BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0109.p (200 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value paaY [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleuc... 247 1e-65 ZcaiE [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleu... 237 1e-62 ECs0038 [R] COG0663 Carbonic anhydrases/acetyltransferases, isol... 237 1e-62 STM0069 [R] COG0663 Carbonic anhydrases/acetyltransferases, isol... 236 2e-62 caiE [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleuc... 235 4e-62 >paaY [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Eco Escherichia coli K12 Length = 196 Score = 247 bits (631), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 113/186 (60%), Positives = 144/186 (77%) Query: 1 MPCYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYIGPAACLRGDFGRIVIHRGANVQD 60 MP Y I+G+ PVV ++VHPTAVLIGDVI+G Y+GP A LRGDFGRIV+ GAN+QD Sbjct: 1 MPIYQIDGLTPVVPEESFVHPTAVLIGDVILGKGVYVGPNASLRGDFGRIVVKDGANIQD 60 Query: 61 TCVVHGFPAHDTVIEENGHIGHGAVLHSCIVRRDALVGMNAVVMDDAEVGEEAIVAASAF 120 CV+HGFP DTV+ E+GHIGH A+LH CI+RR+ALVGMNAVVMD A +GE +IV ASAF Sbjct: 61 NCVMHGFPEQDTVVGEDGHIGHSAILHGCIIRRNALVGMNAVVMDGAVIGENSIVGASAF 120 Query: 121 IRAGMKVPPRSLAAGVPAKILRELTEQEIAWKREGTHTYQDLTKRCLASMKEVQPLQEIE 180 ++A ++P L G PAK +REL+EQE+AWK++GTH YQ L RC ++ +V+PL+EIE Sbjct: 121 VKAKAEMPANYLIVGSPAKAIRELSEQELAWKKQGTHEYQVLVTRCKQTLHQVEPLREIE 180 Query: 181 ADRPKL 186 R +L Sbjct: 181 PGRKRL 186 >ZcaiE [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 203 Score = 237 bits (605), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 104/185 (56%), Positives = 142/185 (76%) Query: 4 YSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYIGPAACLRGDFGRIVIHRGANVQDTCV 63 Y+ EG+IPVV P+A+VHP+AVLIGDVIVG YIGP A LRGD+GR+++ GAN+QD C+ Sbjct: 11 YAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCI 70 Query: 64 VHGFPAHDTVIEENGHIGHGAVLHSCIVRRDALVGMNAVVMDDAEVGEEAIVAASAFIRA 123 +HG+ DT++ ENGHIGHGA+LH C++ RDALVGMN+V+MD A +GEE+IVAA +F++A Sbjct: 71 MHGYTDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKA 130 Query: 124 GMKVPPRSLAAGVPAKILRELTEQEIAWKREGTHTYQDLTKRCLASMKEVQPLQEIEADR 183 G R L G PA+ +R +++ E+ WKR T YQDL RC AS+ E QPL+++E +R Sbjct: 131 GFHGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQMEENR 190 Query: 184 PKLKA 188 P+L+ Sbjct: 191 PRLQG 195 >ECs0038 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Ecs Escherichia coli O157:H7 Length = 203 Score = 237 bits (605), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 104/185 (56%), Positives = 142/185 (76%) Query: 4 YSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYIGPAACLRGDFGRIVIHRGANVQDTCV 63 Y+ EG+IPVV P+A+VHP+AVLIGDVIVG YIGP A LRGD+GR+++ GAN+QD C+ Sbjct: 11 YAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCI 70 Query: 64 VHGFPAHDTVIEENGHIGHGAVLHSCIVRRDALVGMNAVVMDDAEVGEEAIVAASAFIRA 123 +HG+ DT++ ENGHIGHGA+LH C++ RDALVGMN+V+MD A +GEE+IVAA +F++A Sbjct: 71 MHGYTDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKA 130 Query: 124 GMKVPPRSLAAGVPAKILRELTEQEIAWKREGTHTYQDLTKRCLASMKEVQPLQEIEADR 183 G R L G PA+ +R +++ E+ WKR T YQDL RC AS+ E QPL+++E +R Sbjct: 131 GFHGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQMEENR 190 Query: 184 PKLKA 188 P+L+ Sbjct: 191 PRLQG 195 >STM0069 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Sty Salmonella typhimurium LT2 Length = 198 Score = 236 bits (603), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 105/188 (55%), Positives = 141/188 (75%) Query: 1 MPCYSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYIGPAACLRGDFGRIVIHRGANVQD 60 M Y+ EG+IPVV P A+VHP+AVLIGDVIVG YIGP A LRGD+GR+++ G+N+QD Sbjct: 1 MSYYAFEGLIPVVHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLILEAGSNLQD 60 Query: 61 TCVVHGFPAHDTVIEENGHIGHGAVLHSCIVRRDALVGMNAVVMDDAEVGEEAIVAASAF 120 C++HG+ DT++ ENGHIGHGA+LH C+V RDALVGMN+V+MD A +GEE+IVAA +F Sbjct: 61 GCIMHGYCDTDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIMDGAVIGEESIVAAMSF 120 Query: 121 IRAGMKVPPRSLAAGVPAKILRELTEQEIAWKREGTHTYQDLTKRCLASMKEVQPLQEIE 180 ++AG + R L G PA++LR++T+QE+ WK T YQDL RC + E +PL + E Sbjct: 121 VKAGFQGEARQLLVGSPARVLRQVTDQELHWKHLNTKEYQDLAIRCRTGLSETKPLTQAE 180 Query: 181 ADRPKLKA 188 +RP+LK Sbjct: 181 ENRPRLKG 188 >caiE [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily Eco Escherichia coli K12 Length = 203 Score = 235 bits (600), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 103/185 (55%), Positives = 142/185 (76%) Query: 4 YSIEGVIPVVDPSAYVHPTAVLIGDVIVGPDCYIGPAACLRGDFGRIVIHRGANVQDTCV 63 Y+ EG+IPVV P+A+VHP+AVLIGDVIVG YIGP A LRGD+GR+++ GAN+QD C+ Sbjct: 11 YAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCI 70 Query: 64 VHGFPAHDTVIEENGHIGHGAVLHSCIVRRDALVGMNAVVMDDAEVGEEAIVAASAFIRA 123 +HG+ DT++ ENGHIGHGA+LH C++ RDALVGMN+V+MD A +GEE+IVAA +F++A Sbjct: 71 MHGYCDTDTIVGENGHIGHGAILHGCLIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKA 130 Query: 124 GMKVPPRSLAAGVPAKILRELTEQEIAWKREGTHTYQDLTKRCLASMKEVQPLQEIEADR 183 G + R L G PA+ +R +++ E+ WKR T YQDL RC S+ E QPL+++E +R Sbjct: 131 GFRGEKRQLLMGTPARAVRNVSDDELHWKRLNTKEYQDLVGRCHVSLHETQPLRQMEENR 190 Query: 184 PKLKA 188 P+L+ Sbjct: 191 PRLQG 195