BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0717.p (242 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Cgl2513 [Q] COG2761 Predicted dithiol-disulfide isomerase involv... 195 8e-50 DR0659 [Q] COG2761 Predicted dithiol-disulfide isomerase involve... 172 8e-43 AGc3262 [Q] COG2761 Predicted dithiol-disulfide isomerase involv... 143 4e-34 CAC3447 [Q] COG2761 Predicted dithiol-disulfide isomerase involv... 142 9e-34 SMc00952 [Q] COG2761 Predicted dithiol-disulfide isomerase invol... 131 1e-30 >Cgl2513 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Cgl Corynebacterium glutamicum Length = 245 Score = 195 bits (495), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 91/235 (38%), Positives = 139/235 (59%) Query: 8 KMPVEIWSDIMCPFCFIGKRKFDEALAAFGHKDKIQVVWRSYRLFPEVRYREGSDACAVL 67 KM +E+WSDIMCPFC+IGK++ D+AL+ F +I+V ++S+ L P + L Sbjct: 10 KMKIEVWSDIMCPFCYIGKKRLDDALSTFDQAGRIEVEYKSFELMPGLETHPLRSDVEYL 69 Query: 68 AKVKGLATSSMRQAMAHVTALGRDVGIRFDFDRLKMVDTLDSLRLVHLAATRDLASEMKE 127 A KG++ RQ V A+ + G+ + D +T+++ RL H A E+ + Sbjct: 70 ADAKGMSLEQARQMNGQVQAMAQATGLEMNPDETIAANTINAHRLTHFAKAHGKQQEVAQ 129 Query: 128 RLFQAFFEEGQNLEDHQILAQLGKEVGLDAQAAKTMLTSIAYADEVENDVAQARQIGVNG 187 LF+A F +G+N++D +L + EVGLDA AA+ L S Y +EV+ DV +ARQ+GV G Sbjct: 130 ELFKAHFVDGKNVDDLDVLVSIAAEVGLDASAAREALESDVYTNEVQQDVHEARQLGVQG 189 Query: 188 IPFFVLDRQQALSGAQSIAGFTALLQAAFDGWNQNIPSPAKKTMPGESCTPDGQC 242 +PFFV DR+ A++GAQ FT ++ AF+ W P + + G+SC+ DG C Sbjct: 190 VPFFVFDRKYAINGAQQEEVFTGTVEKAFEEWAAENPVSPFEVIDGQSCSVDGTC 244 >DR0659 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Dra Deinococcus radiodurans Length = 252 Score = 172 bits (435), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 96/241 (39%), Positives = 139/241 (57%), Gaps = 7/241 (2%) Query: 5 TSEKMPVEIWSDIMCPFCFIGKRKFDEALAAFGHKDKIQVVWRSYRLFPEVRYREGSDAC 64 SEK+ V+IWSDI CP+C+IGKR+F+ AL F +D+++VVW S+ L P R Sbjct: 8 NSEKIRVDIWSDIACPWCYIGKRRFESALGQFPQRDQVEVVWHSFELDPSARPLNPIAMR 67 Query: 65 AVLAKVKGLATSSMRQAMAHVTALGRDVGIRFDFDRLKMVDTLDSLRLVHLAATRDLASE 124 LA ++ + + ++ H+T G+ + FDR+K+ +T + +L+H AA + Sbjct: 68 DGLAMKYSISPAQAQGSLDHMTQTAAQEGLEYHFDRVKLANTFLAHQLIHYAAEQGQGDA 127 Query: 125 MKERLFQAFFEEGQNLEDHQILAQLGKEVGLDAQAAKTMLTSIAYADEVENDVAQARQIG 184 MKERL +A+ EGQN+ D L +L EVGLDA AA+ L + YA V D AQA+Q+G Sbjct: 128 MKERLLRAYMSEGQNVNDLDTLQKLAAEVGLDAGAARAALEAGTYAQAVRYDEAQAQQLG 187 Query: 185 VNGIPFFVLDRQQALSGAQSIAGFTALLQAAFDGWNQNIPSPAK---KTMPGESCTPDGQ 241 + G+PFFVL + +SGAQ+ LL A W + P+P + P E C DGQ Sbjct: 188 ITGVPFFVLGGKYGVSGAQAP---ETLLGALSQVWAEQHPAPLTMLGQDAPAEGCE-DGQ 243 Query: 242 C 242 C Sbjct: 244 C 244 >AGc3262 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 242 Score = 143 bits (360), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 82/213 (38%), Positives = 129/213 (60%), Gaps = 8/213 (3%) Query: 5 TSEKMPVEIWSDIMCPFCFIGKRKFDEALAAFGHKDKIQVVWRSYRLFPEVRYREGSDAC 64 T E++ V++ SD++CP+C++GK + D A+A + + V WR YRL P+ EG D Sbjct: 20 TMERIVVDVVSDMVCPWCYLGKARLDLAIAEVQDEISVDVNWRPYRLNPDYP-PEGVDQK 78 Query: 65 AVLAKVKGLATSSMRQAMAHVTALGRDVGIRFDFDRLKM-VDTLDSLRL---VHLAATRD 120 A L + L + QA A + LG+ VGI +DFD +K+ +TLD+ RL H A RD Sbjct: 79 AALEE--KLGKDRLEQAHASLVELGKQVGINYDFDAIKIGPNTLDAHRLSLWAH-AEGRD 135 Query: 121 LASEMKERLFQAFFEEGQNLEDHQILAQLGKEVGLDAQAAKTMLTSIAYADEVENDVAQA 180 + + LF+A FEEG+N+ DH +L + + G+DA+ +L S A D V ++ A Sbjct: 136 VQERIVTALFKANFEEGRNIGDHAVLTDIAGKAGMDAKVVARLLASDADKDTVIAEIDAA 195 Query: 181 RQIGVNGIPFFVLDRQQALSGAQSIAGFTALLQ 213 +Q+GV+G+PFF++D++ A+SGAQ+ A L+ Sbjct: 196 QQMGVSGVPFFIVDQKYAISGAQTPDVLIAALR 228 >CAC3447 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Cac Clostridium acetobutylicum Length = 228 Score = 142 bits (357), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 118/204 (57%) Query: 9 MPVEIWSDIMCPFCFIGKRKFDEALAAFGHKDKIQVVWRSYRLFPEVRYREGSDACAVLA 68 M +E+WSD +CPFC++GKR+ + AL F +K +++ ++S+ L P + + ++A Sbjct: 1 MKIEVWSDFVCPFCYMGKRRLEIALNEFEYKTDVEISFKSFELDPSAKKEYSENIHELIA 60 Query: 69 KVKGLATSSMRQAMAHVTALGRDVGIRFDFDRLKMVDTLDSLRLVHLAATRDLASEMKER 128 K ++ + + + +G+ ++F++L +T D+ RL A T+ +E+ E+ Sbjct: 61 KKYKISVEQAKASNDQIVLQAEAIGLNYNFNKLIPTNTFDAHRLSQYAKTKGKMNELSEK 120 Query: 129 LFQAFFEEGQNLEDHQILAQLGKEVGLDAQAAKTMLTSIAYADEVENDVAQARQIGVNGI 188 +F+A+F + N+ D+++LA L +EVG+ + +L S Y +EV D A ++G++ + Sbjct: 121 IFKAYFVDSLNISDYKVLADLAEEVGISRDESLRILESNQYNEEVREDEKNASKLGIDAV 180 Query: 189 PFFVLDRQQALSGAQSIAGFTALL 212 P+FV D + A+SGAQ F L Sbjct: 181 PYFVFDDKYAVSGAQPAEVFLEAL 204 >SMc00952 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Sme Sinorhizobium meliloti Length = 221 Score = 131 bits (330), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 76/210 (36%), Positives = 127/210 (60%), Gaps = 5/210 (2%) Query: 7 EKMPVEIWSDIMCPFCFIGKRKFDEALAAFGHKDKIQVVWRSYRLFPEVRYREGSDACAV 66 E + ++I SD++CP+C++GK + D+A+A + + + WR Y+L P++ EG D Sbjct: 2 ETVNIDIVSDVVCPWCYLGKNRLDQAIANVAGEINVAIQWRPYQLNPDLP-PEGIDHKEH 60 Query: 67 LAKVKGLATSSMRQAMAHVTALGRDVGIRFDFDRLKMV-DTLDSLRLVHLAATRDLASE- 124 LA G +++ +A + LG + GI FDFD +K+ +TLD+ RL+ AAT A++ Sbjct: 61 LAAKLG-GQAAVDEAHRTLEGLGVEDGIAFDFDAVKVSPNTLDAHRLIRWAATGGEAAQD 119 Query: 125 -MKERLFQAFFEEGQNLEDHQILAQLGKEVGLDAQAAKTMLTSIAYADEVENDVAQARQI 183 + LF+A FEEG+NL D +L + ++ GL+ +L S A D V ++ AR+I Sbjct: 120 AVVSLLFKANFEEGRNLGDQAVLLDIAEQAGLERPVIAALLASDADKDAVRQEIDMAREI 179 Query: 184 GVNGIPFFVLDRQQALSGAQSIAGFTALLQ 213 GV G+P F++++Q A+ GAQS+ T+ L+ Sbjct: 180 GVTGVPCFIIEQQYAVMGAQSVEVLTSALR 209