BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0043.p (632 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BS_ywcA [R] COG4147 Predicted symporter Bsu Bacillus subtilis 407 e-113 DR0477 [R] COG4147 Predicted symporter Dra Deinococcus radiodurans 386 e-106 PA3234 [R] COG4147 Predicted symporter Pae Pseudomonas aeruginosa 377 e-104 YPO0251 [R] COG4147 Predicted symporter Ype Yersinia pestis 370 e-102 yjcG [R] COG4147 Predicted symporter Eco Escherichia coli K12 364 e-100 >BS_ywcA [R] COG4147 Predicted symporter Bsu Bacillus subtilis Length = 516 Score = 407 bits (1046), Expect = e-113, Method: Compositional matrix adjust. Identities = 253/588 (43%), Positives = 358/588 (60%), Gaps = 86/588 (14%) Query: 46 FAIFFGATLLITY---LAAKRNRTATDYYTAGGGIGPIRNGLAIAGDYLSAAAFLGVSGL 102 F I FG Y AKR +T +++YTAGGG+ ++NGLAIAGDY+SAA+FLG++G+ Sbjct: 9 FFIIFGDCWPDAYYHVFCAKRTKTTSEFYTAGGGLTGVQNGLAIAGDYMSAASFLGIAGM 68 Query: 103 IALYGYDGIAYLIGFFVAFIPVLLLVAEPCRNLGRYTLGDVLAYRNSFRSTKVAAAVSSI 162 IALYG+DG Y IGF VA++ VL +VAEP RNLG+YT+ D++A R + + AA+++I Sbjct: 69 IALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYTMADMIAARFKEKKIRGVAALNTI 128 Query: 163 IVAVFYMVPQIVGGAVILRALIGIPYEISVLAVGILMLTYVVFGGMRATTSVQVIKAILL 222 ++ FYM+ Q+VG +++ L+G+ Y +VL VG+LM YVVFGGM AT+ VQ+IKA+LL Sbjct: 129 AISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGVLMTIYVVFGGMIATSWVQIIKAVLL 188 Query: 223 ISSCFVLVILSWAPFGFNVSEFFVSL-TRNPLLQSYVSETLLKGSQALGMQEAGQRFLES 281 ++ V+ I+ ++ FGF+++ F + T PL G FL Sbjct: 189 MAGTLVISIIVFSKFGFSLNTMFEQMKTATPL---------------------GADFLNP 227 Query: 282 GLYLKNPLEQLSLGLALVLGTAAMPHILMRFFTVPDAKTARSSVLWAMLAIGVCHLLIVF 341 G K PLE LSL LALVLGTA +PHIL+RF+TV DAKTAR+SV+ A IGV +++ VF Sbjct: 228 GNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIGVFYIMTVF 287 Query: 342 IGFAAAHYVGAKAIVVLDKGGNLAAPMLAQFLGGGADSLAGNFMLAFVAAVAFATIVAVV 401 +GF AA +VG AI D+ GN+AAP+LA+ LG G+F+ AFV+A+AFATI+AVV Sbjct: 288 LGFGAAAFVGFDAITAADQAGNMAAPLLAKALG-------GDFLFAFVSAIAFATILAVV 340 Query: 402 AGLTLAAASALAHDVYVGAIRNGRATEQEQVRAARVATLMMAVICVVCGILAKGQNVAHL 461 GL L+AASA AHD+Y IR G ATE+EQ++AAR A++ ++V+ ++ I A+ NVA L Sbjct: 341 TGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSLNVAFL 400 Query: 462 VGLGYAVAASANLPALLMTLYWKRCSTAGVLAGVIGGTTLSIVLVLVSPNMTYPLQQKAA 521 V L +AVAASANLP ++ T++WKR + +G L G + G ++VLV +SP++ P Sbjct: 401 VALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWDP------ 454 Query: 522 ALATITALDARIAEAETSSAGVTAEARDKLHKDRASAAAQAAGIADDATSLMGLKAPLIS 581 A G L+ L P Sbjct: 455 ----------------------------------------AGGAIFTGDPLIPLSNP--- 471 Query: 582 LRNPGIISIPVGFLLVIIFSLLIADKRAIAR-WEELAVRRETGIGVEQ 628 GIISIP+GFL + ++L +DK + E+ V+ TG+ +EQ Sbjct: 472 ----GIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGVHMEQ 515 >DR0477 [R] COG4147 Predicted symporter Dra Deinococcus radiodurans Length = 528 Score = 386 bits (991), Expect = e-106, Method: Compositional matrix adjust. Identities = 254/594 (42%), Positives = 357/594 (60%), Gaps = 72/594 (12%) Query: 41 MTMAIFAIFFGATLLITYLAAKRNRTATDYYTAGGGIGPIRNGLAIAGDYLSAAAFLGVS 100 MT + A+ TL +T+ A+ RN +A D+Y AGG I +NG+AIAGDY+SAA+FLG++ Sbjct: 1 MTFLLAALIVLITLGVTFWASSRNTSAGDFYVAGGKISATQNGIAIAGDYMSAASFLGIT 60 Query: 101 GLIALYGYDGIAYLIGFFVAFIPVLLLVAEPCRNLGRYTLGDVLAYRNSFRSTKVAAAVS 160 GLIAL GYDG Y +G+F+A++ VL +VAEP RNLG+YTL D+L YR + + AA S Sbjct: 61 GLIALNGYDGFMYSVGWFIAYLTVLFIVAEPLRNLGKYTLADMLVYRLKDQRVRFYAAFS 120 Query: 161 SIIVAVFYMVPQIVGGAVILRALIGIPYE--ISVLAVGILMLTYVVFGGMRATTSVQVIK 218 +I V+ FYM+ Q+VG ++ L G + +++ VG+LM+ YVV GGM ATT VQ+IK Sbjct: 121 TITVSTFYMIAQVVGAGSLISLLSGGLLKPTLAIPLVGLLMIVYVVVGGMLATTWVQIIK 180 Query: 219 AILLISSCFVLVILSWAPFGFNVSEFFVSLTRNPLLQSYVSETLLKGSQALGMQEAGQRF 278 A+LL+ + V+ +L A FGF+ S+ + T + G F Sbjct: 181 AMLLMFATIVMSVLILARFGFSFSDLLGAAT----------------------DKNGAAF 218 Query: 279 LESGLYLKNPLEQLSLGLALVLGTAAMPHILMRFFTVPDAKTARSSVLWAMLAIGVCHLL 338 LE GL KNPL+ +SL LALVLGTA +PHIL+RFFTVP A+ AR SV+ AM IG +++ Sbjct: 219 LEPGLKYKNPLDLISLCLALVLGTAGLPHILVRFFTVPTAQDARKSVVVAMGLIGAFYIM 278 Query: 339 IVFIGFAAAHYVGAKAIVVLDKGGNLAAPMLAQFLGGGADSLAGNFMLAFVAAVAFATIV 398 +G AA VG IV + GN+AAP+LAQ LGGGA +L G F LAFV AVAFATI+ Sbjct: 279 TALMGNAANVLVGKDTIVAANPAGNMAAPLLAQALGGGAGTLGGEFGLAFVTAVAFATIL 338 Query: 399 AVVAGLTLAAASALAHDVYVGAIRNGRATEQEQVRAARVATLMMAVICVVCGILAKGQNV 458 AVVAGLT++A+++ HD+Y G ++ G+A EQEQ + AR+AT+ + ++ +V G+LAK QNV Sbjct: 339 AVVAGLTISASTSFTHDIYNGVMKGGKANEQEQFKVARMATVAVGLLSIVLGLLAKDQNV 398 Query: 459 AHLVGLGYAVAASANLPALLMTLYWKRCSTAGVLAGVIGGTTLSIVLVLVSPNMTYPLQQ 518 A LV L +A+AASANLP +L TL+W+ + G + G++GG +++VL+ +SPN+ Sbjct: 399 AFLVALAFAIAASANLPVILYTLFWRGFNANGAVWGIVGGLAVTLVLIALSPNIM----- 453 Query: 519 KAAALATITALDARIAEAETSSAGVTAEARDKLHKDRASAAAQAAGIADDATSLMGLKAP 578 + D K Q + Sbjct: 454 ----------------------------SVDPPEKTTGRHPVQ--------------RTA 471 Query: 579 LISLRNPGIISIPVGFLLVIIFSLLIADKRAIAR-WEELAVRRETGIGVEQAVA 631 + L NPGI+SIP GF L + +LL + R +EE+ R TG G++ VA Sbjct: 472 IFPLENPGIVSIPAGFALAALGALLGKRRPEDERNFEEMQYRAYTGAGMDGTVA 525 >PA3234 [R] COG4147 Predicted symporter Pae Pseudomonas aeruginosa Length = 551 Score = 377 bits (969), Expect = e-104, Method: Compositional matrix adjust. Identities = 207/473 (43%), Positives = 297/473 (62%), Gaps = 32/473 (6%) Query: 45 IFAIFFGATLLITYLAAKRNRTATDYYTAGGGIGPIRNGLAIAGDYLSAAAFLGVSGLIA 104 +F F GATL ITY A+KRNR+A DYY AGG I +NGLAIAGDY+SAA+FLG+S L+ Sbjct: 39 MFVAFVGATLCITYWASKRNRSAADYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVF 98 Query: 105 LYGYDGIAYLIGFFVAFIPVLLLVAEPCRNLGRYTLGDVLAYRNSFRSTKVAAAVSSIIV 164 GYDG+ Y IGF V + +L L+AE RNLG+YT DV +YR + + +A S++V Sbjct: 99 TSGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQKQIRTLSACGSLVV 158 Query: 165 AVFYMVPQIVGGAVILRALIGIPYEISVLAVGILMLTYVVFGGMRATTSVQVIKAILLIS 224 FY++ Q+VG ++ L G+ Y ++V+ VGILM+ YV+FGGM ATT VQ+IKA+LL+S Sbjct: 159 VAFYLIAQMVGAGKLIELLFGLNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVLLLS 218 Query: 225 SCFVLVILSWAPFGFNVSEFFVSLTRNPLLQSYVSETLLKGSQALGMQEAGQRFLESGLY 284 + I+ F+VS F S+A+ + G+ + G Sbjct: 219 GASFMAIMVLKHVNFDVSTLF--------------------SEAIKVHPKGEAIMSPGGL 258 Query: 285 LKNPLEQLSLGLALVLGTAAMPHILMRFFTVPDAKTARSSVLWAMLAIGVCHLLIVFIGF 344 +K+P+ SLG AL+ GTA +PHILMRFFTV DAK AR SV +A IG ++L IGF Sbjct: 259 VKDPISAFSLGFALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGF 318 Query: 345 AAAHYVGAK-----AIVVLDKGGNLAAPMLAQFLGGGADSLAGNFMLAFVAAVAFATIVA 399 A V A L G N+AA L AD++ G+ L F++AVAFATI+A Sbjct: 319 GAILLVSTNPDFKDATGALIGGNNMAAVHL-------ADAVGGSLFLGFISAVAFATILA 371 Query: 400 VVAGLTLAAASALAHDVYVGAIRNGRATEQEQVRAARVATLMMAVICVVCGILAKGQNVA 459 VVAGLTLA ASA++HD+Y + G+A E++++R +++ T+ + V+ +V GIL + QN+A Sbjct: 372 VVAGLTLAGASAVSHDLYASVFKGGKANEKDELRVSKMTTVALGVVAIVLGILFEKQNIA 431 Query: 460 HLVGLGYAVAASANLPALLMTLYWKRCSTAGVLAGVIGGTTLSIVLVLVSPNM 512 +VGL +++AAS N P LL+++YWK+ +T G + G G ++ L+++ P + Sbjct: 432 FMVGLAFSIAASCNFPVLLLSMYWKKLTTRGAMIGGWMGLITAVGLMVLGPTI 484 >YPO0251 [R] COG4147 Predicted symporter Ype Yersinia pestis Length = 551 Score = 370 bits (950), Expect = e-102, Method: Compositional matrix adjust. Identities = 199/475 (41%), Positives = 298/475 (62%), Gaps = 32/475 (6%) Query: 43 MAIFAIFFGATLLITYLAAKRNRTATDYYTAGGGIGPIRNGLAIAGDYLSAAAFLGVSGL 102 + +F +F G TL ITY A+KR R+ DYYTAGG I +NGLAIAGDY+SAA+FLG+S L Sbjct: 37 IVMFLLFVGGTLYITYWASKRTRSRQDYYTAGGRITGFQNGLAIAGDYMSAASFLGISAL 96 Query: 103 IALYGYDGIAYLIGFFVAFIPVLLLVAEPCRNLGRYTLGDVLAYRNSFRSTKVAAAVSSI 162 + GYDG+ Y IGF + + +L L+AE RNLGRYT DV +YR R + +A S+ Sbjct: 97 VYASGYDGLIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQRPIRTLSACGSL 156 Query: 163 IVAVFYMVPQIVGGAVILRALIGIPYEISVLAVGILMLTYVVFGGMRATTSVQVIKAILL 222 +V Y++ Q+VG +++ L G+ Y ++V+ VGILM+ YV+FGGM ATT VQ+IKA++L Sbjct: 157 VVVALYLIAQMVGAGKLIQLLFGLNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVML 216 Query: 223 ISSCFVLVILSWAPFGFNVSEFFVSLTRNPLLQSYVSETLLKGSQALGMQEAGQRFLESG 282 +S + I+ FN + F S+A+ + G + G Sbjct: 217 LSGATFMAIMVMKSVNFNFNTLF--------------------SEAVKVHPKGLSIMSPG 256 Query: 283 LYLKNPLEQLSLGLALVLGTAAMPHILMRFFTVPDAKTARSSVLWAMLAIGVCHLLIVFI 342 + +P+ LSLGLAL+ GTA +PHILMRFFTV DAK AR SV +A IG ++L I Sbjct: 257 GLVSDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFII 316 Query: 343 GFAAAHYVGAKAIV-----VLDKGGNLAAPMLAQFLGGGADSLAGNFMLAFVAAVAFATI 397 GF A VG L G N+AA L A+++ G+F L F++AVAFATI Sbjct: 317 GFGAILLVGPNQTFKDAAGALLGGNNMAAVHL-------ANAVGGSFFLGFISAVAFATI 369 Query: 398 VAVVAGLTLAAASALAHDVYVGAIRNGRATEQEQVRAARVATLMMAVICVVCGILAKGQN 457 +AVVAGLTLA ASA++HD+Y I+ G+A E++++R +++ +++ ++ + GIL + QN Sbjct: 370 LAVVAGLTLAGASAVSHDLYASVIKKGKANERDELRVSKITVIILGIVAIGLGILFENQN 429 Query: 458 VAHLVGLGYAVAASANLPALLMTLYWKRCSTAGVLAGVIGGTTLSIVLVLVSPNM 512 +A +VGL +++AAS N P +++++YW + +T G + G G + +++L+++ P + Sbjct: 430 IAFMVGLAFSIAASCNFPIIIISMYWDKLTTRGAMIGGWLGLSTAVILMILGPTI 484 >yjcG [R] COG4147 Predicted symporter Eco Escherichia coli K12 Length = 549 Score = 364 bits (934), Expect = e-100, Method: Compositional matrix adjust. Identities = 213/510 (41%), Positives = 312/510 (61%), Gaps = 34/510 (6%) Query: 8 KRALTLVPAMTLFLASSAVCAQTKVLVGDDFLGMTMAIFAIFFGATLLITYLAAKRNRTA 67 KR LT + A TL A++A A + + + +F IF TL ITY A+KR R+ Sbjct: 2 KRVLTALAA-TLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSR 60 Query: 68 TDYYTAGGGIGPIRNGLAIAGDYLSAAAFLGVSGLIALYGYDGIAYLIGFFVAFIPVLLL 127 +DYYTAGG I +NGLAIAGDY+SAA+FLG+S L+ GYDG+ Y +GF V + +L L Sbjct: 61 SDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFL 120 Query: 128 VAEPCRNLGRYTLGDVLAYRNSFRSTKVAAAVSSIIVAVFYMVPQIVGGAVILRALIGIP 187 +AE RNLGRYT DV +YR ++ +A S++V Y++ Q+VG ++ L G+ Sbjct: 121 IAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLN 180 Query: 188 YEISVLAVGILMLTYVVFGGMRATTSVQVIKAILLISSCFVLVILSWAPFGFNVSEFFVS 247 Y I+V+ VG+LM+ YV+FGGM ATT VQ+IKA+LL+ + + GF+ + F Sbjct: 181 YHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLF-- 238 Query: 248 LTRNPLLQSYVSETLLKGSQALGMQEAGQRFLESGLYLKNPLEQLSLGLALVLGTAAMPH 307 S+A+ + G ++ G +K+P+ LSLGL L+ GTA +PH Sbjct: 239 ------------------SEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPH 280 Query: 308 ILMRFFTVPDAKTARSSVLWAMLAIGVCHLLIVFIGFAAAHYVGAK-----AIVVLDKGG 362 ILMRFFTV DA+ AR SV +A +G ++L IGF A VGA A L G Sbjct: 281 ILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGN 340 Query: 363 NLAAPMLAQFLGGGADSLAGNFMLAFVAAVAFATIVAVVAGLTLAAASALAHDVYVGAIR 422 N+AA L A+++ GN L F++AVAFATI+AVVAGLTLA ASA++HD+Y + Sbjct: 341 NMAAVHL-------ANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFK 393 Query: 423 NGRATEQEQVRAARVATLMMAVICVVCGILAKGQNVAHLVGLGYAVAASANLPALLMTLY 482 G ATE+E++R +++ L++ VI ++ G+L + QN+A +VGL +A+AAS N P +L+++Y Sbjct: 394 KG-ATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMY 452 Query: 483 WKRCSTAGVLAGVIGGTTLSIVLVLVSPNM 512 W + +T G + G G ++VL+++ P + Sbjct: 453 WSKLTTRGAMMGGWLGLITAVVLMILGPTI 482