BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0205.p (425 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value AGc5098 [MR] COG4948 L-alanine-DL-glutamate epimerase and relate... 697 0.0 BMEI1707 [MR] COG4948 L-alanine-DL-glutamate epimerase and relat... 681 0.0 YPO1567 [MR] COG4948 L-alanine-DL-glutamate epimerase and relate... 668 0.0 SMb21113 [MR] COG4948 L-alanine-DL-glutamate epimerase and relat... 643 0.0 AGl1470 [MR] COG4948 L-alanine-DL-glutamate epimerase and relate... 125 1e-28 >AGc5098 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 425 Score = 697 bits (1798), Expect = 0.0, Method: Compositional matrix adjust. Identities = 324/423 (76%), Positives = 371/423 (87%) Query: 1 MTTITSMRVLDVRFPTSKTLDGSDAMNPDPDYSAAYVILETDQSGLEGHGLTFTIGRGNE 60 MT IT +RV D+RFPTS++LDGSDAMNPDPDYSAAYVIL+TD+ L+GHGLTFTIGRGN+ Sbjct: 1 MTKITDLRVFDLRFPTSQSLDGSDAMNPDPDYSAAYVILDTDEPRLKGHGLTFTIGRGND 60 Query: 61 ICCAAIKAMEHLVVGLDLAWVSEDMGRFWRTITSDSQLRWIGPDKGAIHLATGAVVNAVW 120 ICC AI+AM HLVVG DLA V+E+ G++WR +TSDSQLRWIGPDKGA+HLATGAVVNAVW Sbjct: 61 ICCMAIEAMRHLVVGTDLATVTENPGKYWRHLTSDSQLRWIGPDKGAMHLATGAVVNAVW 120 Query: 121 DLWAKAEGKPLWKLVAGMSPEELVRSIDFRYITDCITPDEALALLRAQAPGKAERIRLLE 180 DL AK GKP+W+LVA MSPEE+ +D+RY+TD +T D+ALA+LR GK ERI L+ Sbjct: 121 DLLAKKAGKPVWQLVADMSPEEIADIVDYRYLTDVLTRDDALAILRRAEAGKKERIETLK 180 Query: 181 QNGYPCYTTSAGWLGYDDAKLRRLCKEAIDGGFNHIKLKVGRDLADDKRRVTIAREVIGP 240 GY CYTTSAGWLGYDDAKLRRLC+EAID GFNH+K+KVGRDL DD RR+TI REVIGP Sbjct: 181 NEGYACYTTSAGWLGYDDAKLRRLCQEAIDAGFNHVKMKVGRDLEDDIRRLTITREVIGP 240 Query: 241 DRHLMIDANQVWEVDQAIEWVNELAFAKPWFIEEPTSPDDVEGHRKIREGIGAVKVATGE 300 DR+LMIDANQVWEVDQAIEWVN+LAF+KP+FIEEPTSPDD+ GHRKIR IG+VKVATGE Sbjct: 241 DRYLMIDANQVWEVDQAIEWVNKLAFSKPFFIEEPTSPDDIAGHRKIRAAIGSVKVATGE 300 Query: 301 MCQNRVLFKQFIMRGAIDVVQIDSCRLGGVNEILAVLLMAAKYKLPVCPHAGGVGLCEYV 360 MCQNR++FKQFI GAIDVVQIDSCR+GG+NE+LAVLL+AAKY LPV PHAGGVGLCEYV Sbjct: 301 MCQNRIMFKQFIAEGAIDVVQIDSCRMGGLNEVLAVLLIAAKYNLPVWPHAGGVGLCEYV 360 Query: 361 QHLSMIDYVCISGTLEGRVTEYVDHLHEHFIDACVVKGAAYMPPTAPGFSITMKPESLEQ 420 QHLSMIDY+ +SGT EGRV EYVDHLHEHFI+ C ++ AAYMPP PGFSI MKPES+E Sbjct: 361 QHLSMIDYLVVSGTKEGRVIEYVDHLHEHFIEPCDIRNAAYMPPKLPGFSIEMKPESIET 420 Query: 421 YRF 423 Y F Sbjct: 421 YTF 423 >BMEI1707 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Bme Brucella melitensis Length = 425 Score = 681 bits (1757), Expect = 0.0, Method: Compositional matrix adjust. Identities = 318/425 (74%), Positives = 362/425 (85%) Query: 1 MTTITSMRVLDVRFPTSKTLDGSDAMNPDPDYSAAYVILETDQSGLEGHGLTFTIGRGNE 60 MT IT +RV D+RFPTS++LDGSDAMNPDPDYSAAYVIL+TD L+GHGLTFTIGRGN+ Sbjct: 1 MTKITDLRVFDLRFPTSQSLDGSDAMNPDPDYSAAYVILDTDDEALKGHGLTFTIGRGND 60 Query: 61 ICCAAIKAMEHLVVGLDLAWVSEDMGRFWRTITSDSQLRWIGPDKGAIHLATGAVVNAVW 120 ICC AI AM HLVVG L + G+FW +T DSQLRWIGP+KGA+HLATGAVVNA+W Sbjct: 61 ICCHAILAMRHLVVGASLDEIRAAPGKFWHHLTGDSQLRWIGPEKGAMHLATGAVVNAIW 120 Query: 121 DLWAKAEGKPLWKLVAGMSPEELVRSIDFRYITDCITPDEALALLRAQAPGKAERIRLLE 180 DL AK GKP+W+LV+ +SPEE+ +D+RY+TD +T DEA+ +LR GKAERI LE Sbjct: 121 DLLAKQAGKPVWRLVSELSPEEIADIVDYRYLTDVLTRDEAIEILRKAESGKAERIATLE 180 Query: 181 QNGYPCYTTSAGWLGYDDAKLRRLCKEAIDGGFNHIKLKVGRDLADDKRRVTIAREVIGP 240 GY CYTTSAGWLGYDDAKLRRLC+EAID GFNH+K+KVG DL DD RR+TIAREVIGP Sbjct: 181 AEGYACYTTSAGWLGYDDAKLRRLCQEAIDEGFNHVKMKVGHDLEDDIRRLTIAREVIGP 240 Query: 241 DRHLMIDANQVWEVDQAIEWVNELAFAKPWFIEEPTSPDDVEGHRKIREGIGAVKVATGE 300 DR+LMIDANQVWEVDQAIEWV LAFA P+FIEEPTSPDDV GHRKIR IG VKVATGE Sbjct: 241 DRYLMIDANQVWEVDQAIEWVRRLAFANPFFIEEPTSPDDVAGHRKIRAAIGPVKVATGE 300 Query: 301 MCQNRVLFKQFIMRGAIDVVQIDSCRLGGVNEILAVLLMAAKYKLPVCPHAGGVGLCEYV 360 MCQNR++FKQFI GAIDVVQIDSCR+GG+NE+LAVLLMAAKY LPV PHAGGVGLCEYV Sbjct: 301 MCQNRIMFKQFIAEGAIDVVQIDSCRMGGLNEVLAVLLMAAKYDLPVWPHAGGVGLCEYV 360 Query: 361 QHLSMIDYVCISGTLEGRVTEYVDHLHEHFIDACVVKGAAYMPPTAPGFSITMKPESLEQ 420 QHLSMIDYV +SGT EGRV EYVDHLHEHF+D C+++ AAYMPP+ PGFSI MKP+S+ Q Sbjct: 361 QHLSMIDYVAVSGTKEGRVIEYVDHLHEHFLDPCIIRNAAYMPPSLPGFSIEMKPQSIAQ 420 Query: 421 YRFRG 425 Y F+G Sbjct: 421 YAFKG 425 >YPO1567 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Ype Yersinia pestis Length = 400 Score = 668 bits (1723), Expect = 0.0, Method: Compositional matrix adjust. Identities = 306/399 (76%), Positives = 351/399 (87%) Query: 26 MNPDPDYSAAYVILETDQSGLEGHGLTFTIGRGNEICCAAIKAMEHLVVGLDLAWVSEDM 85 MNPDPDYSAAYVIL+TD L GHGLTFTIGRGNEICC AI A+EHL+VG DLA ++ +M Sbjct: 1 MNPDPDYSAAYVILDTDNPALSGHGLTFTIGRGNEICCVAIHALEHLIVGRDLASMTANM 60 Query: 86 GRFWRTITSDSQLRWIGPDKGAIHLATGAVVNAVWDLWAKAEGKPLWKLVAGMSPEELVR 145 G+FWR TSDSQLRWIGP+KGAIHLATGAV+NAVWDLW+KAEGKPLW+LVA MSPEELVR Sbjct: 61 GKFWREFTSDSQLRWIGPEKGAIHLATGAVINAVWDLWSKAEGKPLWRLVADMSPEELVR 120 Query: 146 SIDFRYITDCITPDEALALLRAQAPGKAERIRLLEQNGYPCYTTSAGWLGYDDAKLRRLC 205 IDFRYITDCITP+EAL LL+ +A KA R+ L+ GYPCYTTSAGWLGY D KLRRLC Sbjct: 121 CIDFRYITDCITPEEALTLLQQRAHNKALRLEKLQDEGYPCYTTSAGWLGYPDDKLRRLC 180 Query: 206 KEAIDGGFNHIKLKVGRDLADDKRRVTIAREVIGPDRHLMIDANQVWEVDQAIEWVNELA 265 ++A+D GF+++KLKVGRDL DD RRV I REV+GPDR LMIDANQ+WE ++AI WVN+LA Sbjct: 181 QDAVDAGFDYLKLKVGRDLEDDIRRVRITREVLGPDRKLMIDANQIWETNEAIPWVNQLA 240 Query: 266 FAKPWFIEEPTSPDDVEGHRKIREGIGAVKVATGEMCQNRVLFKQFIMRGAIDVVQIDSC 325 FA PWFIEEPT+PDD+EGHR+IR+G+ VKVATGEMCQNR++FKQFIMR AIDVVQID+C Sbjct: 241 FANPWFIEEPTNPDDIEGHRRIRQGVAPVKVATGEMCQNRIMFKQFIMREAIDVVQIDAC 300 Query: 326 RLGGVNEILAVLLMAAKYKLPVCPHAGGVGLCEYVQHLSMIDYVCISGTLEGRVTEYVDH 385 RLGGVNE+LAV+LMAAKY LPVCPHAGGVGLCEYVQHL+MIDY+CI+GT +GRV EYVDH Sbjct: 301 RLGGVNEVLAVMLMAAKYDLPVCPHAGGVGLCEYVQHLAMIDYLCIAGTDKGRVIEYVDH 360 Query: 386 LHEHFIDACVVKGAAYMPPTAPGFSITMKPESLEQYRFR 424 LHEHF+ CV+K AAYMPP PGFSI M S+E+YRFR Sbjct: 361 LHEHFVHPCVIKNAAYMPPEQPGFSIEMHQSSIEKYRFR 399 >SMb21113 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Sme Sinorhizobium meliloti Length = 400 Score = 643 bits (1658), Expect = 0.0, Method: Compositional matrix adjust. Identities = 302/400 (75%), Positives = 347/400 (86%) Query: 26 MNPDPDYSAAYVILETDQSGLEGHGLTFTIGRGNEICCAAIKAMEHLVVGLDLAWVSEDM 85 MNPDPDYSAAYVIL+TD+ GL GHGLTFTIGRGN+ICC AI+AM HLVVG D++ + + Sbjct: 1 MNPDPDYSAAYVILDTDRPGLAGHGLTFTIGRGNDICCMAIEAMRHLVVGQDISNILKHP 60 Query: 86 GRFWRTITSDSQLRWIGPDKGAIHLATGAVVNAVWDLWAKAEGKPLWKLVAGMSPEELVR 145 GRFWR +TSDSQLRWIGP+KGAIHLATGA+VNAVWDL AK GKP+W+LVA M EE+ Sbjct: 61 GRFWRHLTSDSQLRWIGPEKGAIHLATGAIVNAVWDLLAKHAGKPVWRLVADMPAEEIAD 120 Query: 146 SIDFRYITDCITPDEALALLRAQAPGKAERIRLLEQNGYPCYTTSAGWLGYDDAKLRRLC 205 +D+RY+TD +T D+A+ +LR PGKAERI LE+ GYPCYTTSAGWLGYDDAKLRRL Sbjct: 121 IVDYRYLTDVLTRDDAVEILRRAEPGKAERIATLEKEGYPCYTTSAGWLGYDDAKLRRLA 180 Query: 206 KEAIDGGFNHIKLKVGRDLADDKRRVTIAREVIGPDRHLMIDANQVWEVDQAIEWVNELA 265 +EA+D GF+HIK+KVGRDL DD RR+ IAREVIGPDR+LMIDANQVWEV +AIEWV +LA Sbjct: 181 QEAVDAGFDHIKMKVGRDLDDDIRRLRIAREVIGPDRYLMIDANQVWEVGEAIEWVQKLA 240 Query: 266 FAKPWFIEEPTSPDDVEGHRKIREGIGAVKVATGEMCQNRVLFKQFIMRGAIDVVQIDSC 325 FAKP+FIEEPTSPDDV GHRKIRE IG VKVATGEMCQNR++FKQFI GAID+VQIDSC Sbjct: 241 FAKPFFIEEPTSPDDVAGHRKIREAIGPVKVATGEMCQNRIMFKQFIAEGAIDIVQIDSC 300 Query: 326 RLGGVNEILAVLLMAAKYKLPVCPHAGGVGLCEYVQHLSMIDYVCISGTLEGRVTEYVDH 385 R+GG+NE+LAVLL+AAKY LPV PHAGGVGLCEYVQHLSMIDYV +SGT +GRV EYVDH Sbjct: 301 RMGGLNEVLAVLLIAAKYGLPVWPHAGGVGLCEYVQHLSMIDYVAVSGTKDGRVIEYVDH 360 Query: 386 LHEHFIDACVVKGAAYMPPTAPGFSITMKPESLEQYRFRG 425 LHEHF+D CV++ AAYMPP PGFSI MK +S+E YRF G Sbjct: 361 LHEHFLDPCVIRNAAYMPPERPGFSIEMKQQSIEDYRFDG 400 >AGl1470 [MR] COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 372 Score = 125 bits (315), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 107/386 (27%), Positives = 154/386 (39%), Gaps = 61/386 (15%) Query: 41 TDQSGLEGHGLTFT---IGRGNEICCAAIKAMEHLVVGLDLAWVSEDMGRFWRTITSDSQ 97 T G+EG+G T T + I L++G D + D R W + Sbjct: 38 TTSDGIEGYGFTGTHAHLPSDRLITSCISDCYAPLLLGED----ASDHSRLWTKLARYPS 93 Query: 98 LRWIGPDKGAIHLATGAVVNAVWDLWAKAEGKPLWKLVAGMSPEELVRSIDFRYITDCIT 157 L+W+G G HLA AV A+WD+ AK G PLW + G Sbjct: 94 LQWVG-RAGITHLALAAVDVALWDIKAKKAGVPLWHYLGGA------------------- 133 Query: 158 PDEALALLRAQAPGKAERIRLLEQNGYPCYTTSAGWLGYDDAKLRRLCKEAI-DGGFNHI 216 G Y T GWL + L A+ + GF + Sbjct: 134 ----------------------RTAGVEAYNTDIGWLSFTLEDLLAGSARAVEEDGFTRL 171 Query: 217 KLKVGRDLAD-DKRRVTIAREVIGPDRHLMIDANQVWEVDQAIEWVNELAFAKPWFIEEP 275 K+KVG D + D R+T RE + + ID N W++ + ++ EEP Sbjct: 172 KIKVGHDDPNIDIARLTAVRERVDSAVRIAIDGNGKWDLPTCQRFCAAAKDLDIYWFEEP 231 Query: 276 TSPDDVEGHRKIREGIGAVKVATGEMCQNRVLFKQFIMRGAIDVVQIDSCRLGGVNEILA 335 DDV H ++ ++ +A GE F+ FI GA+ VQ D RLGG+ E + Sbjct: 232 LWYDDVTSHARLARNT-SIPIALGEQLYTVDAFRSFIDAGAVAYVQPDVTRLGGITEYIQ 290 Query: 336 VLLMAAKYKLPVCPHAGGVGLCEYVQHLSMIDYVCISGTLEGRVTEYVDHLHEHFIDACV 395 V +A ++LPV PHAG E Q + Y + T + EY+ + +HF + Sbjct: 291 VADLALAHRLPVVPHAG-----EMSQVHVHLSYWHPAST----ILEYIPWIKDHFEEPIH 341 Query: 396 VKGAAYMPPTAPGFSITMKPESLEQY 421 V+ Y P PG S T ES +Y Sbjct: 342 VRDGVYKRPEQPGASTTPLAESFTRY 367