BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0057.p (456 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superf... 639 0.0 STM2962 [GEPR] COG0477 Permeases of the major facilitator superf... 618 e-177 Z4105 [GEPR] COG0477 Permeases of the major facilitator superfam... 617 e-176 ECs3649 [GEPR] COG0477 Permeases of the major facilitator superf... 617 e-176 ygcZ [GEPR] COG0477 Permeases of the major facilitator superfami... 617 e-176 >BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 455 Score = 639 bits (1647), Expect = 0.0, Method: Compositional matrix adjust. Identities = 300/448 (66%), Positives = 369/448 (82%), Gaps = 10/448 (2%) Query: 7 ASAKENIKPSHVRYLILFMLFIVTTVNYADRATLSIAGTSMKSELGLDPVMMGYIFSAFS 66 AS K + VR+ I+FMLF+VT++NYADRATLSI G S++ +LGLD V MGY+FSAF Sbjct: 6 ASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFG 65 Query: 67 WAYVLAQLPGGWLLDRFGSKKIYALSIFLWSFFTLLQGGVTWFGTAAAVVLLFLLRFMVG 126 WAYV+ QLPGGWLLDRFGSK I ALSIF WSFFTLLQG + +F A++LLF LRF+VG Sbjct: 66 WAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGFFSAGTAIILLFALRFLVG 125 Query: 127 LAEAPSFPANGRIVASWFPTAERGTASAIFNSAQYFAAVLFTPLMGWITHVYGWHHVFTV 186 L+EAPSFP NGR+VASWFP++ERGTASA FNSAQYFA V+F PLMGW+TH +GWH VF V Sbjct: 126 LSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFPPLMGWLTHSFGWHSVFVV 185 Query: 187 MGAFGILLTFLWIRVIHSPKDHPMINQAELQHIEQGGGLVDMDQAKTTKATAGAAASGDA 246 MG GILL +W++ ++ PK HP +N+AEL +IEQGGGL+ MD +K+ + T Sbjct: 186 MGIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQGGGLISMDDSKSKQET--------- 236 Query: 247 GKAKWGYIKQLLSNRMLLGVYIGQYCINTITYFFLTWFPVYLVQERGMSILKAGFVASIP 306 ++KW YIKQLL+NRML+GVYI QYCI T+TYFFLTWFPVYLVQ RGMSIL+AGFVAS+P Sbjct: 237 -ESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLP 295 Query: 307 AVCGFIGGVVGGLISDRLIKRGNSVTMSRKIPIVGGMLLSTTMILCNYVDAQWMVVGIMA 366 A+CGF GGV+GG++SD L+K+G S+T +RK+PI+ GMLLS +MI+CNY D+ W+VV IM+ Sbjct: 296 ALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLLSCSMIVCNYTDSAWLVVVIMS 355 Query: 367 VAFFGKGVGALGWAVVADTAPKEIVGLSGGLFNTFGNIAGITTPIVIGYILKETGSFSGA 426 +AFFGKG GALGWAVV+DT+PKE GLSGGLFNTFGNIA ITTPI+IGYI+ TGSF+GA Sbjct: 356 LAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGA 415 Query: 427 LIFVGANALVTVISYLVIVKEIKRVELK 454 L+FVGANA+ ++SYL++V IKRV LK Sbjct: 416 LVFVGANAIAAILSYLLLVGPIKRVVLK 443 >STM2962 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 452 Score = 618 bits (1594), Expect = e-177, Method: Compositional matrix adjust. Identities = 295/443 (66%), Positives = 361/443 (81%), Gaps = 8/443 (1%) Query: 14 KPSHVRYLILFMLFIVTTVNYADRATLSIAGTSMKSELGLDPVMMGYIFSAFSWAYVLAQ 73 K ++ RY I+ MLFIVT+ NY DRATLSIAG+ M ++GLDPV MGY+FSAFSWAYV+ Q Sbjct: 13 KRTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVFSAFSWAYVIGQ 72 Query: 74 LPGGWLLDRFGSKKIYALSIFLWSFFTLLQGGVTWFGTAAAVVLLFLLRFMVGLAEAPSF 133 +PGGWLLDRFGSK++Y SIF+WS FTLLQG V F +V LF LRF+VGLAE+PSF Sbjct: 73 IPGGWLLDRFGSKRVYFWSIFIWSVFTLLQGFVDIFSGFGIIVALFTLRFLVGLAESPSF 132 Query: 134 PANGRIVASWFPTAERGTASAIFNSAQYFAAVLFTPLMGWITHVYGWHHVFTVMGAFGIL 193 P N RIVA+WFP ERGTA AIFNSAQYFA V+F P+MGW+TH GW HVF MG GI+ Sbjct: 133 PGNSRIVAAWFPAQERGTAVAIFNSAQYFATVIFAPIMGWLTHEVGWSHVFFFMGGLGII 192 Query: 194 LTFLWIRVIHSPKDHPMINQAELQHIEQGGGLVDMDQAKTTKATAGAAASGDAGKAKWGY 253 ++F+W++VIH P +HP +N+ EL++I +GG L++MDQ K TKA + KWG Sbjct: 193 ISFIWLKVIHEPNNHPGVNKKELEYIAEGGALINMDQ-KDTKAKVPFSV-------KWGQ 244 Query: 254 IKQLLSNRMLLGVYIGQYCINTITYFFLTWFPVYLVQERGMSILKAGFVASIPAVCGFIG 313 IKQLL +RM++GVYIGQYCIN +TYFF+TWFPVYLVQ RGMSILKAGFVAS+PAVCGFIG Sbjct: 245 IKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFVASVPAVCGFIG 304 Query: 314 GVVGGLISDRLIKRGNSVTMSRKIPIVGGMLLSTTMILCNYVDAQWMVVGIMAVAFFGKG 373 GV+GG+ISD L++R S+ ++RK PIV GMLLS M+ CNYV+ +WM++G MA+AFFGKG Sbjct: 305 GVLGGIISDWLMRRTGSLNIARKTPIVLGMLLSMVMVFCNYVNVEWMIIGFMALAFFGKG 364 Query: 374 VGALGWAVVADTAPKEIVGLSGGLFNTFGNIAGITTPIVIGYILKETGSFSGALIFVGAN 433 +GALGWAV+ADTAPKEI GLSGGLFN FGNI+GI TPI IGYI+ TGSF+GALI+VG + Sbjct: 365 IGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGSFNGALIYVGVH 424 Query: 434 ALVTVISYLVIVKEIKRVELKPL 456 ALV +ISYLV+V +IKR+ELKP+ Sbjct: 425 ALVAIISYLVLVGDIKRIELKPV 447 >Z4105 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 450 Score = 617 bits (1592), Expect = e-176, Method: Compositional matrix adjust. Identities = 294/454 (64%), Positives = 361/454 (79%), Gaps = 8/454 (1%) Query: 3 AAISASAKENIKPSHVRYLILFMLFIVTTVNYADRATLSIAGTSMKSELGLDPVMMGYIF 62 +++S +A K ++ RY I+ MLFIVT+ NY DRATLSIAG+ M ++GLDPV MGY+F Sbjct: 2 SSLSQAASSVEKRTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVF 61 Query: 63 SAFSWAYVLAQLPGGWLLDRFGSKKIYALSIFLWSFFTLLQGGVTWFGTAAAVVLLFLLR 122 SAFSWAYV+ Q+PGGWLLDRFGSK++Y SIF+WS FTLLQG V F +V LF LR Sbjct: 62 SAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIVALFTLR 121 Query: 123 FMVGLAEAPSFPANGRIVASWFPTAERGTASAIFNSAQYFAAVLFTPLMGWITHVYGWHH 182 F+VGLAEAPSFP N RIVA+WFP ERGTA +IFNSAQYFA V+F P+MGW+TH GW H Sbjct: 122 FLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSH 181 Query: 183 VFTVMGAFGILLTFLWIRVIHSPKDHPMINQAELQHIEQGGGLVDMDQAKTTKATAGAAA 242 VF MG GI ++F+W++VIH P HP +NQ EL++I GG L++MDQ T + Sbjct: 182 VFFFMGGLGIAISFIWLKVIHEPNQHPGVNQKELEYIAAGGALINMDQQNTKVKVPFSV- 240 Query: 243 SGDAGKAKWGYIKQLLSNRMLLGVYIGQYCINTITYFFLTWFPVYLVQERGMSILKAGFV 302 KWG IKQLL +RM++GVYIGQYCIN +TYFF+TWFPVYLVQ RGMSILKAGFV Sbjct: 241 -------KWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFV 293 Query: 303 ASIPAVCGFIGGVVGGLISDRLIKRGNSVTMSRKIPIVGGMLLSTTMILCNYVDAQWMVV 362 AS+PAVCGFIGGV+GG+ISD L++R S+ ++RK PIV GMLLS M+ CNYV+ +WM++ Sbjct: 294 ASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFCNYVNVEWMII 353 Query: 363 GIMAVAFFGKGVGALGWAVVADTAPKEIVGLSGGLFNTFGNIAGITTPIVIGYILKETGS 422 G MA+AFFGKG+GALGWAV+ADTAPKEI GLSGGLFN FGNI+GI TPI IGYI+ TGS Sbjct: 354 GFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGS 413 Query: 423 FSGALIFVGANALVTVISYLVIVKEIKRVELKPL 456 F+GALI+VG +AL+ V+SYLV+V +IKR+ELKP+ Sbjct: 414 FNGALIYVGVHALIAVLSYLVLVGDIKRIELKPV 447 >ECs3649 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 450 Score = 617 bits (1592), Expect = e-176, Method: Compositional matrix adjust. Identities = 294/454 (64%), Positives = 361/454 (79%), Gaps = 8/454 (1%) Query: 3 AAISASAKENIKPSHVRYLILFMLFIVTTVNYADRATLSIAGTSMKSELGLDPVMMGYIF 62 +++S +A K ++ RY I+ MLFIVT+ NY DRATLSIAG+ M ++GLDPV MGY+F Sbjct: 2 SSLSQAASSVEKRTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVF 61 Query: 63 SAFSWAYVLAQLPGGWLLDRFGSKKIYALSIFLWSFFTLLQGGVTWFGTAAAVVLLFLLR 122 SAFSWAYV+ Q+PGGWLLDRFGSK++Y SIF+WS FTLLQG V F +V LF LR Sbjct: 62 SAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIVALFTLR 121 Query: 123 FMVGLAEAPSFPANGRIVASWFPTAERGTASAIFNSAQYFAAVLFTPLMGWITHVYGWHH 182 F+VGLAEAPSFP N RIVA+WFP ERGTA +IFNSAQYFA V+F P+MGW+TH GW H Sbjct: 122 FLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSH 181 Query: 183 VFTVMGAFGILLTFLWIRVIHSPKDHPMINQAELQHIEQGGGLVDMDQAKTTKATAGAAA 242 VF MG GI ++F+W++VIH P HP +NQ EL++I GG L++MDQ T + Sbjct: 182 VFFFMGGLGIAISFIWLKVIHEPNQHPGVNQKELEYIAAGGALINMDQQNTKVKVPFSV- 240 Query: 243 SGDAGKAKWGYIKQLLSNRMLLGVYIGQYCINTITYFFLTWFPVYLVQERGMSILKAGFV 302 KWG IKQLL +RM++GVYIGQYCIN +TYFF+TWFPVYLVQ RGMSILKAGFV Sbjct: 241 -------KWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFV 293 Query: 303 ASIPAVCGFIGGVVGGLISDRLIKRGNSVTMSRKIPIVGGMLLSTTMILCNYVDAQWMVV 362 AS+PAVCGFIGGV+GG+ISD L++R S+ ++RK PIV GMLLS M+ CNYV+ +WM++ Sbjct: 294 ASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFCNYVNVEWMII 353 Query: 363 GIMAVAFFGKGVGALGWAVVADTAPKEIVGLSGGLFNTFGNIAGITTPIVIGYILKETGS 422 G MA+AFFGKG+GALGWAV+ADTAPKEI GLSGGLFN FGNI+GI TPI IGYI+ TGS Sbjct: 354 GFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGS 413 Query: 423 FSGALIFVGANALVTVISYLVIVKEIKRVELKPL 456 F+GALI+VG +AL+ V+SYLV+V +IKR+ELKP+ Sbjct: 414 FNGALIYVGVHALIAVLSYLVLVGDIKRIELKPV 447 >ygcZ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 450 Score = 617 bits (1591), Expect = e-176, Method: Compositional matrix adjust. Identities = 293/454 (64%), Positives = 362/454 (79%), Gaps = 8/454 (1%) Query: 3 AAISASAKENIKPSHVRYLILFMLFIVTTVNYADRATLSIAGTSMKSELGLDPVMMGYIF 62 +++S +A K ++ RY I+ MLFIVT+ NY DRATLSIAG+ M ++GLDPV MGY+F Sbjct: 2 SSLSQAASSVEKRTNARYWIVVMLFIVTSFNYGDRATLSIAGSEMAKDIGLDPVGMGYVF 61 Query: 63 SAFSWAYVLAQLPGGWLLDRFGSKKIYALSIFLWSFFTLLQGGVTWFGTAAAVVLLFLLR 122 SAFSWAYV+ Q+PGGWLLDRFGSK++Y SIF+WS FTLLQG V F +V LF LR Sbjct: 62 SAFSWAYVIGQIPGGWLLDRFGSKRVYFWSIFIWSMFTLLQGFVDIFSGFGIIVALFTLR 121 Query: 123 FMVGLAEAPSFPANGRIVASWFPTAERGTASAIFNSAQYFAAVLFTPLMGWITHVYGWHH 182 F+VGLAEAPSFP N RIVA+WFP ERGTA +IFNSAQYFA V+F P+MGW+TH GW H Sbjct: 122 FLVGLAEAPSFPGNSRIVAAWFPAQERGTAVSIFNSAQYFATVIFAPIMGWLTHEVGWSH 181 Query: 183 VFTVMGAFGILLTFLWIRVIHSPKDHPMINQAELQHIEQGGGLVDMDQAKTTKATAGAAA 242 VF MG GI+++F+W++VIH P HP +N+ EL++I GG L++MDQ T + Sbjct: 182 VFFFMGGLGIVISFIWLKVIHEPNQHPGVNKKELEYIAAGGALINMDQQNTKVKVPFSV- 240 Query: 243 SGDAGKAKWGYIKQLLSNRMLLGVYIGQYCINTITYFFLTWFPVYLVQERGMSILKAGFV 302 KWG IKQLL +RM++GVYIGQYCIN +TYFF+TWFPVYLVQ RGMSILKAGFV Sbjct: 241 -------KWGQIKQLLGSRMMIGVYIGQYCINALTYFFITWFPVYLVQARGMSILKAGFV 293 Query: 303 ASIPAVCGFIGGVVGGLISDRLIKRGNSVTMSRKIPIVGGMLLSTTMILCNYVDAQWMVV 362 AS+PAVCGFIGGV+GG+ISD L++R S+ ++RK PIV GMLLS M+ CNYV+ +WM++ Sbjct: 294 ASVPAVCGFIGGVLGGIISDWLMRRTGSLNIARKTPIVMGMLLSMVMVFCNYVNVEWMII 353 Query: 363 GIMAVAFFGKGVGALGWAVVADTAPKEIVGLSGGLFNTFGNIAGITTPIVIGYILKETGS 422 G MA+AFFGKG+GALGWAV+ADTAPKEI GLSGGLFN FGNI+GI TPI IGYI+ TGS Sbjct: 354 GFMALAFFGKGIGALGWAVMADTAPKEISGLSGGLFNMFGNISGIVTPIAIGYIVGTTGS 413 Query: 423 FSGALIFVGANALVTVISYLVIVKEIKRVELKPL 456 F+GALI+VG +AL+ V+SYLV+V +IKR+ELKP+ Sbjct: 414 FNGALIYVGVHALIAVLSYLVLVGDIKRIELKPV 447