BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0573.p (441 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 566 e-161 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 510 e-144 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 470 e-132 PA4126 [GEPR] COG0477 Permeases of the major facilitator superfa... 380 e-105 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 360 5e-99 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 566 bits (1459), Expect = e-161, Method: Compositional matrix adjust. Identities = 282/430 (65%), Positives = 342/430 (79%), Gaps = 3/430 (0%) Query: 14 NTSANEQE--QNRVYAKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSVDLGFSETVFGL 71 NT+ E +N Y KV +RI+P LM+CY+IAYLDRVNVGFAKLQMS +LGFSE ++GL Sbjct: 23 NTAITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGL 82 Query: 72 GAGVFFLGYFLFEVPSNILMHKVGARVWIARIMITWGILSAAFMYVETPMQFYVLRFLLG 131 GAG+FF+GYF FE+PSNIL+HK+GAR+WIARIMITWG+LSA F +V+T QFY+LRFLLG Sbjct: 83 GAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLG 142 Query: 132 LAEAGFYPGIILYLTYWYPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFHGTTGMHG 191 AEAGFYPG+ILYLTYW+PSHRR + A+F +G P AGI GNPLSGWIMD FH T G G Sbjct: 143 AAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQG 202 Query: 192 WQWMFVIEAVPAVLIGLATLAYLDNGIAKAKWLSAGEKKLLEDEIAADQKGKESVHSFAD 251 WQWMFV+EA+PAV++G+ L YLDN + AKWL+ EK ++ +I AD KGK + HS Sbjct: 203 WQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKAASHSLMS 262 Query: 252 IVSDKRVWLMCLIYFCFVMGQYGLTLWMPTLVKATGVTGNLHIGLLSAIPFGCAIIAMNL 311 +V + +W+M LIYFCFVMGQ+GLTLWMPTL++A+GVT N+ IGLL AIPF CAIIAM + Sbjct: 263 LVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVI 322 Query: 312 IGRSADARRERRWHLIVPALMGAVGFVGAALFADNTAISIAALSLAAAGVLTCAPLFWSL 371 RSAD RERRWHL+VPAL+GAVGFV AA A NT +SI LS+AAAGVL CAPLFWSL Sbjct: 323 FSRSADHYRERRWHLVVPALLGAVGFVVAAS-ATNTTVSIIFLSMAAAGVLACAPLFWSL 381 Query: 372 PTSFLSGAAAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHSGATGMYMLAIMLVIGSAAV 431 PT+ LSGAAAA GIA INSV NLAGF+SPY++G ++D THS GMY+LA L++G+A V Sbjct: 382 PTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGAAIV 441 Query: 432 LKTSPKLVNK 441 L VN+ Sbjct: 442 LCIPASKVNR 451 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 510 bits (1313), Expect = e-144, Method: Compositional matrix adjust. Identities = 256/434 (58%), Positives = 332/434 (76%), Gaps = 4/434 (0%) Query: 8 GAAPAVNTSANEQEQNRVYAKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSVDLGFSET 67 GA P + S E+ Y KV WR++PFL+LCYV+AYLDRVNVGFAKLQM DL FSET Sbjct: 13 GALPPQSASGFEEA---TYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSET 69 Query: 68 VFGLGAGVFFLGYFLFEVPSNILMHKVGARVWIARIMITWGILSAAFMYVETPMQFYVLR 127 V+GLGAG+FF+GYFLFEVPSN+++H+VGAR+WIARIMI+WG++SAA M+V TP FYV+R Sbjct: 70 VYGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMR 129 Query: 128 FLLGLAEAGFYPGIILYLTYWYPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFHGTT 187 FLLGLAEAGF+PGIILYLTYWYP+ RR + FM+ + ++G++G P+SGW + F G Sbjct: 130 FLLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVY 189 Query: 188 GMHGWQWMFVIEAVPAVLIGLATLAYLDNGIAKAKWLSAGEKKLLEDEIAADQKGKESVH 247 G+ GWQWMF+IE +P+V+IGL LAYLDN I+ A+WL+ EK LL IAA++ KE Sbjct: 190 GLAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKEDA- 248 Query: 248 SFADIVSDKRVWLMCLIYFCFVMGQYGLTLWMPTLVKATGVTGNLHIGLLSAIPFGCAII 307 A I++ RVWLM LIYF FVMG YG++ W+PTL+K TGV L +GLL+AIP+G A++ Sbjct: 249 PIAAIMASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVV 308 Query: 308 AMNLIGRSADARRERRWHLIVPALMGAVGFVGAALFADNTAISIAALSLAAAGVLTCAPL 367 AM L+ RSAD RERRWH+ +PAL GA+G V +A++ NT +++AAL+L G+LT PL Sbjct: 309 AMVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPL 368 Query: 368 FWSLPTSFLSGAAAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHSGATGMYMLAIMLVIG 427 FWSLPT+FL+G AA GIA INS+GNLAGF+SPY +G+LKD T S +GMY+LA +V+G Sbjct: 369 FWSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLG 428 Query: 428 SAAVLKTSPKLVNK 441 + L + VN+ Sbjct: 429 ALLTLSVPARTVNR 442 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 470 bits (1210), Expect = e-132, Method: Compositional matrix adjust. Identities = 230/434 (52%), Positives = 310/434 (71%), Gaps = 3/434 (0%) Query: 9 AAPAVNTSANEQEQNRVYAKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSVDLGFSETV 68 + +++ QE+N Y K W ++P LMLCYV+ YLDRVNVGFAKLQM+ DL FS+TV Sbjct: 5 STESLSQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTV 64 Query: 69 FGLGAGVFFLGYFLFEVPSNILMHKVGARVWIARIMITWGILSAAFMYVETPMQFYVLRF 128 +GLGAG+FF+GYF E+PSN+++H+VGAR+WIARIMITWGI+SA +V TPM FYV+RF Sbjct: 65 YGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRF 124 Query: 129 LLGLAEAGFYPGIILYLTYWYPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFHGTTG 188 LLG+AEAGF+PGIILY++YW+PSHRR +V +F+ +P++GI+G PLSGWIM F+G G Sbjct: 125 LLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQG 184 Query: 189 MHGWQWMFVIEAVPAVLIGLATLAYLDNGIAKAKWLSAGEKKLLEDEIAADQKGKESVHS 248 GWQWMF++E +P+VL+G+ + L + I A WL+ EK +L+ I + + HS Sbjct: 185 YAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNI--ENEAAHYAHS 242 Query: 249 -FADIVSDKRVWLMCLIYFCFVMGQYGLTLWMPTLVKATGVTGNLHIGLLSAIPFGCAII 307 D RVWL+ LIYFC + G Y + W+PTL++ +GV L IG L+AIP A + Sbjct: 243 RLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAV 302 Query: 308 AMNLIGRSADARRERRWHLIVPALMGAVGFVGAALFADNTAISIAALSLAAAGVLTCAPL 367 M ++ RSAD RERRWHL + A++GAVG + + F+DN +++ L++ A G L+ PL Sbjct: 303 TMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPL 362 Query: 368 FWSLPTSFLSGAAAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHSGATGMYMLAIMLVIG 427 FWSLPT+FL G+AAA GIA INS GNL GFV+PY++GYLKDLT S TGM +++ L IG Sbjct: 363 FWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIG 422 Query: 428 SAAVLKTSPKLVNK 441 +A V K VN Sbjct: 423 AALVFLIPAKAVNH 436 >PA4126 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 434 Score = 380 bits (977), Expect = e-105, Method: Compositional matrix adjust. Identities = 197/421 (46%), Positives = 290/421 (68%), Gaps = 5/421 (1%) Query: 22 QNRVYAKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSVDLGFSETVFGLGAGVFFLGYF 81 + + +V WR+MP L++CYV A+LDR+N+GFAKLQMS DL FS+TV+GLGAG+FF+ Y Sbjct: 15 SDSTHDRVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLFFIAYA 74 Query: 82 LFEVPSNILMHKVGARVWIARIMITWGILSAAFMYVETPMQFYVLRFLLGLAEAGFYPGI 141 LF +PSN+++ ++G R WIA +M+ WG LS A + VET FY+LRFLLG+AEAGF+PGI Sbjct: 75 LFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAGFFPGI 134 Query: 142 ILYLTYWYPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFHGTTGMHGWQWMFVIEAV 201 ++YL W+P+ RR ++ A+F +P+AG++G PLSGWI++ FH G+ GWQWMF+IE + Sbjct: 135 LVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDALGLRGWQWMFLIEGL 194 Query: 202 PAVLIGLATLAYLDNGIAKAKWLSAGEKKLLEDEIAADQKGKESVHSFADIVSDKRVWLM 261 P VL+G+ L + WLS +K LL +E+A +++ ++++ SF+ I S+ +VWL+ Sbjct: 195 PVVLLGVVVWCSLPESFERVTWLSDEQKHLLREELAGEEQ-RKTITSFSGIFSNPQVWLL 253 Query: 262 CLIYFCFVMGQYGLTLWMPTLVKATGVTGNLHIGLLSAIPF--GCAIIAMNLIGRSADAR 319 IYF ++ + WMP+L+ G+ + IG+LSA+P+ GCA M IGRS+D Sbjct: 254 VAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAF--MIFIGRSSDRL 311 Query: 320 RERRWHLIVPALMGAVGFVGAALFADNTAISIAALSLAAAGVLTCAPLFWSLPTSFLSGA 379 RERRWHL +P LM A G AAL + + + L +A G P+FW LP +FLS A Sbjct: 312 RERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLSSA 371 Query: 380 AAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHSGATGMYMLAIMLVIGSAAVLKTSPKLV 439 A GIA I+S G++A F++PYLIG+++D T S + +Y+LAI++ +G+ VL+T +V Sbjct: 372 TLAAGIALISSFGSIAAFLAPYLIGWMRDTTQSASLALYLLAILIALGAGLVLRTPAAVV 431 Query: 440 N 440 N Sbjct: 432 N 432 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 360 bits (923), Expect = 5e-99, Method: Compositional matrix adjust. Identities = 181/405 (44%), Positives = 265/405 (65%), Gaps = 4/405 (0%) Query: 9 AAPAVNTSANEQEQN-RVYAKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMSVDLGFSET 67 AA A+ A+ E++ VY+ V RI+PFL CY+ AYLDR+N+GFAKLQM DL S+ Sbjct: 2 AANAIPAQAHSGERSTSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDA 61 Query: 68 VFGLGAGVFFLGYFLFEVPSNILMHKVGARVWIARIMITWGILSAAFMYVETPMQFYVLR 127 +GLGAG+FF GY LFEVPSN+L+ K+GAR ++RI+I WGI+SA+ ++V FY LR Sbjct: 62 AYGLGAGIFFFGYMLFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALR 121 Query: 128 FLLGLAEAGFYPGIILYLTYWYPSHRRAKVIAVFMSGIPVAGILGNPLSGWIMDAFHGTT 187 FLLG+ EAGF PG+I YLT WYP R A+ +AV + P+ G++G P S WIM F G Sbjct: 122 FLLGVFEAGFAPGMIYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAG 181 Query: 188 GMHGWQWMFVIEAVPAVLIGLATLAYLDNGIAKAKWLSAGEKKLLEDEIAADQKGKESVH 247 G+ GWQWMF+ E +P++L+G+A YL + A A+WL+ +K ++ +IA G+ S Sbjct: 182 GLAGWQWMFLAEGIPSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIARAAPGQAS-- 239 Query: 248 SFADIVSDKRVWLMCLIYFCFVMGQYGLTLWMPTLVKATGVTGNLHIGLLSAIPFGCAII 307 SF +++ +++++ YFC + G Y + W+P+++K+ G++ IGL SAIP I+ Sbjct: 240 SFGKALTEPKLYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAMIV 299 Query: 308 AMNLIGRSADARRERRWHLIVPALMGAVGFVGAALFADNTAISIAALSLAAAGVLTCAPL 367 AM +GR +D R ER H + A++GA G + A +A + ++ +++LA+A + + Sbjct: 300 AMYALGRRSDRRGERHLHSAITAVLGA-GLLAWAAYATSFPAALISITLASAAIFASYSV 358 Query: 368 FWSLPTSFLSGAAAAVGIAAINSVGNLAGFVSPYLIGYLKDLTHS 412 FW++P L G AAA GIA INS+G GF SP LIG+ K+ T S Sbjct: 359 FWAIPQQHLKGTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGS 403