BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0095.p (409 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SSO1505 [GEPR] COG0477 Permeases of the major facilitator superf... 171 2e-42 PA2262 [GEPR] COG0477 Permeases of the major facilitator superfa... 170 6e-42 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 167 5e-41 YPO2535 [GEPR] COG0477 Permeases of the major facilitator superf... 160 6e-39 RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 157 5e-38 >SSO1505 [GEPR] COG0477 Permeases of the major facilitator superfamily Sso Sulfolobus solfataricus Length = 421 Score = 171 bits (434), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 113/406 (27%), Positives = 208/406 (51%), Gaps = 15/406 (3%) Query: 3 ILPTVFIVYMLSYFDRVNIAMALP-HMTKELGLTSTQGGWI----GGAFAWGYALTQLLA 57 ILP +F +Y++++ DRVNI+ A+ HM + LG+ + Q G I F GY + Q+ + Sbjct: 16 ILPILFFLYIVNFLDRVNISYAIDAHMFQYLGVPTRQVGIIASLASSLFFIGYFIPQIFS 75 Query: 58 GYLAMKFGARRLVAVCLVLFGAAAMLTGLATTFWQVLSVRILLGLAEGPVYAGTSILLAQ 117 ++G R++ ++G +LTG ++ QV +R LLG+AEGP +AG L+ Sbjct: 76 NLGINRYGVRKIFLAAFTVWGIITILTGFVSSVSQVYVLRFLLGIAEGPFFAGVMFYLSL 135 Query: 118 WFMKAERGRAFGIWNLGAPLGGFLAGPISGAIIAHY----DWRVMLIAEGLPAWIFCLIW 173 WF+K ER A + P+ G G I+GAI A Y WR + I EG+ A I ++ Sbjct: 136 WFLKPERATANSFFTAAIPVSGIFGGLIAGAIFATYGDYPGWRYLFIYEGILAIIGGILA 195 Query: 174 FKSIPKSLDAAAWLPAGDRDTIKRTLDEEQAAHQAPETDPWWTIFNEPAVWLMTLGFGLN 233 + + A WL ++ I+ EE+ + W V ++ + + L Sbjct: 196 YFILTDFPKDAKWLSNEEKIAIQNAFKEEETEKVNVK---WTKALTNRDVIILAIVYFLG 252 Query: 234 TILLYGITLWLPTVMKSYGQLSETAIGFFAGAPFVMSMLGIYYISRRSDRNGQERRWHAA 293 LYG ++WLP+++ S+G+++ T F + P+V++ + + +I+ +DR Q R + Sbjct: 253 VTSLYGYSIWLPSIISSFGKVNATVASFLSVIPYVIASISLIFIAHLADRT-QRHRSITS 311 Query: 294 IPTMITGLLMAAAAFVPASLFYVQIALFILIGFTLKMLMPLIFSRLTEILPLRKAMPAVA 353 I +I G+ + +A + ++F + F + + + ++ + L A A+ Sbjct: 312 IVFIIAGVGLGLSA-LTQNIFVLSFIFFAIAAIGIYSFIATFWAVPQKFLHGDAAAAAIG 370 Query: 354 FVSGVGNLIGQFLGPLLVGYVRSISPDYKMSLLMLGVAAFLGGVAI 399 ++ VGNL G +GP++VG+++S + + + M+ + +FL G+ I Sbjct: 371 LINAVGNL-GGIVGPIVVGFLKSFTGSFIDGVYMMALFSFLAGLVI 415 >PA2262 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 435 Score = 170 bits (430), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 113/377 (29%), Positives = 188/377 (49%), Gaps = 5/377 (1%) Query: 3 ILPTVFIVYMLSYFDRVNIAMALPH-MTKELGLTSTQGGWIGGAFAWGYALTQLLAGYLA 61 I+P VF+ Y L+Y DR N A M +L +T +G F GY Q+ A Sbjct: 14 IMPIVFVTYSLAYLDRANYGFAAASGMADDLRITPGLSSLLGALFFLGYFFFQVPGAIYA 73 Query: 62 MKFGARRLVAVCLVLFGAAAMLTGLATTFWQVLSVRILLGLAEGPVYAGTSILLAQWFMK 121 K ++L+ V L+L+G A LTG+ + ++ +R LLG+ E V + L WF + Sbjct: 74 EKRSVKKLIFVSLILWGGLATLTGMVANVYLLIGIRFLLGVVEAAVMPAMLVYLCHWFTR 133 Query: 122 AERGRAFGIWNLGAPLGGFLAGPISGAIIAHYDWRVMLIAEGLPAWIFCLIWFKSIPKSL 181 AER RA LG P+ +SG ++ H+ WR M I EGLPA I+ IW++ + Sbjct: 134 AERSRANTFLILGNPVTILWMSVVSGYLVEHFSWRWMFIIEGLPAVIWAFIWWRLVDDRP 193 Query: 182 DAAAWLPAGDRDTIKRTLDEEQAAHQAPETDPWWTIFNEPAVWLMTLGFGLNTILLYGIT 241 AAWL ++ ++ L EQ + + + F P V +++L + +I +YG Sbjct: 194 RQAAWLSGSEKRDLEDALAAEQQGIKPVKN--YREAFRSPKVIVLSLQYFCWSIGVYGFV 251 Query: 242 LWLPTVMKSYGQLSETAIGFFAGAPFVMSMLGIYYISRRSDRNGQERRWHAAIPTMITGL 301 LWLP+++K + G+ + P++ +++ + +S SDR Q+R+ P +I + Sbjct: 252 LWLPSILKHGANIDIIEAGWLSALPYLAAVIAMLGVSWASDRL-QKRKRFVWPPLLIASI 310 Query: 302 LMAAAAFVPASLFYVQIALFILIGFTLKMLMPLIFSRLTEILPLRKAMPAVAFVSGVGNL 361 + + + F++ AL +L G + F+ + E+LP A A+A ++ +G L Sbjct: 311 AFYGSYALGSEHFWLSYALLVLAGACMYAPYGPFFAIVPEVLPANVAGGAMALINSMGAL 370 Query: 362 IGQFLGPLLVGYVRSIS 378 G F G LVGY+ I+ Sbjct: 371 -GSFSGSWLVGYLNGIT 386 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 167 bits (422), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 113/396 (28%), Positives = 193/396 (48%), Gaps = 17/396 (4%) Query: 3 ILPTVFIVYMLSYFDRVNIAMALPHMTKELGLTSTQGGWIGGAFAWGYALTQLLAGYLAM 62 I+P + I Y+++Y DRVN+ A M++ELG + G G F GY ++ + L Sbjct: 44 IIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAGLFFIGYFFFEIPSNILLH 103 Query: 63 KFGARRLVAVCLVLFGAAAMLTGLATTFWQVLSVRILLGLAEGPVYAGTSILLAQWFMKA 122 K GAR +A ++ +G + L T WQ +R LLG AE Y G + L WF Sbjct: 104 KLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLGAAEAGFYPGVILYLTYWFPSH 163 Query: 123 ERGRAFGIWNLGAPLGGFLAGPISGAIIAHYD-------WRVMLIAEGLPAWIFCLIWFK 175 RG F ++ G+P G P+SG I+ + W+ M + E +PA + ++ Sbjct: 164 RRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQWMFVLEAIPAVVLGVVILL 223 Query: 176 SIPKSLDAAAWLPAGDRDTIKRTLDEEQAAHQAPETDPWWTIFNEPAVWLMTLGFGLNTI 235 + S+ AA WL ++ I R ++ + A + ++ P +W+M L + + Sbjct: 224 YLDNSVKAAKWLTEEEKAIISRDIEADSKGKAASHS--LMSLVKNPMLWVMMLIYFCFVM 281 Query: 236 LLYGITLWLPTVMKSYGQLSETAIGFFAGAPFVMSMLGIYYISRRSDRNGQERRWHAAIP 295 +G+TLW+PT++++ G S IG PF+ +++ + SR +D +ERRWH +P Sbjct: 282 GQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIFSRSADHY-RERRWHLVVP 340 Query: 296 TMI--TGLLMAAAAFVPASLFYVQIALFILIGFTLKMLMPLIFSRLTEILPLRKAMPAVA 353 ++ G ++AA+ A+ V I + + PL +S T IL A +A Sbjct: 341 ALLGAVGFVVAAS----ATNTTVSIIFLSMAAAGVLACAPLFWSLPTAILSGAAAAAGIA 396 Query: 354 FVSGVGNLIGQFLGPLLVGYVRSISPDYKMSLLMLG 389 ++ V NL G F+ P +VG +R + ++ + +L Sbjct: 397 LINSVANLAG-FISPYMVGIIRDATHSSELGMYVLA 431 >YPO2535 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 443 Score = 160 bits (404), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 127/384 (33%), Positives = 196/384 (51%), Gaps = 26/384 (6%) Query: 2 IILPTVFIVYMLSYFDRVNIAMALPH-MTKELGLTSTQGGWIGGAFAWGYALTQLLAGYL 60 +I+P + I ++S+ DRVNI+ ALP M +L +TS G GG F GY Q+ G + Sbjct: 18 VIVP-IMIACIISFMDRVNISFALPGGMESDLAITSQMAGLAGGIFFIGYLFLQVPGGRI 76 Query: 61 AMKFGARRLVAVCLVLFGAAAMLTGLATTFWQVLSVRILLGLAEGPVYAGTSILLAQWFM 120 A+ R+ +A L ++ ++LTG T +Q+L +R +LG++EG + +++ WF Sbjct: 77 AVHGSGRKFIAYSLAVWAIVSILTGFVTHHYQLLFLRFVLGVSEGGMLPVVLTMVSNWFP 136 Query: 121 KAERGRAFGIWNLGAPLGGFLAGPISGAIIAHYDWRVMLIAEGLPAWIFCLIWFKSIPKS 180 + E GRA + AP+GG P+SG II DWR + EG + + ++W+ I Sbjct: 137 EREIGRANAFVMMFAPIGGMFTAPLSGFIINTLDWRWLFFLEGGLSALVLVMWWFVISDR 196 Query: 181 LDAAAWLPAGDRDTIKRTLDEEQAAH--QAPETD-PWWTIF-NEPAVWLMTLGFGLNTIL 236 + A WL A +RD + L E+A P T+ P +F N+ + L+ L F T Sbjct: 197 PEEAKWLSARERDYLVTELSRERAERMFNKPVTNAPLKAVFLNKGLMKLVALNFFYQT-G 255 Query: 237 LYGITLWLPTVMKSYGQLSETAIGFFAGAPFVMSMLGIYYISRRSDRNGQERRWHAAIPT 296 YG TLWLPT++K+ + ++G A PFV + GIY IS +D+ G+ R + Sbjct: 256 DYGYTLWLPTILKNLTGGNMASVGILAVLPFVATTAGIYVISALADKTGKRR-----LLI 310 Query: 297 MITGLLMAAAAFVPASLFYVQIAL----FILIGFTLKMLMPLIFSRLTEILPLRKAMPAV 352 MI+ L AAA V + +F + + ++ GF LK +S +P R A+P V Sbjct: 311 MIS-LFCFAAALVASVIFRHNVLVSYLALVVCGFFLKAATSPFWS-----IPGRIAVPEV 364 Query: 353 A----FVSGVGNLIGQFLGPLLVG 372 A +G F GP LVG Sbjct: 365 AGGARGGINGLGNLGGFCGPYLVG 388 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 157 bits (397), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 118/382 (30%), Positives = 183/382 (47%), Gaps = 15/382 (3%) Query: 3 ILPTVFIVYMLSYFDRVNIAMALPHMTKELGLTSTQGGWIGGAFAWGYALTQLLAGYLAM 62 ILP VF +Y++SY DR NI A M +EL L+S G++ G F GY L ++ + + Sbjct: 37 ILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFFIGYFLFEVPSNLMLN 96 Query: 63 KFGARRLVAVCLVLFGAAAMLTGLATTFWQVLSVRILLGLAEGPVYAGTSILLAQWFMKA 122 +FGARR +A LV +G AM + + Q+ ++R LLG+AE + G + L WF Sbjct: 97 RFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLGVAEAGFFPGIIVYLTYWFRAR 156 Query: 123 ERGRAFGIWNLGAPLGGFLAGPISGAIIAHYD------WRVMLIAEGLPAWIFCLIWFKS 176 E ++ P+ + P+S I+ H WR ML+ EG PA I L+ + Sbjct: 157 ELATTVALFTAAIPVSYVVGAPLSTWIMDHVHWLQWSGWRWMLLLEGAPAVIGGLLCYGY 216 Query: 177 IPKSLDAAAWLPAGDRDTIKRTLDEEQAAHQAPETDPWWTIFNEPAVWLMTLGFGLNTIL 236 + A WL +RD + L+ ++ A A + P V + + + Sbjct: 217 LADRPKDARWLSEAERDWLLAELERDRKARPAAAHLATLKVMTHPRVLYLAFIYFVYQCG 276 Query: 237 LYGITLWLPTVMKSYGQ-LSETAIGFFAGAPFVMSMLGIYYISRRSDRNGQERRWHAAIP 295 GI W+P ++K + LS T +G A P+V + + + SRRSD ERR H+A+P Sbjct: 277 SLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMIWWSRRSDLRA-ERRLHSAVP 335 Query: 296 TMITGLLMAAAAFV--PASLFYVQIALFILIGFTLKMLMPLIFSRLTEILPLRKAMPAVA 353 + L A F+ PA V +A+ L L ++ T L A ++A Sbjct: 336 LGVAALAFVGAGFIGHPA----VAMAMLSLSLAGLYAFKSPFWALPTLFLTRSTAAVSIA 391 Query: 354 FVSGVGNLIGQFLGPLLVGYVR 375 ++ VGNL G F+GP +GY + Sbjct: 392 VINSVGNL-GGFVGPFAIGYFK 412