BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0176.p (336 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RC0457 [MG] COG1086 Predicted nucleoside-diphosphate sugar epime... 488 e-138 RP333 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimer... 487 e-137 PM1007 [MG] COG1086 Predicted nucleoside-diphosphate sugar epime... 476 e-134 SA0148 [MG] COG1086 Predicted nucleoside-diphosphate sugar epime... 471 e-132 SP0358 [MG] COG1086 Predicted nucleoside-diphosphate sugar epime... 428 e-120 >RC0457 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Rco Rickettsia conorii Length = 341 Score = 488 bits (1257), Expect = e-138, Method: Compositional matrix adjust. Identities = 234/338 (69%), Positives = 280/338 (82%), Gaps = 4/338 (1%) Query: 1 MFDNKVLMITGGTGSFGNTVLKRFLDTAV----REIRIFSRDEKKQEDMRIALKNDKVKF 56 MF +K LMITGGTGSFGN VL RFL + + +EIRIFSRDEKKQEDMRIAL N K+KF Sbjct: 1 MFVDKTLMITGGTGSFGNAVLSRFLKSGIINDIKEIRIFSRDEKKQEDMRIALNNPKLKF 60 Query: 57 YIGDVRNYDSIAQAMVGVDFVFHAAALKQVPSCEFYPMEAIRTNILGTENVLNAAIASKV 116 YIGDVRNY SI +AM GVD+VFHAAALKQVP+CEFYPMEAI TN+LG ENVL+AAI +KV Sbjct: 61 YIGDVRNYKSIDEAMHGVDYVFHAAALKQVPTCEFYPMEAINTNVLGAENVLSAAINNKV 120 Query: 117 KRVVVLSTDKAVYPINAMGISKAMAEKLVTAKSRGIPADGPRICATRYGNVMASRGSVIP 176 +V+VLSTDKAVYPINAMG+SKA+ EKL AK+R +C TRYGNVMASRGSVIP Sbjct: 121 TKVIVLSTDKAVYPINAMGLSKALMEKLAIAKARMRSPGETVLCVTRYGNVMASRGSVIP 180 Query: 177 LFVSQLKAGQPLTVTDPNMTRFLMSLEDSVDLVLHAFEHAQQGDLFVQKAPASTVADLAQ 236 LF++Q+K G+ LT+T+P+MTRFLMSL DSVDLVL+AFEH QGD+FVQK+PAST+ LA+ Sbjct: 181 LFINQIKQGKVLTITEPSMTRFLMSLVDSVDLVLYAFEHGHQGDIFVQKSPASTIEVLAK 240 Query: 237 ALRELFKLDNPVKVIGTRHGEKLYESLISREEMAKAEDMGRYYRVPADNRDLNYNKYFVE 296 AL+++F N ++ IGTRHGEK YESL+S EEMAKA+D+ YYR+P D RDLNY KYFVE Sbjct: 241 ALQDIFDSKNEIRFIGTRHGEKHYESLVSSEEMAKADDLRDYYRIPMDGRDLNYAKYFVE 300 Query: 297 GESHISELDDYTSHNTQRLNVEEIKTLLLKLPEIREAL 334 GE ++ L+DYTSHNT+RLN+EE+K LLL L ++E L Sbjct: 301 GEKKVALLEDYTSHNTKRLNLEEVKELLLTLDYVQEEL 338 >RP333 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Rpr Rickettsia prowazekii Length = 341 Score = 487 bits (1254), Expect = e-137, Method: Compositional matrix adjust. Identities = 233/338 (68%), Positives = 279/338 (82%), Gaps = 4/338 (1%) Query: 1 MFDNKVLMITGGTGSFGNTVLKRFLDTAV----REIRIFSRDEKKQEDMRIALKNDKVKF 56 MF +K LMITGGTGSFGN VL RFL + + +EIRIFSRDEKKQEDMRIAL N K+KF Sbjct: 1 MFVDKTLMITGGTGSFGNAVLSRFLKSNIINDIKEIRIFSRDEKKQEDMRIALNNSKLKF 60 Query: 57 YIGDVRNYDSIAQAMVGVDFVFHAAALKQVPSCEFYPMEAIRTNILGTENVLNAAIASKV 116 YIGDVRNY SI AM GVD+VFHAAALKQVP+CEFYPMEAI TN+LG ENVL+AAI +KV Sbjct: 61 YIGDVRNYQSIDDAMHGVDYVFHAAALKQVPTCEFYPMEAINTNVLGAENVLSAAINNKV 120 Query: 117 KRVVVLSTDKAVYPINAMGISKAMAEKLVTAKSRGIPADGPRICATRYGNVMASRGSVIP 176 +V+VLSTDKAVYPINAMG+SKA+ EKL AK+R +C TRYGNVMASRGSVIP Sbjct: 121 TKVIVLSTDKAVYPINAMGLSKALMEKLAIAKARMRSPGETILCVTRYGNVMASRGSVIP 180 Query: 177 LFVSQLKAGQPLTVTDPNMTRFLMSLEDSVDLVLHAFEHAQQGDLFVQKAPASTVADLAQ 236 LF+ Q+K G+ LT+T+P+MTRFLMSL DSVDLVL+AFEH +QGD+FVQK+PAST+ LA+ Sbjct: 181 LFIHQIKQGKELTITEPSMTRFLMSLVDSVDLVLYAFEHGRQGDIFVQKSPASTIEVLAK 240 Query: 237 ALRELFKLDNPVKVIGTRHGEKLYESLISREEMAKAEDMGRYYRVPADNRDLNYNKYFVE 296 AL+E+F N ++ IGTRHGEK YESL+S E+MAKA+D+G YYR+P D RDLNY KYFV Sbjct: 241 ALQEIFGSKNAIRFIGTRHGEKHYESLVSSEDMAKADDLGGYYRIPMDGRDLNYAKYFVT 300 Query: 297 GESHISELDDYTSHNTQRLNVEEIKTLLLKLPEIREAL 334 GE ++ LDDYTSHNT+RLN++E+K LLL L +++ L Sbjct: 301 GEKKVALLDDYTSHNTKRLNLKEVKELLLTLDYVQKEL 338 >PM1007 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Pmu Pasteurella multocida Length = 344 Score = 476 bits (1226), Expect = e-134, Method: Compositional matrix adjust. Identities = 222/337 (65%), Positives = 276/337 (81%), Gaps = 1/337 (0%) Query: 1 MFDNKVLMITGGTGSFGNTVLKRFLDTAVREIRIFSRDEKKQEDMRIALKNDKVKFYIGD 60 MF NK L+ITGGTGSFGN VLKRFL+T +REIR+FSRDEKKQ+DMR + K+KFYIGD Sbjct: 1 MFKNKTLLITGGTGSFGNAVLKRFLETDIREIRVFSRDEKKQDDMRKKYNDAKLKFYIGD 60 Query: 61 VRNYDSIAQAMVGVDFVFHAAALKQVPSCEFYPMEAIRTNILGTENVLNAAIASKVKRVV 120 VR+YDSI A GVD+++HAAALKQVPSCEFYP+EA++TNILGT NVL AAI +++KRVV Sbjct: 61 VRDYDSILNASRGVDYIYHAAALKQVPSCEFYPLEAVKTNILGTANVLEAAIQNQIKRVV 120 Query: 121 VLSTDKAVYPINAMGISKAMAEKLVTAKSRGIPADGPRICATRYGNVMASRGSVIPLFVS 180 LSTDKAVYPINAMGISKAM EK++ AKSR + IC TRYGNVMASRGSVIPLFV Sbjct: 121 CLSTDKAVYPINAMGISKAMMEKVIIAKSRNLEGTPTTICCTRYGNVMASRGSVIPLFVD 180 Query: 181 QLKAGQPLTVTDPNMTRFLMSLEDSVDLVLHAFEHAQQGDLFVQKAPASTVADLAQALRE 240 Q++ G+P T+TDP MTRF+M+LED+VDLVL+AF++ Q GD+FVQKAPA+T+ LA+A+ E Sbjct: 181 QIRQGKPFTITDPEMTRFMMTLEDAVDLVLYAFKNGQNGDVFVQKAPAATIGTLAKAITE 240 Query: 241 LFKLDN-PVKVIGTRHGEKLYESLISREEMAKAEDMGRYYRVPADNRDLNYNKYFVEGES 299 L + N P+ +IGTRHGEK +E+L+SREEM A + G YYR+PAD R LNY+KY +GE Sbjct: 241 LLSVPNHPISIIGTRHGEKAFEALLSREEMVHAINEGNYYRIPADQRSLNYSKYVEKGEP 300 Query: 300 HISELDDYTSHNTQRLNVEEIKTLLLKLPEIREALDA 336 I+E+ DY SHNT+RL V+E+K LLLKL I++ ++ Sbjct: 301 KITEVTDYNSHNTERLTVKEMKQLLLKLEFIQKMIEG 337 >SA0148 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Sau Staphylococcus aureus N315 Length = 342 Score = 471 bits (1212), Expect = e-132, Method: Compositional matrix adjust. Identities = 220/335 (65%), Positives = 273/335 (81%) Query: 1 MFDNKVLMITGGTGSFGNTVLKRFLDTAVREIRIFSRDEKKQEDMRIALKNDKVKFYIGD 60 MFD+K+L+ITGGTGSFGN V+KRFLD+ ++EIRIFSRDEKKQ+D+R N K+KFYIGD Sbjct: 1 MFDDKILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLKFYIGD 60 Query: 61 VRNYDSIAQAMVGVDFVFHAAALKQVPSCEFYPMEAIRTNILGTENVLNAAIASKVKRVV 120 VR+ S+ AM VD+VFHAAALKQVPSCEF+P+EA++TNI+GTENVL +AI VK+V+ Sbjct: 61 VRDSQSVETAMRDVDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVI 120 Query: 121 VLSTDKAVYPINAMGISKAMAEKLVTAKSRGIPADGPRICATRYGNVMASRGSVIPLFVS 180 LSTDKA YPINAMGISKAM EK+ AKSR I ++ IC TRYGNVMASRGSVIPLF+ Sbjct: 121 CLSTDKAAYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGTRYGNVMASRGSVIPLFID 180 Query: 181 QLKAGQPLTVTDPNMTRFLMSLEDSVDLVLHAFEHAQQGDLFVQKAPASTVADLAQALRE 240 ++KAG+PLT+TDP+MTRFLMSLED+V+LV+HAF+HA+ GD+ VQKAP+STV DLA AL E Sbjct: 181 KIKAGEPLTITDPDMTRFLMSLEDAVELVVHAFKHAETGDIMVQKAPSSTVGDLATALLE 240 Query: 241 LFKLDNPVKVIGTRHGEKLYESLISREEMAKAEDMGRYYRVPADNRDLNYNKYFVEGESH 300 LF+ DN +++IGTRHGEK E+L++REE A+ EDMG Y+RVPAD+RDLNY+ Y G Sbjct: 241 LFEADNAIEIIGTRHGEKKAETLLTREEYAQCEDMGDYFRVPADSRDLNYSNYVETGNEK 300 Query: 301 ISELDDYTSHNTQRLNVEEIKTLLLKLPEIREALD 335 I++ +Y S NT L VEEIK LL L +R L+ Sbjct: 301 ITQSYEYNSDNTHILTVEEIKEKLLTLEYVRNELN 335 >SP0358 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Spn Streptococcus pneumoniae TIGR4 Length = 351 Score = 428 bits (1100), Expect = e-120, Method: Compositional matrix adjust. Identities = 200/339 (58%), Positives = 265/339 (78%), Gaps = 6/339 (1%) Query: 2 FDNKVLMITGGTGSFGNTVLKRFLDTAVREIRIFSRDEKKQEDMRIALK------NDKVK 55 F K L+ITGGTGSFGN VLKRFL+T V EIRIFSRDEKKQ+DMR + K++ Sbjct: 4 FTGKTLLITGGTGSFGNAVLKRFLETDVSEIRIFSRDEKKQDDMRHEFQVKVPEVAGKIR 63 Query: 56 FYIGDVRNYDSIAQAMVGVDFVFHAAALKQVPSCEFYPMEAIRTNILGTENVLNAAIASK 115 FY+GDVR+ S+ AM GVD+VFHAAALKQVPSCEF+P+EA++TNILGTENVL AAI + Sbjct: 64 FYLGDVRDLASVKNAMHGVDYVFHAAALKQVPSCEFFPVEAVKTNILGTENVLTAAIEAG 123 Query: 116 VKRVVVLSTDKAVYPINAMGISKAMAEKLVTAKSRGIPADGPRICATRYGNVMASRGSVI 175 VK+V+ LSTDKA YP+NAMG SKAM EK+ AKSR + + +IC TRYGNV+ SRGSV+ Sbjct: 124 VKQVICLSTDKAAYPVNAMGTSKAMMEKIAVAKSRTVNPEHTKICVTRYGNVLCSRGSVV 183 Query: 176 PLFVSQLKAGQPLTVTDPNMTRFLMSLEDSVDLVLHAFEHAQQGDLFVQKAPASTVADLA 235 PL++ Q+K G LT+T+P+MTRF+M+LE++VDLVL AFE + GD+ VQKAPA T+ LA Sbjct: 184 PLWIEQIKQGNALTITEPSMTRFVMTLEEAVDLVLFAFEEGKSGDILVQKAPACTIEVLA 243 Query: 236 QALRELFKLDNPVKVIGTRHGEKLYESLISREEMAKAEDMGRYYRVPADNRDLNYNKYFV 295 +A+ E+F + +K+IG RHGEK YE+L++ EE A A D+G +YRVP+DNR+LNY+KYF Sbjct: 244 KAVSEIFASEQDIKIIGIRHGEKRYETLLTNEECANAIDLGDFYRVPSDNRNLNYDKYFK 303 Query: 296 EGESHISELDDYTSHNTQRLNVEEIKTLLLKLPEIREAL 334 +G ++ + L ++ S+NT ++VE++K LL+L EI+ A+ Sbjct: 304 DGSTNRNLLTEFNSNNTDLMDVEQVKRKLLELDEIQTAI 342