BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0276.p (314 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGc2648 [GER] COG0697 Permeases of the drug/metabolite transport... 308 7e-84 RSc0233 [GER] COG0697 Permeases of the drug/metabolite transport... 266 5e-71 CC0848 [GER] COG0697 Permeases of the drug/metabolite transporte... 248 1e-65 RSc1428 [GER] COG0697 Permeases of the drug/metabolite transport... 213 4e-55 ytfF [GER] COG0697 Permeases of the drug/metabolite transporter ... 151 2e-36 >AGc2648 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 310 Score = 308 bits (790), Expect = 7e-84, Method: Compositional matrix adjust. Identities = 158/309 (51%), Positives = 219/309 (70%), Gaps = 1/309 (0%) Query: 1 MKSNILVGVGNGVAAGAFWGLVFLAPQVLGSFSALQLSAARYLAYGVVAVLLLAPRWRTL 60 M + +GV G+ AGA WG +FLAP+++ FSALQLS ARYL YG+++++++ PR + + Sbjct: 1 MNNRTGLGVFYGMLAGALWGGIFLAPKLVPDFSALQLSTARYLTYGLISLIIIGPRLKRV 60 Query: 61 SGRLGRAEWLALAYLSLLGNILYYLFLASAVQWAGGASTSLIIGLLPVVVTLVGARDEGA 120 S G EW+AL +LS++GNI YY+F+++AV+ +G A TS+IIG LPV VT++G+RD GA Sbjct: 61 SAHFGAREWIALGWLSMIGNIAYYVFISTAVKLSGVAFTSIIIGFLPVAVTIIGSRDHGA 120 Query: 121 LKLSSLMAPLALCLLGVGLVGVQALSAEHATTDLATRAAGLLCAFGALASWSVYSVRNSR 180 + L L LA +G+ + Q+L+ A D+ +R GL A GALASW+ ++V N+R Sbjct: 121 VSLKRLWPSLAFGAIGIVGISWQSLTENDAGLDV-SRLIGLASALGALASWTAFAVGNAR 179 Query: 181 WLSRRPDISSHDWSLLTGVVTGALALLLVVPAFTQGMDGHGGSDWLRFWAVAAAVAIFAS 240 WLSR D+S+ DW+++TGVVTG LALLL +PAF G + H DWL F A+AA + AS Sbjct: 180 WLSRLHDVSADDWNMMTGVVTGGLALLLAIPAFGFGGESHSSGDWLHFAAIAAGLGFTAS 239 Query: 241 VVGNAFWNRASRLLPLTLTGQMIIFETLFALLYGFLWEQRWPTRLEVLAIVCLVSGVVWC 300 ++GNAFWNR SR+LPLT+ GQMI+FETLFALLYGFLWE PT +E++AI +V VV C Sbjct: 240 ILGNAFWNRMSRMLPLTMVGQMILFETLFALLYGFLWEGHGPTFVEIVAICSVVLSVVLC 299 Query: 301 ASLHRSHAM 309 HR + Sbjct: 300 MRAHRPEKV 308 >RSc0233 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 326 Score = 266 bits (679), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 164/307 (53%), Positives = 204/307 (66%), Gaps = 5/307 (1%) Query: 2 KSNILVGVGNGVAAGAFWGLVFLAPQVLGSFSALQLSAARYLAYGVVAVLLLAPRWRTLS 61 + + L G+G G+AAGA WG++F+AP++L +FS L LSAARYL YGV+++ L P WR L Sbjct: 20 RRDRLTGLGCGIAAGALWGIIFVAPRMLPAFSPLALSAARYLLYGVLSLALALPVWRPLW 79 Query: 62 GRLGRAEWLALAYLSLLGNILYYLFLASAVQWAGGASTSLIIGLLPVVVTLVGARDEGAL 121 + R +WLAL LSL GN+LYYL +A VQ AG A SLI+GLLPV VTL GA + G+L Sbjct: 80 RKTTRRDWLALVLLSLPGNVLYYLCVAGGVQRAGVAPVSLIVGLLPVTVTLAGAAEHGSL 139 Query: 122 KLSSLMAPLALCLLGVGLVGVQALSAEHATTDLATRAAGLLCAFGALASWSVYSVRNSRW 181 L L PL + GV + A A A AT GLL A GALA W+VY+V N+R+ Sbjct: 140 PLRRLALPLLMAAAGVACIYADA-PATQAGAGGATHLLGLLMAAGALACWTVYAVCNARY 198 Query: 182 LSRRPDISSHDWSLLTGVVTGALALLLVVPAF-TQGM---DGHGGSDWLRFWAVAAAVAI 237 L R P +S +WSLLTG+ TGAL+L+L VPAF GM S W FW V VA+ Sbjct: 199 LRRHPQFTSREWSLLTGIATGALSLVLAVPAFLMPGMATAAPQPASAWGLFWLVNTGVAL 258 Query: 238 FASVVGNAFWNRASRLLPLTLTGQMIIFETLFALLYGFLWEQRWPTRLEVLAIVCLVSGV 297 ASV+GN+ WN ASR LPLTL+GQMI+FET+FALLYGF+ E RWP LEV A + L+SGV Sbjct: 259 GASVLGNSLWNTASRKLPLTLSGQMIVFETVFALLYGFIQEGRWPHGLEVAAALLLMSGV 318 Query: 298 VWCASLH 304 A H Sbjct: 319 GLAARRH 325 >CC0848 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Ccr Caulobacter vibrioides Length = 312 Score = 248 bits (634), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 155/294 (52%), Positives = 200/294 (68%), Gaps = 1/294 (0%) Query: 12 GVAAGAFWGLVFLAPQVLGSFSALQLSAARYLAYGVVAVLLLAPRWRTLSGRLGRAEWLA 71 GV AGAFWG VFLAP++L F+ LQ +A RYLAYG+ A +LLAP W+ + R+ +W Sbjct: 14 GVIAGAFWGGVFLAPKLLADFTPLQATAGRYLAYGLAAAVLLAPSWKAVMARMDGRDWRD 73 Query: 72 LAYLSLLGNILYYLFLASAVQWAGGASTSLIIGLLPVVVTLVGARDEGALKLSSLMAPLA 131 L LSLLGN++YY+ LA AVQ AG A SL+IGLLPV +TLVGA+ L L+ PLA Sbjct: 74 LLLLSLLGNLIYYVGLAIAVQSAGVALASLVIGLLPVTITLVGAKAGEGTPLRRLVWPLA 133 Query: 132 LCLLGVGLVGVQALSAEHATTDLATRAAGLLCAFGALASWSVYSVRNSRWLSRRPDISSH 191 L + G + + A +A ++ GLL A ALA W+ Y+V N+R L+ P +SH Sbjct: 134 LIVAGGVCINLDAFAAA-GRAGMSKTLVGLLGALLALAVWTAYAVWNARRLAATPKFNSH 192 Query: 192 DWSLLTGVVTGALALLLVVPAFTQGMDGHGGSDWLRFWAVAAAVAIFASVVGNAFWNRAS 251 +WSLLTGV TG L+L++VVPAF H W FW V+ AVAI ASV+GN WN AS Sbjct: 193 EWSLLTGVATGLLSLVIVVPAFAFDGKTHAAGAWGLFWGVSFAVAIGASVIGNGLWNAAS 252 Query: 252 RLLPLTLTGQMIIFETLFALLYGFLWEQRWPTRLEVLAIVCLVSGVVWCASLHR 305 RLLPL+L+GQ+I+FET+FALLYGFL E RWP LE +A+ +++GV+W A LHR Sbjct: 253 RLLPLSLSGQLIVFETVFALLYGFLHEGRWPRSLESVAMALMLAGVLWSARLHR 306 >RSc1428 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 313 Score = 213 bits (543), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 144/306 (47%), Positives = 193/306 (63%), Gaps = 9/306 (2%) Query: 7 VGVGNGVAAGAFWGLVFLAPQVLGSFSALQLSAARYLAYGVVAVLLLAPRWRTLSGRLGR 66 +GV + AGA WG+VF+AP+ L +FS +L+ RYLAYG +A L AP ++ +L R Sbjct: 3 IGVLCALLAGAMWGMVFIAPRALPAFSPWELALGRYLAYGAIAALAAAPILPRIARKLTR 62 Query: 67 AEWLALAYLSLLGNILYYLFLASAVQWAGGASTSLIIGLLPVVVTLVGARDEGALKLSSL 126 A+ LAL + GN++YY+ LA VQ AG A SLIIG+LP+ VT++G RD GA+ LS L Sbjct: 63 ADCLALMRQACSGNLVYYVLLAFGVQLAGVAPVSLIIGVLPITVTVLGRRDHGAVPLSRL 122 Query: 127 MAPLALCLLGVGLVGVQALSAEHATTDLA----TRAAGLLCAFGALASWSVYSVRNSRWL 182 PL + G+ + + S + A +R AG+ CA GAL SW+ Y++ N+R L Sbjct: 123 AWPLLVVAAGIACINIDLFSHDAVAAGDAHPIWSRIAGIACAAGALCSWTWYAIDNARHL 182 Query: 183 SRRPDISSHDWSLLTGVVTGALALLLVVPAFTQGM----DGHGGSDWLRFWAVAAAVAIF 238 R P SS++WS L G+ TGAL+ L A +G GG W FWAV AAVA+ Sbjct: 183 QRNPHFSSNEWSALYGISTGALSAALTAAAVLAAGTGWAEG-GGRVWTTFWAVNAAVALG 241 Query: 239 ASVVGNAFWNRASRLLPLTLTGQMIIFETLFALLYGFLWEQRWPTRLEVLAIVCLVSGVV 298 AS++GN WN A+R LPLTL+GQMI+FETLFAL YGF+++ RWP LE+ AI L+ GV Sbjct: 242 ASLIGNNLWNIAARRLPLTLSGQMIVFETLFALAYGFVYDHRWPRPLEMAAIALLIVGVG 301 Query: 299 WCASLH 304 W LH Sbjct: 302 WSVRLH 307 >ytfF [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Eco Escherichia coli K12 Length = 324 Score = 151 bits (382), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 109/303 (35%), Positives = 165/303 (54%), Gaps = 15/303 (4%) Query: 8 GVGNGVAAGAFWGLVFLAPQVLGSFSALQLSAARYLAYGVVAVLLLAPRWRTLSGRLGRA 67 GV + AG WGL+F+ P ++ + A+ S RYLA G++A L +A R +L R Sbjct: 7 GVLYALLAGLMWGLIFVGPLIVPEYPAMLQSMGRYLALGLIA-LPIAWLGRVRLRQLARR 65 Query: 68 EWLALAYLSLLGNILYYLFLASAVQWAGGASTSLIIGLLPVVV----TLVGARDEGALKL 123 +WL L+++GN++YY LASA+Q G +++IIG LPVV+ L+ ++ +G L Sbjct: 66 DWLTALMLTMMGNLIYYFCLASAIQRTGAPVSTMIIGTLPVVIPVFANLLYSQRDGKLAW 125 Query: 124 SSLMAPLALCLLGVGLVGVQALSAEHATTDL--ATRAAGLLCAFGALASWSVYSVRNSRW 181 L AP +C+ G+GL V H D A +G++ A ++ W+ Y++RN+RW Sbjct: 126 GKL-APALICI-GIGLACVNIAELNHGLPDFDWARYTSGIVLALVSVVCWAWYALRNARW 183 Query: 182 LSRRPDISSHDWSLLTGVVTGALALL-LVVPAF---TQGMDGH--GGSDWLRFWAVAAAV 235 L PD W+ +VT ++L+ +V + TQ D G L F ++ A+ Sbjct: 184 LRENPDKHPMMWATAQALVTLPVSLIGYLVACYWLNTQTPDFSLPFGPRPLVFISLMVAI 243 Query: 236 AIFASVVGNAFWNRASRLLPLTLTGQMIIFETLFALLYGFLWEQRWPTRLEVLAIVCLVS 295 A+ S VG WN AS+LLP + G +I+FETL LLY FL Q+ P + + I LV Sbjct: 244 AVLCSWVGALCWNVASQLLPTVILGPLIVFETLAGLLYTFLLRQQMPPLMTLSGIALLVI 303 Query: 296 GVV 298 GVV Sbjct: 304 GVV 306