BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0139.p (440 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 313 7e-85 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 299 1e-80 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 290 4e-78 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 280 4e-75 PA2214 [GEPR] COG0477 Permeases of the major facilitator superfa... 251 2e-66 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 313 bits (801), Expect = 7e-85, Method: Compositional matrix adjust. Identities = 169/427 (39%), Positives = 258/427 (60%), Gaps = 13/427 (3%) Query: 14 TAAEERDVTFRRVVWRIVPFVTLIWFLAWVDRVNVGFAKLTMMSDLQWSDAVYGAGAGIF 73 T +E + +R+ VW ++P + L + L ++DRVNVGFAKL M DLQ+SD VYG GAG+F Sbjct: 13 TQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGAGMF 72 Query: 74 FIGYFIFEVPSNLALQKFGARKTIMRITIGWGITCVLMAWVQTATQFYFLRFLMGAFEAG 133 FIGYF E+PSNL L + GAR I RI I WGI MA+V T FY +RFL+G EAG Sbjct: 73 FIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLLGVAEAG 132 Query: 134 LQPGVILYLTYWLPTHRRGKALGIFVSASAVSLVVGSPLAAYIMELSQGLGGFKGWQWLF 193 PG+ILY++YW P+HRRG+ G+FV + +S ++G+PL+ +IM+ G G+ GWQW+F Sbjct: 133 FFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYAGWQWMF 192 Query: 194 VXAGGRA---GAAAYFLLTDRPRDAHWLNDREKEHVETELAAEDQALGPREHSFFASLRS 250 + G + G + L DR A WL D+EK+ ++T + E++A + Sbjct: 193 ILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNI--ENEAAHYAHSRLRDAFLQ 250 Query: 251 GRMWALIMVFFCIIAGNATLVYYGPSLVKEVGFTDIKTLGWVMGGIYCCGWLGMLLNGYL 310 R+W L +++FC+I+G T+ ++ P+L+++ G DI ++G++ + M++ Sbjct: 251 PRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVSRS 310 Query: 311 SDRNKEVRIHTAVAAAIGALGLLLAAYFLGEKSAAGVVFALALSSAGTMGA---IPVFWQ 367 +DR +E R H A+ A +GA+G++L+ YF + +V A+ + G MGA IP+FW Sbjct: 311 ADRLRERRWHLALTAVLGAVGIILSTYF-----SDNIVVAMVCLTIGAMGALSTIPLFWS 365 Query: 368 LPGRFLSGTAIVVGLAVINSVANLAGYFSPQLLGYLKTTTGQYGKGLTTIAIVELMATVM 427 LP FL G+A G+A INS NL G+ +P ++GYLK T G+ I+ + + Sbjct: 366 LPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIGAAL 425 Query: 428 IFAFISK 434 +F +K Sbjct: 426 VFLIPAK 432 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 299 bits (765), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 163/415 (39%), Positives = 250/415 (60%), Gaps = 11/415 (2%) Query: 11 NIDTAAEERDV----TFRRVVWRIVPFVTLIWFLAWVDRVNVGFAKLTMMSDLQWSDAVY 66 N +TA +V T+R+V +RI+P + + + +A++DRVNVGFAKL M +L +S+A+Y Sbjct: 21 NSNTAITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIY 80 Query: 67 GAGAGIFFIGYFIFEVPSNLALQKFGARKTIMRITIGWGITCVLMAWVQTATQFYFLRFL 126 G GAG+FFIGYF FE+PSN+ L K GAR I RI I WG+ L A+VQT QFY LRFL Sbjct: 81 GLGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFL 140 Query: 127 MGAFEAGLQPGVILYLTYWLPTHRRGKALGIFVSASAVSLVVGSPLAAYIMELSQGLGGF 186 +GA EAG PGVILYLTYW P+HRRG +F + S + + G+PL+ +IM+ G+ Sbjct: 141 LGAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGW 200 Query: 187 KGWQWLFVXAGGRA---GAAAYFLLTDRPRDAHWLNDREKEHVETELAAEDQALGPREHS 243 +GWQW+FV A G L + + A WL + EK + ++ A+ + HS Sbjct: 201 QGWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKA-ASHS 259 Query: 244 FFASLRSGRMWALIMVFFCIIAGNATLVYYGPSLVKEVGFTDIKTLGWVMGGIYCCGWLG 303 + +++ +W +++++FC + G L + P+L++ G T T+G + + C + Sbjct: 260 LMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIA 319 Query: 304 MLLNGYLSDRNKEVRIHTAVAAAIGALGLLLAAYFLGEKSAAGVVFALALSSAGTMGAIP 363 M++ +D +E R H V A +GA+G ++AA + ++F L++++AG + P Sbjct: 320 MVIFSRSADHYRERRWHLVVPALLGAVGFVVAAS--ATNTTVSIIF-LSMAAAGVLACAP 376 Query: 364 VFWQLPGRFLSGTAIVVGLAVINSVANLAGYFSPQLLGYLKTTTGQYGKGLTTIA 418 +FW LP LSG A G+A+INSVANLAG+ SP ++G ++ T G+ +A Sbjct: 377 LFWSLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLA 431 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 290 bits (743), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 170/434 (39%), Positives = 259/434 (59%), Gaps = 9/434 (2%) Query: 5 AAAAPANIDTAAEERDVTFRRVVWRIVPFVTLIWFLAWVDRVNVGFAKLTMMSDLQWSDA 64 A A P + EE T+R+V WR++PF+ L + +A++DRVNVGFAKL M++DL++S+ Sbjct: 12 AGALPPQSASGFEE--ATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSET 69 Query: 65 VYGAGAGIFFIGYFIFEVPSNLALQKFGARKTIMRITIGWGITCVLMAWVQTATQFYFLR 124 VYG GAGIFFIGYF+FEVPSN+ L + GAR I RI I WG+ M +V T FY +R Sbjct: 70 VYGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMR 129 Query: 125 FLMGAFEAGLQPGVILYLTYWLPTHRRGKALGIFVSASAVSLVVGSPLAAYIMELSQGLG 184 FL+G EAG PG+ILYLTYW P RRG+ F++A A+S V+G P++ + ++ G+ Sbjct: 130 FLLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVY 189 Query: 185 GFKGWQWLFVXAGGRA---GAAAYFLLTDRPRDAHWLNDREKEHVETELAAEDQALGPRE 241 G GWQW+F+ G + G L +R A WL D EK + +AAE+ + Sbjct: 190 GLAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQ--KED 247 Query: 242 HSFFASLRSGRMWALIMVFFCIIAGNATLVYYGPSLVKEVGFTDIKTLGWVMGGIYCCGW 301 A + S R+W + +++F + G + ++ P+L+K+ G D ++G + Y Sbjct: 248 APIAAIMASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAV 307 Query: 302 LGMLLNGYLSDRNKEVRIHTAVAAAIGALGLLLAAYFLGEKSAAGVVFALALSSAGTMGA 361 + M+L +DR +E R H A+ A GA+GL+L+A + + A + AL L + G + Sbjct: 308 VAMVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLA--MAALTLGTMGILTT 365 Query: 362 IPVFWQLPGRFLSGTAIVVGLAVINSVANLAGYFSPQLLGYLKTTTGQYGKGLTTIAIVE 421 +P+FW LP FL+GT G+A+INS+ NLAG+ SP +G+LK TT G+ +A Sbjct: 366 LPLFWSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASM 425 Query: 422 LMATVMIFAFISKT 435 ++ ++ + ++T Sbjct: 426 VLGALLTLSVPART 439 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 280 bits (717), Expect = 4e-75, Method: Compositional matrix adjust. Identities = 165/413 (39%), Positives = 232/413 (56%), Gaps = 12/413 (2%) Query: 5 AAAAPANIDTAAEERDVTFRRVV-WRIVPFVTLIWFLAWVDRVNVGFAKLTMMSDLQWSD 63 A A PA + ER + VV RI+PF+ + A++DR+N+GFAKL M +DL SD Sbjct: 3 ANAIPAQAHSG--ERSTSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSD 60 Query: 64 AVYGAGAGIFFIGYFIFEVPSNLALQKFGARKTIMRITIGWGITCVLMAWVQTATQFYFL 123 A YG GAGIFF GY +FEVPSNL L K GAR+T+ RI I WGI M +V FY L Sbjct: 61 AAYGLGAGIFFFGYMLFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYAL 120 Query: 124 RFLMGAFEAGLQPGVILYLTYWLPTHRRGKALGIFVSASAVSLVVGSPLAAYIMELSQGL 183 RFL+G FEAG PG+I YLT W P R +A+ + + A+ + V+G P + +IM G Sbjct: 121 RFLLGVFEAGFAPGMIYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGA 180 Query: 184 GGFKGWQWLFVXAGGRA---GAAAYFLLTDRPRDAHWLNDREKEHVETELAAEDQALGPR 240 GG GWQW+F+ G + G AAY L D+P DA WL D +K + ++A +A + Sbjct: 181 GGLAGWQWMFLAEGIPSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIA---RAAPGQ 237 Query: 241 EHSFFASLRSGRMWALIMVFFCIIAGNATLVYYGPSLVKEVGFTDIKTLGWVMGGIYCCG 300 SF +L +++ L +FC+I G + ++ PS++K G +D+ +G Sbjct: 238 ASSFGKALTEPKLYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAM 297 Query: 301 WLGMLLNGYLSDRNKEVRIHTAVAAAIGALGLLLAAYFLGEKSAAGVVFALALSSAGTMG 360 + M G SDR E +H+A+ A +GA L AAY S + ++ L+SA Sbjct: 298 IVAMYALGRRSDRRGERHLHSAITAVLGAGLLAWAAY---ATSFPAALISITLASAAIFA 354 Query: 361 AIPVFWQLPGRFLSGTAIVVGLAVINSVANLAGYFSPQLLGYLKTTTGQYGKG 413 + VFW +P + L GTA G+A+INS+ G+FSP L+G+ K TG G Sbjct: 355 SYSVFWAIPQQHLKGTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGSLQAG 407 >PA2214 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 440 Score = 251 bits (641), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 158/407 (38%), Positives = 228/407 (56%), Gaps = 13/407 (3%) Query: 29 RIVPFVTLIWFLAWVDRVNVGFAKLTMMSDLQWSDAVYGAGAGIFFIGYFIFEVPSNLAL 88 R++PF+ L++ LA++DR NVG+A+ + +D DA + GA IFFIGY FEVPSNL L Sbjct: 21 RLLPFLVLMYVLAFIDRANVGYARAFLQADTGLGDAAFAFGASIFFIGYACFEVPSNLML 80 Query: 89 QKFGARKTIMRITIGWGITCVLMAWVQTATQFYFLRFLMGAFEAGLQPGVILYLTYWLPT 148 + GAR + RI + WG+ M + A FY LRFL+G EAG PG+ILYLTYW P Sbjct: 81 HRLGARVWLCRIMVTWGLVSAAMMFADDAMTFYVLRFLLGVAEAGFFPGIILYLTYWFPQ 140 Query: 149 HRRGKALGIFVSASAVSLVVGSPLAAYIMELSQGLGGFKGWQWLFVXAGGRA---GAAAY 205 R +ALG+F ++LV+G PL+ +++E G+ G WQWLFV G A G AAY Sbjct: 141 RSRAQALGLFYFGLPLALVLGGPLSGWLLEF-HGIFGLANWQWLFVTEGLLASLVGIAAY 199 Query: 206 FLLTDRPRDAHWLNDREKEHVETELAAED---QALGPREHSFFASLRSGRMWALIMVFFC 262 F L DRPRDA WL+D +K +E ELA ED QA GP H F ++LRSG++ +V+F Sbjct: 200 FYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGP--HGFLSALRSGQVLKFCLVYFT 257 Query: 263 IIAGNATLVYYGPSLVKEVGFTDIKTLGWVMGGIYCCGWLGMLLNGYLSDRNKEVR-IHT 321 I +V+Y P+ + F D +G +G I W+ L+ L R + H Sbjct: 258 IQMSVYGVVFYLPTRIAS--FLD-GQVGLNVGLITAIPWVCALVVTRLVTRQADRSGQHR 314 Query: 322 AVAAAIGALGLLLAAYFLGEKSAAGVVFALALSSAGTMGAIPVFWQLPGRFLSGTAIVVG 381 +A A+ + A + V A +++G + P+FW LP +LSG A G Sbjct: 315 QLAVAMLGMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAAAASG 374 Query: 382 LAVINSVANLAGYFSPQLLGYLKTTTGQYGKGLTTIAIVELMATVMI 428 +A+INS+ NL G+ +P L +++ G+ +A V L+ ++ Sbjct: 375 IALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLLGACLL 421