220 (2%) Query: 9 RDNPDKPVIWTVSVSRLVELFRDITLEFDDRADIEPIPLGFEDAVRHIRERLATEHCDAV 68 RDN DKPVIWTVSV+RL ELFRDI+LEFD A I PI LGFE AV +IR++LATE CDA+ Sbjct: 9 RDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAI 68 Query: 69 IAAGSNGAYLKSRLSVPVIIAKASGFDVMQALAKARKISPDIGMITYQETMPSLVEFQNT 128 IAAGSNGAYLKSRLS+PVI+ K SGFDV+QALAKA K++ IG++TYQET+P+L+ FQ T Sbjct: 69 IAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKT 128 Query: 129 FGLNIVQRTYATEEDARSQINELKAAGIKAIVGAGLITGLAQEAGLAGIFVYSAASIRQA 188 F L + QR+Y TEEDAR QINELKA GI+A+VGAGLIT LA+EAG+ IF+YSAA++RQA Sbjct: 129 FHLRLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIYSAATVRQA 188 Query: 189 FDDALELARLTQLESTRGRI-LPVADTLRARHHLNDLRSR 227 F DAL++ RLT+ R R+ P L+ R+ L D+R + Sbjct: 189 FHDALDMTRLTR----RQRVDYPSGKGLQTRYELGDIRGQ 224 Score = 288 bits (738), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 145/233 (62%), Positives = 174/233 (74%), Gaps = 10/233 (4%) Query: 226 SRRGGRAGLFEAAHRGTLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRPIPVNVRIIS 285 SRRGGRAGLFE AH GTL LDEIGEMPLPLQTRLLRVLEE+ V RVGG +PIPV+VR+IS Sbjct: 309 SRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVIS 368 Query: 286 ATHCDLDARVRDGRFRADLFYRLSVLRMTLPPLRERPDDLAPLAEWCLKNALAAMDIRPH 345 ATHCDLD + GRFR DLFYRLS+LR+TLPPLRER D+ PLAE LK +LAAM+I Sbjct: 369 ATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSLAAMEIPFT 428 Query: 346 ANLHAEILRCTPLLARYRWPGNVRELRNMMERLALFLAAEPLQALTPNLIGRIAPEILRD 405 ++ + +C PLL +RWPGN+RELRNMMERLALFL+ +P L + ++ PE++ + Sbjct: 429 ESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQLLPELMVN 488 Query: 406 DVSTTTAPVASVLRAAHADTDESLQDVLARFDGNRTAAASYLGISRTTLWRRL 458 T + V + +LQDVLARF G++TAAA YLGISRTTLWRRL Sbjct: 489 TAELTPSTVDA----------NALQDVLARFKGDKTAAARYLGISRTTLWRRL 531 >prpR [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Eco Escherichia coli K12 Length = 528 Score = 284 bits (726), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 142/224 (63%), Positives = 175/224 (78%), Gaps = 6/224 (2%) Query: 1 MKRPPFSSRDNPDKPVIWTVSVSRLVELFRDITLEFDDRADIEPIPLGFEDAVRHIRERL 60 M PP R N DKPVIWTVSV+RL ELFRDI+LEFD A+I PI LGFE AV +IR++L Sbjct: 1 MAHPP---RLNDDKPVIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKL 57 Query: 61 ATEHCDAVIAAGSNGAYLKSRLSVPVIIAKASGFDVMQALAKARKISPDIGMITYQETMP 120 A E CDA+IAAGSNGAYLKSRLSVPVI+ K SG+DV+QALAKA K++ IG++TYQET+P Sbjct: 58 ANERCDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIP 117 Query: 121 SLVEFQNTFGLNIVQRTYATEEDARSQINELKAAGIKAIVGAGLITGLAQEAGLAGIFVY 180 +LV FQ TF L + QR+Y TEEDAR QINELKA G +A+VGAGLIT LA+EAG+ GIF+Y Sbjct: 118 ALVAFQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIY 177 Query: 181 SAASIRQAFDDALELARLTQLESTRGRILPVADTLRARHHLNDL 224 SAA++RQAF DAL++ R++ +T + LR R+ L D+ Sbjct: 178 SAATVRQAFSDALDMTRMSLRHNTHD---ATRNALRTRYVLGDM 218 Score = 268 bits (686), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 138/233 (59%), Positives = 167/233 (71%), Gaps = 12/233 (5%) Query: 226 SRRGGRAGLFEAAHRGTLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRPIPVNVRIIS 285 SRRGGRAGLFE AH GTL LDEIGEMPLPLQTRLLRVLEE+EV RVGG +P+PV+VR+IS Sbjct: 306 SRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQPVPVDVRVIS 365 Query: 286 ATHCDLDARVRDGRFRADLFYRLSVLRMTLPPLRERPDDLAPLAEWCLKNALAAMDIRPH 345 ATHC+L+ ++ GRFR DLFYRLS+LR+ LPPLRER D+ PLAE LK +LAA+ Sbjct: 366 ATHCNLEEDMQQGRFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVSLAALSAPFS 425 Query: 346 ANLHAEILRCTPLLARYRWPGNVRELRNMMERLALFLAAEPLQALTPNLIGRIAPEILRD 405 A L + +L Y WPGN+RELRNMMERLALFL+ EP LTP + + PE+ R+ Sbjct: 426 AALRQGLQASETVLLHYDWPGNIRELRNMMERLALFLSVEPTPDLTPQFMQLLLPELARE 485 Query: 406 DVSTTTAPVASVLRAAHADTDESLQDVLARFDGNRTAAASYLGISRTTLWRRL 458 T P +L + Q L +F+G++TAAA+YLGISRTT WRRL Sbjct: 486 SAKT---PAPRLL---------TPQQALEKFNGDKTAAANYLGISRTTFWRRL 526 >ZprpR [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain EcZ Escherichia coli O157:H7 EDL933 Length = 528 Score = 283 bits (725), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 142/224 (63%), Positives = 175/224 (78%), Gaps = 6/224 (2%) Query: 1 MKRPPFSSRDNPDKPVIWTVSVSRLVELFRDITLEFDDRADIEPIPLGFEDAVRHIRERL 60 M PP R N DKPVIWTVSV+RL ELFRDI+LEFD A+I PI LGFE AV +IR++L Sbjct: 1 MAHPP---RLNDDKPVIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKL 57 Query: 61 ATEHCDAVIAAGSNGAYLKSRLSVPVIIAKASGFDVMQALAKARKISPDIGMITYQETMP 120 A E CDA+IAAGSNGAYLKSRLSVPVI+ K SG+DV+QALAKA K++ IG++TYQET+P Sbjct: 58 ANERCDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIP 117 Query: 121 SLVEFQNTFGLNIVQRTYATEEDARSQINELKAAGIKAIVGAGLITGLAQEAGLAGIFVY 180 +LV FQ TF L + QR+Y TEEDAR QINELKA G +A+VGAGLIT LA+EAG+ GIF+Y Sbjct: 118 ALVAFQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIY 177 Query: 181 SAASIRQAFDDALELARLTQLESTRGRILPVADTLRARHHLNDL 224 SAA++RQAF DAL++ R++ +T + LR R+ L D+ Sbjct: 178 SAATVRQAFSDALDMTRMSLRHNTHD---ATRNALRTRYVLGDM 218 Score = 267 bits (682), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 137/233 (58%), Positives = 167/233 (71%), Gaps = 12/233 (5%) Query: 226 SRRGGRAGLFEAAHRGTLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRPIPVNVRIIS 285 SRRGGRAGLFE AH GTL LDEIGEMPLPLQTRLLRVLEE+EV RVGG +P+PV+VR+IS Sbjct: 306 SRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQPVPVDVRVIS 365 Query: 286 ATHCDLDARVRDGRFRADLFYRLSVLRMTLPPLRERPDDLAPLAEWCLKNALAAMDIRPH 345 ATHC+L+ +R G+FR DLFYRLS+LR+ LPPLRER D+ PLAE LK +LAA+ Sbjct: 366 ATHCNLEEDMRQGQFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVSLAALSAPFS 425 Query: 346 ANLHAEILRCTPLLARYRWPGNVRELRNMMERLALFLAAEPLQALTPNLIGRIAPEILRD 405 A L + +L Y WPGN+RELRNMMERLALFL+ EP LTP + + PE+ R+ Sbjct: 426 AALRQGLQASETVLVHYDWPGNIRELRNMMERLALFLSVEPTPDLTPQFLQLLLPELARE 485 Query: 406 DVSTTTAPVASVLRAAHADTDESLQDVLARFDGNRTAAASYLGISRTTLWRRL 458 + P +L + Q L +F+G++TAAA+YLGISRTT WRRL Sbjct: 486 ---SAKIPAPRLL---------TPQQALEKFNGDKTAAANYLGISRTTFWRRL 526 >ECs0384 [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Ecs Escherichia coli O157:H7 Length = 528 Score = 283 bits (725), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 142/224 (63%), Positives = 175/224 (78%), Gaps = 6/224 (2%) Query: 1 MKRPPFSSRDNPDKPVIWTVSVSRLVELFRDITLEFDDRADIEPIPLGFEDAVRHIRERL 60 M PP R N DKPVIWTVSV+RL ELFRDI+LEFD A+I PI LGFE AV +IR++L Sbjct: 1 MAHPP---RLNDDKPVIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKL 57 Query: 61 ATEHCDAVIAAGSNGAYLKSRLSVPVIIAKASGFDVMQALAKARKISPDIGMITYQETMP 120 A E CDA+IAAGSNGAYLKSRLSVPVI+ K SG+DV+QALAKA K++ IG++TYQET+P Sbjct: 58 ANERCDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIP 117 Query: 121 SLVEFQNTFGLNIVQRTYATEEDARSQINELKAAGIKAIVGAGLITGLAQEAGLAGIFVY 180 +LV FQ TF L + QR+Y TEEDAR QINELKA G +A+VGAGLIT LA+EAG+ GIF+Y Sbjct: 118 ALVAFQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIY 177 Query: 181 SAASIRQAFDDALELARLTQLESTRGRILPVADTLRARHHLNDL 224 SAA++RQAF DAL++ R++ +T + LR R+ L D+ Sbjct: 178 SAATVRQAFSDALDMTRMSLRHNTHD---ATRNALRTRYVLGDM 218 Score = 267 bits (682), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 137/233 (58%), Positives = 167/233 (71%), Gaps = 12/233 (5%) Query: 226 SRRGGRAGLFEAAHRGTLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRPIPVNVRIIS 285 SRRGGRAGLFE AH GTL LDEIGEMPLPLQTRLLRVLEE+EV RVGG +P+PV+VR+IS Sbjct: 306 SRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQPVPVDVRVIS 365 Query: 286 ATHCDLDARVRDGRFRADLFYRLSVLRMTLPPLRERPDDLAPLAEWCLKNALAAMDIRPH 345 ATHC+L+ +R G+FR DLFYRLS+LR+ LPPLRER D+ PLAE LK +LAA+ Sbjct: 366 ATHCNLEEDMRQGQFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVSLAALSAPFS 425 Query: 346 ANLHAEILRCTPLLARYRWPGNVRELRNMMERLALFLAAEPLQALTPNLIGRIAPEILRD 405 A L + +L Y WPGN+RELRNMMERLALFL+ EP LTP + + PE+ R+ Sbjct: 426 AALRQGLQASETVLVHYDWPGNIRELRNMMERLALFLSVEPTPDLTPQFLQLLLPELARE 485 Query: 406 DVSTTTAPVASVLRAAHADTDESLQDVLARFDGNRTAAASYLGISRTTLWRRL 458 + P +L + Q L +F+G++TAAA+YLGISRTT WRRL Sbjct: 486 ---SAKIPAPRLL---------TPQQALEKFNGDKTAAANYLGISRTTFWRRL 526 >CAC0459 [KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Cac Clostridium acetobutylicum Length = 627 Score = 188 bits (477), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 97/234 (41%), Positives = 143/234 (61%), Gaps = 9/234 (3%) Query: 226 SRRGGRAGLFEAAHRGTLLLDEIGEMPLPLQTRLLRVLEEREVVRVGGTRPIPVNVRIIS 285 +++ G+ GLFE AH GT+ LDEIGE+ PLQ +LLRVLEE+E++ +GG + IPV++RIIS Sbjct: 400 AKKEGKQGLFELAHNGTIFLDEIGELSKPLQAQLLRVLEEKEIMHIGGDKIIPVDIRIIS 459 Query: 286 ATHCDLDARVRDGRFRADLFYRLSVLRMTLPPLRERPDDLAPLAEWCLKNALAAMDIRPH 345 +T+ +L + +G FR DL+YRL+V +TLPPLRER D+ LAE L+N Sbjct: 460 STNRNLLNSIENGTFREDLYYRLNVFNLTLPPLRERGKDIEILAEHFLENT------HNF 513 Query: 346 ANLHAEIL-RCTPLLARYRWPGNVRELRNMMERLALFLAAEPLQALTPNLIGRIAPEILR 404 ++ ++IL + TP L Y WPGN REL N+MER++LF+ + L + E + Sbjct: 514 SSNRSKILNQITPFLMAYNWPGNTRELSNVMERISLFIENSMTINWSQVLYKVVHKEKIE 573 Query: 405 DDVSTTTAPVASVLRAAHADTDE-SLQDVLARFDGNRTAAASYLGISRTTLWRR 457 D + T P ++ T++ + +L R+D + A L I RTTLWR+ Sbjct: 574 DTL-TLKVPYNLTMKEIIELTEKRVIHSLLERYDNDHNRVAEILNIGRTTLWRK 626 Score = 73.6 bits (179), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 39/141 (27%), Positives = 79/141 (56%), Gaps = 1/141 (0%) Query: 63 EHCDAVIAAGSNGAYLKSRLSVPVIIAKASGFDVMQALAKARKISPDIGMITYQETMPSL 122 + DA+I+ G+ Y+K +S+P I K + FD M+A+ A++ ++ +I Y+ ++ Sbjct: 48 DEVDAIISRGATSDYIKKSVSIPSISIKVTRFDTMRAVYNAKRFGNELALIAYKHSIVDK 107 Query: 123 VEFQNTFGLNIVQRTYATEEDARSQINELKAAGIKAIVGAGLITGLAQEAGLAGIFVYSA 182 E + G+ I + +++E++ + I+++K IK +V +T A + GL G + S Sbjct: 108 HEIEAMLGVKIKEFLFSSEDEITTLISKVKTENIKIVVSGKTVTDEAIKQGLYGETINSG 167 Query: 183 -ASIRQAFDDALELARLTQLE 202 S+R+A ++AL L + +E Sbjct: 168 EESLRRAIEEALNLIEVRNIE 188