BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0177.p (375 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RP334 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Rpr Ricket... 496 e-140 RC0458 Non COG 488 e-137 PM1009 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Pmu Paste... 456 e-128 SA0150 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Sau Staph... 424 e-118 SP0360 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Spn Strep... 355 8e-98 >RP334 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Rpr Rickettsia prowazekii Length = 376 Score = 496 bits (1277), Expect = e-140, Method: Compositional matrix adjust. Identities = 226/376 (60%), Positives = 299/376 (79%), Gaps = 2/376 (0%) Query: 1 MLKVMTLVGTRPELIKMSRVIAECDRQFNHVLVHSGQNYDYELNQIFFNDLEIRQPDFFL 60 MLKVMT++GTRPELIKM VI+E D+ NH+LVH+GQNY YELN +FF+D+ IR+PD+FL Sbjct: 1 MLKVMTILGTRPELIKMCLVISEFDKYTNHILVHTGQNYAYELNHVFFDDMGIRKPDYFL 60 Query: 61 EAAGETAAKTIAAVIEKSDALFAQEKPDALLLYGDTNTCLAVISAKRRKIPVFHMEAGNR 120 E A + AK+I VI K D + +EKPDA+L YGDTN+CL+ I+AKRRKIP+FHMEAGNR Sbjct: 61 EIASDNTAKSIGIVIAKVDEVLEKEKPDAVLFYGDTNSCLSAIAAKRRKIPIFHMEAGNR 120 Query: 121 CFDQRVPEELNRKVLDHLSDINMVLTEHARRYLIGEGIKPETIIKTGSHMREVIDHYRPK 180 CFDQRVPEE+NRK++DH+SD+N+ LTEHARRYLI EG PE I+K+GSHM EV++H+ PK Sbjct: 121 CFDQRVPEEINRKIIDHISDVNITLTEHARRYLISEGFPPERILKSGSHMPEVLNHFMPK 180 Query: 181 IENSDVLSRLNFEPGKFFVVSAHREENVDSPEAIKDLLETLQALVRKYGLPIFVSTHPRT 240 I SD+L +L + ++F++S+HREENVD ++DLL +LQ L+++Y PI STHPRT Sbjct: 181 ILKSDILEKLLLKAKQYFLISSHREENVDVKNNLQDLLSSLQILIQEYNYPIIFSTHPRT 240 Query: 241 RKRLEEI-GYEELDSRIVFSKPLGFFDYMKLQMNALCVLSDSGTITEEASLLNLPAITIR 299 +KRL+++ ++EL+ +I F P F DY+KLQ+NA C+LSDSGT+TEEAS+LNLPA+ IR Sbjct: 241 KKRLKDLECFQELEDKIRFLPPFSFTDYVKLQINAFCILSDSGTLTEEASILNLPALNIR 300 Query: 300 NAHERPEGMDVGTLIMAGLKAERVIDAIEIIASQRKRKSQPVLPVADY-ENPNVSKQVVR 358 AHERPEGMD GTLIM+G KAER++ ++++I +Q K V+DY E VSK+++R Sbjct: 301 EAHERPEGMDAGTLIMSGFKAERILQSVKVITAQHKNNKCLQNIVSDYAEASIVSKKILR 360 Query: 359 VVASYVDYINRVVWSK 374 +V SYVDY+NR VW K Sbjct: 361 IVLSYVDYVNRTVWFK 376 >RC0458 Non COG Length = 377 Score = 488 bits (1255), Expect = e-137, Method: Compositional matrix adjust. Identities = 225/376 (59%), Positives = 296/376 (78%), Gaps = 2/376 (0%) Query: 1 MLKVMTLVGTRPELIKMSRVIAECDRQFNHVLVHSGQNYDYELNQIFFNDLEIRQPDFFL 60 MLKVMT+VGTRPELIK+ VI+E D+ +H+LVH+GQNY YEL+Q+FF+D+ IR+PD+FL Sbjct: 1 MLKVMTIVGTRPELIKLCCVISEFDKYTHHILVHTGQNYAYELHQVFFDDMGIRKPDYFL 60 Query: 61 EAAGETAAKTIAAVIEKSDALFAQEKPDALLLYGDTNTCLAVISAKRRKIPVFHMEAGNR 120 E A + AK+I +IEK DA+ +EKPDA+L YGDTN+CL+ I+AKRRKIP+FHMEAGNR Sbjct: 61 EVAADNTAKSIGLIIEKVDAVLEKEKPDAVLFYGDTNSCLSAIAAKRRKIPIFHMEAGNR 120 Query: 121 CFDQRVPEELNRKVLDHLSDINMVLTEHARRYLIGEGIKPETIIKTGSHMREVIDHYRPK 180 CFDQRVPEE+NRK++DH+SD+N+ LTEHARRYLI EG+ PE I K+GSHM EV+D + K Sbjct: 121 CFDQRVPEEINRKIIDHISDVNITLTEHARRYLIFEGLPPELIFKSGSHMPEVLDRFMSK 180 Query: 181 IENSDVLSRLNFEPGKFFVVSAHREENVDSPEAIKDLLETLQALVRKYGLPIFVSTHPRT 240 I SD+L +L+ ++F++S+HREENVD +K+LL +LQ L+++Y P+ STHPRT Sbjct: 181 ILKSDILDKLSLTTKQYFLISSHREENVDVKNNLKELLSSLQTLIKEYNFPVIFSTHPRT 240 Query: 241 RKRLEEI-GYEELDSRIVFSKPLGFFDYMKLQMNALCVLSDSGTITEEASLLNLPAITIR 299 +KRLE++ ++EL +I F GF DY+KLQMNA C+LSDSGTITEEAS+LNLPA+ IR Sbjct: 241 KKRLEDLEEFKELGDKIRFLPAFGFTDYVKLQMNAFCILSDSGTITEEASILNLPALNIR 300 Query: 300 NAHERPEGMDVGTLIMAGLKAERVIDAIEIIASQRKRKSQPVLPVADY-ENPNVSKQVVR 358 AHERPEGMD GTLIM+G KAERV+ +++ I + + + V DY E VSK+++R Sbjct: 301 EAHERPEGMDAGTLIMSGFKAERVLQSVKAITEEHENNKRLQEIVPDYAEAGLVSKKILR 360 Query: 359 VVASYVDYINRVVWSK 374 +V SYVDY+N VW K Sbjct: 361 IVLSYVDYVNHTVWFK 376 >PM1009 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Pmu Pasteurella multocida Length = 376 Score = 456 bits (1173), Expect = e-128, Method: Compositional matrix adjust. Identities = 210/373 (56%), Positives = 280/373 (75%), Gaps = 1/373 (0%) Query: 2 LKVMTLVGTRPELIKMSRVIAECDRQFNHVLVHSGQNYDYELNQIFFNDLEIRQPDFFLE 61 LKVMT+VGTRPE+I++SRVI CD+ F H+LVH+GQNYDYELN++FF+DL IR+PD+FL Sbjct: 4 LKVMTVVGTRPEIIRLSRVIVACDKHFQHILVHTGQNYDYELNEVFFHDLGIRKPDYFLN 63 Query: 62 AAGETAAKTIAAVIEKSDALFAQEKPDALLLYGDTNTCLAVISAKRRKIPVFHMEAGNRC 121 AAG+T++ TI VI D L + +P+ALL+ GDTN+CLAV+ AKRRKIP FHMEAGNRC Sbjct: 64 AAGKTSSATIGNVIIAVDQLLEETQPEALLVLGDTNSCLAVLPAKRRKIPTFHMEAGNRC 123 Query: 122 FDQRVPEELNRKVLDHLSDINMVLTEHARRYLIGEGIKPETIIKTGSHMREVIDHYRPKI 181 FD RVPEE+NR+++DH +DIN+ + AR YL+ EG+ P+ IIKTGS M EV+ Y +I Sbjct: 124 FDMRVPEEINRRIVDHTADINLTYSTIARDYLLAEGLSPDLIIKTGSPMFEVLHFYHEQI 183 Query: 182 ENSDVLSRLNFEPGKFFVVSAHREENVDSPEAIKDLLETLQALVRKYGLPIFVSTHPRTR 241 ++S +L +L P ++FVVSAHREEN++S DL+ TL A+ +KY P+ VSTHPRTR Sbjct: 184 KHSKILDKLGLTPFQYFVVSAHREENINSEPHFLDLIHTLNAVAKKYQYPVIVSTHPRTR 243 Query: 242 KRLEEIGYEELDSRIVFSKPLGFFDYMKLQMNALCVLSDSGTITEEASLLNLPAITIRNA 301 KR+EE+ I KPLGF DY KLQ+ A LSDSGTI EE+S+LN PA+ +R A Sbjct: 244 KRIEELNI-TFHPLIQLLKPLGFLDYNKLQLMAKATLSDSGTINEESSILNFPALNLRQA 302 Query: 302 HERPEGMDVGTLIMAGLKAERVIDAIEIIASQRKRKSQPVLPVADYENPNVSKQVVRVVA 361 HERPEGM+ +++ GL+AERV+ + I+ QR+ + + + VADY PNVS +V+R++ Sbjct: 303 HERPEGMEEAAVMLVGLQAERVLQGLAILDEQRRGQERDLRLVADYSMPNVSAKVIRILL 362 Query: 362 SYVDYINRVVWSK 374 SY DY+NRV+W K Sbjct: 363 SYTDYVNRVIWKK 375 >SA0150 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Sau Staphylococcus aureus N315 Length = 374 Score = 424 bits (1090), Expect = e-118, Method: Compositional matrix adjust. Identities = 194/373 (52%), Positives = 272/373 (72%), Gaps = 2/373 (0%) Query: 2 LKVMTLVGTRPELIKMSRVIAECDRQFNHVLVHSGQNYDYELNQIFFNDLEIRQPDFFLE 61 LK+MT+VGTRPE+I++S I CD+ FN +LVH+GQNYDY LNQIFF+DLE+RQPD +LE Sbjct: 4 LKLMTIVGTRPEIIRLSSTIKACDQYFNQILVHTGQNYDYTLNQIFFDDLELRQPDHYLE 63 Query: 62 AAGETAAKTIAAVIEKSDALFAQEKPDALLLYGDTNTCLAVISAKRRKIPVFHMEAGNRC 121 A G +T+ +I K+ + +E+PDALL+ GDTN+CLA +SAKR KIPVFHMEAGNRC Sbjct: 64 AVGSNLGETMGNIIAKTYDVLLREQPDALLILGDTNSCLAAVSAKRLKIPVFHMEAGNRC 123 Query: 122 FDQRVPEELNRKVLDHLSDINMVLTEHARRYLIGEGIKPETIIKTGSHMREVIDHYRPKI 181 FDQ VPEE+NRK++DH+SD+N+ TEH+RRYL+ EG I TGS M EVI+ +R KI Sbjct: 124 FDQNVPEEINRKIVDHVSDVNLPYTEHSRRYLLDEGFNKANIFVTGSPMTEVIEAHRDKI 183 Query: 182 ENSDVLSRLNFEPGKFFVVSAHREENVDSPEAIKDLLETLQALVRKYGLPIFVSTHPRTR 241 +SDVL++L EP ++ +VSAHREEN+D+ + K L+ + + +KY +P+ STHPR+ Sbjct: 184 NHSDVLNKLGLEPQQYILVSAHREENIDNEKNFKSLMNAINDIAKKYKMPVIYSTHPRSW 243 Query: 242 KRLEEIGYEELDSRIVFSKPLGFFDYMKLQMNALCVLSDSGTITEEASLLNLPAITIRNA 301 K++EE + E D + KP GFFDY LQ +A VLSDSGT++EE+S+L P + IR + Sbjct: 244 KKIEESKF-EFDPLVKQLKPFGFFDYNALQKDAFVVLSDSGTLSEESSILKFPGVLIRTS 302 Query: 302 HERPEGMDVGTLIMAGLKAERVIDAIEIIASQRKRKSQPVLPVADYENPNVSKQVVRVVA 361 ERPE +D GT+I+ G+ +I ++E +A + + ++P++ DY++ NVS +VV+++ Sbjct: 303 TERPEVLDKGTVIVGGITYNNLIQSVE-LAREMQNNNEPMIDAIDYKDTNVSTKVVKIIQ 361 Query: 362 SYVDYINRVVWSK 374 SY D INR W K Sbjct: 362 SYKDIINRNTWRK 374 >SP0360 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase Spn Streptococcus pneumoniae TIGR4 Length = 394 Score = 355 bits (912), Expect = 8e-98, Method: Compositional matrix adjust. Identities = 171/378 (45%), Positives = 248/378 (65%), Gaps = 7/378 (1%) Query: 2 LKVMTLVGTRPELIKMSRVIAECDRQFNHVLVHSGQNYDYELNQIFFNDLEIRQPDFFLE 61 LK++ +VGTRPE+I++S VI +C + F+ +L H+GQNYDY LN IFF++L + PD +++ Sbjct: 18 LKLLIIVGTRPEIIRLSSVITKCRKYFDVILAHTGQNYDYNLNGIFFDNLGLDTPDVYMD 77 Query: 62 AAGETAAKTIAAVIEKSDALFAQEKPDALLLYGDTNTCLAVISAKRRKIPVFHMEAGNRC 121 A G+ T+ +I S L Q KPDALL+ GDTN+CL+ I+AKR IP+FHMEAGNRC Sbjct: 78 AVGDDLGATVGNIINTSYKLMNQIKPDALLILGDTNSCLSAIAAKRLHIPIFHMEAGNRC 137 Query: 122 FDQRVPEELNRKVLDHLSDINMVLTEHARRYLIGEGIKPETIIKTGSHMREVIDHYRPKI 181 D+ +PEE NR+++D +SD+N+ +EHAR+YL G+ E TGS M EV+ I Sbjct: 138 KDECLPEETNRRIVDVISDVNLAYSEHARKYLHECGLPKERTYVTGSPMAEVLHKNLSAI 197 Query: 182 ENSDVLSRLNFEPGKFFVVSAHREENVDSPEAIKDLLETLQALVRKYGLPIFVSTHPRTR 241 E+SD+ RL + G + ++SAHREEN+D+ + L + L KY +PI S HPR++ Sbjct: 198 ESSDIHERLGLKKGGYILLSAHREENIDTDKNFISLFTAINQLAEKYNMPILYSCHPRSK 257 Query: 242 KRLEEIGYEELDSRIVFSKPLGFFDYMKLQMNALCVLSDSGTITEEASLLN-----LPAI 296 KRL+E G+ +LD R++ +PLGF DY LQMNA V+SDSGT+ EE+S PA+ Sbjct: 258 KRLQESGF-KLDKRVIQHEPLGFHDYNCLQMNAFVVVSDSGTLPEESSFFTSQGYPFPAV 316 Query: 297 TIRNAHERPEGMDVGTLIMAGLKAERVIDAIEIIASQRKRKSQPVLPVADYENPNVSKQV 356 IR + ERPE +D I+AG+ ++ A+E S + + LPV DY NVS +V Sbjct: 317 CIRTSTERPESLDKAGFILAGIDENSLLQAVETAVSLAQDEDFG-LPVPDYVEENVSTKV 375 Query: 357 VRVVASYVDYINRVVWSK 374 V+++ SY ++++VW K Sbjct: 376 VKIIQSYTGIVDKIVWRK 393