BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0079.p (450 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMa1115 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP fami... 446 e-125 CAC3329 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP fami... 169 2e-41 CAC0685 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP fami... 142 2e-33 CAC0628 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP fami... 91 5e-18 ML2667 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP famil... 85 3e-16 >SMa1115 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP family Sme Sinorhizobium meliloti Length = 547 Score = 446 bits (1146), Expect = e-125, Method: Compositional matrix adjust. Identities = 238/433 (54%), Positives = 303/433 (69%), Gaps = 13/433 (3%) Query: 7 PRDALLSWRRIHTTNDN-------PAPVDTTMRKSKSISWLKRLGPGLITGAADDDPSGI 59 PR SW H ND+ PV +R++ + L +LGPGLITGAADDDPSGI Sbjct: 104 PRMRRKSW---HVDNDDRVQSGLLAKPVVYRLRRA---ALLDKLGPGLITGAADDDPSGI 157 Query: 60 ATYSQAGAQFGFNTLWTVLLTYPLMVGIQMVSARIGAFSGHGLATNIGRHFPRWMLHGIV 119 ATYSQAGAQFG N LW + YPLM +QM+SARIG SGHGLA N+ R FP W++ +V Sbjct: 158 ATYSQAGAQFGANMLWMMFFLYPLMCTMQMISARIGRVSGHGLAANMRRIFPSWVVTSLV 217 Query: 120 ILLLLANIINIAADLVAMGDAVTLVIGGPHHLYALGLGIASILLQVWVPYQRYVNVLKWL 179 LL +AN INI ADL AMG A LV+G HL+ L +AS+ +QV VPY RYV LKWL Sbjct: 218 ALLFIANTINIGADLAAMGAAAELVLGWGRHLFTLVFAVASLTVQVLVPYHRYVLYLKWL 277 Query: 180 TLSLFAYVGTVFALHIEWSEVWSRTFFPHITLSRDYITMIVAIFGTTISPYLFFWQASQE 239 TL LFAYVG VF + I+WSE R P + L+R+ M+VA+FGTTISPYL FWQAS+E Sbjct: 278 TLVLFAYVGVVFTIEIDWSETALRMVTPQLALTRETAIMVVAVFGTTISPYLLFWQASEE 337 Query: 240 VEEQQRAPAEEALKRRPEEAAAGVSRMQFDTCVGMGVSNAVAFFIMLTTAITLHQHGVHD 299 VE+ + P + L PE+A +SR+++DT +GM +N VAFFI+LTTA+TLH GV + Sbjct: 338 VEDDEADPTTDPLIDHPEQALVQLSRIRWDTYIGMAFANLVAFFIILTTALTLHAAGVTE 397 Query: 300 IESSTRAASALKPVAGQLAFILFSLGIIGSGMLAIPVLAGSAAYAMAGTFKWSNSLEDKP 359 IE+S AA AL+P+AG LAF LFSLGIIG+G+LA+P+LAGSAAYA+ + W LE KP Sbjct: 398 IETSADAAEALRPIAGDLAFALFSLGIIGTGLLAVPILAGSAAYAVCESRGWPIGLEHKP 457 Query: 360 AAAKRFYGVIALATIIGAALAFSSVNTIQALFWSAVINGVIAVPVMAIMMLLAVNAGVMG 419 A FY VI LAT+IG A+ +S ++ I+ALFWSAV+NGV++VP+MA MM++ MG Sbjct: 458 REAVGFYTVIGLATLIGLAVDYSDLDPIRALFWSAVLNGVVSVPLMAAMMIVVSRKDEMG 517 Query: 420 RFVIGRKMRVLGW 432 +FV ++RV+GW Sbjct: 518 QFVASFRLRVMGW 530 >CAC3329 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP family Cac Clostridium acetobutylicum Length = 411 Score = 169 bits (427), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 126/424 (29%), Positives = 219/424 (51%), Gaps = 36/424 (8%) Query: 32 RKSKSISWLKRLGPGLITGAADDDPSGIATYSQAGAQFGFNTLWTVLL-TYPLMVGIQMV 90 +K+K + L +GPGLIT A +D GIATY+ GA +G+ LW +LL T+ L + IQ + Sbjct: 3 KKNKLLFILGIIGPGLITVNAGNDAGGIATYATVGASYGYKMLWGLLLITFSLAI-IQEM 61 Query: 91 SARIGAFSGHGLATNIGRHF-PRWMLHGIVILLLLANIINIAADLVAMGDAVTLVIGGPH 149 +AR+ +G GL+ I ++ +W L + IL + AN D G A +L + G Sbjct: 62 NARMAVVTGKGLSDLIRENYGVKWSLFAMCILFI-ANFGVCVGDFA--GIAASLELFGIS 118 Query: 150 HLYALGLGIASILLQVWV-----PYQRYVNVLKWLTLSLFAYVGTVFALHIEWSEVWSRT 204 + + + VW Y++ V T F Y+ T +H W+ V T Sbjct: 119 KY----ITVPIMAFLVWFVITKGSYEKTEKVFLAFTFVFFTYIITCIKVHPNWNVVMKAT 174 Query: 205 FFPHITLSRDYITMIVAIFGTTISPYLFFWQASQEVEEQQRAPAEEALKRRPEEAAAGVS 264 P ++ ++ Y+ ++ + GTTI+PY+ F+ S V++ ++K E Sbjct: 175 ITPSLSFTKGYVLTLIGMIGTTITPYMQFYLQSSVVDKGL------SVKEYKYE------ 222 Query: 265 RMQFDTCVGMGVSNAVAFFIMLTTAITLHQHGVHDIESSTRAASALKPVAGQLAFILFSL 324 + D +G + V+FFI++ TA+TL++ G+ I+S+ +AA ALKP+AG A ILF+ Sbjct: 223 --KIDVYLGAIWGDLVSFFIIVCTAVTLYKAGIK-IDSAEQAAMALKPLAGNYATILFAA 279 Query: 325 GIIGSGMLAIPVLAGSAAYAMAGTFKWSNSLEDKPAAAKRFYGVIALATIIGAALAF-SS 383 G+ G+ +LA V+ S YA+ F + + L++ + AK FYG+ + AAL Sbjct: 280 GLFGASVLATMVIPLSTTYAICEAFGFESGLDNSFSEAKTFYGIFTFMILFSAALVLVPK 339 Query: 384 VNTIQALFWSAVINGVIAVPVMAIMMLLAVNAGVMGRFVIGRKMRVLGWCATVVMAVAVI 443 ++ + + + I G+++ ++ M+LL N +MG+++ + V+ V + VA I Sbjct: 340 LSLVGIMLITQQIAGILSPVILIFMVLLINNKDIMGKYINNKLQNVI-----VYLTVAFI 394 Query: 444 AMLA 447 +L+ Sbjct: 395 IILS 398 >CAC0685 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP family Cac Clostridium acetobutylicum Length = 408 Score = 142 bits (358), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 106/384 (27%), Positives = 192/384 (50%), Gaps = 27/384 (7%) Query: 43 LGPGLITGAADDDPSGIATYSQAGAQFGFNTLWTVLLTYPLMVGIQMVSARIGAFSGHGL 102 +GPGLIT A +D G+ TYS G+++G++ LW + + +Q ++AR+ +G GL Sbjct: 15 VGPGLITANAGNDAGGVTTYSVIGSKYGYSMLWGLFAIGIGLAVVQEMNARMAVVTGKGL 74 Query: 103 ATNIGRHFPRWMLHGIVILLLLANIINIAADLVAMGDAVTLVIGGPHHLYALGLGIASIL 162 + I + + +++L++AN+ AD + ++ L + + + + Sbjct: 75 SDLIRERYGVKLAFFAMLVLMIANLGVCIADFAGIAASLQLFNINKY------ISVPILA 128 Query: 163 LQVWV-----PYQRYVNVLKWLTLSLFAYVGTVFALHIEWSEVWSRTFFPHITLSRDYIT 217 + +W+ Y + V LTL+ F YV T F L WS V+S P TLS++Y Sbjct: 129 IMIWIIMTKGNYSKAEKVFLLLTLTFFGYVITAFMLKPNWSNVFSHISNPGGTLSKNYWL 188 Query: 218 MIVAIFGTTISPYLFFWQASQEVEEQQRAPAEEALKRRPEEAAAGVSRMQFDTCVGMGVS 277 ++ + GTTI+PY+ F+ S V++ +LK E + D +G Sbjct: 189 DLIGMVGTTITPYMQFYLQSSIVDKGI------SLKEYGYE--------KLDVYLGTVWG 234 Query: 278 NAVAFFIMLTTAITLHQHGVHDIESSTRAASALKPVAGQLAFILFSLGIIGSGMLAIPVL 337 A FI + T+ TL + + I S+ AA+ALKP+AGQ +F+LF +G+ G+ LA ++ Sbjct: 235 ILTALFITICTSETLFKAHMA-ISSAQDAAAALKPLAGQYSFVLFGVGLFGASFLACCII 293 Query: 338 AGSAAYAMAGTFKWSNSLEDKPAAAKRFYGVIALATIIGAALAF-SSVNTIQALFWSAVI 396 S +YA+ F + + L++K A F+G+ I + +++ I + ++ + Sbjct: 294 PLSTSYAVCEAFGFESGLDNKIKEAPVFFGLFFFMIITSVIIVLMPNISLISIILFTQQL 353 Query: 397 NGVIAVPVMAIMMLLAVNAGVMGR 420 GV+ V+ M+ L + +MG+ Sbjct: 354 AGVLCPVVLIFMIKLVNDKEIMGK 377 >CAC0628 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP family Cac Clostridium acetobutylicum Length = 417 Score = 90.9 bits (224), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 107/446 (23%), Positives = 204/446 (45%), Gaps = 44/446 (9%) Query: 15 RRIHTTNDNPAPVDTTMRKSKSISWLKRLGPGLITGAADDDPSGIATYSQAGAQFGFNTL 74 R+I+ P T +I + K +GPGL+ DP A+ AG+ +G++ L Sbjct: 2 RKINIFKGKHNPQRT------AIDFFKYVGPGLLVTVGFIDPGNWASNVSAGSDYGYSLL 55 Query: 75 WTVLLTYPLMVGIQMVSARIGAFSGHGLATNIGRHFPRWMLHGIVILLLLANIINIAADL 134 W V L+ +++ +Q +A +G +G L+ + + F W L NII +A Sbjct: 56 WIVTLSTIMLIILQHNAAHLGIVTGDCLSEAVSKKFKPW----------LTNIILYSAIG 105 Query: 135 VAMGDAVTLVIGGP---HHLYALGLGIASIL---LQVWVPY-QRYVNVLKWLTLSLFAYV 187 A+ A+ ++GG + L+ L + I +++ L +W+ + Y + +W+ + + + Sbjct: 106 AAISTAMAELLGGAIALNMLFRLPIKIGTLIMLSLVIWMLFSSSYKKLERWI-IGFVSII 164 Query: 188 GTVFALHIEWSEV-W--SRTFFPHITLSRDYITMIVAIFGTTISPYLFFWQASQEVEEQQ 244 G F + +V W + F + ++ + +I+++ G + P+ F + Q Sbjct: 165 GLSFIFELLLVKVNWQVAAVSFVSPSFPKNSMPIIMSVLGAVVMPHNLFLHSEIIQSRQW 224 Query: 245 RAPAEEALKRRPEEAAAGVSRMQF-DTCVGMGVSNAVAFFIMLTTAITLHQHGVHDIESS 303 E+ +KR+ R +F DT + M V A+ ++L A T + V + Sbjct: 225 NVEKEDVIKRQL--------RYEFLDTIISMIVGFAINSAMVLLAASTFFKMHV-SVSEL 275 Query: 304 TRAASALKPVAGQLAFILFSLGIIGSGMLAIPVLAGSAAYAM-AGTFKWSNSLEDKPAAA 362 ++A + LKP+ G A ++F+L ++ SG +A V AG A ++ AG +K +ED Sbjct: 276 SQAQALLKPLLGGSASVVFALALLFSG-IASTVTAGMAGGSIFAGIYKEPYDIEDSHTQI 334 Query: 363 KRFYGVIALATIIGAALAFSSVNTIQALFWSAVINGVIAVPVMAIMMLLAVNAGVMGRFV 422 GVI + ++ A + F + + L +S +I + + + L + VMG+F Sbjct: 335 ----GVI-ITMVLAAVIIFFIKDPFKGLIYSQMILSIQLPITIFTQIYLTSSKKVMGKFS 389 Query: 423 IGRKMRVLGWCATVVMAVAVIAMLAT 448 RVL V++ IA+L + Sbjct: 390 NSLLDRVLLGIIAVIVTALNIALLVS 415 >ML2667 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP family Mle Mycobacterium leprae Length = 618 Score = 85.1 bits (209), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 112/419 (26%), Positives = 188/419 (44%), Gaps = 37/419 (8%) Query: 44 GPGLITGAADDDPSGIATYSQAGAQFGFNTLWTVLLTYPLMVGIQMVSARIGAFSGHGLA 103 GPGLI D+D G+ATY+QAG ++G N LWT++L P++ Q + R+GA + G A Sbjct: 98 GPGLIAMIGDNDAGGVATYAQAGQKYGMNLLWTLVLLIPVLYVNQEMVLRLGAVTRVGHA 157 Query: 104 TNIGRHFPRWMLHGIVILLLLANIINIAADLVAMGDAVTLVIGGPHHLYALGLGIASILL 163 I F ++ V LL+ N + I + + + A+ +G P + + +A++LL Sbjct: 158 RLIFERFGKFWGAFSVGDLLILNALTIVTEFIGVSLALDF-LGCPK---TIAIPVAAVLL 213 Query: 164 QVWV---PYQRYVNVLKWLTLSLFAYVGTVFALHIEWSEVWSRTFFPHITLSRDYIT--- 217 V ++R+ V+ L A + V ++H P + D T Sbjct: 214 FAMVAGGSFRRWEQVMFMLISVNVAVIPLVLSVHPALGPSL-HGLLPSLPGKPDSPTSVV 272 Query: 218 --MIVAIFGTTISPYLFFWQASQEVEEQQRAPAEEALKRRPEEAAAGVSRMQFDTCVGMG 275 +I+AI GTT++P+ F+Q S V++ + P G + D VG+ Sbjct: 273 LLVIMAIVGTTVAPWQLFFQQSSVVDK----------RITPRWMRYG----RADLVVGIV 318 Query: 276 VSNAVAFFIMLTTAITLHQHGVHDIESSTRA---ASALKPVAGQLAFILFSLGIIGSGML 332 A A +M TA L G D + T A AS L G +LF++ ++ + ++ Sbjct: 319 GVMAGAIALMSATAFGL--AGTADSGNFTDAGAVASHLSDHVGHPIGVLFAIILLDASLI 376 Query: 333 AIPVLAGSAAYAMAGTFKWSNSLEDKPAAAKRFYGVIALATIIGAALAFSSVNTIQALFW 392 V+ + YA+ +SL K A FYG I A +AFS I L Sbjct: 377 GANVVGLATTYALGDALGKPHSLHWKITEAPLFYGSYTALLGISAVVAFSP-GHILGLIT 435 Query: 393 SAV--INGVIAVPVMAIMMLLAVNAGVMGRFVIGRKMRVLGWCATVVMAVAVIAMLATM 449 V + GV+ ++LL + V+G +V + V W +V ++ V++++ T+ Sbjct: 436 QGVQALAGVLLPSATVFLVLLCNDRPVLGPWVNTARQNVFAW--MIVWSLVVLSLMLTV 492