BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0166.p (594 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Cj1130c [V] COG1132 ABC-type multidrug transport system, ATPase ... 241 3e-63 HP1206 [V] COG1132 ABC-type multidrug transport system, ATPase a... 212 2e-54 jhp1129 [V] COG1132 ABC-type multidrug transport system, ATPase ... 211 3e-54 alr2835 [V] COG1132 ABC-type multidrug transport system, ATPase ... 200 1e-50 STM0984 [V] COG1132 ABC-type multidrug transport system, ATPase ... 196 2e-49 >Cj1130c [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Cje Campylobacter jejuni Length = 564 Score = 241 bits (616), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 163/553 (29%), Positives = 291/553 (52%), Gaps = 30/553 (5%) Query: 24 LLLSVLLMSVLDLIGIAIIFPYLQIISLPGEFAQKWLPVGMRD---ISARALLFWLSGGL 80 LL+ + +S ++ I+++ P++ + S F + + +++ I ++ + GL Sbjct: 20 LLVFSVFISFIETFAISLVMPFITLASDFSYFDRNKYLISLKEYLNIPVFEIIVYFGVGL 79 Query: 81 ALFYIAKNFLQMRLTRYQFKSAAELTQ----RLTDDTISLVLGARYATFQKFPASEIVGI 136 +FY+ + L Y F A ++ + S L Y F + SEI+ Sbjct: 80 IVFYV----FRALLNAYYFHLLARFSKGRYHAIAYKVFSKFLNINYEKFTQKNQSEILKS 135 Query: 137 ASSNTVHATLVFQALLQIINEIVFLSLLLLAIFKINFSLGCASVVMIVL---LTIGLYFS 193 + + + + + L +++EI + LL + IN+ + + +VL + + + Sbjct: 136 ITGEVYNLSTMISSFLLLMSEIFVVLLLYALMLLINYKITLFLSIFMVLNAFILVKILSP 195 Query: 194 VIKRTQQLGYVQAVANRKRYELQFSIVTAIRDIKVM----GLAVLFDRRSRKISESFADV 249 +IK+ G + A + +E+ + + + IK+ G+ LF +S E+F+ Sbjct: 196 IIKKA---GVRREEAMKNFFEILNTNLNNFKFIKLKTKEDGVLSLFKAQS----EAFSKA 248 Query: 250 TWKYGLNGVLPRLYIE-LFMLLAFVCAIVLLVLSGGDLKSMVPVLGVIAITAIRAIPSFS 308 +PR+Y+E + + + L++ + D+ ++ + + + R +PS + Sbjct: 249 NITNESVAAVPRIYLEGIGFCVLVFIVVFLVLKNESDISGILSTISIFVLALYRLMPSAN 308 Query: 309 RLIVGVNAVRYSLSSMEDLILTRDTLVQSAHVRSVDQITFEREIELRNVSFNY-GDSPIL 367 R+I + + Y SS++ + L Q ++++F +E+++ N+SF Y G + Sbjct: 309 RIITSYHDLLYYHSSLD---IIYQNLRQEEENLGEEKLSFNQELKICNLSFGYEGKKYLF 365 Query: 368 RNVNLRIPRGGAIGIVGPSGSGKTTLLDIITGLQEADSGAIYADDRQFNPFTSHSLEQMV 427 +N+NL I +G I +G SG GK+TL+D+I GL + G I D+++ N + + Q + Sbjct: 366 KNLNLNIKKGEKIAFIGESGCGKSTLVDLIIGLLKPKEGQILIDEQELNANNTKNYRQKI 425 Query: 428 GYVPQAITLLNESIAFNITFEQEYDGQRLAKVLSIANLDAFIEGLPDGVMTLAGEDGLRL 487 GY+PQ I L N+SIA NITF D ++L +V+ ANL+ FI+ LP GV T G+ G L Sbjct: 426 GYIPQNIYLFNDSIAKNITFGDAVDEEKLNRVIKQANLEHFIKNLPQGVQTKVGDGGSNL 485 Query: 488 SGGQRQRIGIARALYRDPQLLVFDEATSALDTISEDEISKEIEQLRKTISIVIVAHRLST 547 SGGQ+QRI IARALY +P++LV DEATSALDT SE +I EI ++ K +++I+AHRLST Sbjct: 486 SGGQKQRIAIARALYLEPEMLVLDEATSALDTQSEAKIMDEIYKISKDKTMIIIAHRLST 545 Query: 548 VVSCDVIYVMAHG 560 + CD +Y + HG Sbjct: 546 ITQCDKVYRLEHG 558 >HP1206 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Hpy Helicobacter pylori 26695 Length = 578 Score = 212 bits (540), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 167/586 (28%), Positives = 281/586 (47%), Gaps = 55/586 (9%) Query: 12 LSSFVGRKTGIALLLSVLLMSVLDLIGIAIIFPYLQIISLPGEF--AQKWLPVG--MRDI 67 L +F + L+L + S ++++ + ++ P++ + S P + W V Sbjct: 24 LITFKEKMVFFLLVLMAVFSSFVEVMSLTLLMPFITLASDPNRALDDKDWKMVYDFFHFS 83 Query: 68 SARALLFWLSGGLALFYIAKNFLQMRLT----RYQFKSAAELTQRLTDDTISLVLGARYA 123 S L+++ S L Y+ + F + T R+ K A ++ Q+L I + Y Sbjct: 84 SPVRLMYFFSFCLVGIYLFRMFYGVSFTYLKGRFSNKKAYQIKQQLFLQHIK----SNYL 139 Query: 124 TFQKFPASEIVGIASSNTVHATLVFQALLQIINEIV----FLSLLLLAIFKIN--FSLGC 177 + + I ++ + F A L ++ EI F S L+L +KI F++ Sbjct: 140 SHLNHNLDSLRDIINNKAEGMFMSFNAFLSLLTEITVIVFFYSTLILTNWKITLVFTMIL 199 Query: 178 ASVVMIVLLTIGLYFSVIKRTQQLGYVQAVANRKRYELQFS--IVTAIRDIKVMGLAVLF 235 A + +++ + + +IK+ ++ K + FS +T ++D LF Sbjct: 200 ALQIFLIVKKVTV---LIKKKGEMAAKSKAQTLKVFSKFFSNFKITKLKDNHEEAHK-LF 255 Query: 236 DRRSRKISESFADVTWKYGLNGVLPRLYIELFMLLAFVCAIVLLVLSGGDLKSMVPVLGV 295 SRK D Y V+PR IE + A+ ++ G+ K ++P + + Sbjct: 256 GENSRKAH----DTEIIYATLQVVPRYSIETVGFSLLILAVAYILFKYGEAKMVLPTISM 311 Query: 296 IAITAIRAIPSFSRLIVGVNAVRYS-------LSSMEDLILTRDTLVQSAHVRSVDQITF 348 A+ R +PS + +I N + Y+ S+ I+ D + + F Sbjct: 312 YALALYRILPSVTGMINYYNEIAYNQLATNMVFKSLSKTIVEEDLV----------PLDF 361 Query: 349 EREIELRNVSFNY-GDSPILRNVNLRIPRGGAIGIVGPSGSGKTTLLDIITGLQEADSGA 407 +I L+N+SF Y P+L++ NL I RG + ++G SG GK+TL DII GL SG Sbjct: 362 NEKITLQNISFAYKSKHPVLKDFNLTIQRGQKVALIGHSGCGKSTLADIIMGLTYPKSGE 421 Query: 408 IYADDRQFNPFTSHSLEQMVGYVPQAITLLNESIAFNITFEQEYDGQRLAKVLSIANLDA 467 I+ D+ S + +GY+PQ I L + ++ NI F D +RL KV +A++ Sbjct: 422 IFIDNTLLTNKNRRSWRKKIGYIPQNIYLFDGTVGDNIAFGSAIDEKRLIKVCKMAHIYD 481 Query: 468 FIEGLPDGVMTLAGEDGLRLSGGQRQRIGIARALYRDPQLLVFDEATSALDTISEDEISK 527 F+ +G+ T GE G +LSGGQ+QRIGIARALY +P++LV DEATSALD +E +I Sbjct: 482 FL-CEHEGLKTQVGEGGAKLSGGQKQRIGIARALYDNPEILVLDEATSALDNETESKIMD 540 Query: 528 EIEQLRKTISIVIVAHRLSTVVSCDVIYVMAHGYVVDAGSHQELLA 573 EI Q+ K +++++AHRLST+ C+VI +D H++ L Sbjct: 541 EIYQIAKNKTLIVIAHRLSTIERCEVI--------IDMSQHKDNLG 578 >jhp1129 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components jHp Helicobacter pylori J99 Length = 578 Score = 211 bits (538), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 167/578 (28%), Positives = 275/578 (47%), Gaps = 63/578 (10%) Query: 24 LLLSVLLMSVLDLIGIAIIFPYLQIISLPGEF--AQKWLPVG--MRDISARALLFWLSGG 79 L+L + S ++++ + ++ P++ + S P + W V S L+++ S Sbjct: 36 LVLMAVFSSFVEVMSLTLLMPFITLASDPSRALDDKDWKMVYDFFHFSSPVRLMYFFSFC 95 Query: 80 LALFYIAKNFLQMRLT----RYQFKSAAELTQRLTDDTISLVLGARYATFQKFPASEIVG 135 L Y+ + F + T R+ K A ++ Q+L I Y + + Sbjct: 96 LVGIYLFRMFYGVFFTYLRGRFSNKKAYQIKQQLFLQHIK----NNYLSHLNHNLDSLRD 151 Query: 136 IASSNTVHATLVFQALLQIINEIV----FLSLLLLAIFKINFSLGCASVVMIVLLTIGLY 191 I ++ + F A L ++ EI F S L+L +KI ++V +L + ++ Sbjct: 152 IINNKAEGMFMSFNAFLSLLTEITVIVFFYSTLILTNWKI-------TLVFTTILALQIF 204 Query: 192 FSV------IKRTQQLGYVQAVANRKRYELQFS--IVTAIRDIKVMGLAVLFDRRSRKIS 243 F V IK+ ++ K + FS +T ++D LF SRK Sbjct: 205 FIVKKVTVLIKKKGEMAAKSKAQTLKVFSKFFSNFKITKLKDNHEEAHK-LFGENSRKAH 263 Query: 244 ESFADVTWKYGLNGVLPRLYIELFMLLAFVCAIVLLVLSGGDLKSMVPVLGVIAITAIRA 303 D Y V+PR IE + A+ ++ G+ + ++P + + A+ R Sbjct: 264 ----DTEIIYSTLQVVPRYSIETVGFSLLILAVAYILFKYGEARMVLPTISMYALALYRI 319 Query: 304 IPSFSRLIVGVNAVRYS-------LSSMEDLILTRDTLVQSAHVRSVDQITFEREIELRN 356 +PS + +I N + Y+ S+ I+ D + + F +I L+N Sbjct: 320 LPSVTGVISYYNEIAYNQLATNVVFKSLSKTIVEEDLV----------PLDFNEKITLQN 369 Query: 357 VSFNY-GDSPILRNVNLRIPRGGAIGIVGPSGSGKTTLLDIITGLQEADSGAIYADDRQF 415 +SF Y P+L+N NL I +G I ++G SG GK+TL DII GL SG I+ D+ Sbjct: 370 ISFAYKSKHPVLKNFNLTIQKGQKIALIGHSGCGKSTLADIIMGLTYPKSGEIFIDNTLL 429 Query: 416 NPFTSHSLEQMVGYVPQAITLLNESIAFNITFEQEYDGQRLAKVLSIANLDAFIEGLPDG 475 S + +GY+PQ I L + ++ NI F D +RL KV +A++ F+ +G Sbjct: 430 TSENRRSWRKKIGYIPQNIYLFDGTVGDNIAFGSAIDEKRLIKVCKMAHIYDFL-CEHEG 488 Query: 476 VMTLAGEDGLRLSGGQRQRIGIARALYRDPQLLVFDEATSALDTISEDEISKEIEQLRKT 535 + T GE G +LSGGQ+QRIGIARALY +P++LV DEATSALD +E +I EI Q+ K Sbjct: 489 LKTQVGEGGAKLSGGQKQRIGIARALYDNPEILVLDEATSALDNETESKIMDEIYQIAKN 548 Query: 536 ISIVIVAHRLSTVVSCDVIYVMAHGYVVDAGSHQELLA 573 +++++AHRLST+ C+VI +D H++ L Sbjct: 549 KTLIVIAHRLSTIERCEVI--------IDMSQHKDNLG 578 >alr2835 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Nos Nostoc sp. PCC 7120 Length = 607 Score = 200 bits (508), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 151/504 (29%), Positives = 249/504 (49%), Gaps = 15/504 (2%) Query: 97 YQFKSAAELTQRLTDDTISLVLGARYATFQKFPASEIVGIASSNTVHATLVFQALLQIIN 156 Y + L RL + R + F + + E++ ++ F L ++ Sbjct: 112 YTESAQLNLADRLHKQIFEQLQALRLSYFAQTRSGELINTITTEIERIKQGFSGLAFVLT 171 Query: 157 EIVFLSLLLLAIFKINFSLGCASVVMIVLLTIGLYFSVIKRTQQLGYVQAVANRKRYELQ 216 I+ + + + +F I++ L SV++ +LL +GL ++ KR ++ + + AN + + Sbjct: 172 RIMTVCVYFVVMFSISWQLSIISVLIFLLLAVGLS-TLNKRVRETSFGISHANAQFTAVA 230 Query: 217 FSIVTAIRDIKVMGLAVLFDRRSRKISESFADVTWKYGLNGVLPRLYIELFMLLAFVCAI 276 + IR I+ G +R K S + + K L L + E +A I Sbjct: 231 VEFINGIRTIQAFGTQEFERQRFYKASTNQLNAAIKVVLAWTLVKPIAEG---IATTVLI 287 Query: 277 VLLVLSGGDLKSMVPVLGVIAITAIRAIPSFSRLIVGVNAVRYSLSSMEDLILTRDTLVQ 336 L+V+S V L +R IP+ I +N LS+++ ++Q Sbjct: 288 SLIVISFATFTLPVASLLTFFFVLVRVIPN----IQDINGTVAFLSTLQGSSENIKNILQ 343 Query: 337 SAHVRSVD--QITFE---REIELRNVSFNY-GDSPILRNVNLRIPRGGAIGIVGPSGSGK 390 + + + ++ F+ R I+L +V F Y D+ +L N+ L I RG +VG SG+GK Sbjct: 344 TNNKPYLKNGKLHFQGLKRSIDLVSVDFGYTADNLVLNNITLTIERGKTTALVGASGAGK 403 Query: 391 TTLLDIITGLQEADSGAIYADDRQFNPFTSHSLEQMVGYVPQAITLLNESIAFNITFEQE 450 TTL D+I + G I D F +SL + + V Q + N SI NI + Sbjct: 404 TTLADLIPRFYDPTEGQILVDGLDVQYFEINSLRRKMAVVSQDTFIFNTSIRDNIAYGTS 463 Query: 451 YDGQ-RLAKVLSIANLDAFIEGLPDGVMTLAGEDGLRLSGGQRQRIGIARALYRDPQLLV 509 + + +V +AN FIE +P+G T G+ G+RLSGGQRQRI IARAL RDP++L+ Sbjct: 464 GASEAEIREVARLANALQFIEEMPEGFDTKLGDRGVRLSGGQRQRIAIARALLRDPEILI 523 Query: 510 FDEATSALDTISEDEISKEIEQLRKTISIVIVAHRLSTVVSCDVIYVMAHGYVVDAGSHQ 569 DEATSALD++SE I + IE+L +++ +AHRLST+ D + VM G +V+ G++Q Sbjct: 524 LDEATSALDSVSERLIQESIEKLSVGRTVIAIAHRLSTIAKADKVVVMEQGRIVEQGNYQ 583 Query: 570 ELLARCALYREMHVLQAQSGSEHT 593 ELL + + H +Q +SG ++ Sbjct: 584 ELLEQRGKLWKYHQMQHESGQTNS 607 >STM0984 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Sty Salmonella typhimurium LT2 Length = 582 Score = 196 bits (497), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 104/249 (41%), Positives = 156/249 (62%), Gaps = 6/249 (2%) Query: 341 RSVDQITFEREIELRNVSFNYG--DSPILRNVNLRIPRGGAIGIVGPSGSGKTTLLDIIT 398 R +D+ T ++E RNV+F Y + P LRN+NL+IP G + +VG SGSGK+T+ +IT Sbjct: 333 RVIDRAT--GDLEFRNVTFTYPGREVPALRNINLKIPAGKTVALVGRSGSGKSTIASLIT 390 Query: 399 GLQEADSGAIYADDRQFNPFTSHSLEQMVGYVPQAITLLNESIAFNITF--EQEYDGQRL 456 + D G I D +T SL V V Q + L N+++A NI + +EY +++ Sbjct: 391 RFYDIDEGHILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEEYSREQI 450 Query: 457 AKVLSIANLDAFIEGLPDGVMTLAGEDGLRLSGGQRQRIGIARALYRDPQLLVFDEATSA 516 + +A FI + +G+ T+ GE+G+ LSGGQRQRI IARAL RD +L+ DEATSA Sbjct: 451 EEAARMAYAMDFINKMDNGLDTIIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSA 510 Query: 517 LDTISEDEISKEIEQLRKTISIVIVAHRLSTVVSCDVIYVMAHGYVVDAGSHQELLARCA 576 LDT SE I +++L+K + +++AHRLST+ D I V+ G +V+ G+H ELLA+ Sbjct: 511 LDTESERAIQAALDELQKNRTSLVIAHRLSTIEQADEIVVVEDGIIVERGTHSELLAQHG 570 Query: 577 LYREMHVLQ 585 +Y ++H +Q Sbjct: 571 VYAQLHKMQ 579