BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0748.p (1248 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0294 [E] COG1410 Methionine synthase I, cobalamin-binding dom... 1382 0.0 VC0390_2 [E] COG1410 Methionine synthase I, cobalamin-binding do... 1156 0.0 ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1149 0.0 ZmetH_2 [E] COG1410 Methionine synthase I, cobalamin-binding dom... 1149 0.0 STM4188_2 [E] COG1410 Methionine synthase I, cobalamin-binding d... 1145 0.0 >RSc0294 [E] COG1410 Methionine synthase I, cobalamin-binding domain Rso Ralstonia solanacearum Length = 905 Score = 1382 bits (3576), Expect = 0.0, Method: Compositional matrix adjust. Identities = 673/903 (74%), Positives = 767/903 (84%), Gaps = 4/903 (0%) Query: 348 HEMLLSGLEPFIINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVARQQVENGAQI 407 H M LSGLEPF I + +L+VNVGERTNVTGSKAFAR+ILN Q+DEALAVARQQVENGAQ+ Sbjct: 4 HLMRLSGLEPFNIGEDTLFVNVGERTNVTGSKAFARMILNSQFDEALAVARQQVENGAQV 63 Query: 408 IDINMDEAMLDSLAAMTRFLNLIASEPDIARVPVMIDSSKWSVIEAGLKCVQGKSIVNSI 467 IDINMDEAMLDS AAM RFLNLIASEPDIARVP+MIDSSKW VIEAGLKCVQGK+IVNSI Sbjct: 64 IDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWEVIEAGLKCVQGKAIVNSI 123 Query: 468 SMKEGEEKFLHEAKLCRRYGAAVIVMAFDEVGQADTYERKIEICERAYRLLVDKVGFPPE 527 S+KEGEE+F H AKL +RYGAA +VMAFDE GQADT+ RK EIC+R+Y LV++VGF PE Sbjct: 124 SLKEGEEQFAHHAKLIKRYGAAAVVMAFDEQGQADTFARKTEICKRSYDFLVNQVGFAPE 183 Query: 528 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSFSFRGNDPARE 587 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWI Q LP+AK+SGGVSNVSFSFRGND RE Sbjct: 184 DIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQKLPHAKVSGGVSNVSFSFRGNDVVRE 243 Query: 588 AIHTVFLYHAVKAGMTMGIVNAGMIGVYDDLPAELREAVEDVVLNRRPDATERMIDIAAT 647 AIHTVFLYHA+ AGM MGIVNAG +GVY++L ELRE VEDVVLNRRPDAT+R+++IA Sbjct: 244 AIHTVFLYHAIGAGMDMGIVNAGQLGVYENLAPELRERVEDVVLNRRPDATDRLLEIADR 303 Query: 648 LKAGDKKEEATLEWRSEPVEKRLAHALVLGITQWIVEDTEEARQNLLKSGGRPIHVIEGP 707 K G K E L WR EPVEKRLAHALV GIT ++VEDTEE RQ + +GGRPI VIEGP Sbjct: 304 YKGGGAKREENLAWRQEPVEKRLAHALVHGITDYVVEDTEEVRQKIFAAGGRPIQVIEGP 363 Query: 708 LMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRLIEQETGIVAKPKGK 767 LMDGMN+VGDLFG GKMFLPQVVKSARVMKQAVAHLIPFIEEEKR I G V + +GK Sbjct: 364 LMDGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRQIAAAGGDV-RSRGK 422 Query: 768 IVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCSQILAKAKEENADIIGLSGLIT 827 IVIATVKGDVHDIGKNIV+VVLQCNNFEVVNMGVMVPC++ILAKAK E ADIIGLSGLIT Sbjct: 423 IVIATVKGDVHDIGKNIVTVVLQCNNFEVVNMGVMVPCNEILAKAKVEGADIIGLSGLIT 482 Query: 828 PSLEEMAYVAKEMQRDSYFSGVKMPLLIGGATTSRAHTAVKIAPNYSGPVVYVPDASRAV 887 PSLEEMAYVA EMQRD YF K+PLLIGGATTSR HTAVKIAPNY GPVVYVPDASR+V Sbjct: 483 PSLEEMAYVASEMQRDEYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSV 542 Query: 888 SVAQSLLTPEQKDQYIADIATDYERIREQHANKKAVPLVPIAAARDNKMQLE---FAPVK 944 SVA SLL+ E +YI ++ DY+RIR QHA+KKA+P+V +AAAR NK +++ + P K Sbjct: 543 SVASSLLSDEAAARYIEELHADYDRIRTQHASKKAMPMVSLAAARANKTRIDWSNYTPPK 602 Query: 945 PKFIGRRVFKNVDLATLAKYIDWGPFFQTWDLAGPYPAILKDEVVGEAASKVFEEAQALL 1004 PKF+GRRVF+N DL LA+YIDWGPFFQTWDLAG +P IL D +VGE+A +VF + +++L Sbjct: 603 PKFVGRRVFRNYDLNELAQYIDWGPFFQTWDLAGKFPDILNDAIVGESARRVFSDGKSML 662 Query: 1005 KKVIDGRWLTANGIVSLLPANTVNDDDIEIYTDDTRTQVALTYYGVRQQTEKPVIDGVAR 1064 ++I GRWLTANG+++LLPANTVNDDDIEIYTD+TR++VALT+ +RQQ+E+P+IDGV R Sbjct: 663 ARLIAGRWLTANGVIALLPANTVNDDDIEIYTDETRSEVALTWRNIRQQSERPIIDGVMR 722 Query: 1065 PNQCLADFIAPKASGIADYIGMFAVTSGLGIEKYEKRFEEAHDDYSSIMLKALADRLAEA 1124 PN+CLADFIAPK +GIADYIG+FAVT G+GI+K E FE HDDYS+IMLKALADR AEA Sbjct: 723 PNRCLADFIAPKDTGIADYIGLFAVTGGIGIDKREAAFEADHDDYSAIMLKALADRFAEA 782 Query: 1125 FAEYLHERVRTDLWGYASQESLSAEELIKEKYVGIRPAAGYPACPEHTVKAEAFRVMQCD 1184 FAE LH RVR DLWGYA E+L + LI+E+Y GIRPA GYPACPEHTVK + FRV+ Sbjct: 783 FAECLHARVRRDLWGYAQDETLDNDALIREEYRGIRPAPGYPACPEHTVKRDLFRVLDAQ 842 Query: 1185 EIGMTVTESYAMFPGASVSGFYFAHPDSKYFVVGKIGDDQVADMAERRGVSKDDVERWLA 1244 EIGM +TE+ AM P ASVSGF +HPDS YF +GKIG DQV DMA R G + +VER LA Sbjct: 843 EIGMNLTEALAMTPAASVSGFQLSHPDSTYFTIGKIGQDQVDDMAARSGEDRRNVERALA 902 Query: 1245 PNL 1247 PNL Sbjct: 903 PNL 905 >VC0390_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Vch Vibrio cholerae Length = 899 Score = 1156 bits (2991), Expect = 0.0, Method: Compositional matrix adjust. Identities = 584/919 (63%), Positives = 710/919 (77%), Gaps = 32/919 (3%) Query: 338 IAPRQVPEGKHEMLLSGLEPFIINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 + PR +P+ K E LSGLEP I ++L+VNVGERTNVTGS F RLI EQYDEAL VA Sbjct: 2 VKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNVTGSARFKRLIKEEQYDEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSLAAMTRFLNLIASEPDIARVPVMIDSSKWSVIEAGLKC 457 R+QVENGAQIIDINMDE MLD+ A M RFLNL ASEP+I++VPVM+DSSKW VIEAGLKC Sbjct: 62 REQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEISKVPVMVDSSKWEVIEAGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLHEAKLCRRYGAAVIVMAFDEVGQADTYERKIEICERAYRL 517 +QGK IVNSIS+KEG+EKF+ +AKL RRYGAAVIVMAFDEVGQADT ERK+EIC RAY + Sbjct: 122 IQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIVMAFDEVGQADTRERKLEICRRAYHI 181 Query: 518 LVDKVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 LVD+VGFPPEDIIFDPNIFAVATGI+EHNNYA+DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINAVADIKRELPHAMISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAVKAGMTMGIVNAGMIGVYDDLPAELREAVEDVVLNRRPDA 637 SFRGN+ REAIH VFLYH K GM MGIVNAG + +YD++P +LREAVEDV+LNRR D Sbjct: 242 SFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIYDNVPLKLREAVEDVILNRRSDG 301 Query: 638 TERMIDIAATLK---AGDKKEEATLEWRSEPVEKRLAHALVLGITQWIVEDTEEARQNLL 694 TER+++IA + G +++ + LEWR+ PV KRL HALV GIT++IV+DTEEARQ Sbjct: 302 TERLLEIAEAYRENSVGKEEDASALEWRAWPVAKRLEHALVKGITEFIVQDTEEARQ--- 358 Query: 695 KSGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRLI 754 +P+ VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFI +K Sbjct: 359 -QASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFINAQK--- 414 Query: 755 EQETGIVAKPKGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCSQILAKAKE 814 +G + GKI++ATVKGDVHDIGKNIV VVLQCNNFE++++GVMVPC QIL A+E Sbjct: 415 ---SG--STSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVPCEQILKVARE 469 Query: 815 ENADIIGLSGLITPSLEEMAYVAKEMQRDSYFSGVKMPLLIGGATTSRAHTAVKIAPNYS 874 +N DIIGLSGLITPSL+EM +VAKEM+R G ++PLLIGGATTS+AHTAVKI NY Sbjct: 470 QNVDIIGLSGLITPSLDEMVHVAKEMER----QGFELPLLIGGATTSKAHTAVKIEQNYH 525 Query: 875 GPVVYVPDASRAVSVAQSLLTPEQKDQYIADIATDYERIREQHANK--KAVPLVPIAAAR 932 PVVYV +ASRAV V SLL+ EQ+ +I + DYER R+QHA K K+ P V + AR Sbjct: 526 APVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTPKSRP-VTLEQAR 584 Query: 933 DNKMQLEFA---PVKPKFIGRRVFKNVDLATLAKYIDWGPFFQTWDLAGPYPAILKDEVV 989 NK L++A P P G VF+N+ LATL YIDW PFF TW L G YPAIL+ E V Sbjct: 585 ANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMGKYPAILEHEEV 644 Query: 990 GEAASKVFEEAQALLKKVIDGRWLTANGIVSLLPANTVNDDDIEIYTDDTRTQVALTYYG 1049 GE A ++F +A ALL KV L A+G+ +L PA +V DDIE+Y+D++RTQVA Y Sbjct: 645 GEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVG-DDIEVYSDESRTQVAHVLYN 703 Query: 1050 VRQQTEKPVIDGVARPNQCLADFIAPKASGIADYIGMFAVTSGLGIEKYEKRFEEAHDDY 1109 +RQQTEKP N CL+D++APK SG D+IG FAVT G+G ++ DDY Sbjct: 704 LRQQTEKP-----KGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDY 758 Query: 1110 SSIMLKALADRLAEAFAEYLHERVRTDLWGYASQESLSAEELIKEKYVGIRPAAGYPACP 1169 ++IM++A+ADRLAEAFAEYLHE+VR ++WGYAS E+LS ++LI+E+Y GIRPA GYPACP Sbjct: 759 NAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPGYPACP 818 Query: 1170 EHTVKAEAFRVMQCDE-IGMTVTESYAMFPGASVSGFYFAHPDSKYFVVGKIGDDQVADM 1228 EHT KA ++++ +E IGM++T SYAM+PGASVSG+YF+HPDS+YF V +I DQ+ Sbjct: 819 EHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPDQLHSY 878 Query: 1229 AERRGVSKDDVERWLAPNL 1247 AER+G ++ E+WLAPNL Sbjct: 879 AERKGWRLEEAEKWLAPNL 897 >ECs4937_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Ecs Escherichia coli O157:H7 Length = 901 Score = 1149 bits (2972), Expect = 0.0, Method: Compositional matrix adjust. Identities = 592/917 (64%), Positives = 687/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRQVPEGKHEMLLSGLEPFIINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APR++PE LSGLEP I D SL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSLAAMTRFLNLIASEPDIARVPVMIDSSKWSVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVP+MIDSSKW VIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLHEAKLCRRYGAAVIVMAFDEVGQADTYERKIEICERAYRL 517 +QGK IVNSISMKEG + F+H AKL RRYGAAV+VMAFDE GQADT RKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L ++VGFPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAVKAGMTMGIVNAGMIGVYDDLPAELREAVEDVVLNRRPDA 637 SFRGNDP REAIH VFLY+A++ GM MGIVNAG + +YDDLPAELR+AVEDV+LNRR D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIDIAATLKAGDKKEEAT---LEWRSEPVEKRLAHALVLGITQWIVEDTEEARQNLL 694 TER++++A + + A EWRS V KRL ++LV GIT++I +DTEEARQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQ--- 358 Query: 695 KSGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRLI 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Sbjct: 359 -QATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASK--- 414 Query: 755 EQETGIVAKPKGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCSQILAKAKE 814 EQ K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 415 EQ-----GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 ENADIIGLSGLITPSLEEMAYVAKEMQRDSYFSGVKMPLLIGGATTSRAHTAVKIAPNYS 874 NAD+IGLSGLITPSL+EM VAKEM+R G +PLLIGGATTS+AHTAVKI NYS Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMER----QGFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLTPEQKDQYIADIATDYERIREQHANKKA-VPLVPIAAARD 933 GP VYV +ASR V V +LL+ Q+D ++A +YE +R QH KK P V + AARD Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKMQLEFAPVKPKFIGRRVFKNVD--LATLAKYIDWGPFFQTWDLAGPYPAILKDEVVGE 991 N ++ P R + V+ + TL YIDW PFF TW LAG YP IL+DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AASKVFEEAQALLKKVIDGRWLTANGIVSLLPANTVNDDDIEIYTDDTRTQVALTYYGVR 1051 A ++F++A +L K+ + L G+V L PAN V DDIEIY D+TRT V + +R Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVIDGVARPNQCLADFIAPKASGIADYIGMFAVTSGLGIEKYEKRFEEAHDDYSS 1111 QQTEK G A N CLADF+APK SG ADYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRTDLWGYASQESLSAEELIKEKYVGIRPAAGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVR WGYA E+LS EELI+E Y GIRPA GYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKAEAFRVMQCDE-IGMTVTESYAMFPGASVSGFYFAHPDSKYFVVGKIGDDQVADMAE 1230 T KA + +++ ++ GM +TES+AM+PGASVSG+YF+HPDSKY+ V +I DQV D A Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRGVSKDDVERWLAPNL 1247 R+G+S DVERWLAPNL Sbjct: 880 RKGMSVSDVERWLAPNL 896 >ZmetH_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain EcZ Escherichia coli O157:H7 EDL933 Length = 901 Score = 1149 bits (2972), Expect = 0.0, Method: Compositional matrix adjust. Identities = 592/917 (64%), Positives = 687/917 (74%), Gaps = 29/917 (3%) Query: 338 IAPRQVPEGKHEMLLSGLEPFIINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 +APR++PE LSGLEP I D SL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSLAAMTRFLNLIASEPDIARVPVMIDSSKWSVIEAGLKC 457 RQQVENGAQIIDINMDE MLD+ AAM RFLNLIA EPDIARVP+MIDSSKW VIE GLKC Sbjct: 62 RQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLHEAKLCRRYGAAVIVMAFDEVGQADTYERKIEICERAYRL 517 +QGK IVNSISMKEG + F+H AKL RRYGAAV+VMAFDE GQADT RKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L ++VGFPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAVKAGMTMGIVNAGMIGVYDDLPAELREAVEDVVLNRRPDA 637 SFRGNDP REAIH VFLY+A++ GM MGIVNAG + +YDDLPAELR+AVEDV+LNRR D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIDIAATLKAGDKKEEAT---LEWRSEPVEKRLAHALVLGITQWIVEDTEEARQNLL 694 TER++++A + + A EWRS V KRL ++LV GIT++I +DTEEARQ Sbjct: 302 TERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQ--- 358 Query: 695 KSGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRLI 754 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Sbjct: 359 -QATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASK--- 414 Query: 755 EQETGIVAKPKGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCSQILAKAKE 814 EQ K GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL AKE Sbjct: 415 EQ-----GKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKE 469 Query: 815 ENADIIGLSGLITPSLEEMAYVAKEMQRDSYFSGVKMPLLIGGATTSRAHTAVKIAPNYS 874 NAD+IGLSGLITPSL+EM VAKEM+R G +PLLIGGATTS+AHTAVKI NYS Sbjct: 470 VNADLIGLSGLITPSLDEMVNVAKEMER----QGFTIPLLIGGATTSKAHTAVKIEQNYS 525 Query: 875 GPVVYVPDASRAVSVAQSLLTPEQKDQYIADIATDYERIREQHANKKA-VPLVPIAAARD 933 GP VYV +ASR V V +LL+ Q+D ++A +YE +R QH KK P V + AARD Sbjct: 526 GPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARD 585 Query: 934 NKMQLEFAPVKPKFIGRRVFKNVD--LATLAKYIDWGPFFQTWDLAGPYPAILKDEVVGE 991 N ++ P R + V+ + TL YIDW PFF TW LAG YP IL+DEVVG Sbjct: 586 NDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGV 645 Query: 992 AASKVFEEAQALLKKVIDGRWLTANGIVSLLPANTVNDDDIEIYTDDTRTQVALTYYGVR 1051 A ++F++A +L K+ + L G+V L PAN V DDIEIY D+TRT V + +R Sbjct: 646 EAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVG-DDIEIYRDETRTHVINVSHHLR 704 Query: 1052 QQTEKPVIDGVARPNQCLADFIAPKASGIADYIGMFAVTSGLGIEKYEKRFEEAHDDYSS 1111 QQTEK G A N CLADF+APK SG ADYIG FAVT GL + FE HDDY+ Sbjct: 705 QQTEKT---GFA--NYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNK 759 Query: 1112 IMLKALADRLAEAFAEYLHERVRTDLWGYASQESLSAEELIKEKYVGIRPAAGYPACPEH 1171 IM+KALADRLAEAFAEYLHERVR WGYA E+LS EELI+E Y GIRPA GYPACPEH Sbjct: 760 IMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEH 819 Query: 1172 TVKAEAFRVMQCDE-IGMTVTESYAMFPGASVSGFYFAHPDSKYFVVGKIGDDQVADMAE 1230 T KA + +++ ++ GM +TES+AM+PGASVSG+YF+HPDSKY+ V +I DQV D A Sbjct: 820 TEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYAR 879 Query: 1231 RRGVSKDDVERWLAPNL 1247 R+G+S DVERWLAPNL Sbjct: 880 RKGMSVSDVERWLAPNL 896 >STM4188_2 [E] COG1410 Methionine synthase I, cobalamin-binding domain Sty Salmonella typhimurium LT2 Length = 901 Score = 1145 bits (2962), Expect = 0.0, Method: Compositional matrix adjust. Identities = 590/918 (64%), Positives = 690/918 (75%), Gaps = 31/918 (3%) Query: 338 IAPRQVPEGKHEMLLSGLEPFIINDQSLYVNVGERTNVTGSKAFARLILNEQYDEALAVA 397 + PRQ+P+ LSGLEP I D SL+VNVGERTNVTGS F RLI E+Y EAL VA Sbjct: 2 LLPRQLPDIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVA 61 Query: 398 RQQVENGAQIIDINMDEAMLDSLAAMTRFLNLIASEPDIARVPVMIDSSKWSVIEAGLKC 457 RQQVE+GAQIIDINMDE MLD+ AAM RFL+LIA EPDIARVP+MIDSSKW VIE GLKC Sbjct: 62 RQQVESGAQIIDINMDEGMLDAEAAMVRFLSLIAGEPDIARVPIMIDSSKWEVIEKGLKC 121 Query: 458 VQGKSIVNSISMKEGEEKFLHEAKLCRRYGAAVIVMAFDEVGQADTYERKIEICERAYRL 517 +QGK IVNSISMKEG E F+H AKL RRYGAAV+VMAFDE GQADT RKIEIC RAY++ Sbjct: 122 IQGKGIVNSISMKEGVEAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKI 181 Query: 518 LVDKVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIHQNLPYAKISGGVSNVSF 577 L ++VGFPPEDIIFDPNIFAVATGIEEHNNYA DFI A I + LP+A ISGGVSNVSF Sbjct: 182 LTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSF 241 Query: 578 SFRGNDPAREAIHTVFLYHAVKAGMTMGIVNAGMIGVYDDLPAELREAVEDVVLNRRPDA 637 SFRGNDP REAIH VFLY+A++ GM MGIVNAG + +YDDLPAELR+AVEDV+LNRR D Sbjct: 242 SFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDG 301 Query: 638 TERMIDIAATLKAGDKKEEAT----LEWRSEPVEKRLAHALVLGITQWIVEDTEEARQNL 693 TER++D+A + G K +EA EWRS V+KRL ++LV GIT++I +DTEEARQ Sbjct: 302 TERLLDLAEKYR-GSKTDEAANAQQAEWRSWDVKKRLEYSLVKGITEFIEQDTEEARQQ- 359 Query: 694 LKSGGRPIHVIEGPLMDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLIPFIEEEKRL 753 RPI VIEGPLMDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L PFIE K Sbjct: 360 ---AARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASK-- 414 Query: 754 IEQETGIVAKPKGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCSQILAKAK 813 E G GK+VIATVKGDVHDIGKNIV VVLQCNN+E+V++GVMVP +IL A+ Sbjct: 415 ---EKG---SSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAR 468 Query: 814 EENADIIGLSGLITPSLEEMAYVAKEMQRDSYFSGVKMPLLIGGATTSRAHTAVKIAPNY 873 E NAD+IGLSGLITPSL+EM VAKEM+R G +PLLIGGATTS+AHTAVKI NY Sbjct: 469 EVNADLIGLSGLITPSLDEMVNVAKEMER----QGFTIPLLIGGATTSKAHTAVKIEQNY 524 Query: 874 SGPVVYVPDASRAVSVAQSLLTPEQKDQYIADIATDYERIREQHANKKA-VPLVPIAAAR 932 SGP VYV +ASR V V +LL+ Q+D ++A +YE +R QHA KK P V + AAR Sbjct: 525 SGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHARKKPRTPPVTLEAAR 584 Query: 933 DNKMQLEFAPVKPKFIGRRVFKNVD--LATLAKYIDWGPFFQTWDLAGPYPAILKDEVVG 990 DN + ++ P R + V+ + TL YIDW PFF TW LAG YP IL+DEVVG Sbjct: 585 DNDLAFDWERYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVG 644 Query: 991 EAASKVFEEAQALLKKVIDGRWLTANGIVSLLPANTVNDDDIEIYTDDTRTQVALTYYGV 1050 A ++F++A +L K+ + L G+V L PAN V DDIEIY D+TRT V + + Sbjct: 645 VEAQRLFKDANDMLDKLSAEKLLNPRGVVGLFPANRVG-DDIEIYRDETRTHVLTVSHHL 703 Query: 1051 RQQTEKPVIDGVARPNQCLADFIAPKASGIADYIGMFAVTSGLGIEKYEKRFEEAHDDYS 1110 RQQTEK V N CLADF+APK SG ADYIG FAVT GL + FE HDDY+ Sbjct: 704 RQQTEK-----VGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYN 758 Query: 1111 SIMLKALADRLAEAFAEYLHERVRTDLWGYASQESLSAEELIKEKYVGIRPAAGYPACPE 1170 IM+KA+ADRLAEAFAEYLHERVR WGYA ESLS +ELI+E Y GIRPA GYPACPE Sbjct: 759 KIMVKAIADRLAEAFAEYLHERVRKVYWGYAPNESLSNDELIRENYQGIRPAPGYPACPE 818 Query: 1171 HTVKAEAFRVMQCDE-IGMTVTESYAMFPGASVSGFYFAHPDSKYFVVGKIGDDQVADMA 1229 HT K ++++ ++ GM +TES+AM+PGASVSG+YF+HP+SKYF V +I DQV D A Sbjct: 819 HTEKGTIWQLLDVEKHTGMKLTESFAMWPGASVSGWYFSHPESKYFAVAQIQRDQVTDYA 878 Query: 1230 ERRGVSKDDVERWLAPNL 1247 R+G+S +DVERWLAPNL Sbjct: 879 FRKGMSVEDVERWLAPNL 896