BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0010.0009.p (460 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1438 [T] COG0642 Signal transduction histidine kinase Pae Pseu... 411 e-114 YPO2000 [T] COG0642 Signal transduction histidine kinase Ype Yer... 330 3e-90 RSp0488 [T] COG0642 Signal transduction histidine kinase Rso Ral... 223 6e-58 ZybcZ [T] COG0642 Signal transduction histidine kinase EcZ Esche... 213 6e-55 ECs0608 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 213 6e-55 >PA1438 [T] COG0642 Signal transduction histidine kinase Pae Pseudomonas aeruginosa Length = 481 Score = 411 bits (1057), Expect = e-114, Method: Compositional matrix adjust. Identities = 213/452 (47%), Positives = 294/452 (65%), Gaps = 4/452 (0%) Query: 4 SIIARLVMMFAAAALVIFSLIGGVLYAVVKNELLRHERDGLVTTFNDIEYMVSRVGTVER 63 S+ RL MFA AA+VIF+LIG +LY ++ + R ++ + FN + M+ ER Sbjct: 12 SLSTRLAGMFAGAAVVIFALIGTMLYCILDRQTERLQQGEVDVRFNMVSRMLDHPDLAER 71 Query: 64 WARVQTKLDTLTPADGKVRFWVFSDDPQFSYGKDLAELHDFDYDPNNIGRLRIKGKEFPM 123 W +Q KLD L+ +RFW+ SDDP++ YG+ + D L + + + Sbjct: 72 WPHLQGKLDNLSQEYELIRFWIDSDDPRYHYGRFSEPVQRLIADGAGRYELELPEHRYAL 131 Query: 124 HTLTKVLPAYLDRPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILFGYWIARAG 183 VLPA RP + +D+ + E + + ++GLS G+ L L G+WIAR G Sbjct: 132 TARVGVLPAREGRPRLTYVTAIDSAAFHEARTSTLKWLLGLSALGVLLASLLGHWIARLG 191 Query: 184 LQPLKKMSDKAQTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQLEAFNADV 243 L P+ ++S++A+ +SP+ LS+RL +S LP EL +L AFNGALDR+E AY +LE+FNADV Sbjct: 192 LWPVHRLSEEARRISPRQLSQRLQLSPLPAELRELVGAFNGALDRLEQAYVRLESFNADV 251 Query: 244 AHELRTPLANLIGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFLARCDQGEA 303 AHELRTPL NLIG+TQVALSRERS +E VLQSNLEEL+RLR+I+NDMLFLAR DQG Sbjct: 252 AHELRTPLTNLIGQTQVALSRERSGEHYEEVLQSNLEELERLRAIVNDMLFLARADQGRL 311 Query: 304 ATSLVYTAIADEVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRALTNLLQNAI 363 A T++A E+ T++F E + DE + +EV G +A++++E ALF+RA+TNLL NA Sbjct: 312 ACEREETSLAGEIATTVDFLEVIFDEAGVGIEVRG--EARALVERALFQRAVTNLLYNAA 369 Query: 364 QHSPAGARITVSIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRDFDGVHGHG 423 QH+ AG + V ++ + +V+VAVSNPG PI H LF+RFYRVD+AR + + HG Sbjct: 370 QHTAAGGTLRVGVERRGDEVRVAVSNPGVPIADEHRRHLFERFYRVDAARSNSEA--NHG 427 Query: 424 LGLAIVKAIALMHGGTAFASSRGGKTTIGFTV 455 LGL+IVKA+A MHGG+ F S G T GFTV Sbjct: 428 LGLSIVKAVASMHGGSVFVDSADGWNTFGFTV 459 >YPO2000 [T] COG0642 Signal transduction histidine kinase Ype Yersinia pestis Length = 463 Score = 330 bits (847), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 196/461 (42%), Positives = 285/461 (61%), Gaps = 12/461 (2%) Query: 1 MRHSIIARLVMMFAAAALVIFSLIGGVLYAVVKNELLRHERDGLVTTFNDIE-YMVSRVG 59 ++ SI RL +MFA A+++I S +G VL + + N L + + L T + + +++SR Sbjct: 4 IKRSISGRLALMFALASILIVSALGIVLRSSLHNSLQKQMHNELQFTESLMAPWILSRT- 62 Query: 60 TVERWARVQTKLDTLTPADG-KVRFWVFSDDPQFSYGKDLAELHDFDYDPNNIGRLRIKG 118 T++ W + TK L A+G +V++WV SDDPQ G + + G ++ G Sbjct: 63 TLDGWQTLATKFTDLAAAEGGRVQYWVLSDDPQLQVGGPAPR--GVTWASLSKGFSKVPG 120 Query: 119 ---KEFPMHTLTKVLPAYLDRPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILF 175 + + L +PA +RPA+R + +D+ PY TL F +I ++ G+ V L Sbjct: 121 ATDESCSLFLLMSEIPAQGERPALRYVVAIDSTPYMGTLNEFTRTLIVITAIGVLFVALL 180 Query: 176 GYWIARAGLQPLKKMSDKAQTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQ 235 G+ IAR G++P+ K+S++AQ L+P +RL LPDEL LA AFNG L+R E A++Q Sbjct: 181 GFVIARIGMRPVNKLSEQAQHLAPGNHGQRLDTLTLPDELQKLAVAFNGVLERQEIAWRQ 240 Query: 236 LEAFNADVAHELRTPLANLIGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFL 295 LE+FNADVAHELRTPL NL+G+TQ+ LSR+R E E +L+SNLEEL+R+ SI+NDMLFL Sbjct: 241 LESFNADVAHELRTPLTNLMGQTQLGLSRKRETHELEDLLESNLEELERMTSIVNDMLFL 300 Query: 296 ARCDQGEAATSLVYTAIADEVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRAL 355 + GE AT L ++ +E KT E+ E E +S+ V GD+ A+ I+ LF R+L Sbjct: 301 SHAQAGEHATQLTDVSLREETYKTTEYVEPSFAEKNLSIHVEGDITAR--IDRRLFHRSL 358 Query: 356 TNLLQNAIQHSPAGARITVSIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRD 415 NLL+N+ +H+ G + V+I + +AV+N G PI HL RLF+RFYRVDS+R Sbjct: 359 ANLLENSARHAVTGTTVKVTISRENNLASIAVANIGAPIAAEHLNRLFERFYRVDSSRAR 418 Query: 416 FDGVHGHGLGLAIVKAIALMHGGTAFASSRGGKTTIGFTVG 456 D H HGLGL+IV+A+A+MH G FASS+ G T G T+ Sbjct: 419 SD-TH-HGLGLSIVRAVAIMHRGDVFASSQNGINTFGLTLA 457 >RSp0488 [T] COG0642 Signal transduction histidine kinase Rso Ralstonia solanacearum Length = 465 Score = 223 bits (569), Expect = 6e-58, Method: Compositional matrix adjust. Identities = 120/277 (43%), Positives = 169/277 (61%), Gaps = 4/277 (1%) Query: 174 LFGYWIARAGLQPLKKMSDKAQTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAY 233 L W+ R+ L+ L ++ +A ++ P L RLT+ P ELSDL A N L R+++ + Sbjct: 185 LLSLWLVRSTLKGLARIGRQAASVVPSQLDTRLTLEGAPRELSDLLAALNAMLTRLQDGF 244 Query: 234 KQLEAFNADVAHELRTPLANLIGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDML 293 +L F+AD+AH+ RTPLANLIG+T+V L+ R A E+ VL+S+LEE RL +I DML Sbjct: 245 ARLSQFSADLAHDFRTPLANLIGQTEVTLAHPRPAGEYRAVLESSLEEYARLSRMIEDML 304 Query: 294 FLARCDQGEAATSLVYTAIADEVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRR 353 FLAR D A S+ E+Q +++FE V + ++++V G+ ++ + L RR Sbjct: 305 FLARADHARVALSVAPLDARHEIQVLVDYFEAVAADRDITIQVCGNGRVRA--DLTLLRR 362 Query: 354 ALTNLLQNAIQHSPAGARITVSIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSAR 413 A+ NLL NA++H+P GARI V++ +AV NPG I LP LFDRFYR D AR Sbjct: 363 AINNLLDNALRHTPGGARIDVAVQVLPHSTAIAVRNPGPGIPAASLPLLFDRFYRGDPAR 422 Query: 414 RDFDGVHGHGLGLAIVKAIALMHGGTAFASSRGGKTT 450 + + GLGLAIV+ I +HGGTA ASS G T Sbjct: 423 ANSE--RSAGLGLAIVQTIMDLHGGTAQASSPPGGLT 457 >ZybcZ [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 482 Score = 213 bits (543), Expect = 6e-55, Method: Compositional matrix adjust. Identities = 122/319 (38%), Positives = 189/319 (59%), Gaps = 7/319 (2%) Query: 136 RPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILFGYWIA-RAGLQPLKKMSDKA 194 +P L I + + + + + +I ++ + I ++I+F +A G P++ +S + Sbjct: 162 KPIYTLYIALSIDFHLHYINDLMNKLI-MTASVISILIVFIVLLAVHKGHAPIRSVSRQI 220 Query: 195 QTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQLEAFNADVAHELRTPLANL 254 Q ++ + L RL +P EL L +FN ++R+E+ + + F+AD+AHE+RTP+ NL Sbjct: 221 QNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNL 280 Query: 255 IGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFLARCDQGEAATSLVYTAIAD 314 I +T++ALS+ RS E E VL SNLEEL R+ +++DMLFLA+ D + +AD Sbjct: 281 ITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLAD 340 Query: 315 EVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRALTNLLQNAIQHSPAGARITV 374 EV K +FFE + ++ + ++ VGD + + + + RRAL+NLL NA++++P G I V Sbjct: 341 EVGKVFDFFEALAEDRGVELQFVGD-ECQVAGDPLMLRRALSNLLSNALRYTPPGEAIVV 399 Query: 375 SIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRDFDGVHGHGLGLAIVKAIAL 434 VQV V NPG PI HLPRLFDRFYRVD +R+ G G+GLAIVK+I + Sbjct: 400 RCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKG--EGSGIGLAIVKSIVV 457 Query: 435 MHGGTAFASS--RGGKTTI 451 H GT +S RG + I Sbjct: 458 AHKGTVAVTSNARGTRFVI 476 >ECs0608 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 482 Score = 213 bits (543), Expect = 6e-55, Method: Compositional matrix adjust. Identities = 122/319 (38%), Positives = 189/319 (59%), Gaps = 7/319 (2%) Query: 136 RPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILFGYWIA-RAGLQPLKKMSDKA 194 +P L I + + + + + +I ++ + I ++I+F +A G P++ +S + Sbjct: 162 KPIYTLYIALSIDFHLHYINDLMNKLI-MTASVISILIVFIVLLAVHKGHAPIRSVSRQI 220 Query: 195 QTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQLEAFNADVAHELRTPLANL 254 Q ++ + L RL +P EL L +FN ++R+E+ + + F+AD+AHE+RTP+ NL Sbjct: 221 QNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNL 280 Query: 255 IGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFLARCDQGEAATSLVYTAIAD 314 I +T++ALS+ RS E E VL SNLEEL R+ +++DMLFLA+ D + +AD Sbjct: 281 ITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLAD 340 Query: 315 EVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRALTNLLQNAIQHSPAGARITV 374 EV K +FFE + ++ + ++ VGD + + + + RRAL+NLL NA++++P G I V Sbjct: 341 EVGKVFDFFEALAEDRGVELQFVGD-ECQVAGDPLMLRRALSNLLSNALRYTPPGEAIVV 399 Query: 375 SIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRDFDGVHGHGLGLAIVKAIAL 434 VQV V NPG PI HLPRLFDRFYRVD +R+ G G+GLAIVK+I + Sbjct: 400 RCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKG--EGSGIGLAIVKSIVV 457 Query: 435 MHGGTAFASS--RGGKTTI 451 H GT +S RG + I Sbjct: 458 AHKGTVAVTSNARGTRFVI 476