BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0139.p (399 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM2372 [GEPR] COG0477 Permeases of the major facilitator superf... 278 2e-74 ECs3206 [GEPR] COG0477 Permeases of the major facilitator superf... 265 2e-70 yfcJ [GEPR] COG0477 Permeases of the major facilitator superfami... 265 2e-70 Z3585 [GEPR] COG0477 Permeases of the major facilitator superfam... 262 9e-70 PA1993 [GEPR] COG0477 Permeases of the major facilitator superfa... 240 4e-63 >STM2372 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 392 Score = 278 bits (710), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 165/393 (41%), Positives = 243/393 (61%), Gaps = 4/393 (1%) Query: 1 MTTTTQQSNDSVAS-GLLPLVAIVFTSFLCIGIPLPALPLHVNGVLGFSALTVGWVVGIQ 59 MT +Q++ A+ L + VF +++ +G+PLP +PL V+ LG+S VG VGIQ Sbjct: 1 MTAVSQKTTTPSANFSLFRIAFAVFLTYMTVGLPLPVIPLFVHHELGYSNTMVGIAVGIQ 60 Query: 60 SFSTILSRKFSGSYCDRHGPKRAVAVG-LPMAAAAGLLYLASTLIADAGASLEVLFIGRL 118 F+T+L+R ++G D++G KR+ G L A LA+ L A +L +GRL Sbjct: 61 FFATVLTRGYAGRLADQYGAKRSALQGMLACGLAGAAWLLAALLPVSAPVKFALLIVGRL 120 Query: 119 LMGPAESLFLTGTMTWGIGRVGMQRTGKVMAWQGIAMFAALGLGAPIGIAIQQRFGFAGV 178 ++G ES LTGT+TWG+G VG R+GKVM+W G+A++ AL GAP+G+ I FGFA + Sbjct: 121 ILGFGESQLLTGTLTWGLGLVGPTRSGKVMSWNGMAIYGALAAGAPLGLLIHSHFGFAAL 180 Query: 179 ALTTMVLPLVGLAIATTLRGLPALGNKGGGVAMSEVLRLIWRFGMALALSAMPFAIITSF 238 A TTMVLPL+ A T+R +PA G ++ V+ LIW+ G+ LAL + FA+I +F Sbjct: 181 AGTTMVLPLLAWAFNGTVRKVPA--YTGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTF 238 Query: 239 LVLLYASNNWSGAGIAILGFSVGYVGVRLFFAHLPDRIGGAKVGAVSVAIELVGQLLLWQ 298 + L + SN W+ AG + F +V +R+ F +PDR GG KV VS+ +E G LLLW Sbjct: 239 ISLYFVSNGWTMAGFTLTAFGGAFVLMRILFGWMPDRFGGVKVAVVSLLVETAGLLLLWL 298 Query: 299 SHDPLMAGLGTLLTGIGFSLVFPSMGVQAMARVPAHSRGLAVATFMAFIDLAAGLTGPVV 358 + +A +G LTG G SL+FP++GV+ + RVPA RG A+ + AF D++ G+TGP+ Sbjct: 299 APTAWIALVGAALTGAGCSLIFPALGVEVVKRVPAQVRGTALGGYAAFQDISYGVTGPLA 358 Query: 359 GVLIGYFGYGSAFLAGAAACVLALLLMVAGMSR 391 G+L +GY S FLAGA + V+ +L+ + R Sbjct: 359 GMLATSYGYPSVFLAGAISAVVGILVTILSFRR 391 >ECs3206 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 392 Score = 265 bits (676), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 163/393 (41%), Positives = 243/393 (61%), Gaps = 4/393 (1%) Query: 1 MTTTTQQSNDSVAS-GLLPLVAIVFTSFLCIGIPLPALPLHVNGVLGFSALTVGWVVGIQ 59 MT +Q S A+ L + VF +++ +G+PLP +PL V+ LG+ VG VGIQ Sbjct: 1 MTAVSQTETRSSANFSLFRIAFAVFLTYMTVGLPLPVIPLFVHHDLGYGNTMVGIAVGIQ 60 Query: 60 SFSTILSRKFSGSYCDRHGPKRAVAVGLPMAAAAGLLYLASTLI-ADAGASLEVLFIGRL 118 +T+L+R ++G D++G KR+ G+ AG L + ++ A +L IGRL Sbjct: 61 FLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGGALLLAAILPVSAPFKFALLVIGRL 120 Query: 119 LMGPAESLFLTGTMTWGIGRVGMQRTGKVMAWQGIAMFAALGLGAPIGIAIQQRFGFAGV 178 ++G ES LTG +TWG+G VG + +GKVM+W G+A++ AL +GAP+G+ I +GFA + Sbjct: 121 ILGFGESQLLTGALTWGLGIVGPKHSGKVMSWNGMAIYGALAVGAPLGLLIHSHYGFAAL 180 Query: 179 ALTTMVLPLVGLAIATTLRGLPALGNKGGGVAMSEVLRLIWRFGMALALSAMPFAIITSF 238 ALTTM LPL+ A T+R +PAL G ++ V+ LIW+ G+ LAL + FA+I +F Sbjct: 181 ALTTMALPLLAWACNGTVRKVPAL--AGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTF 238 Query: 239 LVLLYASNNWSGAGIAILGFSVGYVGVRLFFAHLPDRIGGAKVGAVSVAIELVGQLLLWQ 298 + L +AS W+ AG + F +V +R+ F +PDR GG KV VS+ +E VG LLLWQ Sbjct: 239 VSLYFASKGWAMAGFTLTAFGGAFVVMRVMFGWMPDRFGGVKVAIVSLLVETVGLLLLWQ 298 Query: 299 SHDPLMAGLGTLLTGIGFSLVFPSMGVQAMARVPAHSRGLAVATFMAFIDLAAGLTGPVV 358 + +A G LTG G SL+FP++GV+ + RVP+ RG A+ + AF D+A G++GP+ Sbjct: 299 APGAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIALGVSGPLA 358 Query: 359 GVLIGYFGYGSAFLAGAAACVLALLLMVAGMSR 391 G+L FGY S FLAGA + VL +++ + R Sbjct: 359 GMLATTFGYSSVFLAGAISAVLGIIVTILSFRR 391 >yfcJ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 392 Score = 265 bits (676), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 161/393 (40%), Positives = 244/393 (62%), Gaps = 4/393 (1%) Query: 1 MTTTTQQSNDSVAS-GLLPLVAIVFTSFLCIGIPLPALPLHVNGVLGFSALTVGWVVGIQ 59 MT +Q S A+ L + VF +++ +G+PLP +PL V+ LG+ VG VGIQ Sbjct: 1 MTAVSQTETRSSANFSLFRIAFAVFLTYMTVGLPLPVIPLFVHHELGYGNTMVGIAVGIQ 60 Query: 60 SFSTILSRKFSGSYCDRHGPKRAVAVGLPMAAAAGLLYLASTLI-ADAGASLEVLFIGRL 118 +T+L+R ++G D++G KR+ G+ AG L + ++ A +L +GRL Sbjct: 61 FLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGGALLLAAILPVSAPFKFALLVVGRL 120 Query: 119 LMGPAESLFLTGTMTWGIGRVGMQRTGKVMAWQGIAMFAALGLGAPIGIAIQQRFGFAGV 178 ++G ES LTG +TWG+G VG + +GKVM+W G+A++ AL +GAP+G+ I +GFA + Sbjct: 121 ILGFGESQLLTGALTWGLGIVGPKHSGKVMSWNGMAIYGALAVGAPLGLLIHSHYGFAAL 180 Query: 179 ALTTMVLPLVGLAIATTLRGLPALGNKGGGVAMSEVLRLIWRFGMALALSAMPFAIITSF 238 A+TTMVLP++ A T+R +PAL G ++ V+ LIW+ G+ LAL + FA+I +F Sbjct: 181 AITTMVLPVLAWACNGTVRKVPAL--AGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTF 238 Query: 239 LVLLYASNNWSGAGIAILGFSVGYVGVRLFFAHLPDRIGGAKVGAVSVAIELVGQLLLWQ 298 + L +AS W+ AG + F +V +R+ F +PDR GG KV VS+ +E VG LLLWQ Sbjct: 239 VSLYFASKGWAMAGFTLTAFGGAFVVMRVMFGWMPDRFGGVKVAIVSLLVETVGLLLLWQ 298 Query: 299 SHDPLMAGLGTLLTGIGFSLVFPSMGVQAMARVPAHSRGLAVATFMAFIDLAAGLTGPVV 358 + +A G LTG G SL+FP++GV+ + RVP+ RG A+ + AF D+A G++GP+ Sbjct: 299 APGAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIALGVSGPLA 358 Query: 359 GVLIGYFGYGSAFLAGAAACVLALLLMVAGMSR 391 G+L FGY S FLAGA + VL +++ + R Sbjct: 359 GMLATTFGYSSVFLAGAISAVLGIIVTILSFRR 391 >Z3585 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 392 Score = 262 bits (670), Expect = 9e-70, Method: Compositional matrix adjust. Identities = 162/393 (41%), Positives = 242/393 (61%), Gaps = 4/393 (1%) Query: 1 MTTTTQQSNDSVAS-GLLPLVAIVFTSFLCIGIPLPALPLHVNGVLGFSALTVGWVVGIQ 59 MT +Q S A+ L + VF +++ + +PLP +PL V+ LG+ VG VGIQ Sbjct: 1 MTAVSQTETRSSANFSLFRIAFAVFLTYMTVXLPLPVIPLFVHHDLGYGNTMVGIAVGIQ 60 Query: 60 SFSTILSRKFSGSYCDRHGPKRAVAVGLPMAAAAGLLYLASTLI-ADAGASLEVLFIGRL 118 +T+L+R ++G D++G KR+ G+ AG L + ++ A +L IGRL Sbjct: 61 FLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGGALLLAAILPVSAPFKFALLVIGRL 120 Query: 119 LMGPAESLFLTGTMTWGIGRVGMQRTGKVMAWQGIAMFAALGLGAPIGIAIQQRFGFAGV 178 ++G ES LTG +TWG+G VG + +GKVM+W G+A++ AL +GAP+G+ I +GFA + Sbjct: 121 ILGFGESQLLTGALTWGLGIVGPKHSGKVMSWNGMAIYGALAVGAPLGLLIHSHYGFAAL 180 Query: 179 ALTTMVLPLVGLAIATTLRGLPALGNKGGGVAMSEVLRLIWRFGMALALSAMPFAIITSF 238 ALTTM LPL+ A T+R +PAL G ++ V+ LIW+ G+ LAL + FA+I +F Sbjct: 181 ALTTMALPLLAWACNGTVRKVPAL--AGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTF 238 Query: 239 LVLLYASNNWSGAGIAILGFSVGYVGVRLFFAHLPDRIGGAKVGAVSVAIELVGQLLLWQ 298 + L +AS W+ AG + F +V +R+ F +PDR GG KV VS+ +E VG LLLWQ Sbjct: 239 VSLYFASKGWAMAGFTLTAFGGAFVVMRVMFGWMPDRFGGVKVAIVSLLVETVGLLLLWQ 298 Query: 299 SHDPLMAGLGTLLTGIGFSLVFPSMGVQAMARVPAHSRGLAVATFMAFIDLAAGLTGPVV 358 + +A G LTG G SL+FP++GV+ + RVP+ RG A+ + AF D+A G++GP+ Sbjct: 299 APGAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIALGVSGPLA 358 Query: 359 GVLIGYFGYGSAFLAGAAACVLALLLMVAGMSR 391 G+L FGY S FLAGA + VL +++ + R Sbjct: 359 GMLATTFGYSSVFLAGAISAVLGIIVTILSFRR 391 >PA1993 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 402 Score = 240 bits (612), Expect = 4e-63, Method: Compositional matrix adjust. Identities = 157/400 (39%), Positives = 230/400 (57%), Gaps = 9/400 (2%) Query: 2 TTTTQQS-NDSVASGLLPLVAIVFTSFLCIGIPLPALPLHVNGVLGFSALTVGWVVGIQS 60 T Q S +V ++ +V F +L IGIPL LP +V+ LG+ ++ G V+ +Q Sbjct: 8 TPPAQDSARQNVTLQIVSVVMFTFIGYLTIGIPLAVLPGYVHDDLGYGSVLAGLVISLQY 67 Query: 61 FSTILSRKFSGSYCDRHGPKRAVAVGLPMAAAAGLLYLASTLIADAGA-SLEVLFIGRLL 119 +T+L+R ++G D GPKRAV G+ +AA+GL L S I A SL L +GRL+ Sbjct: 68 LATLLARPYAGRVIDGLGPKRAVLYGMAGSAASGLFMLLSVAIQGWPALSLASLLVGRLV 127 Query: 120 MGPAESLFLTGTMTWGIGRVGMQRTGKVMAWQGIAMFAALGLGAPIGIAIQQRFGFAGVA 179 +G AESL + + WGIGRVG T KV++W GIA + A+ LGAP+G+ + Q G + Sbjct: 128 LGAAESLVGSAAIGWGIGRVGAPHTAKVISWNGIASYGAIALGAPLGVLLVQWLGLWSMG 187 Query: 180 LTTMVLPLVGLAIATTLRGLPALGNKGGGVAMSEVLRLIWRFGMALALSAMPFAIITSFL 239 + ++L +G A+A LPA G + VL + GM LAL A+ F I +F+ Sbjct: 188 ASIVLLGALGFALAWP--KLPAPLVHGERLPFHHVLGRVTPHGMGLALGAIGFGTIATFI 245 Query: 240 VLLYASNNWSGAGIAILGFSVGYVGVRLFFAHLPDRIGGAKVGAVSVAIELVGQLLLWQS 299 L YAS W+ A + + F ++G RL FA+ +R+GG +V + + +E +G LLLW + Sbjct: 246 TLYYASRGWANAVLCLSAFGGCFIGARLLFANSINRLGGFRVAIICLGVESLGLLLLWSA 305 Query: 300 HDPLMAGLGTLLTGIGFSLVFPSMGVQAMARVPAHSRGLAVATFMAFIDLAAGLTGPVVG 359 +P + G LTG GFSLVFP+ GV+A+ VPA +RG A+ + F+DL+ G+TGP+VG Sbjct: 306 PNPWVGLAGAALTGFGFSLVFPAFGVEAVNLVPASNRGAALGAYSLFVDLSLGITGPLVG 365 Query: 360 VLIGYFGYGSAFLAGAAACVLALLLMVAGMSRQHHERHQR 399 + FG+ S FL A + L L VA H R +R Sbjct: 366 FVANLFGFRSMFLFACLASLGGLALAVA-----LHRRSRR 400