BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0148.p (466 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3504 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pse... 345 9e-95 SMa2213 [C] COG1012 NAD-dependent aldehyde dehydrogenases Sme Si... 204 3e-52 AGpA320 [C] COG1012 NAD-dependent aldehyde dehydrogenases Atu Ag... 197 3e-50 mll7608 [C] COG1012 NAD-dependent aldehyde dehydrogenases Mlo Me... 193 7e-49 BMEI1382 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bme B... 186 1e-46 >PA3504 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pseudomonas aeruginosa Length = 494 Score = 345 bits (886), Expect = 9e-95, Method: Compositional matrix adjust. Identities = 161/203 (79%), Positives = 177/203 (87%) Query: 1 MVFDDADIDHAVAGVLYGIFSSSGESCIAGSRLFVARSIYDSFMERLAAGAAALRVGDPA 60 MV DAD+DHAVAGVLYGIFSSSGESCIAGSRLFVA YD FMERLA GAAALRVGDPA Sbjct: 260 MVLADADLDHAVAGVLYGIFSSSGESCIAGSRLFVASERYDEFMERLATGAAALRVGDPA 319 Query: 61 DERTQMGPLITARHREGIESYVSIGVADGGRIRTGGTRLAGDQFARGYYYAPTIIEGVTN 120 DERTQMGPLI+ARHRE +E YV +GVA+GGR+RTGG R G F RGY+Y PTIIEG+TN Sbjct: 320 DERTQMGPLISARHRESVERYVEMGVAEGGRLRTGGLRPHGGAFDRGYFYTPTIIEGLTN 379 Query: 121 DQRICQEEIFGPVLAAMPFDNEEDLIAQANDSVYALAAGIWTRDYKKAWRFGRAVQAGNV 180 R+C+EE+FGPVL AMPF +EE LI +ANDS YALAAGIWTRD+++AWR GRAVQAG V Sbjct: 380 GARLCREEVFGPVLVAMPFASEEALIEEANDSCYALAAGIWTRDFQRAWRLGRAVQAGTV 439 Query: 181 WINTYKQFSISTPFGGWRDSGLG 203 WINTYKQFSISTPFGGWRDSGLG Sbjct: 440 WINTYKQFSISTPFGGWRDSGLG 462 Score = 322 bits (825), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 170/207 (82%), Positives = 186/207 (89%) Query: 205 FRTSGWAQKKPHERAIVLYRVAQLIRERGEALAQRQRLDNGKPITETRNLVGSAAATFQF 264 FR SGWAQ+KPHERA VLYR+A LIRER E LAQ QRLDNGKPI ETRNLV SAAATFQF Sbjct: 57 FRESGWAQRKPHERATVLYRIAALIRERSEELAQLQRLDNGKPIRETRNLVASAAATFQF 116 Query: 265 FAAACETLEETITPMRGDNLTMSVYEAMGVVAAITPWNSPIASEAQKMAPALAAGNAVVV 324 FAAACETLEE+ITP RGD ++MSVYE MGVV AITPWNSPIASEAQK+APALAAGNAVVV Sbjct: 117 FAAACETLEESITPSRGDFVSMSVYEPMGVVVAITPWNSPIASEAQKLAPALAAGNAVVV 176 Query: 325 KPAEVTPLMALELARICEEAGVPKGLISVLPGKGSVIGDAITLHPLVKRVSFTGGTTTGK 384 KPAE+TPL AL LARIC+EAG+P+GL+SVLPGKG++IGDA+T HPL +RVSFTGGT TGK Sbjct: 177 KPAEITPLAALALARICDEAGLPRGLVSVLPGKGALIGDALTRHPLARRVSFTGGTRTGK 236 Query: 385 HIAHIAADKMMPVSLELGGKSPASPMA 411 HIA IAADKMMPVSLELGGKSP +A Sbjct: 237 HIARIAADKMMPVSLELGGKSPTMVLA 263 >SMa2213 [C] COG1012 NAD-dependent aldehyde dehydrogenases Sme Sinorhizobium meliloti Length = 494 Score = 204 bits (520), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 95/203 (46%), Positives = 136/203 (66%) Query: 1 MVFDDADIDHAVAGVLYGIFSSSGESCIAGSRLFVARSIYDSFMERLAAGAAALRVGDPA 60 +VF DAD+D+AV GV+ GIF + G++CIAGSRL V RSI+D F+E+LA R+GDP Sbjct: 260 IVFGDADLDNAVRGVVGGIFGAVGQTCIAGSRLLVHRSIHDEFLEKLAVFTKTARIGDPR 319 Query: 61 DERTQMGPLITARHREGIESYVSIGVADGGRIRTGGTRLAGDQFARGYYYAPTIIEGVTN 120 TQ+GP+ + E + Y+ I +G + GG R ++ GY+ PTI GV+N Sbjct: 320 KVETQIGPIANSMQFEKVLGYIDIARREGAELILGGGRPDLEECGTGYFIEPTIFAGVSN 379 Query: 121 DQRICQEEIFGPVLAAMPFDNEEDLIAQANDSVYALAAGIWTRDYKKAWRFGRAVQAGNV 180 D RI +EE+FGPVL+A+ FD E+ +A ANDS + L AG+WT D + A + ++AG+V Sbjct: 380 DMRIAREEVFGPVLSAIVFDEPEEALAIANDSEFGLGAGVWTSDMRLALKMSERLEAGSV 439 Query: 181 WINTYKQFSISTPFGGWRDSGLG 203 W+NTY+ S +TPFGG++ SG+G Sbjct: 440 WVNTYRDISYTTPFGGYKKSGIG 462 Score = 160 bits (405), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 82/202 (40%), Positives = 118/202 (58%) Query: 205 FRTSGWAQKKPHERAIVLYRVAQLIRERGEALAQRQRLDNGKPITETRNLVGSAAATFQF 264 F W + P ER ++ R A LI E +ALA + DNG+ + E + + + + Sbjct: 57 FSQGPWGKMHPTERGRIIQRFAALIEEHADALADIEVRDNGRLLAEMTHQIRYIPRWYHY 116 Query: 265 FAAACETLEETITPMRGDNLTMSVYEAMGVVAAITPWNSPIASEAQKMAPALAAGNAVVV 324 +A + +E T+ P L+ S +E +GV I PWN+P+ + K APALAAGN +V+ Sbjct: 117 YAGFADKIEGTLHPCDKPALSFSRHEPLGVCVGIVPWNAPLLLFSLKAAPALAAGNTLVM 176 Query: 325 KPAEVTPLMALELARICEEAGVPKGLISVLPGKGSVIGDAITLHPLVKRVSFTGGTTTGK 384 KPAE T AL+L + E+AG P G+I+V+ G G +G+ + HPL + V FTG T TG Sbjct: 177 KPAEFTSATALKLMELVEKAGFPTGVINVVTGYGPEVGEPLVTHPLTRHVGFTGSTKTGA 236 Query: 385 HIAHIAADKMMPVSLELGGKSP 406 H+ +AA + VSLELGGKSP Sbjct: 237 HLYSLAAKDVKRVSLELGGKSP 258 >AGpA320 [C] COG1012 NAD-dependent aldehyde dehydrogenases Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 507 Score = 197 bits (502), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 91/219 (41%), Positives = 140/219 (63%), Gaps = 2/219 (0%) Query: 1 MVFDDADIDHAVAGVLYGIFSSSGESCIAGSRLFVARSIYDSFMERLAAGAAALRVGDPA 60 +VF D DI+ V GV+ G+F+++G++C+AGSR FV +IYD F+E L +++GDP Sbjct: 271 VVFSDVDIEKTVNGVVSGVFAAAGQTCVAGSRCFVEANIYDRFIEALVERTRNIKLGDPM 330 Query: 61 DERTQMGPLITARHREGIESYVSIGVADGGRIRTGGTRLAGDQFARGYYYAPTIIEGVTN 120 D+ T +GPL +E YV+ GV +G RI GG R ++ +RG+Y+ PT++ TN Sbjct: 331 DDATDIGPLALESQLSKLEGYVASGVREGSRIAIGGKRPQSEELSRGWYFEPTVMADATN 390 Query: 121 DQRICQEEIFGPVLAAMPFDNEEDLIAQANDSVYALAAGIWTRDYKKAWRFGRAVQAGNV 180 D + E+FGP++ MPF +EE++I+ AND+ Y LA+GIWT++ +A RF + AG V Sbjct: 391 DMSFMRHELFGPMVGVMPFSSEEEMISLANDTNYGLASGIWTQNIDRAMRFANQIDAGTV 450 Query: 181 WINTYKQFSISTPFGGWRDSGLGPFRTSGWAQKKPHERA 219 WINTY+ + + GG+++SG G R G+ + RA Sbjct: 451 WINTYRSAAYMSANGGFKESGYG--RRGGFDVMREFSRA 487 Score = 128 bits (321), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 80/212 (37%), Positives = 120/212 (56%), Gaps = 1/212 (0%) Query: 205 FRTSGWAQKKPHERAIVLYRVAQLIRERGEALAQRQRLDNGKPITETRNLVGSAAATFQF 264 FR W + R ++ R+A L+ E E LA + DNGK I E R + + ++ + Sbjct: 67 FRDPSWRRMTQTARGKLVRRLADLVLEHAEDLALLETRDNGKLIKEMRAQMRAIPDSYLY 126 Query: 265 FAAACETLE-ETITPMRGDNLTMSVYEAMGVVAAITPWNSPIASEAQKMAPALAAGNAVV 323 FA + L+ +TI + D L ++ E +GV+ +TPWNSP+ +AP LA GN VV Sbjct: 127 FAGMADKLQGDTIPVNKLDQLNFNMREPLGVIGMVTPWNSPLMLLTGTLAPCLAIGNTVV 186 Query: 324 VKPAEVTPLMALELARICEEAGVPKGLISVLPGKGSVIGDAITLHPLVKRVSFTGGTTTG 383 +KP+E L LA + EAG P G+++V+ G G+V G+A+T H + + FTG T TG Sbjct: 187 IKPSEHATASTLALAELIVEAGFPAGVVNVVTGGGAVTGEALTRHNGIAKFVFTGSTATG 246 Query: 384 KHIAHIAADKMMPVSLELGGKSPASPMAAVSV 415 + IA AA ++P +ELGGKSP + V + Sbjct: 247 RRIAANAAANLVPCQMELGGKSPHVVFSDVDI 278 >mll7608 [C] COG1012 NAD-dependent aldehyde dehydrogenases Mlo Mesorhizobium loti Length = 487 Score = 193 bits (491), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 88/203 (43%), Positives = 130/203 (64%) Query: 1 MVFDDADIDHAVAGVLYGIFSSSGESCIAGSRLFVARSIYDSFMERLAAGAAALRVGDPA 60 +VFDDADI++A+ G + G F S+G+ C G+R+FV I+D F+ERL +R+G+P Sbjct: 257 IVFDDADIENAIGGAMLGNFYSTGQICSNGTRVFVQSGIHDRFVERLVERTKKIRIGNPL 316 Query: 61 DERTQMGPLITARHREGIESYVSIGVADGGRIRTGGTRLAGDQFARGYYYAPTIIEGVTN 120 D TQMGPL++ E + Y+ IG DG + GG + F G++ PT+ GVT+ Sbjct: 317 DPETQMGPLVSKAQHEKVVGYIGIGKQDGAVLACGGNVPSLQGFDGGFFVEPTVFTGVTD 376 Query: 121 DQRICQEEIFGPVLAAMPFDNEEDLIAQANDSVYALAAGIWTRDYKKAWRFGRAVQAGNV 180 RI +EEIFGPV++ + FD E+++I +AND+ + LAAG++TRD +A R +QAG Sbjct: 377 TMRIAREEIFGPVMSVLKFDGEDEVIDRANDTEFGLAAGVFTRDLPRAHRVIAELQAGTC 436 Query: 181 WINTYKQFSISTPFGGWRDSGLG 203 WIN Y + PFGG++ SG+G Sbjct: 437 WINAYNLTPVEIPFGGFKQSGIG 459 Score = 133 bits (335), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 85/196 (43%), Positives = 108/196 (55%), Gaps = 7/196 (3%) Query: 214 KPHERAIVLYRVAQLIRERGEALAQRQRLDNGKPITETRNLVG---SAAATFQFFAAACE 270 KP ER +L R A ++R R LA+ + LD GK I ET LV SAA ++F A Sbjct: 64 KPVERGRILRRAADILRARNADLARIETLDTGKAIQET--LVADAPSAADCLEYFGGAVA 121 Query: 271 TLEETITPMRGDNLTMSVYEAMGVVAAITPWNSPIASEAQKMAPALAAGNAVVVKPAEVT 330 + G + EA+GV I WN PI K APALA GNA+V KP+E T Sbjct: 122 AYNGEAVDL-GGPFAYTRREALGVCVGIGAWNYPIQIAGWKSAPALAMGNAMVFKPSENT 180 Query: 331 PLMALELARICEEAGVPKGLISVLPGKGSVIGDAITLHPLVKRVSFTGGTTTGKHIAHIA 390 PL AL LA I EAG+P GL +V+ G G V G + H +V +VS TG TG+ + +A Sbjct: 181 PLSALALAEIYSEAGLPDGLFNVVQGYGDV-GAGLVGHDVVAKVSVTGSVPTGRKVLSLA 239 Query: 391 ADKMMPVSLELGGKSP 406 KM ++ELGGKSP Sbjct: 240 GSKMKHATMELGGKSP 255 >BMEI1382 [C] COG1012 NAD-dependent aldehyde dehydrogenases Bme Brucella melitensis Length = 500 Score = 186 bits (471), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 89/223 (39%), Positives = 138/223 (61%), Gaps = 2/223 (0%) Query: 1 MVFDDADIDHAVAGVLYGIFSSSGESCIAGSRLFVARSIYDSFMERLAAGAAALRVGDPA 60 +VFDDAD++ A+ G + G F S+G+ C G+R+FV ++I + F+ERL +R+GDP Sbjct: 270 IVFDDADLESAIGGAMLGNFYSTGQVCSNGTRVFVHKNIRERFIERLVERTRKIRIGDPF 329 Query: 61 DERTQMGPLITARHREGIESYVSIGVADGGRIRTGGTRLAGDQFARGYYYAPTIIEGVTN 120 DE TQMGPLI+A R+ + SY+ G A+G + GG F +G++ PT+ VT+ Sbjct: 330 DEATQMGPLISAAQRDKVLSYIKKGKAEGATLACGGGVPKLQGFDKGFFIEPTVFADVTD 389 Query: 121 DQRICQEEIFGPVLAAMPFDNEEDLIAQANDSVYALAAGIWTRDYKKAWRFGRAVQAGNV 180 I +EEIFGPV++ + F +E+++IA+ANDS + LAAG++T D + ++AG Sbjct: 390 TMTIAREEIFGPVMSVLEFSDEDEVIARANDSEFGLAAGVFTADLSRGHHVIGQIKAGTC 449 Query: 181 WINTYKQFSISTPFGGWRDSGLGPFRTSGWAQKKPHERAIVLY 223 WIN Y + PFGG++ SG+G R +G A + + +Y Sbjct: 450 WINAYNLTPVEVPFGGYKQSGIG--RENGIAALAHYSQIKTVY 490 Score = 135 bits (340), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 82/198 (41%), Positives = 111/198 (56%), Gaps = 3/198 (1%) Query: 210 WAQKKPHERAIVLYRVAQLIRERGEALAQRQRLDNGKPITETR-NLVGSAAATFQFFAAA 268 WA KP ER +L R A+++RE+ L++ + LD GK + ET SAA +FF Sbjct: 73 WAALKPVERGRILRRTAEILREKNRKLSKLETLDTGKALQETLVADAASAADALEFFGGI 132 Query: 269 CETLEETITPMRGDNLTMSVYEAMGVVAAITPWNSPIASEAQKMAPALAAGNAVVVKPAE 328 + G + + EA+G+ I WN PI A K APALA GNA + KP+E Sbjct: 133 ISGFNGEFVEL-GGSFAYTRREALGICVGIGAWNYPIQIAAWKSAPALAMGNAFIFKPSE 191 Query: 329 VTPLMALELARICEEAGVPKGLISVLPGKGSVIGDAITLHPLVKRVSFTGGTTTGKHIAH 388 TPL AL LA +EAG+P GL +V+ G G V G A+ H L +VS TG TG+ I Sbjct: 192 NTPLSALALAEAYKEAGLPDGLFNVVQGYGDV-GAALVNHRLTAKVSLTGSVPTGRRIMA 250 Query: 389 IAADKMMPVSLELGGKSP 406 A +++ V++ELGGKSP Sbjct: 251 QAGEQLKHVTMELGGKSP 268