BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0034.p (459 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0654 [T] COG0642 Signal transduction histidine kinase Rso Ral... 424 e-118 PA2810 [T] COG0642 Signal transduction histidine kinase Pae Pseu... 287 4e-77 ZybcZ [T] COG0642 Signal transduction histidine kinase EcZ Esche... 284 3e-76 ECs0608 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 284 3e-76 ybcZ [T] COG0642 Signal transduction histidine kinase Eco Escher... 279 1e-74 >RSp0654 [T] COG0642 Signal transduction histidine kinase Rso Ralstonia solanacearum Length = 466 Score = 424 bits (1089), Expect = e-118, Method: Compositional matrix adjust. Identities = 224/461 (48%), Positives = 307/461 (66%), Gaps = 4/461 (0%) Query: 3 RQRSLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVNERGA 62 R+ SLT RLTALF+L S AVL+GLG++I + +HF +D L + + +I +V A Sbjct: 3 RRLSLTARLTALFSLCSAAVLLGLGVVIALAMEQHFAVEDFTALGEHVSVIGKIVESGPA 62 Query: 63 DAITSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAPILAAAQSAVPGRSFAVPVGQH 122 + +AL + GF I +ALY++ A A PG V Sbjct: 63 PQAEARIRDALQHRTGFVARILGPDRRALYASDGFDFRAADEALARARPGSDRLVWAQGG 122 Query: 123 QKFQAIKARLK-DDQSARELQVIVAVDTEIHDHFMRNFQTTLVLYIAGSVLIVVLLSWWA 181 Q+++A+ + D +A L ++VA++T+IH HF+ F+ TL YIA + L + WWA Sbjct: 123 QQYRAMHTTVALRDGTAGRLDMLVAMNTDIHAHFLHTFRGTLAFYIALAALASGVFGWWA 182 Query: 182 ARRGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEIADLAAKLNAMLERLQRDFNRITNF 241 ARRGLAPLR ++ + + V++ ERM V+ +P E+ADLA LNAMLERLQ DF R+++F Sbjct: 183 ARRGLAPLRTLASRARTVTADKLDERMPVDTVPAEVADLAVTLNAMLERLQHDFRRLSDF 242 Query: 242 STDIAHELRTPITNLLTQTDVVLTQQRTNEAYRDILSSNAEELQRLARTISDMLFLAQTE 301 STDIAHE+RTPITNLLTQT+VVL+Q R YRD+L+SNAEELQRLAR +SDML+LA+ E Sbjct: 243 STDIAHEIRTPITNLLTQTEVVLSQPREGAKYRDVLTSNAEELQRLARMVSDMLYLAKME 302 Query: 302 NGITLPSYERLSLQEEISELFDFYDALAEEKNVLMRLAGEASIRGDRLMVRRALSNLISN 361 + +TLPS E + L +E+ LF+FYDALAE+K V + L G+ + GDRLM+RRALSNL+SN Sbjct: 303 HSLTLPSAEDIHLADELRALFEFYDALAEDKAVRLELRGDGRVSGDRLMLRRALSNLLSN 362 Query: 362 AMRYTPPAGVIAVSIDRSEKDISVHVENDGPEIPSEHLPHLFDRFYRADKARTKLDSDSA 421 A+R+ PP G + VSI + ++V V+NDG EIP + L +F+RFYRADK+R + +SDS Sbjct: 363 AIRHAPPRGAVLVSIADTGHGVTVSVDNDGDEIPPQVLSRIFERFYRADKSRARPESDST 422 Query: 422 GLGLSITKAIMRAHQGEVSVRSAQGKTRFTLLF---PNAAA 459 GLGL+ITKAI+ AH G ++V G+TRF L F P A A Sbjct: 423 GLGLAITKAIVVAHGGSIAVSRVGGRTRFALHFARRPEAGA 463 >PA2810 [T] COG0642 Signal transduction histidine kinase Pae Pseudomonas aeruginosa Length = 443 Score = 287 bits (734), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 170/453 (37%), Positives = 248/453 (54%), Gaps = 28/453 (6%) Query: 6 SLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVNERGADAI 65 SL VRL+ LFA + AV + GL+ + +HF + D + +L + R + G++ Sbjct: 10 SLGVRLSLLFAACTAAVSLIAGLIFSRAIDEHFVELDHMAMSAKLAVFRDELRGLGSEQQ 69 Query: 66 T----STFGEALHNHPGFYVHISSLSGQALYSTLNHATAPILAAAQSAVPGRSFAVPVGQ 121 + L HP + ++ G + L P L A R P+ Sbjct: 70 MRRREAELLRELARHPDLGLRLNGPDGNLWFERLPQPAHPGLPA------NRELGAPLEP 123 Query: 122 HQKFQAIKARLKDDQSARELQVIVAVDTEIHDHFMRNFQTTLVLYIAGSVLIVVLLSWWA 181 +D S R + V +D H HF++ + + L ++ S L LL WA Sbjct: 124 -----------GNDASPR---LTVILDISHHQHFLQRMRQLIWLTMSLSALATALLGAWA 169 Query: 182 ARRGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEIADLAAKLNAMLERLQRDFNRITNF 241 LAPLR M + VS+++ R+ +P E+ LA +LNAML RL+ F R++ F Sbjct: 170 TGASLAPLRRMREVAARVSANSLTTRLDASRMPEELRGLAGELNAMLARLEEAFQRLSAF 229 Query: 242 STDIAHELRTPITNLLTQTDVVLTQQRTNEAYRDILSSNAEELQRLARTISDMLFLAQTE 301 S DIAHELRTP+T+LLTQT VVL++ R+ E YR+ L N EEL+RL ++DML LA+ + Sbjct: 230 SADIAHELRTPLTSLLTQTQVVLSRPRSLEDYREALHGNLEELERLTAMVNDMLLLAKAD 289 Query: 302 NGITLPSYERLSLQEEISELFDFYDALAEEKNVLMRLAGEASIRGDRLMVRRALSNLISN 361 +G+ PS + L L E+ L +FY LAE++++ + G S+ GDR M+RR L+NL+ N Sbjct: 290 HGLLAPSRQALDLGAEVDSLLEFYQPLAEDRDIRLLREGSLSLPGDRGMLRRVLANLLDN 349 Query: 362 AMRYTPPAGVIAVSIDRSEKDISVHVENDGPEIPSEHLPHLFDRFYRADKARTKLDSDSA 421 A+R+T G I + + D + VEN GP IP E LP LFDRFYRAD AR + + A Sbjct: 350 ALRFTADGGEIRIRL----GDRRLSVENQGPAIPPERLPRLFDRFYRADPARREGQGEHA 405 Query: 422 GLGLSITKAIMRAHQGEVSVRSAQGKTRFTLLF 454 GLGL+I ++I++AH GE+ SA G TRF + F Sbjct: 406 GLGLAICRSIVQAHGGEIRCESADGWTRFVIDF 438 >ZybcZ [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 482 Score = 284 bits (727), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 169/479 (35%), Positives = 269/479 (56%), Gaps = 33/479 (6%) Query: 3 RQRSLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVN---E 59 R SL RLT +LA+ A ++I +V HF +QD L++ + V+N E Sbjct: 8 RPFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDE 67 Query: 60 RGADAITSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAP-ILAAAQSAVP------- 111 A + T + + + + ++ G+ +Y + AP I A+ A+P Sbjct: 68 TQARRLM-TLEDIVSGYSNVLISLADSHGKTVYHS---PGAPDIREFARDAIPDKDARGG 123 Query: 112 ------GRSFAVPVGQHQKFQAIKAR--------LKDDQSARELQVIVAVDTEIHDHFMR 157 G + +P H + R L D + L + +++D H H++ Sbjct: 124 EVFLLSGPTMMMPGHGHGHMEHSNWRMISLPVGPLVDGKPIYTLYIALSID--FHLHYIN 181 Query: 158 NFQTTLVLYIAGSVLIVVLLSWWAARRGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEI 217 + L++ + +++V + A +G AP+R++S ++Q ++S + R+ + +PIE+ Sbjct: 182 DLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIEL 241 Query: 218 ADLAAKLNAMLERLQRDFNRITNFSTDIAHELRTPITNLLTQTDVVLTQQRTNEAYRDIL 277 L N M+ER++ F R +NFS DIAHE+RTPITNL+TQT++ L+Q R+ + D+L Sbjct: 242 EQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVL 301 Query: 278 SSNAEELQRLARTISDMLFLAQTENGITLPSYERLSLQEEISELFDFYDALAEEKNVLMR 337 SN EEL R+A+ +SDMLFLAQ +N +P + L+L +E+ ++FDF++ALAE++ V ++ Sbjct: 302 YSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELQ 361 Query: 338 LAG-EASIRGDRLMVRRALSNLISNAMRYTPPAGVIAVSIDRSEKDISVHVENDGPEIPS 396 G E + GD LM+RRALSNL+SNA+RYTPP I V + + V VEN G I Sbjct: 362 FVGDECQVAGDPLMLRRALSNLLSNALRYTPPGEAIVVRCQTVDHLVQVIVENPGTPIAP 421 Query: 397 EHLPHLFDRFYRADKARTKLDSDSAGLGLSITKAIMRAHQGEVSVRSAQGKTRFTLLFP 455 EHLP LFDRFYR D +R + + +G+GL+I K+I+ AH+G V+V S TRF ++ P Sbjct: 422 EHLPRLFDRFYRVDPSRQR-KGEGSGIGLAIVKSIVVAHKGTVAVTSNARGTRFVIVLP 479 >ECs0608 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 482 Score = 284 bits (727), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 169/479 (35%), Positives = 269/479 (56%), Gaps = 33/479 (6%) Query: 3 RQRSLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVN---E 59 R SL RLT +LA+ A ++I +V HF +QD L++ + V+N E Sbjct: 8 RPFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDE 67 Query: 60 RGADAITSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAP-ILAAAQSAVP------- 111 A + T + + + + ++ G+ +Y + AP I A+ A+P Sbjct: 68 TQARRLM-TLEDIVSGYSNVLISLADSHGKTVYHS---PGAPDIREFARDAIPDKDARGG 123 Query: 112 ------GRSFAVPVGQHQKFQAIKAR--------LKDDQSARELQVIVAVDTEIHDHFMR 157 G + +P H + R L D + L + +++D H H++ Sbjct: 124 EVFLLSGPTMMMPGHGHGHMEHSNWRMISLPVGPLVDGKPIYTLYIALSID--FHLHYIN 181 Query: 158 NFQTTLVLYIAGSVLIVVLLSWWAARRGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEI 217 + L++ + +++V + A +G AP+R++S ++Q ++S + R+ + +PIE+ Sbjct: 182 DLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIEL 241 Query: 218 ADLAAKLNAMLERLQRDFNRITNFSTDIAHELRTPITNLLTQTDVVLTQQRTNEAYRDIL 277 L N M+ER++ F R +NFS DIAHE+RTPITNL+TQT++ L+Q R+ + D+L Sbjct: 242 EQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVL 301 Query: 278 SSNAEELQRLARTISDMLFLAQTENGITLPSYERLSLQEEISELFDFYDALAEEKNVLMR 337 SN EEL R+A+ +SDMLFLAQ +N +P + L+L +E+ ++FDF++ALAE++ V ++ Sbjct: 302 YSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELQ 361 Query: 338 LAG-EASIRGDRLMVRRALSNLISNAMRYTPPAGVIAVSIDRSEKDISVHVENDGPEIPS 396 G E + GD LM+RRALSNL+SNA+RYTPP I V + + V VEN G I Sbjct: 362 FVGDECQVAGDPLMLRRALSNLLSNALRYTPPGEAIVVRCQTVDHLVQVIVENPGTPIAP 421 Query: 397 EHLPHLFDRFYRADKARTKLDSDSAGLGLSITKAIMRAHQGEVSVRSAQGKTRFTLLFP 455 EHLP LFDRFYR D +R + + +G+GL+I K+I+ AH+G V+V S TRF ++ P Sbjct: 422 EHLPRLFDRFYRVDPSRQR-KGEGSGIGLAIVKSIVVAHKGTVAVTSNARGTRFVIVLP 479 >ybcZ [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 480 Score = 279 bits (713), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 167/479 (34%), Positives = 266/479 (55%), Gaps = 33/479 (6%) Query: 3 RQRSLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVN---E 59 R SL RLT +LA+ A ++I +V HF +QD L++ + V+N E Sbjct: 8 RPFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDE 67 Query: 60 RGADAITSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAP-ILAAAQSAVP------- 111 A + T + + + + ++ G+ +Y + AP I + A+P Sbjct: 68 TQARRLM-TLEDIVSGYSNVLISLADSQGKTVYHS---PGAPDIREFTRDAIPDKDAQGG 123 Query: 112 ------GRSFAVPVGQHQKFQAIKAR--------LKDDQSARELQVIVAVDTEIHDHFMR 157 G + +P H + R L D + L + +++D H H++ Sbjct: 124 EVYLLSGPTMMMPGHGHGHMEHSNWRMINLPVGPLVDGKPIYTLYIALSID--FHLHYIN 181 Query: 158 NFQTTLVLYIAGSVLIVVLLSWWAARRGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEI 217 + L++ + +++V + A +G AP+R++S ++Q ++S + R+ + +PIE+ Sbjct: 182 DLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIEL 241 Query: 218 ADLAAKLNAMLERLQRDFNRITNFSTDIAHELRTPITNLLTQTDVVLTQQRTNEAYRDIL 277 L N M+ER++ F R +NFS DIAHE+RTPITNL+TQT++ L+Q R+ + D+L Sbjct: 242 EQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVL 301 Query: 278 SSNAEELQRLARTISDMLFLAQTENGITLPSYERLSLQEEISELFDFYDALAEEKNVLMR 337 SN EEL R+A+ +SDMLFLAQ +N +P + L+L +E+ ++FDF++ALAE++ V +R Sbjct: 302 YSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELR 361 Query: 338 LAGE-ASIRGDRLMVRRALSNLISNAMRYTPPAGVIAVSIDRSEKDISVHVENDGPEIPS 396 G+ + GD LM+RRALSNL+SNA+RYTP I V + + V VEN G I Sbjct: 362 FVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAP 421 Query: 397 EHLPHLFDRFYRADKARTKLDSDSAGLGLSITKAIMRAHQGEVSVRSAQGKTRFTLLFP 455 EHLP LFDRFYR D +R + + +G+GL+I K+I+ AH+G V+V S TRF + P Sbjct: 422 EHLPRLFDRFYRVDPSRQR-KGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVITLP 479