BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0336.p (304 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2192 [H] COG0408 Coproporphyrinogen III oxidase Rso Ralstonia... 450 e-126 PA0024 [H] COG0408 Coproporphyrinogen III oxidase Pae Pseudomona... 405 e-113 hemF [H] COG0408 Coproporphyrinogen III oxidase Eco Escherichia ... 403 e-112 STM2451 [H] COG0408 Coproporphyrinogen III oxidase Sty Salmonell... 395 e-110 ECs3307 [H] COG0408 Coproporphyrinogen III oxidase Ecs Escherich... 392 e-109 >RSc2192 [H] COG0408 Coproporphyrinogen III oxidase Rso Ralstonia solanacearum Length = 302 Score = 450 bits (1157), Expect = e-126, Method: Compositional matrix adjust. Identities = 216/302 (71%), Positives = 246/302 (81%), Gaps = 6/302 (1%) Query: 7 ASTIKAYLQDLQHRIVAALEGVDGKSFLTDSWERPEG----GGGISRIIEEGNVFERGGV 62 ++AYL DLQ RI A+ +DG +F+TD+W++P G G + I+E G V ERGGV Sbjct: 3 TQAVRAYLLDLQDRITTAVGTLDGGTFVTDTWDKPPTERLRGSGRTCILENGAVLERGGV 62 Query: 63 GFSHVMGKNLPPSAAANRPEIAGREWEAMGVSLVLHPRNPYAPTVHMNVRFFVAKADGQN 122 GFSHVMG LPPSA ANRPE+AGR +EAMGVSLV HPRNPYAPTVHMNVR FVA+ + Sbjct: 63 GFSHVMGDTLPPSATANRPELAGRGFEAMGVSLVFHPRNPYAPTVHMNVRCFVAQR--PD 120 Query: 123 QEPVWWFGGGMDLTPYYGFAEDATHFHRSCRDALAPFGDELHPRFKKWCDEYFYLKHRKE 182 EPVWWFGGGMDLTPYYGFAEDA HFHR+C+ AL PFG+EL+PRFK+WCD+YFYLKHRKE Sbjct: 121 AEPVWWFGGGMDLTPYYGFAEDAAHFHRTCKQALEPFGEELYPRFKQWCDDYFYLKHRKE 180 Query: 183 ARGVGGIFFDDFNALPLDESFALMRSVGDGFIGAYLPILELRKDTPYGERERDFQAYRRG 242 ARGVGGIFFDDF L + SF +MR+VGD + A+LPI E R TPYGERER FQAYRRG Sbjct: 181 ARGVGGIFFDDFAELGFERSFEMMRAVGDALLPAWLPIAEQRHATPYGERERAFQAYRRG 240 Query: 243 RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVVKWRYDWQPPDGSPEARLYSDFLPHKE 302 RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPV WRYDWQP GSPEA LY+DFLP ++ Sbjct: 241 RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYDWQPEPGSPEAALYTDFLPARD 300 Query: 303 WI 304 W+ Sbjct: 301 WV 302 >PA0024 [H] COG0408 Coproporphyrinogen III oxidase Pae Pseudomonas aeruginosa Length = 305 Score = 405 bits (1041), Expect = e-113, Method: Compositional matrix adjust. Identities = 191/302 (63%), Positives = 236/302 (78%), Gaps = 3/302 (0%) Query: 4 TATASTIKAYLQDLQHRIVAALEGVDGKS-FLTDSWERPEGGGGISRIIEEGNVFERGGV 62 T + +K YL DLQ RI AALE DGK+ F D+WERP GGGG +R+I +G + E+GGV Sbjct: 2 TDRIAAVKTYLLDLQDRICAALEAEDGKARFAEDAWERPAGGGGRTRVIGDGALIEKGGV 61 Query: 63 GFSHVMGKNLPPSAAANRPEIAGREWEAMGVSLVLHPRNPYAPTVHMNVRFFVAKADGQN 122 FSHV G +LPPSA+A+RPE+AGR ++A+GVSLV+HP NP+ PT H NVRFF A+ +G+ Sbjct: 62 NFSHVFGDSLPPSASAHRPELAGRGFQALGVSLVIHPENPHVPTSHANVRFFCAEKEGE- 120 Query: 123 QEPVWWFGGGMDLTPYYGFAEDATHFHRSCRDALAPFGDELHPRFKKWCDEYFYLKHRKE 182 EPVWWFGGG DLTPYY ED H+HR RDA APFG +++PR+K+WCD YF+LKHR E Sbjct: 121 -EPVWWFGGGFDLTPYYAHEEDCVHWHRVARDACAPFGADVYPRYKEWCDRYFHLKHRNE 179 Query: 183 ARGVGGIFFDDFNALPLDESFALMRSVGDGFIGAYLPILELRKDTPYGERERDFQAYRRG 242 RG+GG+FFDD N D FA +R++GD +I AYLPI++ RK TP+ ER+R+FQAYRRG Sbjct: 180 PRGIGGLFFDDLNQWDFDTCFAFIRAIGDAYIDAYLPIVQRRKHTPFDERQREFQAYRRG 239 Query: 243 RYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVVKWRYDWQPPDGSPEARLYSDFLPHKE 302 RYVEFNLVFDRGTLFGLQSGGRTESILMS+PP V+W YDW+P GS EARL FL ++ Sbjct: 240 RYVEFNLVFDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKPEPGSEEARLTEYFLADRD 299 Query: 303 WI 304 W+ Sbjct: 300 WL 301 >hemF [H] COG0408 Coproporphyrinogen III oxidase Eco Escherichia coli K12 Length = 299 Score = 403 bits (1035), Expect = e-112, Method: Compositional matrix adjust. Identities = 189/298 (63%), Positives = 231/298 (77%), Gaps = 3/298 (1%) Query: 7 ASTIKAYLQDLQHRIVAALEGVDGKSFLTDSWERPEGGGGISRIIEEGNVFERGGVGFSH 66 A +K +L +LQ I L VDG F+ DSW+R GGGG SR++ G VFE+ GV FSH Sbjct: 5 AHQVKQFLLNLQDTICQQLTAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSH 64 Query: 67 VMGKNLPPSAAANRPEIAGREWEAMGVSLVLHPRNPYAPTVHMNVRFFVAKADGQNQEPV 126 V G+ +P SA A+RPE+AGR +EAMGVSLV+HP NPY PT H NVRFF+A+ G + PV Sbjct: 65 VHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAD--PV 122 Query: 127 WWFGGGMDLTPYYGFAEDATHFHRSCRDALAPFGDELHPRFKKWCDEYFYLKHRKEARGV 186 WWFGGG DLTP+YGF EDA H+HR+ RD PFG++++PR+KKWCDEYFYLKHR E RG+ Sbjct: 123 WWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDEYFYLKHRNEQRGI 182 Query: 187 GGIFFDDFNALPLDESFALMRSVGDGFIGAYLPILELRKDTPYGERERDFQAYRRGRYVE 246 GG+FFDD N D FA M++VG G+ AYLPI+E RK YGERER+FQ YRRGRYVE Sbjct: 183 GGLFFDDLNTPDFDRCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGRYVE 242 Query: 247 FNLVFDRGTLFGLQSGGRTESILMSMPPVVKWRYDWQPPDGSPEARLYSDFLPHKEWI 304 FNLV+DRGTLFGLQ+GGRTESILMSMPP+V+W YD+QP DGSPEA L S+F+ ++W+ Sbjct: 243 FNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAAL-SEFIKVRDWV 299 >STM2451 [H] COG0408 Coproporphyrinogen III oxidase Sty Salmonella typhimurium LT2 Length = 299 Score = 395 bits (1016), Expect = e-110, Method: Compositional matrix adjust. Identities = 188/298 (63%), Positives = 228/298 (76%), Gaps = 3/298 (1%) Query: 7 ASTIKAYLQDLQHRIVAALEGVDGKSFLTDSWERPEGGGGISRIIEEGNVFERGGVGFSH 66 A +K +L LQ I L VDG +F+ DSW R GGGG SR++ G +FE+ GV FSH Sbjct: 5 AHHVKQFLLRLQDDICQTLSAVDGANFVEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSH 64 Query: 67 VMGKNLPPSAAANRPEIAGREWEAMGVSLVLHPRNPYAPTVHMNVRFFVAKADGQNQEPV 126 V G +P SA A+RPE+AGR +EAMGVSLV+HP NPY PT H NVRFF+A+ G +PV Sbjct: 65 VHGDAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGA--DPV 122 Query: 127 WWFGGGMDLTPYYGFAEDATHFHRSCRDALAPFGDELHPRFKKWCDEYFYLKHRKEARGV 186 WWFGGG DLTPYYGF EDA H+HR+ RD PFGD+++PR+KKWCD+YF+LKHR E RGV Sbjct: 123 WWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVYPRYKKWCDDYFFLKHRNEQRGV 182 Query: 187 GGIFFDDFNALPLDESFALMRSVGDGFIGAYLPILELRKDTPYGERERDFQAYRRGRYVE 246 GG+FFDD N D F M++VG+G+ AYLPI+E RK +GERER+FQ YRRGRYVE Sbjct: 183 GGLFFDDLNTPDFDHCFDFMQAVGNGYTRAYLPIVERRKAMVWGERERNFQLYRRGRYVE 242 Query: 247 FNLVFDRGTLFGLQSGGRTESILMSMPPVVKWRYDWQPPDGSPEARLYSDFLPHKEWI 304 FNLV+DRGTLFGLQ+GGRTESILMSMPP+V+W YDWQP GSPEA L S+F+ ++WI Sbjct: 243 FNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAAL-SEFIQVRDWI 299 >ECs3307 [H] COG0408 Coproporphyrinogen III oxidase Ecs Escherichia coli O157:H7 Length = 299 Score = 392 bits (1008), Expect = e-109, Method: Compositional matrix adjust. Identities = 189/298 (63%), Positives = 230/298 (77%), Gaps = 3/298 (1%) Query: 7 ASTIKAYLQDLQHRIVAALEGVDGKSFLTDSWERPEGGGGISRIIEEGNVFERGGVGFSH 66 A +K +L +LQ I L VDG F+ DSW+R GGGG SR++ G VFE+ GV FSH Sbjct: 5 AHQVKQFLLNLQDTICQQLTAVDGAEFVEDSWQREGGGGGRSRVLRNGGVFEQAGVNFSH 64 Query: 67 VMGKNLPPSAAANRPEIAGREWEAMGVSLVLHPRNPYAPTVHMNVRFFVAKADGQNQEPV 126 V G+ +P SA A+RPE+AGR +EAMGVSLV+HP NPY PT H NVRFF+A+ G EPV Sbjct: 65 VHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGA--EPV 122 Query: 127 WWFGGGMDLTPYYGFAEDATHFHRSCRDALAPFGDELHPRFKKWCDEYFYLKHRKEARGV 186 WWFGGG DLTP+YGF EDA H+HR+ RD PFG +++PR+KKWCD+YFYLKHR E RG+ Sbjct: 123 WWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGKDVYPRYKKWCDDYFYLKHRNEQRGI 182 Query: 187 GGIFFDDFNALPLDESFALMRSVGDGFIGAYLPILELRKDTPYGERERDFQAYRRGRYVE 246 GG+FFDD N D FA M++VG G+ AYLPI+E RK YGERER+FQ YRRGRYVE Sbjct: 183 GGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGRYVE 242 Query: 247 FNLVFDRGTLFGLQSGGRTESILMSMPPVVKWRYDWQPPDGSPEARLYSDFLPHKEWI 304 FNLV+DRGTLFGLQ+GGRTESILMSMPP+V+W YD+QP DGSPEA L S+F+ ++W+ Sbjct: 243 FNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAAL-SEFIKVRDWV 299