BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0019.p (402 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC2812 Non COG 592 e-169 CC0532 Non COG 571 e-162 rspA [MR] COG4948 L-alanine-DL-glutamate epimerase and related e... 561 e-160 STM1505 [MR] COG4948 L-alanine-DL-glutamate epimerase and relate... 546 e-155 SMb20510 [MR] COG4948 L-alanine-DL-glutamate epimerase and relat... 209 1e-53 >CC2812 Non COG Length = 403 Score = 592 bits (1527), Expect = e-169, Method: Compositional matrix adjust. Identities = 283/401 (70%), Positives = 319/401 (79%) Query: 2 KILSAKVIVTCPGRNFVTLKIETDQGIYGIGDATLNGRELAVKSYLEDHIIPCLIGRDAS 61 KI++AK IVTCPGRNFVTLKI TD+G+YG+GDATLNGRELAV++YL H+IPCLIGRDA Sbjct: 3 KIIAAKTIVTCPGRNFVTLKIMTDEGVYGLGDATLNGRELAVEAYLTQHVIPCLIGRDAH 62 Query: 62 RIEDTWQYLYRGGYWRCGPVTMTAIAAVDMALWDIKGKAANLPVYQLLGGKSRDAVMVYG 121 +IED WQYLYRG YWR GPVTM AIAAVD ALWDIKGK A LPVYQLLGG R VMVYG Sbjct: 63 QIEDIWQYLYRGCYWRRGPVTMAAIAAVDTALWDIKGKIAGLPVYQLLGGACRVGVMVYG 122 Query: 122 HANGRDHAEALDAVGHYIDMGYKAIRVQSGVPGLDKAYGVGKGNMYYEPADKGLPDEEIW 181 HANG E LD Y GYKAIR+Q+GVPG+ YGV K +YEPAD LP E IW Sbjct: 123 HANGETIDETLDNAAVYAQQGYKAIRLQTGVPGMSGTYGVSKDKFFYEPADSDLPKETIW 182 Query: 182 DTPLYLRHTPDLFEKVRVKYGSDHHLLHDCHHRLKPIEAAQLGKSLEQFKLFWMEDATPA 241 T YLR TP LFE R + G D HLLHD HHRL PIEAA+LGK LE ++LFWMEDATPA Sbjct: 183 STERYLRSTPALFEAARERLGDDLHLLHDVHHRLTPIEAARLGKDLEPYRLFWMEDATPA 242 Query: 242 ENQEAFKLIRQHTTTPLAVGEIMSSIWDCKELIQNQLIDYIRTTVVHAGGITHLRRIADL 301 ENQ +F+LIRQHTTTPLAVGEI +SIWDCK+LI+ QLIDYIR TVVHAGGITHL+++A Sbjct: 243 ENQASFRLIRQHTTTPLAVGEIFNSIWDCKQLIEEQLIDYIRATVVHAGGITHLKKLASF 302 Query: 302 ASLYQVHTGCHGATDLSPVSMAAALNFNMWVPNFGIQEYMRHTPETDAVFPHGYYFDKGY 361 A L+ V TGCHGATDLSPV M AAL+F++ +PNFG+QEYMRHTPETDAVFPH Y F G Sbjct: 303 ADLHHVRTGCHGATDLSPVCMGAALHFDLSIPNFGVQEYMRHTPETDAVFPHAYTFKDGM 362 Query: 362 LVLPDAPGLGVDIDESAALKFPYERAYLPTCRLRDGTVWNW 402 L DAPGLGVDIDE A K+PY+RAYLP R DG++ +W Sbjct: 363 LHPGDAPGLGVDIDEDLAAKYPYQRAYLPIARRLDGSMHDW 403 >CC0532 Non COG Length = 403 Score = 571 bits (1471), Expect = e-162, Method: Compositional matrix adjust. Identities = 271/402 (67%), Positives = 313/402 (77%) Query: 1 MKILSAKVIVTCPGRNFVTLKIETDQGIYGIGDATLNGRELAVKSYLEDHIIPCLIGRDA 60 +KI+ AKVIVTCPGRNFVTLKI T+ GI G+GDATLNGREL+V S+L+DH++P LIGRDA Sbjct: 2 LKIIDAKVIVTCPGRNFVTLKITTEDGITGVGDATLNGRELSVVSFLQDHMVPSLIGRDA 61 Query: 61 SRIEDTWQYLYRGGYWRCGPVTMTAIAAVDMALWDIKGKAANLPVYQLLGGKSRDAVMVY 120 +IED WQ+ YRG YWR GPV MTA+AAVDMALWDIKGK A LPVYQLLGG R V VY Sbjct: 62 HQIEDIWQFFYRGSYWRGGPVAMTALAAVDMALWDIKGKVAGLPVYQLLGGACRTGVTVY 121 Query: 121 GHANGRDHAEALDAVGHYIDMGYKAIRVQSGVPGLDKAYGVGKGNMYYEPADKGLPDEEI 180 GHANG + + Y MGYKAIR+Q+GVPGL YGV K M+YEPAD LP E I Sbjct: 122 GHANGETIEDTIAEAVKYKAMGYKAIRLQTGVPGLASTYGVSKDKMFYEPADNDLPTENI 181 Query: 181 WDTPLYLRHTPDLFEKVRVKYGSDHHLLHDCHHRLKPIEAAQLGKSLEQFKLFWMEDATP 240 W T YL P LFE+ R G D HLLHD HHRL PIEAA+LGK LE ++LFW+ED+ P Sbjct: 182 WSTAKYLNSVPKLFERAREVLGWDVHLLHDVHHRLTPIEAARLGKDLEPYRLFWLEDSVP 241 Query: 241 AENQEAFKLIRQHTTTPLAVGEIMSSIWDCKELIQNQLIDYIRTTVVHAGGITHLRRIAD 300 AENQ F+LIRQHTTTPLAVGEI + +WD K+LI+ QLIDY+R TV+HAGGIT+L++IA Sbjct: 242 AENQAGFRLIRQHTTTPLAVGEIFAHVWDAKQLIEEQLIDYLRATVLHAGGITNLKKIAA 301 Query: 301 LASLYQVHTGCHGATDLSPVSMAAALNFNMWVPNFGIQEYMRHTPETDAVFPHGYYFDKG 360 A L+ V TGCHGATDLSPV+MAAAL+F+M + NFG+QEYMRHTPETDAVFPH Y F G Sbjct: 302 FADLHHVKTGCHGATDLSPVTMAAALHFDMSITNFGLQEYMRHTPETDAVFPHAYTFSDG 361 Query: 361 YLVLPDAPGLGVDIDESAALKFPYERAYLPTCRLRDGTVWNW 402 L D PGLGVDIDE A K PY+RAYLP RL DGT++NW Sbjct: 362 MLHPGDKPGLGVDIDEDLAAKHPYKRAYLPVNRLEDGTMFNW 403 >rspA [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Eco Escherichia coli K12 Length = 404 Score = 561 bits (1447), Expect = e-160, Method: Compositional matrix adjust. Identities = 263/404 (65%), Positives = 318/404 (78%), Gaps = 2/404 (0%) Query: 1 MKILSAKVIVTCPGRNFVTLKIETDQGIYGIGDATLNGRELAVKSYLEDHIIPCLIGRDA 60 MKI+ A+V VTCPGRNFVTLKI T+ GI G+GDATLNGREL+V SYL+DH+ P LIGRDA Sbjct: 1 MKIVKAEVFVTCPGRNFVTLKITTEDGITGLGDATLNGRELSVASYLQDHLCPQLIGRDA 60 Query: 61 SRIEDTWQYLYRGGYWRCGPVTMTAIAAVDMALWDIKGKAANLPVYQLLGGKSRDAVMVY 120 RIED WQ+ Y+G YWR GPVTM+AI+AVDMALWDIK KAAN+P+YQLLGG SR+ VMVY Sbjct: 61 HRIEDIWQFFYKGAYWRRGPVTMSAISAVDMALWDIKAKAANMPLYQLLGGASREGVMVY 120 Query: 121 GHANGRDHAEALDAVGHYIDMGYKAIRVQSGVPGLDKAYGVGKGN-MYYEPADKG-LPDE 178 H G EALD + ++G+KAIRVQ G+PG+ YG+ KG + YEPA KG P+E Sbjct: 121 CHTTGHSIDEALDDYARHQELGFKAIRVQCGIPGMKTTYGMSKGKGLAYEPATKGQWPEE 180 Query: 179 EIWDTPLYLRHTPDLFEKVRVKYGSDHHLLHDCHHRLKPIEAAQLGKSLEQFKLFWMEDA 238 ++W T YL P LF+ VR K+G + HLLHD HHRL PIEAA+ GKS+E +++FWMED Sbjct: 181 QLWSTEKYLDFMPKLFDAVRNKFGFNEHLLHDMHHRLTPIEAARFGKSIEDYRMFWMEDP 240 Query: 239 TPAENQEAFKLIRQHTTTPLAVGEIMSSIWDCKELIQNQLIDYIRTTVVHAGGITHLRRI 298 TPAENQE F+LIRQHT TP+AVGE+ +SIWDCK+LI+ QLIDYIRTT+ HAGGIT +RRI Sbjct: 241 TPAENQECFRLIRQHTVTPIAVGEVFNSIWDCKQLIEEQLIDYIRTTLTHAGGITGMRRI 300 Query: 299 ADLASLYQVHTGCHGATDLSPVSMAAALNFNMWVPNFGIQEYMRHTPETDAVFPHGYYFD 358 AD ASLYQV TG HG +DLSPV MAAAL+F++WVPNFG+QEYM ++ + VFPH + FD Sbjct: 301 ADFASLYQVRTGSHGPSDLSPVCMAAALHFDLWVPNFGVQEYMGYSEQMLEVFPHNWTFD 360 Query: 359 KGYLVLPDAPGLGVDIDESAALKFPYERAYLPTCRLRDGTVWNW 402 GY+ D PGLG++ DE A K+PYE AYLP RL DGT+WNW Sbjct: 361 NGYMHPGDKPGLGIEFDEKLAAKYPYEPAYLPVARLEDGTLWNW 404 >STM1505 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Sty Salmonella typhimurium LT2 Length = 404 Score = 546 bits (1406), Expect = e-155, Method: Compositional matrix adjust. Identities = 257/404 (63%), Positives = 312/404 (77%), Gaps = 2/404 (0%) Query: 1 MKILSAKVIVTCPGRNFVTLKIETDQGIYGIGDATLNGRELAVKSYLEDHIIPCLIGRDA 60 MKI+ A+V VTCPGRNFVTLKI T+ GI G+GDATLNGREL V SYL DH+ P LIGRDA Sbjct: 1 MKIVGAEVFVTCPGRNFVTLKITTEDGITGLGDATLNGRELPVASYLTDHLCPQLIGRDA 60 Query: 61 SRIEDTWQYLYRGGYWRCGPVTMTAIAAVDMALWDIKGKAANLPVYQLLGGKSRDAVMVY 120 RIED WQ+ Y+G YWR GPVTM+AI+AVDMALWDIK KAAN+P+YQLLGG SR+ VMVY Sbjct: 61 RRIEDIWQFFYKGAYWRRGPVTMSAISAVDMALWDIKAKAANMPLYQLLGGASREGVMVY 120 Query: 121 GHANGRDHAEALDAVGHYIDMGYKAIRVQSGVPGLDKAYGVGKGN-MYYEPADKG-LPDE 178 H G + L+ + + G+KAIRVQ GVPG+ YG+ KG + YEPA KG P+E Sbjct: 121 CHTTGHTIDDVLEDYARHKEQGFKAIRVQCGVPGMKTTYGMAKGKGLAYEPATKGQWPEE 180 Query: 179 EIWDTPLYLRHTPDLFEKVRVKYGSDHHLLHDCHHRLKPIEAAQLGKSLEQFKLFWMEDA 238 ++W T YL TP LF+ VR +G + HLLHD HHRL PIEAA+ GK +E ++LFWMED Sbjct: 181 QLWSTEKYLDFTPKLFDAVRNTFGFNEHLLHDMHHRLTPIEAARFGKCIEDYRLFWMEDP 240 Query: 239 TPAENQEAFKLIRQHTTTPLAVGEIMSSIWDCKELIQNQLIDYIRTTVVHAGGITHLRRI 298 TPAENQ F+LIRQHT TP+AVGE+ +SIWDCK+LI+ QLIDYIRTT+ HAGGIT +RRI Sbjct: 241 TPAENQACFRLIRQHTVTPIAVGEVFNSIWDCKQLIEEQLIDYIRTTLTHAGGITGMRRI 300 Query: 299 ADLASLYQVHTGCHGATDLSPVSMAAALNFNMWVPNFGIQEYMRHTPETDAVFPHGYYFD 358 AD ASLYQV TG HG +DLSPV MAAAL+F++WVPNFG+QE+M ++ + VFPH + F+ Sbjct: 301 ADFASLYQVRTGSHGPSDLSPVCMAAALHFDLWVPNFGVQEFMGYSEQMLEVFPHNWTFE 360 Query: 359 KGYLVLPDAPGLGVDIDESAALKFPYERAYLPTCRLRDGTVWNW 402 GY+ D PGLG++ DE A K+PY+ AYLP RL DGT+WNW Sbjct: 361 GGYMHPGDKPGLGIEFDEKLAAKYPYDPAYLPVARLEDGTLWNW 404 >SMb20510 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Sme Sinorhizobium meliloti Length = 382 Score = 209 bits (531), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 134/411 (32%), Positives = 209/411 (50%), Gaps = 38/411 (9%) Query: 1 MKILSAKVIVTCPGRNFVTLKIETDQGIYGIGDATLNGRELAVKSYLEDHIIPCLIGRDA 60 MKI + P ++ LKIETD+G+ G G+ + GR L V++ + + + L+G+D Sbjct: 1 MKITKLTTYIVPP--RWLFLKIETDEGVVGWGEPVVEGRALTVEAAVHE-LSDYLVGKDP 57 Query: 61 SRIEDTWQYLYRGGYWRCGPVTMTAIAAVDMALWDIKGKAANLPVYQLLGGKSRDAVMVY 120 IED W LYRGG++R G + M+A+A +D ALWDIKGKA PV+ LLGG+ RD + VY Sbjct: 58 FLIEDHWNVLYRGGFYRGGAIHMSALAGIDQALWDIKGKALGQPVHSLLGGQCRDRIKVY 117 Query: 121 GHANGRDHAEALDAVGHYIDMGYKAIRVQSGVPGLDKAYGVGKGNMYYEPADKGLPDEEI 180 G ++ + + G+KAI++ G + +I Sbjct: 118 SWIGGDRPSDVANNAREVVARGFKAIKLN------------------------GCEEMQI 153 Query: 181 WDTPLYLRHTPDLFEKVRVKYGSDHHLLHDCHHRLKPIEAAQLGKSLEQFKLFWMEDATP 240 DT + + +R G + D H R+ A L K LE FKL ++E+ Sbjct: 154 VDTNEKIDKAVETIGLIRDAIGPHVGIGVDFHGRVHRPMAKVLAKELEPFKLMFIEEPVL 213 Query: 241 AENQEAFKLIRQHTTTPLAVGEIMSSIWDCKELIQNQLIDYIRTTVVHAGGITHLRRIAD 300 +EN+EA + I H +TP+A+GE + S WD K ++ + +D I+ + HAGGIT R+IA Sbjct: 214 SENREALREIANHCSTPIALGERLYSRWDFKSVLSDGFVDIIQPDLSHAGGITECRKIAA 273 Query: 301 LASLYQVHTGCHGATDLSPVSMAAALNFNMWVPNFGIQEYMR--HTPETDAVFPH----- 353 +A Y V H L P+++AA L + N IQE H E + + + Sbjct: 274 MAEAYDVALAPH--CPLGPIALAACLQVDAVSYNAFIQEQSLGIHYNEANDILDYISNKE 331 Query: 354 GYYFDKGYLVLPDAPGLGVDIDESAALKFPYE--RAYLPTCRLRDGTVWNW 402 + ++ G++ +P PGLG+++DE+ ++ E R P R DG+V W Sbjct: 332 VFAYEDGFVSIPQGPGLGIEVDEAYVMERAKEGHRWRNPVWRHSDGSVAEW 382