BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0270.p (436 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 352 8e-97 RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 348 1e-95 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 343 5e-94 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 340 3e-93 STM1107 [GEPR] COG0477 Permeases of the major facilitator superf... 336 7e-92 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 352 bits (904), Expect = 8e-97, Method: Compositional matrix adjust. Identities = 197/423 (46%), Positives = 281/423 (66%), Gaps = 8/423 (1%) Query: 6 EERVSRKLMLRIIPFVMLLYFISFLDRVNVGFAAITMNKDLGLSPTAFGLGGGLFFIGYF 65 EE RK+ R+IPF++L Y +++LDRVNVGFA + M DL S T +GLG G+FFIGYF Sbjct: 24 EEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYGLGAGIFFIGYF 83 Query: 66 LFEVPSNLILHKVGARIWIARVMITWGIISAISAFVVGPNSFYLLRFLLGVAEAGFFPGI 125 LFEVPSN+ILH+VGAR+WIAR+MI+WG+ISA FV P FY++RFLLG+AEAGFFPGI Sbjct: 84 LFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRFLLGLAEAGFFPGI 143 Query: 126 ILYLSLWFPAKQRAVAAAWFMAAAPISVALGSPLSG-AIMQLPGLFGLKDWQMLYIIEAA 184 ILYL+ W+PA++R +FM A +S +G P+SG A+ G++GL WQ +++IE Sbjct: 144 ILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGWQWMFLIEGI 203 Query: 185 PAVILGFVVLKYMTDKPEQAHWLAQDEREWLVARLKSEADAKKGGHGHTASAWSALKDPR 244 P+V++G VL Y+ ++ A WL +E+ L + +E K+ A + + PR Sbjct: 204 PSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKE-----DAPIAAIMASPR 258 Query: 245 VLALALIYFGTSAGLYTLGLWVPLMIREFGF-TPFETGLLTGVPSVVAVVAMVLWARHSD 303 V ++LIYF GLY + W+P +I++ G P GLLT +P AVVAMVL AR +D Sbjct: 259 VWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMVLVARSAD 318 Query: 304 RSGERTWHVVIPCVVACVGFLLAGN-ATTALFVVLSLIVVNVGISSAKAPLWAMPSTFLS 362 R+ ER WH+ IP + +G +L+ T + +L + +GI + W++P+ FL+ Sbjct: 319 RTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWSLPTAFLA 378 Query: 363 GAGAAAGIAMINSLGNLGGFVGPFAIGWLKNVTGGYAAGLYVVAASLALSAVVTLMLSRQ 422 G GAAAGIA+INSLGNL GF+ P+A+GWLK+ T +G+Y++AAS+ L A++TL + + Sbjct: 379 GTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLGALLTLSVPAR 438 Query: 423 TAQ 425 T Sbjct: 439 TVN 441 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 348 bits (894), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 196/426 (46%), Positives = 266/426 (62%), Gaps = 5/426 (1%) Query: 6 EERVSRKLMLRIIPFVMLLYFISFLDRVNVGFAAITMNKDLGLSPTAFGLGGGLFFIGYF 65 E + RK+ RI+PFV LY IS+LDR N+G+AA+ MN++L LS AFG G+FFIGYF Sbjct: 26 ERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFFIGYF 85 Query: 66 LFEVPSNLILHKVGARIWIARVMITWGIISAISAFVVGPNSFYLLRFLLGVAEAGFFPGI 125 LFEVPSNL+L++ GAR WIAR+++TWG+++ SAFV Y LRFLLGVAEAGFFPGI Sbjct: 86 LFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLGVAEAGFFPGI 145 Query: 126 ILYLSLWFPAKQRAVAAAWFMAAAPISVALGSPLSGAIMQLPGLFGLKDWQMLYIIEAAP 185 I+YL+ WF A++ A A F AA P+S +G+PLS IM W+ + ++E AP Sbjct: 146 IVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWIMDHVHWLQWSGWRWMLLLEGAP 205 Query: 186 AVILGFVVLKYMTDKPEQAHWLAQDEREWLVARLKSEADAKKGGHGHTASAWSALKDPRV 245 AVI G + Y+ D+P+ A WL++ ER+WL+A L+ + A+ H A+ + PRV Sbjct: 206 AVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERDRKARPAA-AHLATL-KVMTHPRV 263 Query: 246 LALALIYFGTSAGLYTLGLWVPLMIREF--GFTPFETGLLTGVPSVVAVVAMVLWARHSD 303 L LA IYF G +G W+P +I+ F + E GL+ +P V A M+ W+R SD Sbjct: 264 LYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMIWWSRRSD 323 Query: 304 RSGERTWHVVIPCVVACVGFLLAGNATTALFVVLSLIVVNVGISSAKAPLWAMPSTFLSG 363 ER H +P VA + F+ AG + L + G+ + K+P WA+P+ FL+ Sbjct: 324 LRAERRLHSAVPLGVAALAFVGAGFIGHPAVAMAMLSLSLAGLYAFKSPFWALPTLFLTR 383 Query: 364 AGAAAGIAMINSLGNLGGFVGPFAIGWLKNVTGGYAAGLYVVAASLALSAVVTLMLSRQT 423 + AA IA+INS+GNLGGFVGPFAIG+ K AGL +A LA+S V+TL L Sbjct: 384 STAAVSIAVINSVGNLGGFVGPFAIGYFKGQMHSTTAGLLFLAGLLAVSFVMTLRLRVTE 443 Query: 424 AQ-PDR 428 A PDR Sbjct: 444 AHAPDR 449 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 343 bits (879), Expect = 5e-94, Method: Compositional matrix adjust. Identities = 189/417 (45%), Positives = 277/417 (66%), Gaps = 6/417 (1%) Query: 5 IEERVSRKLMLRIIPFVMLLYFISFLDRVNVGFAAITMNKDLGLSPTAFGLGGGLFFIGY 64 +E RK+ RIIP +M+ Y I++LDRVNVGFA + M+++LG S +GLG GLFFIGY Sbjct: 32 VENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAGLFFIGY 91 Query: 65 FLFEVPSNLILHKVGARIWIARVMITWGIISAISAFVVGPNSFYLLRFLLGVAEAGFFPG 124 F FE+PSN++LHK+GAR+WIAR+MITWG++SA+ AFV FY+LRFLLG AEAGF+PG Sbjct: 92 FFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLGAAEAGFYPG 151 Query: 125 IILYLSLWFPAKQRAVAAAWFMAAAPISVALGSPLSGAIM-QLPGLFGLKDWQMLYIIEA 183 +ILYL+ WFP+ +R A F A +P + G+PLSG IM Q G + WQ ++++EA Sbjct: 152 VILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQWMFVLEA 211 Query: 184 APAVILGFVVLKYMTDKPEQAHWLAQDEREWLVARLKSEADAKKGGHGHTASAWSALKDP 243 PAV+LG V+L Y+ + + A WL ++E+ +++R EAD+K H S S +K+P Sbjct: 212 IPAVVLGVVILLYLDNSVKAAKWLTEEEKA-IISR-DIEADSKGKAASH--SLMSLVKNP 267 Query: 244 RVLALALIYFGTSAGLYTLGLWVPLMIREFGFTPFET-GLLTGVPSVVAVVAMVLWARHS 302 + + LIYF G + L LW+P +IR G T T GLL +P + A++AMV+++R + Sbjct: 268 MLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIFSRSA 327 Query: 303 DRSGERTWHVVIPCVVACVGFLLAGNATTALFVVLSLIVVNVGISSAKAPLWAMPSTFLS 362 D ER WH+V+P ++ VGF++A +AT ++ L + G+ + W++P+ LS Sbjct: 328 DHYRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLACAPLFWSLPTAILS 387 Query: 363 GAGAAAGIAMINSLGNLGGFVGPFAIGWLKNVTGGYAAGLYVVAASLALSAVVTLML 419 GA AAAGIA+INS+ NL GF+ P+ +G +++ T G+YV+A L L A + L + Sbjct: 388 GAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGAAIVLCI 444 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 340 bits (873), Expect = 3e-93, Method: Compositional matrix adjust. Identities = 184/421 (43%), Positives = 267/421 (63%), Gaps = 8/421 (1%) Query: 2 KTEIEERVSRKLMLRIIPFVMLLYFISFLDRVNVGFAAITMNKDLGLSPTAFGLGGGLFF 61 + + E RK + ++P +ML Y +++LDRVNVGFA + M DL S T +GLG G+FF Sbjct: 14 QLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGAGMFF 73 Query: 62 IGYFLFEVPSNLILHKVGARIWIARVMITWGIISAISAFVVGPNSFYLLRFLLGVAEAGF 121 IGYF E+PSNLILH+VGAR+WIAR+MITWGIISA AFV P SFY++RFLLGVAEAGF Sbjct: 74 IGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLLGVAEAGF 133 Query: 122 FPGIILYLSLWFPAKQRAVAAAWFMAAAPISVALGSPLSGAIMQ-LPGLFGLKDWQMLYI 180 FPGIILY+S WFP+ +R F+ + P+S +G+PLSG IMQ G G WQ ++I Sbjct: 134 FPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYAGWQWMFI 193 Query: 181 IEAAPAVILGFVVLKYMTDKPEQAHWLAQDEREWLVARLKSEADAKKGGHGHTASAWSAL 240 +E P+V++G +++ + D+ A WL E++ L +++EA H + A Sbjct: 194 LEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEA-----AHYAHSRLRDAF 248 Query: 241 KDPRVLALALIYFGTSAGLYTLGLWVPLMIREFGFTP-FETGLLTGVPSVVAVVAMVLWA 299 PRV L LIYF +G YT+G W+P +IR+ G G LT +PS A V M++ + Sbjct: 249 LQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVS 308 Query: 300 RHSDRSGERTWHVVIPCVVACVGFLLAGNATTALFVVLSLIVVNVGISSAKAPL-WAMPS 358 R +DR ER WH+ + V+ VG +L+ + + V + + + + + PL W++P+ Sbjct: 309 RSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLFWSLPT 368 Query: 359 TFLSGAGAAAGIAMINSLGNLGGFVGPFAIGWLKNVTGGYAAGLYVVAASLALSAVVTLM 418 FL G+ AAAGIA INS GNLGGFV P+ +G+LK++T G+ +++ +L + A + + Sbjct: 369 AFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIGAALVFL 428 Query: 419 L 419 + Sbjct: 429 I 429 >STM1107 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 458 Score = 336 bits (861), Expect = 7e-92, Method: Compositional matrix adjust. Identities = 176/430 (40%), Positives = 259/430 (60%), Gaps = 9/430 (2%) Query: 6 EERVSRKLMLRIIPFVMLLYFISFLDRVNVGFAAITMNKDLGLSPTAFGLGGGLFFIGYF 65 ++ V KL R+I F+ +L+ SFLDR+N+GFA +TM +DLGLS T FGL LF+ Y Sbjct: 25 QQTVINKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMGQDLGLSATMFGLATTLFYATYV 84 Query: 66 LFEVPSNLILHKVGARIWIARVMITWGIISAISAFVVGPNSFYLLRFLLGVAEAGFFPGI 125 +F +PSN++L VGAR WIA +M+ WGI S + F VGP S Y+LR L+G+ EAGF PGI Sbjct: 85 IFGIPSNVMLSIVGARHWIATIMVLWGIASTATMFAVGPKSLYVLRMLVGITEAGFLPGI 144 Query: 126 ILYLSLWFPAKQRAVAAAWFMAAAPISVALGSPLSGAIMQLPGLFGLKDWQMLYIIEAAP 185 +LYL+ WFPA RA A A FM A P + ALGS +SG I+ L G+F L WQ L+++E P Sbjct: 145 LLYLTYWFPAFFRARANALFMIAMPATTALGSIVSGYILSLDGIFNLHGWQWLFLLEGFP 204 Query: 186 AVILGFVVLKYMTDKPEQAHWLAQDEREWLVARLKSEA---DAKKGGHGHTA----SAWS 238 +V+LG +V Y+ D P +A WL ++++ L + S+ +G H A S W Sbjct: 205 SVLLGIMVWFYLDDTPAKAKWLTAEDKKCLQEMMDSDRLTLVQPEGAISHNAMQQRSLWR 264 Query: 239 ALKDPRVLALALIYFGTSAGLYTLGLWVPLMIREF--GFTPFETGLLTGVPSVVAVVAMV 296 + P VL L YF + L + +W P +++ F G + GLL +P + ++ M+ Sbjct: 265 EVFTPIVLMYTLAYFCLTNTLSAISIWTPQILKSFNEGSSNITIGLLAAIPQICTILGMI 324 Query: 297 LWARHSDRSGERTWHVVIPCVVACVGFLLAGNATTALFVVLSLIVVNVGISSAKAPLWAM 356 W+RHSD+ ER H +P + A G+LLA L +L +++ + G SA A W Sbjct: 325 YWSRHSDKHQERKHHTALPFLFAAAGWLLASATDHNLIQLLGIVMASTGSFSAMAIFWTT 384 Query: 357 PSTFLSGAGAAAGIAMINSLGNLGGFVGPFAIGWLKNVTGGYAAGLYVVAASLALSAVVT 416 P +S A GIA+IN+ GN+G + PF IGWLK++TG + +GL+ VA+ L + A + Sbjct: 385 PDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDITGSFNSGLWFVASLLVVGAAII 444 Query: 417 LMLSRQTAQP 426 ++ + ++P Sbjct: 445 WLIPMKASRP 454