BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0222.p (280 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ECs4359_1 [V] COG1131 ABC-type multidrug transport system, ATPas... 388 e-108 PA5231_1 [V] COG1131 ABC-type multidrug transport system, ATPase... 388 e-108 ZyhiH_1 [V] COG1131 ABC-type multidrug transport system, ATPase ... 387 e-107 yhiH_1 [V] COG1131 ABC-type multidrug transport system, ATPase c... 386 e-107 STM3586_1 [V] COG1131 ABC-type multidrug transport system, ATPas... 379 e-105 >ECs4359_1 [V] COG1131 ABC-type multidrug transport system, ATPase component Ecs Escherichia coli O157:H7 Length = 516 Score = 388 bits (996), Expect = e-108, Method: Compositional matrix adjust. Identities = 187/260 (71%), Positives = 221/260 (85%), Gaps = 1/260 (0%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 TGVDPLSRAQFWDLI IR ++ MSV+VATAYMEEA+RFDWLVAM+ G++LATG+ EL Sbjct: 159 TGVDPLSRAQFWDLIDSIRQRQSNMSVLVATAYMEEAERFDWLVAMNAGEVLATGSAEEL 218 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRAVVVTPLQPSDNEETAIEAKGLTMRFGDFVAVAH 137 ++ +A+LE AFI +LP+A+R+ H+AVV+ P QP +N E AIEA+ LTMRFG FVAV H Sbjct: 219 RQQTQSATLEEAFINLLPQAQRQAHQAVVIPPYQP-ENAEIAIEARDLTMRFGSFVAVDH 277 Query: 138 VDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVDGSDITTRQRVGYM 197 V+F+I RGEIFGFLGSNGCGKSTTMKMLTGL+PASEG+AWLFG+ VD DI TR+RVGYM Sbjct: 278 VNFRIPRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGEAWLFGQPVDPKDIDTRRRVGYM 337 Query: 198 SQAFSLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRFDLRQVLDKLPEGLPLGVRQ 257 SQAFSLY ELTVRQNL LHARLF +PE+ I ARV EM++RF L V D LPE LPLG+RQ Sbjct: 338 SQAFSLYNELTVRQNLELHARLFHIPEAEIPARVAEMSERFKLNDVEDVLPESLPLGIRQ 397 Query: 258 RLSLAVAMVHRPELLILDEP 277 RLSLAVA++HRPE+LILDEP Sbjct: 398 RLSLAVAVIHRPEMLILDEP 417 Score = 76.3 bits (186), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 39/87 (44%), Positives = 60/87 (68%), Gaps = 1/87 (1%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 +GVDP++R FW L+ + + +++ ++T +M EA+R D + M GK+LA+GTP+EL Sbjct: 419 SGVDPVARDMFWQLMVDL-SRQDKVTIFISTHFMNEAERCDRISLMHAGKVLASGTPQEL 477 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRA 104 E+ GAASLE AFIA L EA +++ A Sbjct: 478 VEKRGAASLEEAFIAYLQEAAGQSNEA 504 Score = 74.7 bits (182), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 82/159 (51%), Gaps = 8/159 (5%) Query: 125 LTMRFGDFVAVAHVDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVD 184 ++ +G VA+ ++ I + G +G +G GKS+ + +++G +G + G D Sbjct: 1 MSQHYGKTVALNNITLDIPARCMVGLIGPDGVGKSSLLSLISGARVIEQGNVIVLGG--D 58 Query: 185 GSDITTRQ----RVGYMSQAF--SLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRF 238 D R+ R+ +M Q +LY L+V +N+ ARLF ++ R++E+ Sbjct: 59 MRDPKHRRDVCPRIAWMPQGLGKNLYHTLSVYENVDFFARLFGHDKAEREVRINELLTST 118 Query: 239 DLRQVLDKLPEGLPLGVRQRLSLAVAMVHRPELLILDEP 277 L D+ L G++Q+L L A++H PELLILDEP Sbjct: 119 GLAPFRDRPAGKLSGGMKQKLGLCCALIHDPELLILDEP 157 >PA5231_1 [V] COG1131 ABC-type multidrug transport system, ATPase component Pae Pseudomonas aeruginosa Length = 547 Score = 388 bits (996), Expect = e-108, Method: Compositional matrix adjust. Identities = 190/261 (72%), Positives = 218/261 (83%), Gaps = 1/261 (0%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 TGVDPLSR QFW+LIG+IR R GMSV+VATAYMEEA+RFDWLVAMDDGK+LATGTP+EL Sbjct: 172 TGVDPLSRNQFWELIGRIRAGREGMSVLVATAYMEEAERFDWLVAMDDGKVLATGTPQEL 231 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRAVVVTPLQPSDN-EETAIEAKGLTMRFGDFVAVA 136 ER G SLE+AFIA+LPE+KR H +V+ P S+ AIEA+GLT RFGDFVAV Sbjct: 232 RERTGTQSLESAFIALLPESKRAGHHRLVIPPRPQSEGAPRIAIEAEGLTCRFGDFVAVD 291 Query: 137 HVDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVDGSDITTRQRVGY 196 HV F+I RGEIFGFLGSNGCGKSTTMKMLTGL+PASEG LFG+ VD SD+ TR+RVGY Sbjct: 292 HVSFRIERGEIFGFLGSNGCGKSTTMKMLTGLLPASEGTCALFGQPVDASDMATRRRVGY 351 Query: 197 MSQAFSLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRFDLRQVLDKLPEGLPLGVR 256 MSQAFSLY EL+VRQNLVLHARLF +P I ARV EM +RFDL +V D+LP LPLG+R Sbjct: 352 MSQAFSLYAELSVRQNLVLHARLFHLPADGIPARVGEMLRRFDLEKVADELPNDLPLGIR 411 Query: 257 QRLSLAVAMVHRPELLILDEP 277 QRLSLAVA++H+PE+LILDEP Sbjct: 412 QRLSLAVAVIHKPEILILDEP 432 Score = 76.6 bits (187), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 51/164 (31%), Positives = 87/164 (53%), Gaps = 14/164 (8%) Query: 123 KGLTMRFGDFVAVAHVDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRK 182 +G+++R+G+ AV V +I + G +G +G GKS+ + +L G +G+ R Sbjct: 12 RGVSLRYGETRAVDDVSLEIPANRMVGLIGPDGVGKSSLLALLAGARKMQDGEI----RV 67 Query: 183 VDGSDITTRQ-------RVGYMSQAF--SLYGELTVRQNLVLHARLFQVPESAIAARVDE 233 +DG D+ R+ R+ YM Q +LY L+V +N+ RLF ++ R+ + Sbjct: 68 LDG-DMRDRRHRRAVCPRIAYMPQGLGKNLYPTLSVFENVDFFGRLFGHDKAERERRIAD 126 Query: 234 MAQRFDLRQVLDKLPEGLPLGVRQRLSLAVAMVHRPELLILDEP 277 + Q L ++ L G++Q+L L A++H P+LLILDEP Sbjct: 127 LLQSTGLAPFAERPAGKLSGGMKQKLGLCCALIHDPDLLILDEP 170 Score = 62.8 bits (151), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 31/74 (41%), Positives = 49/74 (66%), Gaps = 1/74 (1%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 +GVDP++R FW+L+ ++ R G+++ ++T +M EA R D + M GK+LA+ TP EL Sbjct: 434 SGVDPVARDGFWELMVEL-SRRDGVTIFISTHFMNEAQRCDRISLMHAGKVLASDTPDEL 492 Query: 78 HERVGAASLEAAFI 91 + G +LEA FI Sbjct: 493 VRQRGLPTLEATFI 506 >ZyhiH_1 [V] COG1131 ABC-type multidrug transport system, ATPase component EcZ Escherichia coli O157:H7 EDL933 Length = 532 Score = 387 bits (994), Expect = e-107, Method: Compositional matrix adjust. Identities = 187/260 (71%), Positives = 221/260 (85%), Gaps = 1/260 (0%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 TGVDPLSRAQFWDLI IR ++ MSV+VATAYMEEA+RFDWLVAM+ G++LATG+ EL Sbjct: 159 TGVDPLSRAQFWDLIDSIRQRQSNMSVLVATAYMEEAERFDWLVAMNAGEVLATGSAEEL 218 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRAVVVTPLQPSDNEETAIEAKGLTMRFGDFVAVAH 137 ++ +A+LE AFI +LP+A+R+ H+AVV+ P QP +N E AIEA+ LTMRFG FVAV H Sbjct: 219 RQQTQSATLEEAFINLLPQAQRQAHQAVVIPPYQP-ENAEIAIEARDLTMRFGSFVAVDH 277 Query: 138 VDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVDGSDITTRQRVGYM 197 V+F+I RGEIFGFLGSNGCGKSTTMKMLTGL+PASEG+AWLFG+ VD DI TR+RVGYM Sbjct: 278 VNFRIPRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGEAWLFGQPVDPKDIDTRRRVGYM 337 Query: 198 SQAFSLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRFDLRQVLDKLPEGLPLGVRQ 257 SQAFSLY ELTVRQNL LHARLF +PE+ I ARV EM++RF L V D LPE LPLG+RQ Sbjct: 338 SQAFSLYNELTVRQNLELHARLFHIPEAEIPARVAEMSERFKLNDVEDVLPESLPLGIRQ 397 Query: 258 RLSLAVAMVHRPELLILDEP 277 RLSLAVA++HRPE+LILDEP Sbjct: 398 RLSLAVAVIHRPEMLILDEP 417 Score = 76.3 bits (186), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 39/87 (44%), Positives = 60/87 (68%), Gaps = 1/87 (1%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 +GVDP++R FW L+ + + +++ ++T +M EA+R D + M GK+LA+GTP+EL Sbjct: 419 SGVDPVARDMFWQLMVDL-SRQDKVTIFISTHFMNEAERCDRISLMHAGKVLASGTPQEL 477 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRA 104 E+ GAASLE AFIA L EA +++ A Sbjct: 478 VEKRGAASLEEAFIAYLQEAAGQSNEA 504 Score = 74.3 bits (181), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 82/159 (51%), Gaps = 8/159 (5%) Query: 125 LTMRFGDFVAVAHVDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVD 184 ++ +G VA+ ++ I + G +G +G GKS+ + +++G +G + G D Sbjct: 1 MSQHYGKTVALNNITLDIPARCMVGLIGPDGVGKSSLLSLISGARVIEQGNVIVLGG--D 58 Query: 185 GSDITTRQ----RVGYMSQAF--SLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRF 238 D R+ R+ +M Q +LY L+V +N+ ARLF ++ R++E+ Sbjct: 59 MRDPKHRRDVCPRIAWMPQGLGKNLYHTLSVYENVDFFARLFGHDKAEREVRINELLTST 118 Query: 239 DLRQVLDKLPEGLPLGVRQRLSLAVAMVHRPELLILDEP 277 L D+ L G++Q+L L A++H PELLILDEP Sbjct: 119 GLAPFRDRPAGKLSGGMKQKLGLCCALIHDPELLILDEP 157 >yhiH_1 [V] COG1131 ABC-type multidrug transport system, ATPase component Eco Escherichia coli K12 Length = 532 Score = 386 bits (992), Expect = e-107, Method: Compositional matrix adjust. Identities = 186/260 (71%), Positives = 221/260 (85%), Gaps = 1/260 (0%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 TGVDPLSR+QFWDLI IR ++ MSV+VATAYMEEA+RFDWLVAM+ G++LATG+ EL Sbjct: 159 TGVDPLSRSQFWDLIDSIRQRQSNMSVLVATAYMEEAERFDWLVAMNAGEVLATGSAEEL 218 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRAVVVTPLQPSDNEETAIEAKGLTMRFGDFVAVAH 137 ++ +A+LE AFI +LP+A+R+ H+AVV+ P QP +N E AIEA+ LTMRFG FVAV H Sbjct: 219 RQQTQSATLEEAFINLLPQAQRQAHQAVVIPPYQP-ENAEIAIEARDLTMRFGSFVAVDH 277 Query: 138 VDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVDGSDITTRQRVGYM 197 V+F+I RGEIFGFLGSNGCGKSTTMKMLTGL+PASEG+AWLFG+ VD DI TR+RVGYM Sbjct: 278 VNFRIPRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGEAWLFGQPVDPKDIDTRRRVGYM 337 Query: 198 SQAFSLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRFDLRQVLDKLPEGLPLGVRQ 257 SQAFSLY ELTVRQNL LHARLF +PE+ I ARV EM++RF L V D LPE LPLG+RQ Sbjct: 338 SQAFSLYNELTVRQNLELHARLFHIPEAEIPARVAEMSERFKLNDVEDILPESLPLGIRQ 397 Query: 258 RLSLAVAMVHRPELLILDEP 277 RLSLAVA++HRPE+LILDEP Sbjct: 398 RLSLAVAVIHRPEMLILDEP 417 Score = 76.6 bits (187), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 39/87 (44%), Positives = 60/87 (68%), Gaps = 1/87 (1%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 +GVDP++R FW L+ + + +++ ++T +M EA+R D + M GK+LA+GTP+EL Sbjct: 419 SGVDPVARDMFWQLMVDL-SRQDKVTIFISTHFMNEAERCDRISLMHAGKVLASGTPQEL 477 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRA 104 E+ GAASLE AFIA L EA +++ A Sbjct: 478 VEKRGAASLEEAFIAYLQEAAGQSNEA 504 Score = 74.7 bits (182), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 82/159 (51%), Gaps = 8/159 (5%) Query: 125 LTMRFGDFVAVAHVDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVD 184 ++ +G VA+ ++ I + G +G +G GKS+ + +++G +G + G D Sbjct: 1 MSQHYGKTVALNNITLDIPARCMVGLIGPDGVGKSSLLSLISGARVIEQGNVMVLGG--D 58 Query: 185 GSDITTRQ----RVGYMSQAF--SLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRF 238 D R+ R+ +M Q +LY L+V +N+ ARLF ++ R++E+ Sbjct: 59 MRDPKHRRDVCPRIAWMPQGLGKNLYHTLSVYENVDFFARLFGHDKAEREVRINELLTST 118 Query: 239 DLRQVLDKLPEGLPLGVRQRLSLAVAMVHRPELLILDEP 277 L D+ L G++Q+L L A++H PELLILDEP Sbjct: 119 GLAPFRDRPAGKLSGGMKQKLGLCCALIHDPELLILDEP 157 >STM3586_1 [V] COG1131 ABC-type multidrug transport system, ATPase component Sty Salmonella typhimurium LT2 Length = 534 Score = 379 bits (972), Expect = e-105, Method: Compositional matrix adjust. Identities = 184/260 (70%), Positives = 218/260 (83%), Gaps = 1/260 (0%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 TGVDPLSRAQFWDLI IR + MSV+VATAYMEEA+RFDWLVAM+ G+ILATG+ ++L Sbjct: 159 TGVDPLSRAQFWDLIDSIRQRQTNMSVLVATAYMEEAERFDWLVAMNAGEILATGSAQQL 218 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRAVVVTPLQPSDNEETAIEAKGLTMRFGDFVAVAH 137 + +A+LE AFIA+LPEA+R+ H+ VV+ P ++ EE AIEAK LTMRFG FVAV H Sbjct: 219 RAKTHSATLEQAFIALLPEAQRQAHKPVVIPPYH-AEQEEIAIEAKDLTMRFGKFVAVDH 277 Query: 138 VDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVDGSDITTRQRVGYM 197 V+F+I RGEIFGFLGSNGCGKSTTMKMLTGL+PASEG+AWLFG+ VD +DI TR+RVGYM Sbjct: 278 VNFRIPRGEIFGFLGSNGCGKSTTMKMLTGLLPASEGQAWLFGQPVDPNDIDTRRRVGYM 337 Query: 198 SQAFSLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRFDLRQVLDKLPEGLPLGVRQ 257 SQAFSLY ELTVRQNL LHARLF +P + I ARV +M +RF L +V D LP LPLG+RQ Sbjct: 338 SQAFSLYNELTVRQNLELHARLFHIPPAEIPARVAQMIERFMLTEVEDTLPASLPLGIRQ 397 Query: 258 RLSLAVAMVHRPELLILDEP 277 RLSLAVA++HRPE+LILDEP Sbjct: 398 RLSLAVAVIHRPEMLILDEP 417 Score = 74.7 bits (182), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 82/159 (51%), Gaps = 8/159 (5%) Query: 125 LTMRFGDFVAVAHVDFKIRRGEIFGFLGSNGCGKSTTMKMLTGLIPASEGKAWLFGRKVD 184 ++ +G VA+ ++ I + G +G +G GKS+ + +++G +G + G D Sbjct: 1 MSQHYGKTVALNNITLDIPARSMVGLIGPDGVGKSSLLSLISGARVIEQGNVIVLGG--D 58 Query: 185 GSDITTRQ----RVGYMSQAF--SLYGELTVRQNLVLHARLFQVPESAIAARVDEMAQRF 238 D R+ R+ +M Q +LY L+V +N+ ARLF ++ AR+ E+ Sbjct: 59 MRDAKHRRDVCPRIAWMPQGLGKNLYHTLSVYENVDFFARLFGHDKAEREARITELLNST 118 Query: 239 DLRQVLDKLPEGLPLGVRQRLSLAVAMVHRPELLILDEP 277 L D+ L G++Q+L L A+++ PELLILDEP Sbjct: 119 GLAPFRDRPAGKLSGGMKQKLGLCCALIYDPELLILDEP 157 Score = 74.3 bits (181), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/98 (41%), Positives = 63/98 (64%), Gaps = 5/98 (5%) Query: 18 TGVDPLSRAQFWDLIGKIRGERAGMSVIVATAYMEEADRFDWLVAMDDGKILATGTPREL 77 +GVDP++R FW L+ + + +++ ++T +M EA+R D + M GK+LA+GTP+EL Sbjct: 419 SGVDPVARDMFWQLMVDL-SRQDKVTIFISTHFMNEAERCDRMSLMHAGKVLASGTPQEL 477 Query: 78 HERVGAASLEAAFIAMLPEAKRRNHRAVVVTPLQPSDN 115 ++ GAA+LEAAFI+ L EA A TP+ PS Sbjct: 478 VQQRGAANLEAAFISWLQEAA----GAAPETPIPPSQT 511