BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0133.p (362 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1389 [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 323 6e-88 YPO1228 [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 298 1e-80 PA3969 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 248 2e-65 mlr4314 [R] COG2220 Predicted Zn-dependent hydrolases of the bet... 230 5e-60 XF2024 [R] COG2220 Predicted Zn-dependent hydrolases of the beta... 226 5e-59 >RSp1389 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Rso Ralstonia solanacearum Length = 362 Score = 323 bits (827), Expect = 6e-88, Method: Compositional matrix adjust. Identities = 163/336 (48%), Positives = 211/336 (62%), Gaps = 20/336 (5%) Query: 35 YDPEKPNRTPSGFRNTAPQEPR---ASLLKWQWERLTQGLPKAPANNYKFPMATPEIAWL 91 Y+P KP+ TP GFRN P PR S KW ER GLPK P + P++A + Sbjct: 6 YEPSKPHHTPDGFRNRYPHAPRDSNGSAWKWMRERRRLGLPKPPTADLS--CVPPDLAAI 63 Query: 92 QANQSVASVTWISHATALLQISGMNVITDPIFSGRASPFSFVGPLRKVPLNITPEQLPHI 151 + +V VTWI H T LLQI G+NV+TDP+F RASP F GP R P ++ QLPHI Sbjct: 64 RRPSAVPQVTWIGHETLLLQIDGLNVLTDPVFGERASPLPFAGPRRHQPPGLSLAQLPHI 123 Query: 152 DVVVISHNHYDHLDQASVEQLNRQPGGPPLFLVPLGVKEW----MAGVGIT----NVREM 203 D+V++SHNHYDHL +ASV L RQPGG P+F VPLG+ W + G ++ NVR Sbjct: 124 DLVLLSHNHYDHLCRASVRALMRQPGGAPMFFVPLGIDRWFKRHVRGTRLSGEHVNVRAF 183 Query: 204 DWWDKTSAGKLDISFVPAQHWSARSLTDRSETLWGGWVIKTADGAPHP-FSVFFAGDTGY 262 DW + G + F QHWSAR L DR+ TLWG W + HP +F+GD GY Sbjct: 184 DWDTEARFGPFSVHFCAVQHWSARGLYDRNRTLWGSWALL------HPQLRFWFSGDLGY 237 Query: 263 SKDFQDIGRKFGSFDFALIPIGAYAPRWFMQGQHVDPEQAVQIHKDVHAKRSIGIHWGTF 322 S+D +DIG +FG FD A I +GAY PRWFM+ QH+DP +AVQ+ +D+ A+ ++GIHWGTF Sbjct: 238 SQDTRDIGARFGHFDVAAIAVGAYEPRWFMKTQHIDPAEAVQVMQDIGARHAVGIHWGTF 297 Query: 323 ELADEPLDEPPQLLAEAVKKAGLPAQEFTVLKHGET 358 L DEPLD+P LA A++ + A+ F + +HGET Sbjct: 298 PLTDEPLDQPIADLANALRARDIDAERFVLFRHGET 333 >YPO1228 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Ype Yersinia pestis Length = 342 Score = 298 bits (764), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 159/350 (45%), Positives = 217/350 (62%), Gaps = 22/350 (6%) Query: 22 ALVSAGCAAASK--YYDPEKPNRTPSGFRNTAP--QEPRASLLKWQWERLTQGLPKAPAN 77 A+ S G A K YYD KP+ T GF+N P P+ L +W+ ER Q LPK P Sbjct: 6 AVGSKGRKMAKKNPYYDASKPHHTEFGFQNIEPVVHHPQ-DLKRWREERKRQSLPKPPQQ 64 Query: 78 NYKFPMATPEIA---WLQANQS--VASVTWISHATALLQISGMNVITDPIFSGRASPFSF 132 Y P+ W QA+ S ++ W+ HA+ LL+ISG V+ DP+ S R SP +F Sbjct: 65 GY------PQFVTDWWQQADFSGLQDALWWLGHASLLLRISGQAVLFDPVLSSRVSPVNF 118 Query: 133 VGPLRKVPLNITPEQLPHIDVVVISHNHYDHLDQASVEQLNRQPGGPPLFLVPLGVKEWM 192 GP RK P+ + +QLP IDV+VISHNHYDHLD ++ QL R+ +FLVPLG+K W+ Sbjct: 119 YGPQRKTPIPASVQQLPDIDVIVISHNHYDHLDVTTITQLLRR-FPDVVFLVPLGLKNWL 177 Query: 193 AGVGITNVREMDWWDKTSAGKLDISFVPAQHWSARSLTDRSETLWGGWVIKTADGAPHPF 252 G +V E+DWWD+ + VPA+HWS R+ DR+ +LW GWV+K + Sbjct: 178 RQHGARHVHELDWWDQRLVADFEFHCVPARHWSMRTPWDRNHSLWSGWVVKRGE-----V 232 Query: 253 SVFFAGDTGYSKDFQDIGRKFGSFDFALIPIGAYAPRWFMQGQHVDPEQAVQIHKDVHAK 312 + +F+GDTGY + DIG G F++A +PIGAYAPRWFMQ QH+DP+Q+VQ+ + +H Sbjct: 233 NFYFSGDTGYCQQLLDIGEALGPFNYAALPIGAYAPRWFMQAQHMDPQQSVQLFQKLHQP 292 Query: 313 RSIGIHWGTFELADEPLDEPPQLLAEAVKKAGLPAQEFTVLKHGETVKLD 362 +I IHWG FELADEPLDEPP+ L +A+ AG+ +F +K G + L+ Sbjct: 293 VTIPIHWGVFELADEPLDEPPEQLQQALTDAGVAHNKFVPIKIGARIILE 342 >PA3969 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Pae Pseudomonas aeruginosa Length = 361 Score = 248 bits (632), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 146/352 (41%), Positives = 201/352 (57%), Gaps = 25/352 (7%) Query: 14 LRRIALVVALVSAGCAAASKYYDPEKPNRTPSGFRNTAPQEPRA--SLLKWQWERLTQ-- 69 LR L+ L AGCA S Y P + FRN P ++ LLKWQW R Q Sbjct: 4 LRPTWLISLLTLAGCAG-SAYQGPPSDHFDGERFRNIQPTAHKSLRDLLKWQWNRPPQRP 62 Query: 70 --GLPKAPANNYKFPMATPEIAWLQANQSVASVTWISHATALLQISGMNVITDPIFSGRA 127 LP P ATP +A VT+I+HAT L+Q G+N++TDP++S R Sbjct: 63 WVALP---------PTATPPRVNERARGEELRVTYINHATLLIQHRGLNILTDPVWSQRV 113 Query: 128 SPFSFVGPLRKVPLNITPEQLPHIDVVVISHNHYDHLDQASVEQLNRQPGGPPLFLVP-L 186 SP +F+GP R P +T +QLP ID+V++SHNHYDHLD ++ QL+R+ P +V L Sbjct: 114 SPLAFIGPKRHHPPGLTLDQLPPIDLVLVSHNHYDHLDLETLRQLHRR--WPTAKVVSGL 171 Query: 187 GVKEWMAGVGITNVREMDWWDKTSAGK-LDISFVPAQHWSARSLTDRSETLWGGWVIKTA 245 G + G +V E+DWW G L + VP QHWS+R+ +D + TLW G+VI + Sbjct: 172 GNAGLIRQTGFADVVEIDWWQAVPLGAGLTLHGVPVQHWSSRTRSDTNRTLWLGFVIDSP 231 Query: 246 DGAPHPFSVFFAGDTGYSKDFQDIGRKFGSFDFALIPIGAYAPRWFMQGQHVDPEQAVQI 305 DG + F GDTG +F I ++FG+ FA +PIGAY PRWFM+ H++P+ AVQ Sbjct: 232 DG-----PLLFPGDTGLGPEFGLINQRFGAMRFAALPIGAYEPRWFMRDHHMNPDDAVQA 286 Query: 306 HKDVHAKRSIGIHWGTFELADEPLDEPPQLLAEAVKKAGLPAQEFTVLKHGE 357 H+ + A+ S+ IH+GTF L DE D+PP+ L A++ G+ F K GE Sbjct: 287 HRTLQAQTSMAIHFGTFNLTDEQQDDPPKALQAALRSQGVDPATFGTPKPGE 338 >mlr4314 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Mlo Mesorhizobium loti Length = 350 Score = 230 bits (586), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 140/343 (40%), Positives = 195/343 (56%), Gaps = 21/343 (6%) Query: 24 VSAGCAAASKYYD-PEKPNRTPSGFRNTAPQEPR--ASLLKWQWERLTQGLPKAPANNYK 80 ++A AA++YY P + + F N Q P LLKWQ+ P + Sbjct: 12 LAARKKAANRYYSGPPSDHFDGTLFFNPGGQMPGRFTDLLKWQFNGQRAKWPATSPS--P 69 Query: 81 FPMATPEIAWLQANQSVASVTWISHATALLQISGMNVITDPIFSGRASPFSFVGPLRKVP 140 FP A P + + +VT + H+T L+Q +G+N++TDP++S R SPFSF GP R Sbjct: 70 FPQARPAA---KVEGTDLTVTMVGHSTLLIQTAGLNILTDPVWSQRTSPFSFAGPKRVNA 126 Query: 141 LNITPEQLPHIDVVVISHNHYDHLDQASVEQLNRQPGGPPLFLVPLGVKEWMAGVGITNV 200 I + LP ID+V++SHNHYDHLD A++++L + PL + PLG + + G + ++ Sbjct: 127 PGIVFDDLPPIDLVLVSHNHYDHLDLATLKRLKEKHD--PLVVTPLG-NDVLIGEAVPDM 183 Query: 201 R--EMDWWDKTS-AGKLDISFVPAQHWSARSLTDRSETLWGGWVIKTADGAPHPFSVFFA 257 R DW DK A + I PA HWSAR DR LW G+VI+T G ++FA Sbjct: 184 RLSAHDWGDKVDIADRAAIHIEPAHHWSARGARDRRMALWAGFVIETPGG-----KLYFA 238 Query: 258 GDTGYSK--DFQDIGRKFGSFDFALIPIGAYAPRWFMQGQHVDPEQAVQIHKDVHAKRSI 315 GDTG+ +++ + K G F FA++PIGAY PRWFM QH +P +AVQ K A + Sbjct: 239 GDTGFHDGINYRLMADKHGGFRFAILPIGAYEPRWFMAPQHQNPREAVQGMKLCKAAFAA 298 Query: 316 GIHWGTFELADEPLDEPPQLLAEAVKKAGLPAQEFTVLKHGET 358 G HWGTF L DEP+DEP + LAEA+ GLP + F L+ GE Sbjct: 299 GCHWGTFHLTDEPMDEPVRKLAEALDAEGLPQERFRALQPGEV 341 >XF2024 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold Xfa Xylella fastidiosa 9a5c Length = 332 Score = 226 bits (577), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 130/333 (39%), Positives = 193/333 (57%), Gaps = 36/333 (10%) Query: 33 KYYDPEKPNRTPSGFRNTAPQEPRASLLKWQWERLTQGLP---KAPANNYKFPMATPEIA 89 ++++P +PN +P + LL+W+WE ++ LP P + P+A Sbjct: 19 RFFNPGQPNT----------DKPFSDLLRWRWE--SRHLPPWRDVPPTHVATPIA----- 61 Query: 90 WLQANQSVASVTWISHATALLQISGMNVITDPIFSGRASPFSFVGPLRKVPLNITPEQLP 149 ++ + +T I H++ L+QI+G+N++ DP++S R SP S++GP R I LP Sbjct: 62 --RSQHPI--ITMIGHSSVLIQIAGLNLLVDPVWSERVSPLSWLGPRRWNSPGIDFNALP 117 Query: 150 HIDVVVISHNHYDHLDQASVEQLNRQPGGPPLFLVPLGVKEWMAG-VGITNVREMDWWD- 207 ID V+I+HNHYDHLD ++ +L Q P + PLG + V ++ +DWWD Sbjct: 118 PIDYVLITHNHYDHLDLTTLARL--QIAHAPQVVTPLGNDAIIRKRVPDLHIHTLDWWDS 175 Query: 208 -KTSAGKLDISFVPAQHWSARSLTDRSETLWGGWVIKTADGAPHPFSVFFAGDTGYSKD- 265 + + IS VPA HWSAR L DR LWGG+ + T G S++ AGDT Y Sbjct: 176 IQLTNEPTKISVVPAYHWSARGLRDRCMALWGGFHLHTPQG-----SLYIAGDTAYGNGS 230 Query: 266 -FQDIGRKFGSFDFALIPIGAYAPRWFMQGQHVDPEQAVQIHKDVHAKRSIGIHWGTFEL 324 F I ++ G+ D A++PIGAYAPRWFM QH+D +AVQI DV A +++G+HWGTF L Sbjct: 231 IFHAIAQRCGAPDLAILPIGAYAPRWFMHNQHIDAVEAVQIMCDVGAHQALGVHWGTFRL 290 Query: 325 ADEPLDEPPQLLAEAVKKAGLPAQEFTVLKHGE 357 DE ++EPP LLA+A++ G+PA F + G+ Sbjct: 291 TDEAVEEPPTLLAQALQAKGIPATRFIAMTPGQ 323