BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0069.p (219 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value VCA0178 [Q] COG2761 Predicted dithiol-disulfide isomerase involv... 167 1e-41 CAC3447 [Q] COG2761 Predicted dithiol-disulfide isomerase involv... 146 3e-35 AGc3262 [Q] COG2761 Predicted dithiol-disulfide isomerase involv... 128 1e-29 Cgl2513 [Q] COG2761 Predicted dithiol-disulfide isomerase involv... 126 4e-29 SMc00952 [Q] COG2761 Predicted dithiol-disulfide isomerase invol... 125 9e-29 >VCA0178 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Vch Vibrio cholerae Length = 217 Score = 167 bits (424), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 87/211 (41%), Positives = 120/211 (56%), Gaps = 2/211 (0%) Query: 1 MNKALKIDFVSDVVCPWCAIGLAGLNTALERLGPETHVDFTVHPFELNPGMPAAGQEQLE 60 M+K L ID VSD+VCPWC IG L AL RL PE +V HP+ELNP + G+ E Sbjct: 1 MHK-LTIDLVSDIVCPWCVIGYFRLRHALARL-PEVNVTLRWHPYELNPRLAIGGENLRE 58 Query: 61 HITEKYGISADQARINREQIRARAASVGFTMNRDDTSRVYNTFDAHRLLAWAKEKNAQAA 120 H+ +KYG S + ++ R+ + VGF + D R+YNT AH+LL WA +++ Q Sbjct: 59 HLNKKYGTSLEASQQARKTLTELGNDVGFAFHFFDEMRIYNTRKAHQLLLWAHQQDKQLP 118 Query: 121 LKLILLEAYFTDGKNIADRNVLAELASQAGLDTVEASEILASDRFAQEVKEEETFWTQRG 180 L L L AYF G+ I + VL E+A GLD +IL + +A V E W Q G Sbjct: 119 LTLALWSAYFQQGQAIDEDEVLLEIAQTVGLDRSACQQILTDESWANAVANTEQQWLQAG 178 Query: 181 ISSVPAVIVNDRYLISGGQPPDVFEEQLRAI 211 I +VP +I+ +YLISG Q D+ + L+ + Sbjct: 179 IHAVPTLIIEQKYLISGAQTSDILLDVLQRL 209 >CAC3447 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Cac Clostridium acetobutylicum Length = 228 Score = 146 bits (369), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 80/208 (38%), Positives = 120/208 (57%), Gaps = 2/208 (0%) Query: 5 LKIDFVSDVVCPWCAIGLAGLNTALERLGPETHVDFTVHPFELNPGMPAAGQEQL-EHIT 63 +KI+ SD VCP+C +G L AL +T V+ + FEL+P E + E I Sbjct: 1 MKIEVWSDFVCPFCYMGKRRLEIALNEFEYKTDVEISFKSFELDPSAKKEYSENIHELIA 60 Query: 64 EKYGISADQARINREQIRARAASVGFTMNRDDTSRVYNTFDAHRLLAWAKEKNAQAALKL 123 +KY IS +QA+ + +QI +A ++G N + NTFDAHRL +AK K L Sbjct: 61 KKYKISVEQAKASNDQIVLQAEAIGLNYNFNKLIPT-NTFDAHRLSQYAKTKGKMNELSE 119 Query: 124 ILLEAYFTDGKNIADRNVLAELASQAGLDTVEASEILASDRFAQEVKEEETFWTQRGISS 183 + +AYF D NI+D VLA+LA + G+ E+ IL S+++ +EV+E+E ++ GI + Sbjct: 120 KIFKAYFVDSLNISDYKVLADLAEEVGISRDESLRILESNQYNEEVREDEKNASKLGIDA 179 Query: 184 VPAVIVNDRYLISGGQPPDVFEEQLRAI 211 VP + +D+Y +SG QP +VF E L I Sbjct: 180 VPYFVFDDKYAVSGAQPAEVFLEALYKI 207 >AGc3262 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 242 Score = 128 bits (321), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 77/207 (37%), Positives = 105/207 (50%), Gaps = 4/207 (1%) Query: 7 IDFVSDVVCPWCAIGLAGLNTALERLGPETHVDFTVHPFELNPGMPAAGQEQLEHITEKY 66 +D VSD+VCPWC +G A L+ A+ + E VD P+ LNP P G +Q + EK Sbjct: 26 VDVVSDMVCPWCYLGKARLDLAIAEVQDEISVDVNWRPYRLNPDYPPEGVDQKAALEEKL 85 Query: 67 GISADQARINREQIRARAASVGFTMNRDDTSRVYNTFDAHRLLAWA--KEKNAQAALKLI 124 G D+ + VG + D NT DAHRL WA + ++ Q + Sbjct: 86 G--KDRLEQAHASLVELGKQVGINYDFDAIKIGPNTLDAHRLSLWAHAEGRDVQERIVTA 143 Query: 125 LLEAYFTDGKNIADRNVLAELASQAGLDTVEASEILASDRFAQEVKEEETFWTQRGISSV 184 L +A F +G+NI D VL ++A +AG+D + +LASD V E Q G+S V Sbjct: 144 LFKANFEEGRNIGDHAVLTDIAGKAGMDAKVVARLLASDADKDTVIAEIDAAQQMGVSGV 203 Query: 185 PAVIVNDRYLISGGQPPDVFEEQLRAI 211 P IV+ +Y ISG Q PDV LR I Sbjct: 204 PFFIVDQKYAISGAQTPDVLIAALRDI 230 >Cgl2513 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Cgl Corynebacterium glutamicum Length = 245 Score = 126 bits (316), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 71/201 (35%), Positives = 111/201 (55%), Gaps = 2/201 (0%) Query: 5 LKIDFVSDVVCPWCAIGLAGLNTALERLGPETHVDFTVHPFELNPGMPAAG-QEQLEHIT 63 +KI+ SD++CP+C IG L+ AL ++ FEL PG+ + +E++ Sbjct: 11 MKIEVWSDIMCPFCYIGKKRLDDALSTFDQAGRIEVEYKSFELMPGLETHPLRSDVEYLA 70 Query: 64 EKYGISADQARINREQIRARAASVGFTMNRDDTSRVYNTFDAHRLLAWAKEKNAQAALKL 123 + G+S +QAR Q++A A + G MN D+T NT +AHRL +AK Q + Sbjct: 71 DAKGMSLEQARQMNGQVQAMAQATGLEMNPDETIAA-NTINAHRLTHFAKAHGKQQEVAQ 129 Query: 124 ILLEAYFTDGKNIADRNVLAELASQAGLDTVEASEILASDRFAQEVKEEETFWTQRGISS 183 L +A+F DGKN+ D +VL +A++ GLD A E L SD + EV+++ Q G+ Sbjct: 130 ELFKAHFVDGKNVDDLDVLVSIAAEVGLDASAAREALESDVYTNEVQQDVHEARQLGVQG 189 Query: 184 VPAVIVNDRYLISGGQPPDVF 204 VP + + +Y I+G Q +VF Sbjct: 190 VPFFVFDRKYAINGAQQEEVF 210 >SMc00952 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Sme Sinorhizobium meliloti Length = 221 Score = 125 bits (313), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 72/211 (34%), Positives = 110/211 (52%), Gaps = 3/211 (1%) Query: 3 KALKIDFVSDVVCPWCAIGLAGLNTALERLGPETHVDFTVHPFELNPGMPAAGQEQLEHI 62 + + ID VSDVVCPWC +G L+ A+ + E +V P++LNP +P G + EH+ Sbjct: 2 ETVNIDIVSDVVCPWCYLGKNRLDQAIANVAGEINVAIQWRPYQLNPDLPPEGIDHKEHL 61 Query: 63 TEKYGISADQARINREQIRARAASVGFTMNRDDTSRVYNTFDAHRLLAWAKE--KNAQAA 120 K G A +R + G + D NT DAHRL+ WA + AQ A Sbjct: 62 AAKLGGQAAVDEAHR-TLEGLGVEDGIAFDFDAVKVSPNTLDAHRLIRWAATGGEAAQDA 120 Query: 121 LKLILLEAYFTDGKNIADRNVLAELASQAGLDTVEASEILASDRFAQEVKEEETFWTQRG 180 + +L +A F +G+N+ D+ VL ++A QAGL+ + +LASD V++E + G Sbjct: 121 VVSLLFKANFEEGRNLGDQAVLLDIAEQAGLERPVIAALLASDADKDAVRQEIDMAREIG 180 Query: 181 ISSVPAVIVNDRYLISGGQPPDVFEEQLRAI 211 ++ VP I+ +Y + G Q +V LR I Sbjct: 181 VTGVPCFIIEQQYAVMGAQSVEVLTSALREI 211