BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0444.p (525 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA5015 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase... 561 e-159 XF0669 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase... 532 e-151 RSc1600 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 526 e-149 NMB1341 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 522 e-148 NMA1554 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 522 e-147 >PA5015 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Pae Pseudomonas aeruginosa Length = 882 Score = 561 bits (1447), Expect = e-159, Method: Compositional matrix adjust. Identities = 286/525 (54%), Positives = 370/525 (70%), Gaps = 19/525 (3%) Query: 3 KIHAAYHAAASHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFKLP 62 K++AAYH A +H+GQPTVILA+T KGYG G+ GE K H KK+D + L AFR++F +P Sbjct: 363 KVYAAYHQAVNHKGQPTVILAKTIKGYGTGS-GEAKNIAHNVKKVDVDSLRAFRDKFDIP 421 Query: 63 ISDEQCKSLAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETHARFA 122 + D + L FYKP SAE K+L RRA+LGG MP R + + VPP+ET + Sbjct: 422 VKDADLEKLPFYKPEEGSAEAKYLAERRAALGGFMPVRRQKS---MSVPVPPLET-LKAM 477 Query: 123 LDAEG-KEMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQVGIYSSQGQ 181 LD G +E+S+TMA VR++ ++KD +LG +VPIV DEARTFGM +FRQ+GIYSS GQ Sbjct: 478 LDGSGDREISTTMAFVRIISQLVKDKELGPRIVPIVPDEARTFGMEGMFRQLGIYSSVGQ 537 Query: 182 LYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPFYIYYSMFG 241 LYEP D ++ YRE K GQILEEGI EAGA+SSW AA TSYS H PMLPFYI+YSMFG Sbjct: 538 LYEPVDKDQVMFYREDKKGQILEEGINEAGAMSSWIAAGTSYSTHNQPMLPFYIFYSMFG 597 Query: 242 FQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNCVSYDPAYA 301 FQRIGDL WAA D RA GFLIG T+GRTTL GEGLQH+DG SH+ A+ IPNC +YDP YA Sbjct: 598 FQRIGDLAWAAGDSRAHGFLIGGTAGRTTLNGEGLQHEDGHSHLLASTIPNCRTYDPTYA 657 Query: 302 YEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMYCL---APQ 358 YE+AVI+ +G R+M+E +D+FYY+TV NEN QP++P+G ++GI++GMY L + Sbjct: 658 YELAVIIREGSRQMIEEQQDIFYYITVMNENYVQPAMPKG--AEEGIIKGMYLLEEDKKE 715 Query: 359 ADAQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERRARLQPGA 418 A V+LL +G +L+E AA++L+ FG+ A+VWSV SF EL RDG+A ER RL PG Sbjct: 716 AAHHVQLLGSGTILREVEEAAKLLRNDFGIGADVWSVPSFNELRRDGLAVERWNRLHPGQ 775 Query: 419 KGALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPAR-YVTLGTDGFGRSDTRA 477 K YV + L + + PVIA +DY++ +E IR +VP++ Y LGTDGFGRSD+R Sbjct: 776 KPKQSYVEECLGGR----RGPVIASTDYMKLYAEQIRQWVPSKEYKVLGTDGFGRSDSRK 831 Query: 478 NLRDFFEVDARWI---AYTALAEVFGADAARLKDAAAKLGVDLDK 519 LR+FFEVD W+ A ALA+ + + +A AK G+D +K Sbjct: 832 KLRNFFEVDRHWVVLAALEALADRGDIEPKVVAEAIAKYGIDPEK 876 >XF0669 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Xfa Xylella fastidiosa 9a5c Length = 985 Score = 532 bits (1370), Expect = e-151, Method: Compositional matrix adjust. Identities = 260/492 (52%), Positives = 342/492 (69%), Gaps = 16/492 (3%) Query: 3 KIHAAYHAAASHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFKLP 62 KI+AAYH A + +G PTVILA+T KGYGMG AGE THQ KKLD + + FR+RF +P Sbjct: 460 KIYAAYHRAVNTQGMPTVILAKTVKGYGMGTAGESLNPTHQTKKLDHDAIKHFRDRFNIP 519 Query: 63 ISDEQCKS---LAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETHA 119 ISD+Q + + FY P DS E+K++LARR +LGG +P+R + VP ++ + Sbjct: 520 ISDQQLDAADHIPFYHPGPDSPEIKYMLARREALGGFLPQRRTKS--SKSFIVPGLDKYE 577 Query: 120 RFALDAEGKEMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQVGIYSSQ 179 R + + S+TMA V+ L L+D LG ++VPIVADEARTFGM LFRQ+GIY+ Sbjct: 578 RLLTSSGERTYSTTMAFVQSLNITLRDKALGPHIVPIVADEARTFGMEGLFRQIGIYAPF 637 Query: 180 GQLYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPFYIYYSM 239 GQ Y+P D ++ YRE + GQ+L++GITE GAI+SW AA TSYSV +PMLPFYIYYSM Sbjct: 638 GQKYKPVDADQLMYYREDESGQVLQQGITEPGAIASWMAAGTSYSVSDVPMLPFYIYYSM 697 Query: 240 FGFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNCVSYDPA 299 FGFQRIGD+ W AAD R RGFL+G T+GRTTL GEGLQH+DG SH+ A IPN SYDP Sbjct: 698 FGFQRIGDIAWQAADMRTRGFLLGGTAGRTTLNGEGLQHEDGHSHLMAGAIPNVRSYDPT 757 Query: 300 YAYEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMYCL---- 355 + YE+ VI+ GM+ M++ D +YY+T+ NEN P +P G + GI++GMY L Sbjct: 758 FGYEVTVILQHGMKAMMQDQIDEYYYLTLMNENYAHPDMPAG--AEQGIIKGMYLLKDAG 815 Query: 356 -APQADAQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERRARL 414 + + +V+LL +G +L+EA++AA +L + FG+TA++WS SF+EL +DG ER RL Sbjct: 816 KPKKGELRVQLLGSGAILREAIAAAELLHQDFGITADLWSCPSFSELRKDGFDTERWNRL 875 Query: 415 QPGAKGALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPARYVTLGTDGFGRSD 474 P ++ PYV TQQL++ Q P IA +DYVR ++ IRA+VP Y LGTDGFGRSD Sbjct: 876 HPDSEPRTPYV----TQQLENRQGPAIAATDYVRLFADQIRAFVPMHYTVLGTDGFGRSD 931 Query: 475 TRANLRDFFEVD 486 TR+NLR FFEVD Sbjct: 932 TRSNLRRFFEVD 943 >RSc1600 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Rso Ralstonia solanacearum Length = 896 Score = 526 bits (1354), Expect = e-149, Method: Compositional matrix adjust. Identities = 263/531 (49%), Positives = 357/531 (67%), Gaps = 17/531 (3%) Query: 3 KIHAAYHAAASHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFKLP 62 KI AA+ +A H+GQPTVILA+T KGYGMG AGE HQQKK+ + + R+RF +P Sbjct: 375 KIFAAFKSATEHKGQPTVILAKTIKGYGMGEAGEAMNIAHQQKKMPVDAIRKLRDRFNIP 434 Query: 63 ISDEQCKSLAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETH-ARF 121 ++D+Q + + + K S E++++ R LGG +P R AD L+VP + A Sbjct: 435 VADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKAD---ALQVPALAAFDALL 491 Query: 122 ALDAEGKEMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQVGIYSSQGQ 181 EG+E+S+TMA VR+L +LKD ++G++VVPIV DE+RTFGM LFRQVGI++ +GQ Sbjct: 492 KATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQ 551 Query: 182 LYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPFYIYYSMFG 241 Y P+D ++ Y+E++ GQ+L+EGI EAGA+ W AAATSYS HG+ M+PFYIYYSMFG Sbjct: 552 KYVPQDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVAMIPFYIYYSMFG 611 Query: 242 FQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNCVSYDPAYA 301 QRIGDL WAA D R+RGFL+G T+GRTTL GEGLQH+DG SHV A IPNC+SYDP + Sbjct: 612 IQRIGDLCWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVYHAAIPNCISYDPTFQ 671 Query: 302 YEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMYCLAPQAD- 360 YE+AV++ DG+RRM EDV+YY+TV NEN E P +P G + I++GMY + Sbjct: 672 YELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEAD--IIKGMYLFKKGVEN 729 Query: 361 ---AQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERRARLQPG 417 +V+LL +G + +E ++AA +L++ +GV +++W SFTELAR+G AA R L P Sbjct: 730 SNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREGNAAARWNLLHPT 789 Query: 418 AKGALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPARYVTLGTDGFGRSDTRA 477 +V + L+ + PVIA +DYVRT +E IRA+VP RYV LGTDGFGRSDTR Sbjct: 790 DAPRESHV----EKMLKGVRGPVIASTDYVRTFAEQIRAFVPRRYVVLGTDGFGRSDTRE 845 Query: 478 NLRDFFEVDARWI---AYTALAEVFGADAARLKDAAAKLGVDLDKPLSTSV 525 LR FFEVD W+ + ALA+ ++ +A K +D +KP +V Sbjct: 846 KLRHFFEVDRYWVTVASLKALADEGVLPREKVAEALKKYNLDPNKPNPMTV 896 >NMB1341 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Nme Neisseria meningitidis MC58 Length = 887 Score = 522 bits (1345), Expect = e-148, Method: Compositional matrix adjust. Identities = 262/495 (52%), Positives = 343/495 (69%), Gaps = 24/495 (4%) Query: 2 KKIHAAYHAAASH-RGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFK 60 +K++ AY AA+H G+PTVILA+T KGYGMGA+GEG+ HQ KK+D+ L FR+RF Sbjct: 365 QKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEGQNVAHQAKKMDKASLKQFRDRFD 424 Query: 61 LPISDEQCKS--LAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETH 118 +P++DEQ +S L + A D+ E K+L ARR +LGG +P+R + L VP + Sbjct: 425 IPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKPTQE---VLEVPELS-- 479 Query: 119 ARFALDAEGK-----EMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQV 173 A DA+ K E S+TMA VR+L ++LKD +G+ VVPIV DE+RTFGM +FRQ Sbjct: 480 ---AFDAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQY 536 Query: 174 GIYSSQGQLYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPF 233 GI++ +GQ Y P+D ++ Y+E+ DGQIL+EGI E GA++ W AAATSY+ M+PF Sbjct: 537 GIWNPKGQQYTPQDKDQLMFYKESVDGQILQEGINEPGAMADWIAAATSYANSNFAMIPF 596 Query: 234 YIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNC 293 YIYYSMFGFQRIGDL WAA D ARGFL+G T+GRTTL GEGLQH+DG SH+ A IPNC Sbjct: 597 YIYYSMFGFQRIGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQHEDGHSHIQADLIPNC 656 Query: 294 VSYDPAYAYEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMY 353 VSYDP + YE+AVIV DG+RRM NEDVFYY+T+ NEN P +P+G + IL+GMY Sbjct: 657 VSYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEG--AEQDILKGMY 714 Query: 354 CLAP--QADAQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERR 411 L + D +V+L+ +G +L+E ++ A +L+ FGV A++WS SF L RD + ER Sbjct: 715 LLKAGGKGDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERF 774 Query: 412 ARLQPGAKGALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPARYVTLGTDGFG 471 RL P +P+V T QLQ PVIA +DY+R+ ++ IRAY+P Y LGTDGFG Sbjct: 775 NRLHPLEAEKVPFV----TSQLQGHDGPVIAATDYIRSYADRIRAYIPNDYHVLGTDGFG 830 Query: 472 RSDTRANLRDFFEVD 486 RSD+RANLR FFEVD Sbjct: 831 RSDSRANLRRFFEVD 845 >NMA1554 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component NmA Neisseria meningitidis Z2491 Length = 887 Score = 522 bits (1344), Expect = e-147, Method: Compositional matrix adjust. Identities = 261/495 (52%), Positives = 343/495 (69%), Gaps = 24/495 (4%) Query: 2 KKIHAAYHAAASH-RGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFK 60 +K++ AY AA+H G+PTVILA+T KGYGMGA+GEG+ HQ KK+D+ L FR+RF Sbjct: 365 QKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEGQNVAHQAKKMDKASLKQFRDRFD 424 Query: 61 LPISDEQCKS--LAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETH 118 +P++DEQ +S L + A D+ E K+L ARR +LGG +P+R + L VP + Sbjct: 425 IPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKPTQE---VLEVPELS-- 479 Query: 119 ARFALDAEGK-----EMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQV 173 A DA+ K E S+TMA VR+L ++LKD +G+ VVPIV DE+RTFGM +FRQ Sbjct: 480 ---AFDAQLKSSGEREFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQY 536 Query: 174 GIYSSQGQLYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPF 233 GI++ +GQ Y P+D ++ Y+E+ DGQIL+EGI E GA++ W AAATSY+ M+PF Sbjct: 537 GIWNPKGQQYTPQDKDQLMFYKESVDGQILQEGINEPGAMADWIAAATSYANSNFAMIPF 596 Query: 234 YIYYSMFGFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNC 293 YIYYSMFGFQR+GDL WAA D ARGFL+G T+GRTTL GEGLQH+DG SH+ A IPNC Sbjct: 597 YIYYSMFGFQRVGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQHEDGHSHIQADLIPNC 656 Query: 294 VSYDPAYAYEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMY 353 VSYDP + YE+AVIV DG+RRM NEDVFYY+T+ NEN P +P+G + IL+GMY Sbjct: 657 VSYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEG--AEQDILKGMY 714 Query: 354 CLAP--QADAQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERR 411 L + D +V+L+ +G +L+E ++ A +L+ FGV A++WS SF L RD + ER Sbjct: 715 LLKAGGKGDKKVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERF 774 Query: 412 ARLQPGAKGALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPARYVTLGTDGFG 471 RL P +P+V T QLQ PVIA +DY+R+ ++ IRAY+P Y LGTDGFG Sbjct: 775 NRLHPLEAEKVPFV----TSQLQGHDGPVIAATDYIRSYADRIRAYIPNDYHVLGTDGFG 830 Query: 472 RSDTRANLRDFFEVD 486 RSD+RANLR FFEVD Sbjct: 831 RSDSRANLRRFFEVD 845