BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0190.p (1050 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1610 0.0 SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizob... 1348 0.0 AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteri... 1292 0.0 STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1229 0.0 acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 1217 0.0 >RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1049 Score = 1610 bits (4168), Expect = 0.0, Method: Compositional matrix adjust. Identities = 797/1048 (76%), Positives = 908/1048 (86%), Gaps = 2/1048 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIILAGALAITGLPVSQYPSIAPPTIVVTATYPGATAQTLDDS 60 M KFFIDRPVFAWVLA+FII+AGA++IT LP++QYP+IAPP+I++TATYPGA+A+TLDD+ Sbjct: 1 MAKFFIDRPVFAWVLALFIIVAGAISITQLPIAQYPTIAPPSIIITATYPGASAKTLDDA 60 Query: 61 VTSLIEQEMNGADGLQYMESQSQA-NGQVQITVTFSPDTNADLAAVDVQNRLKRVEARLP 119 VTS+IEQEMNGADGL Y+ES SQA NGQ ITVTF P T+ LA VDVQNRLKRVEARLP Sbjct: 61 VTSIIEQEMNGADGLLYIESVSQAGNGQATITVTFKPGTDPALAQVDVQNRLKRVEARLP 120 Query: 120 AAVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEVKRVPGVGQAQLFG 179 ++VTQQGVQV K+RSNFLLF L S DGK+DPVALGDY+SRNVLNEVKRVPGVGQA LFG Sbjct: 121 SSVTQQGVQVDKTRSNFLLFATLISKDGKMDPVALGDYISRNVLNEVKRVPGVGQAVLFG 180 Query: 180 TERAMRIWIDPNKLIGLNLTPADVTAAITAQNALVAGGTLGALPSPTSQQISATVVVNGQ 239 TERAMRIWIDP KL+G LTP DV AI QNALV+ GTLG LPS + Q I+ATVVV GQ Sbjct: 181 TERAMRIWIDPAKLVGYKLTPTDVYNAIRNQNALVSAGTLGDLPSTSDQPIAATVVVEGQ 240 Query: 240 LTSPEQFGNIVLRANADGSSVRMRDVARIEVGGQSYDTSGRLDGKPSSFIGVQLSPTANA 299 +T+ EQFGNIVL + DGS VR++DVAR+E+GGQ+Y TS R++G+P S IGVQLSPT NA Sbjct: 241 MTTTEQFGNIVLVSKPDGSQVRIKDVARLELGGQTYATSARINGQPISAIGVQLSPTGNA 300 Query: 300 LGTATAVHKKMEELARYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFL 359 LGTA AV K++EL++YFPAGV+Y IPYDTSKFV+ISIEEVVKTL EA+ LVFLVM +FL Sbjct: 301 LGTAKAVKAKLDELSKYFPAGVEYKIPYDTSKFVQISIEEVVKTLFEAMALVFLVMLVFL 360 Query: 360 QNIRYTIIPTIVVPVALMGTFATLFVFGFSINVLTMFGMVLAIGILVDDAIVVVENVERI 419 QNIRYT+IP+IVVP++L+G FAT+ GFSINVLTMFG+VLAIGILVDDAIVVVENVERI Sbjct: 361 QNIRYTLIPSIVVPISLLGAFATMNALGFSINVLTMFGLVLAIGILVDDAIVVVENVERI 420 Query: 420 MSEEGLSPKEATRKAMGQITGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLAMVASMV 479 MS+EGL P+EATRKAMGQITGA+IGITLVL+AVFIPMAFF G+VGAIYRQFSL+MVAS+ Sbjct: 421 MSQEGLPPREATRKAMGQITGAIIGITLVLMAVFIPMAFFSGSVGAIYRQFSLSMVASIF 480 Query: 480 FSVLMAFTLTPALCATILLPVEKGHHHEKSGFFGWFNRRFNKTASGYQGFIGKMLTKTGR 539 FS LMA TLTPALC+T+L P+EKG HHEK GFFGWFNR F T YQ + ++L KT R Sbjct: 481 FSALMALTLTPALCSTLLKPIEKGSHHEKKGFFGWFNRMFTSTTDRYQSLVERVLKKTFR 540 Query: 540 YMIVYALIVGCVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTGRTLEVIKTIENYYLK 599 YM++Y ++ V L++RLP+SFLPNEDQGYIITN+QLPP AS RTLEVIK +ENYY Sbjct: 541 YMVIYGALIAAVVFLFMRLPSSFLPNEDQGYIITNIQLPPAASANRTLEVIKHVENYYQH 600 Query: 600 QPAVEHVVAIAGFSFSGNGQNAGLVFTPLKDWSERDKTQSADAVAGRAFGA-FSQIKDAI 658 + AVE++VA+ GFSFSGNG NA LVFT LKDWS R QSADAVAGRAFGA F I+DAI Sbjct: 601 EKAVENIVAVQGFSFSGNGPNAALVFTTLKDWSSRGADQSADAVAGRAFGALFGGIRDAI 660 Query: 659 VFPLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMASQSKVLAGVRPEGLED 718 VFPLNPPPIPELGNATGFTFRLQDR GLGH AL+ ARNQ+LGMA QSKVL VRP+GLED Sbjct: 661 VFPLNPPPIPELGNATGFTFRLQDRGGLGHDALMAARNQLLGMAGQSKVLKNVRPDGLED 720 Query: 719 APQLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADAKRRLQP 778 +PQ Q+DIDR+KANALGV F+ IN+VLSTALGS+Y NDFPN GRQQRVIVQAD R+QP Sbjct: 721 SPQYQVDIDREKANALGVAFADINNVLSTALGSAYANDFPNYGRQQRVIVQADRINRMQP 780 Query: 779 EDLAGLYARNSGGTMVPFSAFTTSKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGDAMTE 838 ED+ LY RN+ G+MVP SAF W+ GPVQL+RYNGYP+++I+G AA G STGDAM E Sbjct: 781 EDIMNLYVRNTQGSMVPMSAFAKGHWVVGPVQLVRYNGYPSVRISGDAATGASTGDAMDE 840 Query: 839 MESFVAKLPPGFGFEWTGQSLEEKTSGSQAPALYALSLIAVFLVLAALYESTSIPLAVML 898 ME ++LP G GFEWTGQSL+EK+SGSQAPALYALSL+AVFLVLAALYES SIP AV+L Sbjct: 841 MEHLASRLPAGIGFEWTGQSLQEKSSGSQAPALYALSLLAVFLVLAALYESWSIPAAVIL 900 Query: 899 VVPLGILGALLGVTLRGMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDLQAQGMGLIEAT 958 VVPLG+LGALLGVTLR MP+DVYFKVG+IAVVGLSAKNAILIIEFAKDLQAQG GLIEAT Sbjct: 901 VVPLGVLGALLGVTLRFMPDDVYFKVGLIAVVGLSAKNAILIIEFAKDLQAQGKGLIEAT 960 Query: 959 LEAVHLRFRPIIMTSLAFILGVLPLVIASGAGSASQRAIGTGVMGGMITATVLAVFLVPI 1018 LEAVHLRFRPIIMTS AFILGVLPL IA+GA SASQRAIGTGVMGGMITATVLAV LVP+ Sbjct: 961 LEAVHLRFRPIIMTSFAFILGVLPLAIATGASSASQRAIGTGVMGGMITATVLAVVLVPV 1020 Query: 1019 FFVVVRKIFKGSERQRQLDAAHHKIDVE 1046 FFVVVR+IFKGSERQR+LDAAH +D E Sbjct: 1021 FFVVVRRIFKGSERQRRLDAAHLPLDEE 1048 >SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1048 Score = 1348 bits (3488), Expect = 0.0, Method: Compositional matrix adjust. Identities = 673/1034 (65%), Positives = 831/1034 (80%), Gaps = 3/1034 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIILAGALAITGLPVSQYPSIAPPTIVVTATYPGATAQTLDDS 60 M FFIDRP+FAWV+AIFI++AG +AI LPVSQYP +APP I + YPGA++Q S Sbjct: 1 MPSFFIDRPIFAWVVAIFIMIAGIIAIPLLPVSQYPDVAPPQISINTNYPGASSQDTYQS 60 Query: 61 VTSLIEQEMNGADGLQYMESQSQANGQVQITVTFSPDTNADLAAVDVQNRLKRVEARLPA 120 VT LIE E+NG +GL Y ES + ++G V I TF P T+ A+VD+QNR++RVE RLP Sbjct: 61 VTRLIEDELNGVEGLLYFESSTSSSGSVSIDATFQPGTDPSQASVDIQNRVQRVEPRLPD 120 Query: 121 AVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEVKRVPGVGQAQLFGT 180 V QQGVQV ++ + FLL I L+STDG +D + LGDYLSRNVL+E++RVPGVG+AQLF T Sbjct: 121 PVRQQGVQVDEAGAGFLLIISLTSTDGSMDAIGLGDYLSRNVLSEIQRVPGVGRAQLFAT 180 Query: 181 ERAMRIWIDPNKLIGLNLTPADVTAAITAQNALVAGGTLGALPSPTSQQISATVVVNGQL 240 ER+MR+W+DP+K++GLNLT ADVTAAI AQNA +A G++GA P+P +QQ++A VV+ GQL Sbjct: 181 ERSMRVWLDPDKMLGLNLTAADVTAAIQAQNAQIASGSIGAQPNPITQQVTAPVVIKGQL 240 Query: 241 TSPEQFGNIVLRANADGSSVRMRDVARIEVGGQSYDTSGRLDGKPSSFIGVQLSPTANAL 300 +SPE+FG IVLRANADGS+VR+RDVAR+E+GG+SY S RL+G PS+ I VQLSP+ NA+ Sbjct: 241 SSPEEFGAIVLRANADGSAVRLRDVARLEIGGESYTFSTRLNGSPSAAIAVQLSPSGNAM 300 Query: 301 GTATAVHKKMEELARYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFLQ 360 T+ A+ +M+ELA +FP G++Y+IPYDTS FV +SIE+V+ TL+EA+ LVFLVMFLFLQ Sbjct: 301 STSAAIKARMDELAEFFPEGLEYSIPYDTSPFVAVSIEKVLHTLVEAVGLVFLVMFLFLQ 360 Query: 361 NIRYTIIPTIVVPVALMGTFATLFVFGFSINVLTMFGMVLAIGILVDDAIVVVENVERIM 420 N+RYTIIPTIVVPVAL+GT A + GFSINVLTMFGMVLAIGILVDDAI+VVENVERIM Sbjct: 361 NVRYTIIPTIVVPVALLGTCAVMLAMGFSINVLTMFGMVLAIGILVDDAIIVVENVERIM 420 Query: 421 SEEGLSPKEATRKAMGQITGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLAMVASMVF 480 SEEGL+PK+ATRKAM QITGA+IGITLVL +VFIPMAFF GAVG IYRQFSL MV S++F Sbjct: 421 SEEGLTPKDATRKAMKQITGAVIGITLVLASVFIPMAFFPGAVGVIYRQFSLTMVVSILF 480 Query: 481 SVLMAFTLTPALCATILLPVEKGHHHEKSGFFGWFNRRFNKTASGYQGFIGKMLTKTGRY 540 S L+A +LTPALCA+ L V KGHHH K GFFGWFNR F++T+ GY +G ++ +TGR+ Sbjct: 481 SALLALSLTPALCASFLKQVPKGHHHAKRGFFGWFNRGFDRTSHGYTRAVGGIVRRTGRF 540 Query: 541 MIVYALIVGCVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTGRTLEVIKTIENYYLKQ 600 M++Y ++ +G +++LP+SFLP+EDQG++I +QLP A+ RT EVI+ E + ++ Sbjct: 541 MVIYLALLAGLGWAFLQLPSSFLPDEDQGFVIVMMQLPSEATANRTTEVIEQTETIFGQE 600 Query: 601 PAVEHVVAIAGFSFSGNGQNAGLVFTPLKDWSERDKTQSADAVAGRAFGAFSQIKDAIVF 660 AV+ +VAI GFSF G+GQNAGL F LKDWSERD SA ++AGRA A SQIKDAI F Sbjct: 601 KAVDTIVAINGFSFFGSGQNAGLAFVTLKDWSERDADNSAQSIAGRATMAMSQIKDAISF 660 Query: 661 PLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMASQSKVLAGVRPEGLEDAP 720 L+PP I LG GF+FRLQDRAGLG AAL +AR+Q+L +ASQSKVL GVR EG+ DA Sbjct: 661 ALSPPAIQGLGTTGGFSFRLQDRAGLGQAALAEARDQLLDLASQSKVLTGVRFEGMPDAA 720 Query: 721 QLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADAKRRLQPED 780 Q+ ++IDR+KAN GV F+ INS +ST LGSSYVNDFPN GR QRV VQAD +R+Q D Sbjct: 721 QVSVNIDREKANTFGVTFADINSTISTNLGSSYVNDFPNAGRMQRVTVQADETKRMQTAD 780 Query: 781 LAGLYARNSGGTMVPFSAFTTSKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGDAMTEME 840 L L RNS G MVP SAF +W+ P Q + YNGYPA++I+G AAPG S+GDA+ EME Sbjct: 781 LLNLNVRNSNGGMVPLSAFADVEWVKAPTQTVGYNGYPAVRISGEAAPGYSSGDAIAEME 840 Query: 841 SFVAKLPPGFGFEWTGQSLEEKTSGSQAPALYALSLIAVFLVLAALYESTSIPLAVMLVV 900 VA+LP GFG+EWTGQSL+E SGSQAP L ALS + VFL LAALYES SIP++V++VV Sbjct: 841 RLVAELPAGFGYEWTGQSLQEIQSGSQAPLLIALSCLLVFLCLAALYESWSIPVSVIMVV 900 Query: 901 PLGILGALLGVTLRGMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDLQAQGMGLIEATLE 960 PLG++GA+L VT+R MPNDVYFKVG+IA++GLSAKNAILIIEFAK+L+ QG LI++TLE Sbjct: 901 PLGVIGAVLAVTMRDMPNDVYFKVGLIAIIGLSAKNAILIIEFAKELREQGKSLIDSTLE 960 Query: 961 AVHLRFRPIIMTSLAFILGVLPLVIASGAGSASQRAIGTGVMGGMITATVLAVFLVPIFF 1020 A HLRFRPI+MTSLAF LGVLPL IA+GA S SQRAIGTGVMGGMI+ATVLA+F VP+FF Sbjct: 961 AAHLRFRPILMTSLAFTLGVLPLAIATGASSGSQRAIGTGVMGGMISATVLAIFFVPVFF 1020 Query: 1021 VVVRKIFKGSERQR 1034 V V KIF ER R Sbjct: 1021 VFVMKIF---ERGR 1031 >AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1044 Score = 1292 bits (3344), Expect = 0.0, Method: Compositional matrix adjust. Identities = 648/1013 (63%), Positives = 813/1013 (80%), Gaps = 1/1013 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIILAGALAITGLPVSQYPSIAPPTIVVTATYPGATAQTLDDS 60 M +FFIDRP+FAWV+AIFI+LAG LAI LP++QYP++APP I + YPGA+ + + S Sbjct: 1 MARFFIDRPIFAWVVAIFIMLAGLLAIPMLPIAQYPNVAPPQISIGTNYPGASPEDIYQS 60 Query: 61 VTSLIEQEMNGADGLQYMESQSQANGQVQITVTFSPDTNADLAAVDVQNRLKRVEARLPA 120 VT IE+E+NG GL Y ES S+++G++ I VTF P TN A V+VQNR+ RVE RLP Sbjct: 61 VTRPIEEELNGVPGLIYFESTSESSGRISINVTFEPGTNIGEAQVEVQNRIARVEPRLPR 120 Query: 121 AVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEVKRVPGVGQAQLFGT 180 +VTQQG++V ++ ++FL+ + L+S DG D + LGDYLSRNVL E++RVPGVG AQLF T Sbjct: 121 SVTQQGLRVEQAGTSFLMMVALTSVDGNTDAIGLGDYLSRNVLGELRRVPGVGSAQLFAT 180 Query: 181 ERAMRIWIDPNKLIGLNLTPADVTAAITAQNALVAGGTLGALPSPTSQQISATVVVNGQL 240 +R+MRIW+DP+K++GL+LT DV AI AQN+ VA G +GA P+P QQISATV V GQL Sbjct: 181 QRSMRIWMDPDKMLGLSLTSDDVINAIQAQNSQVAAGRIGASPNPVGQQISATVNVQGQL 240 Query: 241 TSPEQFGNIVLRANADGSSVRMRDVARIEVGGQSYDTSGRLDGKPSSFIGVQLSPTANAL 300 TSPE+FG+IVLRAN DGSSVR+RDVAR+EVGG+SY+ S RL+GKPS+ IGVQLSPTANA+ Sbjct: 241 TSPEEFGSIVLRANPDGSSVRLRDVARVEVGGESYNFSSRLNGKPSAAIGVQLSPTANAM 300 Query: 301 GTATAVHKKMEELARYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFLQ 360 T+ V MEEL+RYFP G++Y IPYDTS FVKISIE+V+ TLIEA++LVF+VMF+FLQ Sbjct: 301 QTSEGVRATMEELSRYFPQGIEYEIPYDTSPFVKISIEKVIHTLIEAMILVFVVMFVFLQ 360 Query: 361 NIRYTIIPTIVVPVALMGTFATLFVFGFSINVLTMFGMVLAIGILVDDAIVVVENVERIM 420 NIRYTIIPT+VVPVAL+GT A ++V GFSINVLTMF MVLAIGILVDDAIVVVENVERIM Sbjct: 361 NIRYTIIPTLVVPVALLGTCAVMYVSGFSINVLTMFAMVLAIGILVDDAIVVVENVERIM 420 Query: 421 SEEGLSPKEATRKAMGQITGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLAMVASMVF 480 +EE LSPKEATRKAMGQI+GA+IGITLVL AVF+PMAFF GAVG IY+QFSL MV S++F Sbjct: 421 AEEHLSPKEATRKAMGQISGAIIGITLVLTAVFVPMAFFPGAVGIIYQQFSLTMVVSILF 480 Query: 481 SVLMAFTLTPALCATILLPVEKGHHHEKSGFFGWFNRRFNKTASGYQGFIGKMLTKTGRY 540 S +A +LTPALCA+ L P++ G HHEK GFFGWFNR F+K + Y +G ++ ++GR+ Sbjct: 481 SGFLALSLTPALCASFLKPIKAG-HHEKKGFFGWFNRNFDKASHKYSSSVGGIIKRSGRF 539 Query: 541 MIVYALIVGCVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTGRTLEVIKTIENYYLKQ 600 MI+YA ++ +G Y++LP+SFLPNEDQGY+I ++Q P AST RTL+ I+ IE ++++ Sbjct: 540 MIIYAALLAGLGWAYMQLPSSFLPNEDQGYLIVDIQAPAEASTERTLQSIQQIEKIFMEE 599 Query: 601 PAVEHVVAIAGFSFSGNGQNAGLVFTPLKDWSERDKTQSADAVAGRAFGAFSQIKDAIVF 660 PAVE V+AI+GFSFSG+GQNAGL F LKDWSER SA A++ R G + DA+ F Sbjct: 600 PAVERVIAISGFSFSGSGQNAGLAFATLKDWSERGPEDSAAAISARINGKLWGLPDAMSF 659 Query: 661 PLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMASQSKVLAGVRPEGLEDAP 720 L+PPPI LGN++GFTFRLQDR+G G AL A Q++ A QS VLAG+R EG+ DA Sbjct: 660 ALSPPPIQGLGNSSGFTFRLQDRSGAGQTALSAAGAQLMAAARQSPVLAGLRIEGMPDAA 719 Query: 721 QLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADAKRRLQPED 780 Q+ L IDR+KAN GV FS IN+ +S +GSSYVNDFPN GR QRV VQA+ +R++ ED Sbjct: 720 QVNLIIDREKANTFGVTFSDINATISANMGSSYVNDFPNAGRMQRVTVQAEQGQRMKTED 779 Query: 781 LAGLYARNSGGTMVPFSAFTTSKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGDAMTEME 840 L L RN+ G MVP S+F T +W+ GP Q++ YNGYPA++++G +APG S+GDA+ EME Sbjct: 780 LLNLNVRNANGGMVPVSSFATVEWVRGPSQVVGYNGYPAIRVSGQSAPGYSSGDAIAEME 839 Query: 841 SFVAKLPPGFGFEWTGQSLEEKTSGSQAPALYALSLIAVFLVLAALYESTSIPLAVMLVV 900 +LP GFGFEWTGQSL+E SGSQAPAL LS++ VFL+LAALYES SIPL+VMLVV Sbjct: 840 RLARELPGGFGFEWTGQSLQEIQSGSQAPALIGLSVLFVFLLLAALYESWSIPLSVMLVV 899 Query: 901 PLGILGALLGVTLRGMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDLQAQGMGLIEATLE 960 PLG++G++ V LRGMPNDVYF VG++A++GLSAKNAILIIEFAKDL+A+G +AT+E Sbjct: 900 PLGVIGSVAAVMLRGMPNDVYFLVGLVAIIGLSAKNAILIIEFAKDLRAEGKSTYDATVE 959 Query: 961 AVHLRFRPIIMTSLAFILGVLPLVIASGAGSASQRAIGTGVMGGMITATVLAV 1013 A HLRFRPI+MTSLAF LGVLP+ IASGA +ASQ AIGTGV+GGMI+AT+LA+ Sbjct: 960 AAHLRFRPILMTSLAFSLGVLPMAIASGASAASQNAIGTGVLGGMISATILAI 1012 >STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1049 Score = 1229 bits (3179), Expect = 0.0, Method: Compositional matrix adjust. Identities = 602/1019 (59%), Positives = 769/1019 (75%), Gaps = 6/1019 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIILAGALAITGLPVSQYPSIAPPTIVVTATYPGATAQTLDDS 60 M FFIDRP+FAWV+AI I+LAG LAI LPV+QYP+IAPP + ++ATYPGA A+T+ D+ Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDT 60 Query: 61 VTSLIEQEMNGADGLQYMESQSQANGQVQITVTFSPDTNADLAAVDVQNRLKRVEARLPA 120 VT +IEQ MNG D L YM S S + G VQIT+TF T+AD+A V VQN+L+ LP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 AVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEVKRVPGVGQAQLFGT 180 V QQGV V KS S+FL+ +G+ +TDG + + DY++ N+ + + R GVG QLFG+ Sbjct: 121 EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDPISRTSGVGDVQLFGS 180 Query: 181 ERAMRIWIDPNKLIGLNLTPADVTAAITAQNALVAGGTLGALPSPTSQQISATVVVNGQL 240 + AMRIW++P +L LTP DV AI AQNA VA G LG P QQ++A+++ +L Sbjct: 181 QYAMRIWMNPTELTKYQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 TSPEQFGNIVLRANADGSSVRMRDVARIEVGGQSYDTSGRLDGKPSSFIGVQLSPTANAL 300 TS ++FG I+L+ N DGS VR+RDVA+IE+GG++YD + +G+P+S +G++L+ ANAL Sbjct: 241 TSTDEFGKILLKVNQDGSQVRLRDVAKIELGGENYDVIAKFNGQPASGLGIKLATGANAL 300 Query: 301 GTATAVHKKMEELARYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFLQ 360 TATA+ +++++ +FP G+K PYDT+ FVKISI EVVKTL+EAI+LVFLVM+LFLQ Sbjct: 301 DTATAIRAELKKMEPFFPPGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NIRYTIIPTIVVPVALMGTFATLFVFGFSINVLTMFGMVLAIGILVDDAIVVVENVERIM 420 N R T+IPTI VPV L+GTFA L FGFSIN LTMFGMVLAIG+LVDDAIVVVENVER+M Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLSPKEATRKAMGQITGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLAMVASMVF 480 +EEGL PKEATRK+MGQI GAL+GI +VL AVFIPMAFFGG+ GAIYRQFS+ +V++M Sbjct: 421 TEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLMAFTLTPALCATILLPVEKGHHHE-KSGFFGWFNRRFNKTASGYQGFIGKMLTKTGR 539 SVL+A LTPALCAT+L PV KG H E K GFFGWFNR F+K+ Y +G +L TGR Sbjct: 481 SVLVALILTPALCATMLKPVAKGDHGEGKKGFFGWFNRLFDKSTHHYTDSVGNILRSTGR 540 Query: 540 YMIVYALIVGCVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTGRTLEVIKTIENYYLK 599 Y+++Y +IV + L+VRLP+SFLP+EDQG +T VQLP GA+ RT +V+ + +YYL Sbjct: 541 YLLLYLIIVVGMAYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLDEVTDYYLN 600 Query: 600 QPA--VEHVVAIAGFSFSGNGQNAGLVFTPLKDWSER-DKTQSADAVAGRAFGAFSQIKD 656 + VE V A+ GF F+G GQN G+ F LKDW++R + +A+ RA AFSQIKD Sbjct: 601 KEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEKNKVEAITQRATAAFSQIKD 660 Query: 657 AIVFPLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILG-MASQSKVLAGVRPEG 715 A+VF N P I ELG ATGF F L D+AGLGH L QARNQ+ G +A +L GVRP G Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLFGEVAKYPDLLVGVRPNG 720 Query: 716 LEDAPQLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADAKRR 775 LED PQ ++DID++KA ALGV S IN+ L A G SYVNDF ++GR ++V V ++AK R Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 776 LQPEDLAGLYARNSGGTMVPFSAFTTSKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGDA 835 + P+D+ Y R S G MVPFSAF++S+W G +L RYNG P+M+I G AAPG+STG+A Sbjct: 781 MLPDDINDWYVRGSDGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA 840 Query: 836 MTEMESFVAKLPPGFGFEWTGQSLEEKTSGSQAPALYALSLIAVFLVLAALYESTSIPLA 895 M ME +KLP G G++WTG S +E+ SG+QAPALYA+SLI VFL LAALYES SIP + Sbjct: 841 MAMMEELASKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFS 900 Query: 896 VMLVVPLGILGALLGVTLRGMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDL-QAQGMGL 954 VMLVVPLG++GALL T RG+ NDVYF+VG++ +GLSAKNAILI+EFAKDL +G GL Sbjct: 901 VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL 960 Query: 955 IEATLEAVHLRFRPIIMTSLAFILGVLPLVIASGAGSASQRAIGTGVMGGMITATVLAV 1013 +EATLEAV +R RPI+MTSLAF+LGV+PLVI+SGAGS +Q A+GTGV+GGM+TATVLA+ Sbjct: 961 VEATLEAVRMRLRPILMTSLAFMLGVMPLVISSGAGSGAQNAVGTGVLGGMVTATVLAI 1019 >acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1049 Score = 1217 bits (3148), Expect = 0.0, Method: Compositional matrix adjust. Identities = 596/1019 (58%), Positives = 767/1019 (75%), Gaps = 6/1019 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIILAGALAITGLPVSQYPSIAPPTIVVTATYPGATAQTLDDS 60 M FFIDRP+FAWV+AI I+LAG LAI LPV+QYP+IAPP + ++A+YPGA A+T+ D+ Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60 Query: 61 VTSLIEQEMNGADGLQYMESQSQANGQVQITVTFSPDTNADLAAVDVQNRLKRVEARLPA 120 VT +IEQ MNG D L YM S S + G VQIT+TF T+AD+A V VQN+L+ LP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 AVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEVKRVPGVGQAQLFGT 180 V QQGV V KS S+FL+ +G+ +TDG + + DY++ N+ + + R GVG QLFG+ Sbjct: 121 EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180 Query: 181 ERAMRIWIDPNKLIGLNLTPADVTAAITAQNALVAGGTLGALPSPTSQQISATVVVNGQL 240 + AMRIW++PN+L LTP DV AI AQNA VA G LG P QQ++A+++ +L Sbjct: 181 QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 TSPEQFGNIVLRANADGSSVRMRDVARIEVGGQSYDTSGRLDGKPSSFIGVQLSPTANAL 300 TS E+FG I+L+ N DGS V +RDVA+IE+GG++YD +G+P+S +G++L+ ANAL Sbjct: 241 TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300 Query: 301 GTATAVHKKMEELARYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFLQ 360 TA A+ ++ ++ +FP+G+K PYDT+ FVKISI EVVKTL+EAI+LVFLVM+LFLQ Sbjct: 301 DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NIRYTIIPTIVVPVALMGTFATLFVFGFSINVLTMFGMVLAIGILVDDAIVVVENVERIM 420 N R T+IPTI VPV L+GTFA L FGFSIN LTMFGMVLAIG+LVDDAIVVVENVER+M Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLSPKEATRKAMGQITGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLAMVASMVF 480 +EEGL PKEATRK+MGQI GAL+GI +VL AVF+PMAFFGG+ GAIYRQFS+ +V++M Sbjct: 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLMAFTLTPALCATILLPVEKGHHHE-KSGFFGWFNRRFNKTASGYQGFIGKMLTKTGR 539 SVL+A LTPALCAT+L P+ KG H E K GFFGWFNR F K+ Y +G +L TGR Sbjct: 481 SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540 Query: 540 YMIVYALIVGCVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTGRTLEVIKTIENYYL- 598 Y+++Y +IV + L+VRLP+SFLP+EDQG +T VQLP GA+ RT +V+ + +YYL Sbjct: 541 YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600 Query: 599 -KQPAVEHVVAIAGFSFSGNGQNAGLVFTPLKDWSER-DKTQSADAVAGRAFGAFSQIKD 656 ++ VE V A+ GF F+G GQN G+ F LKDW++R + +A+ RA AFSQIKD Sbjct: 601 KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660 Query: 657 AIVFPLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMASQS-KVLAGVRPEG 715 A+VF N P I ELG ATGF F L D+AGLGH L QARNQ+L A++ +L VRP G Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720 Query: 716 LEDAPQLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADAKRR 775 LED PQ ++DID++KA ALGV + IN+ L A G SYVNDF ++GR ++V V ++AK R Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 776 LQPEDLAGLYARNSGGTMVPFSAFTTSKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGDA 835 + P+D+ Y R + G MVPFSAF++S+W G +L RYNG P+M+I G AAPG+STG+A Sbjct: 781 MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA 840 Query: 836 MTEMESFVAKLPPGFGFEWTGQSLEEKTSGSQAPALYALSLIAVFLVLAALYESTSIPLA 895 M ME +KLP G G++WTG S +E+ SG+QAP+LYA+SLI VFL LAALYES SIP + Sbjct: 841 MELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFS 900 Query: 896 VMLVVPLGILGALLGVTLRGMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDL-QAQGMGL 954 VMLVVPLG++GALL T RG+ NDVYF+VG++ +GLSAKNAILI+EFAKDL +G GL Sbjct: 901 VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL 960 Query: 955 IEATLEAVHLRFRPIIMTSLAFILGVLPLVIASGAGSASQRAIGTGVMGGMITATVLAV 1013 IEATL+AV +R RPI+MTSLAFILGV+PLVI++GAGS +Q A+GTGVMGGM+TATVLA+ Sbjct: 961 IEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAI 1019