BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0346.p (429 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ECs5316 [GEPR] COG0477 Permeases of the major facilitator superf... 426 e-119 ZyjiZ [GEPR] COG0477 Permeases of the major facilitator superfam... 424 e-118 yjiZ [GEPR] COG0477 Permeases of the major facilitator superfami... 422 e-118 BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superf... 217 5e-56 yhaU [GEPR] COG0477 Permeases of the major facilitator superfami... 215 2e-55 >ECs5316 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 453 Score = 426 bits (1094), Expect = e-119, Method: Compositional matrix adjust. Identities = 208/427 (48%), Positives = 288/427 (67%), Gaps = 8/427 (1%) Query: 3 VQKSSKLKRIQWVALTFLMLAGIVNYLDRSTLSIANHSVSQELGLSASEMGLLLSAFSLA 62 VQ+S+++KRIQ A+ L A ++NYLDRS+LS+AN ++ +ELGLSA+E+G LLS FSLA Sbjct: 30 VQRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLA 89 Query: 63 YAFSQLPIGAMLDKFGARVMLGAGMMVWSVAQLAGGFVGSLHQFLVARVFLGLGEAPQFP 122 Y +QLP G +LD+ G R+MLG GM WS+ Q G V S QF++ R+ +G+GEAP P Sbjct: 90 YGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNP 149 Query: 123 AGAKVVSEWFAVRERGGPTGIFVASSTIGPALAPPILTVLMLSFGWRMMFVIMGIAGIAV 182 G KV+++WF ++ERG P G F A+STIG A++PPIL +ML GWR MF+ +G+ GI + Sbjct: 150 CGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFL 209 Query: 183 AVGWYIFYRNRNEVELTPSEMLYLADGTDN---DPNANAKLTWHEWKGLFKYRTTWGMLF 239 A+GWY+ YRNR VELT E YL G+ N DP L++ EW+ LF+ RT WGM+ Sbjct: 210 AIGWYMLYRNREHVELTAVEQAYLNAGSVNARRDP-----LSFAEWRSLFRNRTMWGMML 264 Query: 240 GFMGVIYMVWLYLTWLPAYLEHERHLSIARTGWVVVIPYIFGTLGMLSSGYIADGLMKRG 299 GF G+ Y WLYL WLP YL+ +L + TG + IP++FG GML +GY+ D L+K G Sbjct: 265 GFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGG 324 Query: 300 MAPIRSRKWPICAGLIGAGAFTIPAAYTPSTTMAIVYISLAMAFVNMASGGAWALVSVAI 359 MAPI+SRK I AG+ + AFT+ ++ MA++ I +A+ ++ A W L+ VA+ Sbjct: 325 MAPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALFCIHFAGTSCWGLIHVAV 384 Query: 360 PRRLVASLGSLQNFGGYLGGSLAPLITGIVVDKTHSFVNALLISAAVAFAAALVYMFVVN 419 R+ AS+GS+QNF ++ S AP+ITG +VD THSF AL+I V A AL Y+F+V Sbjct: 385 ASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIFLVR 444 Query: 420 KPIEGDR 426 +PI R Sbjct: 445 QPINDPR 451 >ZyjiZ [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 453 Score = 424 bits (1090), Expect = e-118, Method: Compositional matrix adjust. Identities = 207/427 (48%), Positives = 288/427 (67%), Gaps = 8/427 (1%) Query: 3 VQKSSKLKRIQWVALTFLMLAGIVNYLDRSTLSIANHSVSQELGLSASEMGLLLSAFSLA 62 VQ+S+++KRIQ A+ L A ++NYLDRS+LS+AN ++ +ELGLSA+E+G LLS FSLA Sbjct: 30 VQRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLA 89 Query: 63 YAFSQLPIGAMLDKFGARVMLGAGMMVWSVAQLAGGFVGSLHQFLVARVFLGLGEAPQFP 122 Y +QLP G +LD+ G R+MLG GM WS+ Q G V S QF++ R+ +G+GEAP P Sbjct: 90 YGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHSFTQFVLVRIGMGIGEAPMNP 149 Query: 123 AGAKVVSEWFAVRERGGPTGIFVASSTIGPALAPPILTVLMLSFGWRMMFVIMGIAGIAV 182 G KV+++WF ++ERG P G F A+STIG A++PPIL +ML GWR MF+ +G+ GI + Sbjct: 150 CGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFL 209 Query: 183 AVGWYIFYRNRNEVELTPSEMLYLADGTDN---DPNANAKLTWHEWKGLFKYRTTWGMLF 239 A+GWY+ YRNR VELT E YL G+ N DP L++ EW+ LF+ RT WGM+ Sbjct: 210 AIGWYMLYRNREHVELTAVEQAYLNAGSVNARRDP-----LSFAEWRSLFRNRTMWGMML 264 Query: 240 GFMGVIYMVWLYLTWLPAYLEHERHLSIARTGWVVVIPYIFGTLGMLSSGYIADGLMKRG 299 GF G+ Y WLYL WLP YL+ +L + TG + IP++FG GML +GY+ D L+K G Sbjct: 265 GFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGG 324 Query: 300 MAPIRSRKWPICAGLIGAGAFTIPAAYTPSTTMAIVYISLAMAFVNMASGGAWALVSVAI 359 MAPI+SRK I AG+ + AFT+ ++ MA++ I +A+ ++ A W L+ VA+ Sbjct: 325 MAPIKSRKICIIAGMFCSAAFTLIVPQATTSMMAVLLIGMALFCIHFAGTSCWGLIHVAV 384 Query: 360 PRRLVASLGSLQNFGGYLGGSLAPLITGIVVDKTHSFVNALLISAAVAFAAALVYMFVVN 419 R+ AS+GS+QNF ++ S AP+ITG +VD THSF AL+I V A AL Y+F+V Sbjct: 385 ASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIFLVR 444 Query: 420 KPIEGDR 426 +P+ R Sbjct: 445 QPLNDPR 451 >yjiZ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 453 Score = 422 bits (1086), Expect = e-118, Method: Compositional matrix adjust. Identities = 206/427 (48%), Positives = 287/427 (67%), Gaps = 8/427 (1%) Query: 3 VQKSSKLKRIQWVALTFLMLAGIVNYLDRSTLSIANHSVSQELGLSASEMGLLLSAFSLA 62 VQ+S+++KRIQ A+ L A ++NYLDRS+LS+AN ++ +ELGLSA+E+G LLS FSLA Sbjct: 30 VQRSTRIKRIQTTAMLLLFFAAVINYLDRSSLSVANLTIREELGLSATEIGALLSVFSLA 89 Query: 63 YAFSQLPIGAMLDKFGARVMLGAGMMVWSVAQLAGGFVGSLHQFLVARVFLGLGEAPQFP 122 Y +QLP G +LD+ G R+MLG GM WS+ Q G V + QF++ R+ +G+GEAP P Sbjct: 90 YGIAQLPCGPLLDRKGPRLMLGLGMFFWSLFQAMSGMVHNFTQFVLVRIGMGIGEAPMNP 149 Query: 123 AGAKVVSEWFAVRERGGPTGIFVASSTIGPALAPPILTVLMLSFGWRMMFVIMGIAGIAV 182 G KV+++WF ++ERG P G F A+STIG A++PPIL +ML GWR MF+ +G+ GI + Sbjct: 150 CGVKVINDWFNIKERGRPMGFFNAASTIGVAVSPPILAAMMLVMGWRGMFITIGVLGIFL 209 Query: 183 AVGWYIFYRNRNEVELTPSEMLYLADGTDN---DPNANAKLTWHEWKGLFKYRTTWGMLF 239 A+GWY+ YRNR VELT E YL G+ N DP L++ EW+ LF+ RT WGM+ Sbjct: 210 AIGWYMLYRNREHVELTAVEQAYLNAGSVNARRDP-----LSFAEWRSLFRNRTMWGMML 264 Query: 240 GFMGVIYMVWLYLTWLPAYLEHERHLSIARTGWVVVIPYIFGTLGMLSSGYIADGLMKRG 299 GF G+ Y WLYL WLP YL+ +L + TG + IP++FG GML +GY+ D L+K G Sbjct: 265 GFSGINYTAWLYLAWLPGYLQTAYNLDLKSTGLMAAIPFLFGAAGMLVNGYVTDWLVKGG 324 Query: 300 MAPIRSRKWPICAGLIGAGAFTIPAAYTPSTTMAIVYISLAMAFVNMASGGAWALVSVAI 359 MAPI+SRK I AG+ + AFT+ ++ A++ I +A+ ++ A W L+ VA+ Sbjct: 325 MAPIKSRKICIIAGMFCSAAFTLIVPQATTSMTAVLLIGMALFCIHFAGTSCWGLIHVAV 384 Query: 360 PRRLVASLGSLQNFGGYLGGSLAPLITGIVVDKTHSFVNALLISAAVAFAAALVYMFVVN 419 R+ AS+GS+QNF ++ S AP+ITG +VD THSF AL+I V A AL Y+F+V Sbjct: 385 ASRMTASVGSIQNFASFICASFAPIITGFIVDTTHSFRLALIICGCVTAAGALAYIFLVR 444 Query: 420 KPIEGDR 426 +PI R Sbjct: 445 QPINDPR 451 >BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 455 Score = 217 bits (552), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 142/435 (32%), Positives = 216/435 (49%), Gaps = 16/435 (3%) Query: 2 EVQKSSKLKRIQWVALTFLMLAGIVNYLDRSTLSIANHSVSQELGLSASEMGLLLSAFSL 61 V + K ++W + L L +NY DR+TLSI SV +LGL + MG + SAF Sbjct: 7 SVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGW 66 Query: 62 AYAFSQLPIGAMLDKFGARVMLGAGMMVWSVAQLAGGFVG------SLHQFLVARVFLGL 115 AY QLP G +LD+FG++ ++ + WS L G +G ++ R +GL Sbjct: 67 AYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGFFSAGTAIILLFALRFLVGL 126 Query: 116 GEAPQFPAGAKVVSEWFAVRERGGPTGIFVASSTIGPALAPPILTVLMLSFGWRMMFVIM 175 EAP FP +VV+ WF ERG + F ++ + PP++ L SFGW +FV+M Sbjct: 127 SEAPSFPGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFPPLMGWLTHSFGWHSVFVVM 186 Query: 176 GIAGIAVAVGWY-IFYRNRNEVELTPSEMLYLADG------TDNDPNANAKLTWHEWKGL 228 GIAGI +AV W Y + ++ +E+ Y+ G D+ + W K L Sbjct: 187 GIAGILLAVIWLKTVYEPKKHPKVNEAELAYIEQGGGLISMDDSKSKQETESKWPYIKQL 246 Query: 229 FKYRTTWGMLFGFMGVIYMVWLYLTWLPAYLEHERHLSIARTGWVVVIPYIFGTLGMLSS 288 R G+ + + + +LTW P YL R +SI G+V +P + G G + Sbjct: 247 LTNRMLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLG 306 Query: 289 GYIADGLMKRGMAPIRSRKWPICAGLIGAGAFTIPAAYTPSTTMAIVYISLAMAFVNMAS 348 G ++D L+K+G + +RK PI AG++ + + + YT S + +V +SLA + Sbjct: 307 GIVSDILLKKGRSLTFARKVPIIAGMLLSCSMIV-CNYTDSAWLVVVIMSLAFFGKGFGA 365 Query: 349 GGAWALVSVAIPRRLVASLGSLQNFGGYLGGSLAPLITGIVVDKTHSFVNALLISAAVAF 408 G WA+VS P+ G L N G + P+I G +V+ T SF AL+ A A Sbjct: 366 LG-WAVVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAI 424 Query: 409 AAALVYMFVVNKPIE 423 AA L Y+ +V PI+ Sbjct: 425 AAILSYLLLVG-PIK 438 >yhaU [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 444 Score = 215 bits (547), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 142/434 (32%), Positives = 216/434 (49%), Gaps = 23/434 (5%) Query: 3 VQKSSKLKRIQWVALTFLMLAGIVNYLDRSTLSIANHSVSQELGLSASEMGLLLSAFSLA 62 V + K +++ L + + VNY DR+TLSIA V++EL LSA MG + SAF A Sbjct: 6 VDEKKKGVHTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWA 65 Query: 63 YAFSQLPIGAMLDKFGARVMLGAGMMVWSVAQLAGGFVGSLH------QFLVARVFLGLG 116 Y Q+P G +LDKFG++ + + WS+ GFV R LG Sbjct: 66 YLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFMLGFS 125 Query: 117 EAPQFPAGAKVVSEWFAVRERGGPTGIFVASSTIGPALAPPILTVLMLSFGWRMMFVIMG 176 EAP FPA A++V+ WF +ERG + IF ++ AL P+L L ++GW +F +MG Sbjct: 126 EAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMG 185 Query: 177 IAGIAVAVGWYIFYRN-RNEVELTPSEMLYLA------DGTDNDPNANA----KLTWHEW 225 + G + W N + ++ E+ +++ D P + A KL H Sbjct: 186 VIGFVLTALWIKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPGSAAASGPKL--HYI 243 Query: 226 KGLFKYRTTWGMLFGFMGVIYMVWLYLTWLPAYLEHERHLSIARTGWVVVIPYIFGTLGM 285 K L R G+ FG + + W +LTW P YL E+ +SI + G V IP + G G Sbjct: 244 KQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGG 303 Query: 286 LSSGYIADGLMKRGMAPIRSRKWPICAGLIGAGAFTIPAAYTPSTTMAIVYISLAMAFVN 345 + G +D L+KRG++ +RK PI G++ A I YT +TT+ ++ +A+AF Sbjct: 304 VLGGVFSDYLIKRGLSLTLARKLPIVLGMLLAST-IILCNYTNNTTLVVML--MALAFFG 360 Query: 346 MASGG-AWALVSVAIPRRLVASLGSLQNFGGYLGGSLAPLITGIVVDKTHSFVNALLISA 404 G W ++S P+ +V G + N G + + PL+ G +V + HSF AL+ Sbjct: 361 KGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVG 420 Query: 405 AVAFAAALVYMFVV 418 A A + Y+FVV Sbjct: 421 CSALMAMVCYLFVV 434