BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0196.p (1023 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMa0875 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobi... 915 0.0 AGl494 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteriu... 853 0.0 RSp0670_2 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia... 536 e-151 CC3197 [V] COG0841 Cation/multidrug efflux pump Ccr Caulobacter ... 510 e-144 HP0607 [V] COG0841 Cation/multidrug efflux pump Hpy Helicobacter... 471 e-132 >SMa0875 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1065 Score = 915 bits (2365), Expect = 0.0, Method: Compositional matrix adjust. Identities = 484/1051 (46%), Positives = 694/1051 (66%), Gaps = 67/1051 (6%) Query: 1 MWFTRISIGNPVLATMMMMAFVVLGLFSYQRLRVDQFPDITFPVVVVQTTYPGASPENVE 60 M+ TRISI +PV ATMMM+ +VLGLFSY RL VD +P+ PVVVV TTY GASPE+VE Sbjct: 1 MFLTRISINHPVFATMMMVMILVLGLFSYGRLGVDHYPETDLPVVVVATTYTGASPESVE 60 Query: 61 SDVTRKIEEMVNTINGINSLTSHSYEGLSVVIVEFDLTVDPAQGAQDVREKVALVQAAFR 120 S+++R IE +NTI GI+++TS SYEG S+V+V+F++ VD AQ+VR++VA ++ F Sbjct: 61 SEISRPIEAALNTIGGIDTITSESYEGRSIVVVQFEVDVDSQDAAQEVRDRVARLETKFP 120 Query: 121 KEVDQPRITRFDPADQPIFSISVTNDPTAPNTRPRTLRELTTISDQVIKKRLENVRGVGS 180 V P++TR+ P Q I S++V++ RTL E+TT++ +VI RL + GVG Sbjct: 121 DGVATPQVTRYKPEGQAILSVAVSST-------SRTLPEITTLATRVINNRLSVISGVGQ 173 Query: 181 VTLVGGVKRQINIYVKPNEMEALGIGVDQVITAVKNENQELPTGAIRMADAEKVVQVQGR 240 V+L+G +RQ+ + V P+ + A G+ V VI A++ ENQ+ G + +++V V+GR Sbjct: 174 VSLIGSSERQVLVVVDPDRLGAYGLAVSTVIEAIRGENQDRAAGTLISGINQRIVTVEGR 233 Query: 241 VKNPEDFKRIIVARRGSQPVTLEQIATVVDGQEEQETLALYNGQRTLALDILKAQGQNTI 300 + N F RIIVA+R PV L ++AT++D E +LA Y GQ TL L I+K QG NT+ Sbjct: 234 IANTSGFNRIIVAQRNGYPVYLSEVATILDTGAEVTSLANYQGQTTLGLHIVKVQGANTV 293 Query: 301 DVADGLKQAIKDMEPNLQKLYPGVRLQVIKDSSRQIRTGVENVRRTLLEGAALTVLIVFL 360 +VA +++ + + L K V+L + +D+SR I + V V+RTL+EG L+VLIVF+ Sbjct: 294 EVASAVRREVSALNAELTK--DNVQLTITRDNSRPIASQVSQVQRTLVEGGVLSVLIVFI 351 Query: 361 FLNSWRSTVITGLTLPVALIGTFLFMYMFGFTINMITLMALSLCVGLLIDDAIVVRENIV 420 FLNSWRSTVITGLTLP+++IGTF +Y GFT+N++TLMALSL +G+LIDDAIVVRENI Sbjct: 352 FLNSWRSTVITGLTLPISVIGTFAAIYALGFTLNIMTLMALSLSIGILIDDAIVVRENIT 411 Query: 421 RHAGMKVHGKFKTHKMAALEGTAEIGLAVLATTFSIVAVFLPVGFMGGIIGRFFHQFGIT 480 RH M K AAL+GT EIGLAVL+TT IVAVFLPV FMGG+IGRFF QFG+T Sbjct: 412 RHLQMG-----KDPVRAALDGTNEIGLAVLSTTLCIVAVFLPVAFMGGLIGRFFLQFGVT 466 Query: 481 VTAAVLISMFVSFTLDPMLSSIWPDPDVHGEKRKDGWYAKSIGRVLDQFERLVQWLSASY 540 V AV+IS+FVSFTLDPMLSS+W DP + K G++ G+++++F++ + L++ Y Sbjct: 467 VAVAVVISLFVSFTLDPMLSSVWCDPQSQ-KTAKRGFF----GQLIERFDQWFEGLASRY 521 Query: 541 QKLLKWSLRHRIMTLVLALLSFIAGLALPAAGLIGSEFVPQADYSESGVTFYTPVGSSLE 600 + ++ ++ +R T+ + L F+ L L IG+EF+P D E ++ G+SL+ Sbjct: 522 RSVIYFTFDYRKTTIAIVLGMFVVSLLLVPR--IGTEFLPPPDQGEVSISLEANEGASLD 579 Query: 601 LTESKVHQVETVLRQFPEVVDTYSTVNTGNSQGKNYATVFIRLKPRKERQLSTAQLAPQL 660 +KV Q+E LR+F V TYST+N+G +G N A V ++L +R+L TA+ + Sbjct: 580 YMAAKVGQIERALREFNYVSSTYSTINSGEMRGFNKALVAVQLVHSSQRRLKTAETLGPI 639 Query: 661 RERLTRVAGITVTHIGTLDGVGGDNKQVRFSLLGPDLDQLGRLSEEVQTRLRAIPGVADL 720 R RL+R+AG+ ++ +G V G K ++ S+LG ++L R+S+ + + L AIPG ++ Sbjct: 640 RRRLSRIAGLEIS-VGQRSEVVGSIKPLQLSILGDGDEELRRISDHITSVLAAIPGATEI 698 Query: 721 DSSLKPQKPTISIEPKRDIGSDLGVGVAQIGNALR-------------PN---------- 757 +SS++ +PT+++ +R+ SDLGV +A IG+ LR P+ Sbjct: 699 ESSIEKLRPTLAVRVRREAASDLGVSIATIGDTLRSLVAGDAISVWNSPDGETHDVVVRL 758 Query: 758 ---------------------NTDGTPRMVPLRQVADIRNTVGANQINRRDLNREVELSA 796 + +G P MV L QVAD+ + QI R+DL+R++ +S+ Sbjct: 759 PAAGRENAAQLRNLPIATARMDDNGKPIMVLLDQVADVVESTAPAQITRKDLSRDIRISS 818 Query: 797 NAAGRSAGQVNADIKVMLDKINWPPGYRYQIGGSTKSMNESFGYALGALALAIVFIYMIL 856 N GR+ G V AD+K + K++ P G+R GG +++ ES YAL +LA+A++FIY+IL Sbjct: 819 NIEGRTLGDVVADLKAAMTKMDIPVGFRISFGGDAENLTESTAYALQSLAMAVIFIYIIL 878 Query: 857 ASQFASFLQPVAIMSSLPLTLIGVFLALMFFRSTLNMFSIIGFIMLMGLVTKNAILLVDF 916 ASQF SF+QP+AI+ ++PL+L+GV L L+F STLNMFS+IG +MLMGLVTKNAILLVD+ Sbjct: 879 ASQFGSFIQPIAIIMTMPLSLMGVLLGLLFTGSTLNMFSMIGIMMLMGLVTKNAILLVDY 938 Query: 917 ANQARKEGMERGAALLEAAHVRLRPILMTTLAMVFGMVPLAFGIAEGSEQRAPMGQAVIG 976 +N +EG +L +A VRLRPI+MTTLAM+FGM+P A G+ EG QRAPM A+IG Sbjct: 939 SNLGVREGKSLRQSLADAGAVRLRPIVMTTLAMIFGMLPTALGLGEGGAQRAPMAHAIIG 998 Query: 977 GIITSSLLTLVVVPVAYTYLDDLGAWVKRKW 1007 G+I+S+LL+LV VPV TYLD V R+W Sbjct: 999 GLISSTLLSLVFVPVVLTYLDAFAGRV-RRW 1028 >AGl494 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1048 Score = 853 bits (2204), Expect = 0.0, Method: Compositional matrix adjust. Identities = 474/1066 (44%), Positives = 681/1066 (63%), Gaps = 74/1066 (6%) Query: 1 MWFTRISIGNPVLATMMMMAFVVLGLFSYQRLRVDQFPDITFPVVVVQTTYPGASPENVE 60 M+ TRIS+ +PV ATMMM+A +V+G FS QRL +DQ+P++ PVVVV T+YPGA+PE VE Sbjct: 1 MFLTRISVNHPVFATMMMVALLVMGAFSLQRLGLDQYPNVDVPVVVVVTSYPGATPETVE 60 Query: 61 SDVTRKIEEMVNTINGINSLTSHSYEGLSVVIVEFDLTVDPAQGAQDVREKVALVQAAFR 120 +VTR +E+ +N I G++ +TS SYEG SVV+ +F L V + AQ+VR+K+A ++A F Sbjct: 61 MEVTRPVEDALNAIGGLDEVTSTSYEGRSVVVAKFKLEVQSSAAAQEVRDKIAAIEANFP 120 Query: 121 KEVDQPRITRFDPADQPIFSISVTNDPTAPNTRPRTLRELTTISDQVIKKRLENVRGVGS 180 ++ +P I+RFDPA +PI S+++++ + L T+++Q + ++L V G+G Sbjct: 121 EDTKKPVISRFDPAAEPILSLAISSTSL-------DVPALATLAEQKVVRQLTTVAGIGQ 173 Query: 181 VTLVGGVKRQINIYVKPNEMEALGIGVDQVITAVKNENQELPTGAIRMADAEKVVQVQGR 240 TLVGG KRQI++ + M ALGIGV++V+TA++ N P G++ +E+ +Q+Q R Sbjct: 174 ATLVGGRKRQIDVTIDETRMRALGIGVNEVVTALRAGNSNSPAGSVVDPVSERTIQIQSR 233 Query: 241 VKNPEDFKRIIVARRGSQPVTLEQIATVVDGQEEQETLALYNGQRTLALDILKAQGQNTI 300 ++ PE ++VARRG + L +AT+ +G + E A+YNGQ LA+DI+K Q NT+ Sbjct: 234 IEEPEALLDMVVARRGGVAILLRDVATLSEGAADAENRAIYNGQTALAIDIVKVQDANTV 293 Query: 301 DVADGLKQAIKDMEPNLQKLYPGVRLQVIKDSSRQIRTGVENVRRTLLEGAALTVLIVFL 360 V +++ + + L ++L+++ DSS I+ V V+ TL+EGAAL V IVFL Sbjct: 294 QVVSDVRKRLDALNAELSP--QNIQLRIVTDSSIPIQESVTQVQTTLIEGAALAVAIVFL 351 Query: 361 FLNSWRSTVITGLTLPVALIGTFLFMYMFGFTINMITLMALSLCVGLLIDDAIVVRENIV 420 FLNSWRSTVITGLTLP+A+IGT + GFT+N ++L+AL+L +G+L+DDAIVVRENI Sbjct: 352 FLNSWRSTVITGLTLPIAIIGTLTVVDFLGFTLNTLSLLALTLSIGILVDDAIVVRENIT 411 Query: 421 RHAGMKVHGKFKTHKMAALEGTAEIGLAVLATTFSIVAVFLPVGFMGGIIGRFFHQFGIT 480 RH M K+H AAL+GT EIGLAV+ATT +IVAVFLPV FM GI+GRFF+QFG+T Sbjct: 412 RHLHMG-----KSHLRAALDGTGEIGLAVIATTATIVAVFLPVAFMDGIVGRFFYQFGVT 466 Query: 481 VTAAVLISMFVSFTLDPMLSSIWPDPDVHGEKRKDGWYAKSIGRVLDQFERLVQWLSASY 540 V+AAVLIS+FV+FTLDPMLSS+W DPD + ++ IGR++ +F+ +W++ Y Sbjct: 467 VSAAVLISLFVAFTLDPMLSSVWYDPDAQADAKR-----GPIGRLIARFDHGFEWMAGQY 521 Query: 541 QKLLKWSLRHRIMTLVLALLSFIAGLALPAAGLIGSEFVPQADYSESGVTFYTPVGSSLE 600 + + W+LRHR++TL++ FI L + L+G+EFVP AD + PVGSSL+ Sbjct: 522 RHAIDWTLRHRLVTLLVTAGIFIGSLFM--VPLVGTEFVPDADEGRFQINLTAPVGSSLD 579 Query: 601 LTESKVHQVETVLRQFPEVVDTYSTVNTGNSQGKNYATVFIRLKPRKERQLSTAQLAPQL 660 T +K+ QV+ LR+FPEV YST+NTG + GK+ A + + L P R+ + LA + Sbjct: 580 YTTAKLQQVKKALREFPEVEMLYSTINTGGAAGKHRAAILVGLVPLSAREQTPLSLAEPV 639 Query: 661 RERLTRVAGITVTHIGTLDGVGGDNKQVRFSLLGPDLDQLGRLSEEVQTRLRAIPGVADL 720 R+RL+ + GI + + +G+GG V+ S+LG D L +++ + ++ IPG+ ++ Sbjct: 640 RKRLSAIPGIEINILQ--NGLGGGESPVQLSILGDDRAVLEKIANGLVEDMKKIPGLVEV 697 Query: 721 DSSLKPQKPTISIEPKRDIGSDLGV----------------------------------- 745 SS K +S+ K SDLG+ Sbjct: 698 TSSTKDVTSILSVRLKPAAASDLGIARADLAAALSALIGGEDVSKWTDAHGNSYDIVVRL 757 Query: 746 ------GVAQIGNALRP---NNTDGTPRMVPLRQVADIRNTVGANQINRRDLNREVELSA 796 A++G + +G P MV L QVADI +I R D RE+ +SA Sbjct: 758 PVERRSDAARLGELMITTGRTGANGAPLMVRLDQVADIGTVAAPAEIRRFDNRREILVSA 817 Query: 797 NAAGRSAGQVNADIKVMLDKINWPPGYRYQIGGSTKSMNESFGYALGALALAIVFIYMIL 856 N GR+ G V ++ + + P GYR + GG ++M E+ G+ AL++AI+FIY++L Sbjct: 818 NITGRTLGDVTETLQGLTASRDLPAGYRIRFGGEAETMQETVGHMGTALSMAIIFIYIVL 877 Query: 857 ASQFASFLQPVAIMSSLPLTLIGVFLALMFFRSTLNMFSIIGFIMLMGLVTKNAILLVDF 916 ASQF SFLQP+AIM SLPL+LIGV L LM ST+NMFS+IGFIMLMGLVTKN ILLVDF Sbjct: 878 ASQFGSFLQPLAIMVSLPLSLIGVLLGLMVAGSTINMFSLIGFIMLMGLVTKNGILLVDF 937 Query: 917 ANQARKEGMERGAALLEAAHVRLRPILMTTLAMVFGMVPLAFGIAEGSEQRAPMGQAVIG 976 AN+ R+ G+ AL A +R RPI+MTTLAM+FGM+PL + G QRAPM AV+G Sbjct: 938 ANRERRRGLTLNEALANAGVIRFRPIIMTTLAMIFGMIPLGLAVGGGGAQRAPMAHAVVG 997 Query: 977 GIITSSLLTLVVVPVAYTYLDDLGAWVKRKWFGAAVVEDKAEDEHA 1022 G+I+S+LLTL+VVPV +Y+D + R++ A + KA DE A Sbjct: 998 GLISSTLLTLIVVPVILSYIDS----ITRRF---ARLLPKAPDEVA 1036 >RSp0670_2 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1029 Score = 536 bits (1380), Expect = e-151, Method: Compositional matrix adjust. Identities = 363/1058 (34%), Positives = 553/1058 (52%), Gaps = 91/1058 (8%) Query: 1 MWFTRISIGNPVLATMMMMAFVVLGLFSYQRLRVDQFPDITFPVVVVQTTYPGASPENVE 60 M F+ +I P+ + ++ + V GL S++ L + FPDI FP V V T PGA+P +E Sbjct: 1 MNFSAWAIRKPIPSILLFILITVAGLVSFRMLSIQNFPDIDFPAVSVTATLPGATPSQME 60 Query: 61 SDVTRKIEEMVNTINGINSLTSHSYEGLSVVIVEFDLTVDPAQGAQDVREKVALVQAAFR 120 ++VTRK+E+ + +I I ++S +G S +VEF L D + DVR+ V+ ++A Sbjct: 61 TEVTRKVEDSIASIGAIKHISSTINDGSSTTMVEFQLEKDVQEAVNDVRDAVSRIRAQLP 120 Query: 121 KEVDQPRITRFDPADQPIFSISVTNDPTAPNTRPRTLRELTTISDQVIKKRLENVRGVGS 180 +V +P I+R A P+ + +V +L+ D + KRL +VRGV Sbjct: 121 SDVQEPVISRVTFASMPVLTYAV-------QATGMDAEDLSWYVDNTVNKRLLSVRGVAK 173 Query: 181 VTLVGGVKRQINIYVKPNEMEALGIGVDQVITAVKNENQELPTGAIRMADAEKVVQVQGR 240 VT GG R++ + + P ++AL + ++ ++ QE P G + E+ V+ G Sbjct: 174 VTRQGGADREVRVQLDPVRLQALNVTAAEISVQLRGMQQEAPGGRGNIGGQEQAVRTLGT 233 Query: 241 VKNPEDFKRIIVARRGSQPVTLEQIATVVDGQEEQETLALYNGQRTLALDILKAQGQNTI 300 VK+ + R+ + + + L +A V D E +AL G+ ++ + +++G + I Sbjct: 234 VKSAAELARMDIPLSDGRRIRLSDVADVRDTAAEPRQMALLEGKPVVSFQVFRSRGASEI 293 Query: 301 DVADGLKQAIKDMEPNLQKLYPGVRLQVIKDSSRQIRTGVENVRRTLLEGAALTVLIVFL 360 VA ++ AI LQ P VR+ + + + + L EGA L VL+V+L Sbjct: 294 SVAQDVRAAIA----GLQAERPNVRVTEVYNLVKPVSDAYRASMHALYEGAILAVLVVWL 349 Query: 361 FLNSWRSTVITGLTLPVALIGTFLFMYMFGFTINMITLMALSLCVGLLIDDAIVVRENIV 420 FL WR+T ++ + LP+++I TF M M GFT+N +TL+AL+L VG+L+DDAIV ENIV Sbjct: 350 FLRDWRATFVSAVALPLSIIPTFAAMQMLGFTLNGVTLLALTLVVGILVDDAIVEVENIV 409 Query: 421 RHAGMKVHGKFKTHKMAALEGTAEIGLAVLATTFSIVAVFLPVGFMGGIIGRFFHQFGIT 480 RH +GK AA+E EIGLAV+AT+ ++VAVFLP FMGGI G+FF QFG T Sbjct: 410 RHLR---NGKPPFE--AAMEAAQEIGLAVIATSLTLVAVFLPTAFMGGISGKFFRQFGWT 464 Query: 481 VTAAVLISMFVSFTLDPMLSSIWPDPDVHGEKRKDGWYAKSIGRVLDQFERLVQWLSASY 540 + AVL S+ V+ L PM+++ P G +DG W+ Y Sbjct: 465 ASIAVLASLLVARLLTPMMAAYLLKPQREGN--RDG------------------WIMTRY 504 Query: 541 QKLLKWSLRHRIMTLVLALLSFIAGLALPAAGLIGSEFVPQADYSESGVTFYTPVGSSLE 600 + +W L H T +A A +A+ GLI + F+P D+++ +T P GS++ Sbjct: 505 LRAARWCLAHPWRTSGMAAAFLAASVAI--IGLIPATFLPPEDWAQLQMTVEMPPGSTIA 562 Query: 601 LTESKVHQVETVLRQFPEVVDTYSTVNT-------GNSQGK-NYATVFIRLKPRKERQLS 652 T +V V+R +V Y+ + + G+S G+ T+ I L R ER +S Sbjct: 563 QTREATERVRQVVRTHKDVRQVYTAIGSGVMAGVPGSSGGEVRTGTLTISLTGRHERHIS 622 Query: 653 TAQLAPQLRERLTRVAGITVTHIGTLDGVGGDNKQVRFSLLGPDLDQLGRLSEEVQTRLR 712 Q+ +LRERL V G+ + G G +Q++ L G D L + +V LR Sbjct: 623 QQQVQRELRERLESVPGVRIAF-----GAVGSGEQLQIVLTGDDPATLQAAARDVMRDLR 677 Query: 713 AIPGVADLDSSLKPQKPTISIEPKRDIGSDLGVGVAQIGNALR-----------PN---- 757 ++PG+ + SS +P I I P + GV A IG A+R P Sbjct: 678 SVPGLGAITSSASLLRPEIVIRPDFARAAQQGVTAAAIGQAVRVATAGDYDVNLPKLNLP 737 Query: 758 ------------------------NTDGTPRMVPLRQVADIRNTVGANQINRRDLNREVE 793 G VPL +ADI + G QI+R D +R V Sbjct: 738 ERQVYIRVELDPAARHQIDTIRQLRVPGRNGAVPLENIADIALSSGPAQIDRFDRSRNVT 797 Query: 794 LSANAAGRSAGQVNADIKVMLDKINWPPGYRYQIGGSTKSMNESFGYALGALALAIVFIY 853 +S G + G+VN ++ + PPG G + M E FG L A+ ++ +Y Sbjct: 798 ISVGLEGGALGEVNQAVEALPSVRKLPPGVHRIASGDVEGMQELFGGFLLAMFAGVLCVY 857 Query: 854 MILASQFASFLQPVAIMSSLPLTLIGVFLALMFFRSTLNMFSIIGFIMLMGLVTKNAILL 913 +L F F QPV I+++LPL++ G F L F +L++ ++IG +MLMG+VTKN+ILL Sbjct: 858 AVLVLLFHDFTQPVTILAALPLSVGGAFGLLALFGFSLSLPALIGLLMLMGIVTKNSILL 917 Query: 914 VDFANQARKE-GMERGAALLEAAHVRLRPILMTTLAMVFGMVPLAFGIAEGSEQRAPMGQ 972 V++A AR++ GM R AL++A H R RPI+MTT+AM GMVP+A G+ + RAPM Sbjct: 918 VEYAIVARRDFGMSRTEALIDACHKRARPIVMTTVAMTAGMVPMALGLEGDAGFRAPMAV 977 Query: 973 AVIGGIITSSLLTLVVVPVAYTYLDDLGAWVKRKWFGA 1010 AVIGG++TS+LL+L+VVPV + +DDL WV RK GA Sbjct: 978 AVIGGLLTSTLLSLLVVPVVFEKVDDLKVWVLRKLPGA 1015 >CC3197 [V] COG0841 Cation/multidrug efflux pump Ccr Caulobacter vibrioides Length = 1041 Score = 510 bits (1313), Expect = e-144, Method: Compositional matrix adjust. Identities = 354/1053 (33%), Positives = 557/1053 (52%), Gaps = 102/1053 (9%) Query: 7 SIGNPVLATMMMMAFVVLGLFSYQRLRVDQFPDITFPVVVVQTTYPGASPENVESDVTRK 66 +I NP+ ++ +A ++ G+ +Y L + QFP++ FP V V T GA+P +E+ VTR Sbjct: 21 AIRNPIPVAVVFIALMIAGVGAYLGLPIKQFPNVEFPAVTVTVTQSGAAPGEMETQVTRP 80 Query: 67 IEEMVNTINGINSLTSHSYEGLSVVIVEFDLTVDPAQGAQDVREKVALVQAAFRKEVDQP 126 IE+ V +I+ + ++ S +G S +EF+L D + +VR KV +A +EVD+P Sbjct: 81 IEDAVASISNVKTIRSSVVQGASTTTIEFNLGEDLQKVTDEVRSKVDQARAVLPREVDEP 140 Query: 127 RITRFDPADQPIFSISVTNDPTAPNTRPRTLRELTTISDQVIKKRLENVRGVGSVTLVGG 186 + R + PI + +V+ AP + +L+ D + + L+ +GV V VGG Sbjct: 141 LVQRLEITSAPIITYAVS----APGM---SATDLSWFIDDTVTRALQGEKGVAQVARVGG 193 Query: 187 VKRQINIYVKPNEMEALGIGVDQVITAVKNENQELPTGAIRMADAEKVVQVQGRVKNPED 246 V R+IN+ + P+ M + G+ Q+ A+ + + + P G + E+ ++V G E Sbjct: 194 VDREINVIIDPDRMASFGVTAPQLNQALASFSVDAPGGRASIGGREQTLRVLGAATTIEQ 253 Query: 247 FKRIIVARRGSQPVTLEQIATVVDGQEEQETLALYNGQRTLALDILKAQGQNTIDVADGL 306 ++I + G + V L +A V G EE+ A +G+ +A ++K + + + V D + Sbjct: 254 LRQITIPVAGGRYVKLTDVAQVGQGSEEERGFARLDGKPVVAFQVMKTRDSSDVAVEDRV 313 Query: 307 KQAIKDMEPNLQKLYPGVRLQVIKDSSRQIRTGVENVRRTLLEGAALTVLIVFLFLNSWR 366 K A+ L + PGV I + + R + TLLEG L L+VFLFL WR Sbjct: 314 KAAVD----KLAEKTPGVTFVKIFSTVDETRASFKATEHTLLEGMLLASLVVFLFLREWR 369 Query: 367 STVITGLTLPVALIGTFLFMYMFGFTINMITLMALSLCVGLLIDDAIVVRENIVRHAGMK 426 +T+IT L +PV+L+ TF FM GF++N++TL+AL+L +G+L+DDA+V ENI + Sbjct: 370 ATLITALAMPVSLVPTFAFMAFMGFSLNVVTLLALTLVIGILVDDAVVEIENIEKRV--- 426 Query: 427 VHGKFKTHKMAALEGTAEIGLAVLATTFSIVAVFLPVGFMGGIIGRFFHQFGITVTAAVL 486 + + AA+EG IGLAV+ATTF+IVAVF+PV FM G+ G+FF +FG+TV AVL Sbjct: 427 --ARGQRPFQAAMEGADAIGLAVVATTFTIVAVFVPVSFMPGMPGQFFKEFGLTVAVAVL 484 Query: 487 ISMFVSFTLDPMLSSIWPDPDVHGEKRKDGWYAKSIGRVLDQFERLVQWLSASYQKLLKW 546 S+ V+ L P+L++ + P RK FE Y+ +L W Sbjct: 485 FSLVVARLLTPLLAAYFLKPAKAPHPRK-------------PFEGF-------YRNILDW 524 Query: 547 SLRHRIMTLVLALLSFIAGLALPAAGLIGSEFVPQADYSESGVTFYTPVGSSLELTESKV 606 SL HRI+ ++ L F+ + L AGL+ + F P A+ + + P G+++ + V Sbjct: 525 SLDHRILACIIGGLIFVGSIML--AGLLPTAFQPPANNNYYYLKVQGPPGATVADMDRTV 582 Query: 607 HQVETVLRQFPEVVDTYSTV--NTGNSQGKNY------ATVFIRLKPRKERQLSTAQLAP 658 QV T++R+ PEV + ++ V N G+ G AT+ I L R +R+LS ++ Sbjct: 583 QQVTTLMRKRPEVTNVFAQVGSNIGSGWGGQSSADIRDATITIVL--RGDRELSVTEIKQ 640 Query: 659 QLRERLTRVAGITVTHIGTLDGVGGDNKQVRFSLLGPDLDQLGRLSEEVQTRLRAIPGVA 718 ++R L + V L G G + +V+ L+ D L R + +++ ++ + VA Sbjct: 641 EVRASLRDIPDARV----NLQGDWG-SSEVQTILVSEDGPLLERTAAKIEREMQGLSTVA 695 Query: 719 DLDSSLKPQKPTISIEPKRDIGSDLGVG---------VAQIGN----------------- 752 D S P P I I PK D + LGV VA +G+ Sbjct: 696 DPRPSSPPSGPEILIRPKADEAARLGVSSADIAAIARVATVGDIDANVAKMTQGERRIPI 755 Query: 753 ----------------ALR-PNNTDGTPRMVPLRQVADIRNTVGANQINRRDLNREVELS 795 ALR P G+ R L VA++ G +I+R R++ + Sbjct: 756 RVRLPAESRQDLEALGALRVPTANGGSTR---LDTVAELSFQAGPAKIDRFGRKRQMTVE 812 Query: 796 AN-AAGRSAGQVNADIKVMLDKINWPPGYRYQIGGSTKSMNESF-GYALGALALAIVFIY 853 A+ G G+ AD+ + N P G G ++ E F G+A+ AL A+ ++ Sbjct: 813 ADLNNGAQLGEAMADVDNLPTMKNLPAGVAPASAGDQEAFVELFTGFAV-ALLSAVGLVF 871 Query: 854 MILASQFASFLQPVAIMSSLPLTLIGVFLALMFFRSTLNMFSIIGFIMLMGLVTKNAILL 913 +L F SF +P+ I+S+LPL + G F L+ +L+M S+IGF+MLMGL KN+ILL Sbjct: 872 GVLVLLFRSFFKPITILSALPLAIGGAFFGLLVMGQSLSMPSLIGFLMLMGLAAKNSILL 931 Query: 914 VDFANQARKEGMERGAALLEAAHVRLRPILMTTLAMVFGMVPLAFGIAEGSEQRAPMGQA 973 V++A + + GM + A+L+A H R RPI+MTTLAM+ GM+P A GI G+E R PM A Sbjct: 932 VEYAIEQERAGMSQREAILDACHERARPIVMTTLAMMAGMLPTALGIGTGAEFRQPMAVA 991 Query: 974 VIGGIITSSLLTLVVVPVAYTYLDDLGAWVKRK 1006 VIGG+ITS++L+LV+VPV Y +DD W+K K Sbjct: 992 VIGGLITSTVLSLVLVPVVYEIVDDFEMWLKPK 1024 >HP0607 [V] COG0841 Cation/multidrug efflux pump Hpy Helicobacter pylori 26695 Length = 1028 Score = 471 bits (1211), Expect = e-132, Method: Compositional matrix adjust. Identities = 343/1058 (32%), Positives = 539/1058 (50%), Gaps = 94/1058 (8%) Query: 5 RISIGNPVLATMMMMAFVVLGLFSYQRLRVDQFPDITFPVVVVQTTYPGASPENVESDVT 64 + +I P+ M +A V G +++L V FP I P VVV TTYPGAS E +ES VT Sbjct: 3 KTAINRPITTLMFALAIVFFGTMGFKKLSVALFPKIDLPTVVVTTTYPGASAEIIESKVT 62 Query: 65 RKIEEMVNTINGINSLTSHSYEGLSVVIVEFDLTVDPAQGAQDVREKVALVQAAFRKEVD 124 KIEE V I+GI +TS S + +S+V++EF+L + DV K++ V+ + Sbjct: 63 DKIEEAVMGIDGIKKVTSTSSKNVSIVVIEFELEKPNEEALNDVVNKISSVRFD-DSNIK 121 Query: 125 QPRITRFDPADQPIFSISVTNDPTAPNTRPRTLRELTTISDQVIKKRLENVRGVGSVTLV 184 +P I +FD Q I S+ V++ T L + IK L+ + GVG V L Sbjct: 122 KPSINKFDTDSQAIISLFVSSSSVPATT-------LNDYAKNTIKPMLQKINGVGGVQLN 174 Query: 185 GGVKRQINIYVKPNEMEALGIGVDQVITAVKNENQELPTGAIRMADAEKVVQVQGRVKNP 244 G +RQI IY P M + + + +K EN E+ G I + E + + + Sbjct: 175 GFRERQIRIYANPTLMNKYNLTYADLFSTLKAENVEIDGGRIVNSQREFSILINANSYSV 234 Query: 245 EDFKRIIVARRGSQPVTLEQIATVVDGQEEQETLALYNGQRTLALDILKAQGQNTIDVAD 304 D ++I V V L IA + G EE T A + + + L+I K G N I++ D Sbjct: 235 ADVEKIQVGNH----VRLGDIAKIEIGLEEDNTFASFKDKPGVILEIQKIAGANEIEIVD 290 Query: 305 GLKQAIKDMEPNLQKLYPGVRLQVIKDSSRQIRTGVENVRRTLLEGAALTVLIVFLFLNS 364 + +A+K +Q + P ++ D++ IRT +E+V+ L+ GA L VL+VF FL + Sbjct: 291 RVYEALK----RIQAISPNYEIRPFLDTTGYIRTSIEDVKFDLVLGAILAVLVVFAFLRN 346 Query: 365 WRSTVITGLTLPVALIGTFLFMYMFGFTINMITLMALSLCVGLLIDDAIVVRENIVRHAG 424 T+++ +++P++++GTF + GF++NM+T++AL+L +G++IDDAIVV ENI + Sbjct: 347 GTITLVSAISIPISIMGTFALIQWMGFSLNMLTMVALTLAIGIIIDDAIVVIENIHKKLE 406 Query: 425 MKVHGKFKTHKMAALEGTAEIGLAVLATTFSIVAVFLPVGFMGGIIGRFFHQFGITVTAA 484 M + + + A+ EG EIG A++A + +++VF+P+G M GIIGRFF FGITV A Sbjct: 407 MGM-----SKRKASYEGVREIGFALVAISAMLLSVFVPIGNMKGIIGRFFQSFGITVALA 461 Query: 485 VLISMFVSFTLDPMLSSIWPDPDVHGEKRKDGWYAKSIGRVLDQFERLVQWLSASYQKLL 544 + +S V T+ PM+SS+ +P R +Y S E + L + Y KLL Sbjct: 462 IALSYVVVVTIIPMVSSVVVNP------RHSRFYVWS--------EPFFKALESRYTKLL 507 Query: 545 KWSLRHRIMTLVLALLSFIAGLALPAAGLIGSEFVPQADYSESGVTFYTPVGSSLELTES 604 +W L H+I+ + +L F+ L + A IG EF+ + D V G S++ Sbjct: 508 QWVLNHKIIISIAVVLVFVGSLFV--ASKIGMEFMLKEDRGRFLVWLKAKPGVSIDYMTQ 565 Query: 605 KVHQVETVLRQFPEVVDTYSTVNTGNSQGKNYATVFIRLKPRKER----QLSTAQLAPQL 660 K + + + EV T V G +Q A +F++LKP KER QL +L L Sbjct: 566 KSKIFQKAIEKHAEVEFTTLQVGYGTTQNPFKAKIFVQLKPLKERKKEHQLGQFELMSVL 625 Query: 661 RERLTRV---AGITVTHIG--TLDGVGGDNKQVRFSLLGPDLDQLGRLSEEVQTRLRAIP 715 R+ L + G+ ++ TL G GGD+ + + + + + E ++ L P Sbjct: 626 RKELRSLPEAKGLDTINLSEVTLIGGGGDSSPFQTFVFSHSQEAVDKSVENLKKFLLESP 685 Query: 716 ----GVADLDSSLKPQKPTISIEPKRDIGSDLGVGVAQIGNALR---------------- 755 V +S +P + ++ R + GV IG+ + Sbjct: 686 ELKGKVESYHTSTSESQPQLQLKILRQNANKYGVSAQTIGSVVSSAFSGTSQASVFKEDG 745 Query: 756 ---------PNNT-------------DGTPRMVPLRQVADIRNTVGANQINRRDLNREVE 793 P++ + +++ L + +I T + I+R + R V Sbjct: 746 KEYDMIIRVPDDKRVSVEDIKRLQVRNKYDKLMFLDALVEITETKSPSSISRYNRQRSVT 805 Query: 794 LSANA---AGRSAGQVNADIKVMLDKINW-PPGYRYQIGGSTKSMNESFGYALGALALAI 849 + A AG S G++ +V + W G Y+ G + ES G L ALA A Sbjct: 806 VLAEPNRNAGVSLGEILT--QVSKNTKEWLVEGANYRFTGEADNAKESNGEFLVALATAF 863 Query: 850 VFIYMILASQFASFLQPVAIMSSLPLTLIGVFLALMFFRSTLNMFSIIGFIMLMGLVTKN 909 V IYMILA+ + S L+P IM ++PL+ G F AL L+MFS+IG I+L+G+V KN Sbjct: 864 VLIYMILAALYESILEPFIIMVTMPLSFSGAFFALGLVHQPLSMFSMIGLILLIGMVGKN 923 Query: 910 AILLVDFANQARKEGMERGAALLEAAHVRLRPILMTTLAMVFGMVPLAFGIAEGSEQRAP 969 A LL+D AN+ RK+G+ A+L A RLRPILMTT+AMV GM+PLA +G+ ++P Sbjct: 924 ATLLIDVANEERKKGLNIQEAILFAGKTRLRPILMTTIAMVCGMLPLALASGDGAAMKSP 983 Query: 970 MGQAVIGGIITSSLLTLVVVPVAYTYLDDLGAWVKRKW 1007 +G A+ GG++ S +L+L++VPV Y L + +KR + Sbjct: 984 IGIAMSGGLMISMVLSLLIVPVFYRLLAPIDDKIKRFY 1021