BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0002.0578.p         (162 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

PM1366 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relate...   196   1e-50
STM2918 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relat...   189   2e-48
ygbJ [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related ...   186   1e-47
HI1010 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and relate...   181   9e-46
BMEII1090 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and rel...   177   8e-45

>PM1366 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Pmu Pasteurella
           multocida
          Length = 301

 Score =  196 bits (499), Expect = 1e-50,   Method: Compositional matrix adjust.
 Identities = 101/161 (62%), Positives = 127/161 (78%)

Query: 1   MMTSGPAEVYARIEDVLKGMAGKVYRLGDTHGIGSKVKIINQLLAGVHIAASAEAMALGL 60
           +M SG  + + +++ VL  +AGKVY +G+  G+G+ VKII+QLLAGVHIAA AEAMAL  
Sbjct: 139 VMASGSQQAFTKLQPVLDAVAGKVYNIGEEIGLGATVKIIHQLLAGVHIAAGAEAMALAA 198

Query: 61  REGVDPDALYEVITHSAGNSWMFENRVPHILKGDYTPLSAVDIFVKDLGLVLDTARRSKF 120
           R G+  D +Y+V+TH+AGNSWMFENR+ H+++GDYTPLS VDIFVKDLGLV DTA+  KF
Sbjct: 199 RAGIPLDLMYDVVTHAAGNSWMFENRMKHVVEGDYTPLSMVDIFVKDLGLVTDTAKALKF 258

Query: 121 PLPLSAAAHQMFMMASTAGHGGEDDSAVIKIFPGIDLPPSK 161
           PLPL++ A  MF  AS AG+G EDDSAVIKIF GI+LP  K
Sbjct: 259 PLPLASTAFNMFTSASNAGYGKEDDSAVIKIFSGIELPQKK 299


>STM2918 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Sty Salmonella
           typhimurium LT2
          Length = 307

 Score =  189 bits (481), Expect = 2e-48,   Method: Compositional matrix adjust.
 Identities = 101/158 (63%), Positives = 122/158 (77%)

Query: 1   MMTSGPAEVYARIEDVLKGMAGKVYRLGDTHGIGSKVKIINQLLAGVHIAASAEAMALGL 60
           +M SG    + R++ VL  +A  VYR+ DT G GS VKII+QLLAGVHIAA+AEAMAL  
Sbjct: 141 VMASGSEAAFTRLKPVLDAVASNVYRISDTPGAGSTVKIIHQLLAGVHIAAAAEAMALAA 200

Query: 61  REGVDPDALYEVITHSAGNSWMFENRVPHILKGDYTPLSAVDIFVKDLGLVLDTARRSKF 120
           R G+  D +Y+V+TH+AGNSWMFENR+ H++ GDYTP SAVDIFVKDLGLV DTA+  +F
Sbjct: 201 RAGIPLDVMYDVVTHAAGNSWMFENRMQHVVDGDYTPRSAVDIFVKDLGLVADTAKALRF 260

Query: 121 PLPLSAAAHQMFMMASTAGHGGEDDSAVIKIFPGIDLP 158
           PLPL++ A  MF  AS AG+G EDDSAVIKIF GI LP
Sbjct: 261 PLPLASTALNMFTSASNAGYGKEDDSAVIKIFSGITLP 298


>ygbJ [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Eco Escherichia coli K12
          Length = 302

 Score =  186 bits (473), Expect = 1e-47,   Method: Compositional matrix adjust.
 Identities = 102/162 (62%), Positives = 124/162 (76%)

Query: 1   MMTSGPAEVYARIEDVLKGMAGKVYRLGDTHGIGSKVKIINQLLAGVHIAASAEAMALGL 60
           +M SG    + R+  VL+ +AGKVYR+G   G+GS VKII+QLLAGVHIAA AEAMAL  
Sbjct: 141 VMASGSDIAFERLAPVLEAVAGKVYRIGAEPGLGSTVKIIHQLLAGVHIAAGAEAMALAA 200

Query: 61  REGVDPDALYEVITHSAGNSWMFENRVPHILKGDYTPLSAVDIFVKDLGLVLDTARRSKF 120
           R G+  D +Y+V+T++AGNSWMFENR+ H++ GDYTP SAVDIFVKDLGLV DTA+   F
Sbjct: 201 RAGIPLDVMYDVVTNAAGNSWMFENRMRHVVDGDYTPHSAVDIFVKDLGLVADTAKALHF 260

Query: 121 PLPLSAAAHQMFMMASTAGHGGEDDSAVIKIFPGIDLPPSKQ 162
           PLPL++ A  MF  AS AG+G EDDSAVIKIF GI LP +K 
Sbjct: 261 PLPLASTALNMFTSASNAGYGKEDDSAVIKIFSGITLPGAKS 302


>HI1010 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Hin Haemophilus
           influenzae
          Length = 301

 Score =  181 bits (458), Expect = 9e-46,   Method: Compositional matrix adjust.
 Identities = 93/158 (58%), Positives = 121/158 (76%)

Query: 1   MMTSGPAEVYARIEDVLKGMAGKVYRLGDTHGIGSKVKIINQLLAGVHIAASAEAMALGL 60
           +M SG  + +  ++ VL   A KVY +G+  G+G+ VKI++QLLAGVHIAA AEAMAL  
Sbjct: 140 VMASGSKQAFELLQPVLDATAAKVYNIGEEIGLGATVKIVHQLLAGVHIAAGAEAMALAS 199

Query: 61  REGVDPDALYEVITHSAGNSWMFENRVPHILKGDYTPLSAVDIFVKDLGLVLDTARRSKF 120
           + G+  D +Y+V+T++AGNSWMFENR+ H+++GDYTPLS VDIFVKDLGLV DTA+   F
Sbjct: 200 KAGIPLDVMYDVVTNAAGNSWMFENRMKHVVEGDYTPLSMVDIFVKDLGLVNDTAKSLHF 259

Query: 121 PLPLSAAAHQMFMMASTAGHGGEDDSAVIKIFPGIDLP 158
           PL L++ A+ MF  AS AG+G EDDSAVIKIF G+ LP
Sbjct: 260 PLHLASTAYSMFTEASNAGYGKEDDSAVIKIFSGVSLP 297


>BMEII1090 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related
           beta-hydroxyacid dehydrogenases Bme Brucella melitensis
          Length = 302

 Score =  177 bits (449), Expect = 8e-45,   Method: Compositional matrix adjust.
 Identities = 93/158 (58%), Positives = 115/158 (72%)

Query: 1   MMTSGPAEVYARIEDVLKGMAGKVYRLGDTHGIGSKVKIINQLLAGVHIAASAEAMALGL 60
           +M SG  E + ++  VL   AGKVY +G   G+G+ VKII+QLLAGVHIAA AEAMAL  
Sbjct: 141 VMASGSREAFEKLRPVLNAAAGKVYEIGQEIGLGATVKIIHQLLAGVHIAAGAEAMALAA 200

Query: 61  REGVDPDALYEVITHSAGNSWMFENRVPHILKGDYTPLSAVDIFVKDLGLVLDTARRSKF 120
           R G+  D +Y+V+TH+AGNSWMFENR+ H++ GDYTP SAVDIFVKDL LV +T     F
Sbjct: 201 RSGIPLDIMYDVVTHAAGNSWMFENRMKHVVDGDYTPKSAVDIFVKDLRLVTETGLSMNF 260

Query: 121 PLPLSAAAHQMFMMASTAGHGGEDDSAVIKIFPGIDLP 158
           PLPL+  A+ +F  AS AG G EDD+AVIK + GI LP
Sbjct: 261 PLPLATTAYSLFANASNAGFGKEDDAAVIKTYAGIKLP 298