BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0153.p (291 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC2187 [M] COG2089 Sialic acid synthase Cac Clostridium acetobu... 333 3e-91 CC2868 [M] COG2089 Sialic acid synthase Ccr Caulobacter vibrioides 317 2e-86 HP0178 [M] COG2089 Sialic acid synthase Hpy Helicobacter pylori ... 228 1e-59 jhp0166 [M] COG2089 Sialic acid synthase jHp Helicobacter pylori... 224 2e-58 Cj1317 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni 218 9e-57 >CAC2187 [M] COG2089 Sialic acid synthase Cac Clostridium acetobutylicum Length = 350 Score = 333 bits (853), Expect = 3e-91, Method: Compositional matrix adjust. Identities = 150/291 (51%), Positives = 215/291 (73%), Gaps = 1/291 (0%) Query: 1 MTLDLDEGEFHIGDPNSLWAGTSLYKLYGEAYTPWEWHKAIFDRAQELGIIIFSTPFDDT 60 +T D D F I ++W GT+L+KLY EAYTPW+W + + A+E G+I FS+PFD+T Sbjct: 60 ITFDSDNEYFQIKQ-GTIWDGTTLHKLYEEAYTPWQWQPKLKEIAEEEGLICFSSPFDNT 118 Query: 61 AVDFLDDLNVPCYKIASFENTDLPLIRRVAATGKPVIISTGMATVAELEDTVNAARQAGC 120 +VDFL+ + VP YK+ASFE TD+P I +A+ GKPVI+STG+A + E+ + V A R+ G Sbjct: 119 SVDFLEKMEVPAYKVASFELTDIPFIEYIASKGKPVIMSTGIAEMGEIYEAVAACRRQGN 178 Query: 121 TDLILLKCTSTYPATAKNTNILTIPHMRQLFNCEIGLSDHTMGVGVSVASVALGATVIEK 180 ++ILLKC+S+YP+ ++ N+ TIP+MR+ FNC +GLSDHTMG V+ A+VALGATVIEK Sbjct: 179 ENVILLKCSSSYPSPLEDINLKTIPNMREAFNCSVGLSDHTMGYSVATAAVALGATVIEK 238 Query: 181 HFTLSRADGGVDSAFSMEPAEMAQLVLETERAWEALGRVSYGPTEAEKKSLQYRRTLYVV 240 HFTL R+DGG DSAFSMEP E + +V +ALG+V+Y TE +K S Q+ R+L+VV Sbjct: 239 HFTLKRSDGGPDSAFSMEPEEFSAMVKSIREVEKALGKVTYELTEKQKNSRQHSRSLFVV 298 Query: 241 KDMSAGDLLSSDNVRAIRPGSGLQTKHLPQILGKAVKSAVKRGTPVSWDLI 291 KD+ G+ + +NV++IRP GL+TK++ +++GK + VK+GTP+ W+L+ Sbjct: 299 KDIKKGETFTKENVKSIRPAFGLKTKYIEEVIGKKARVDVKKGTPLDWNLL 349 >CC2868 [M] COG2089 Sialic acid synthase Ccr Caulobacter vibrioides Length = 356 Score = 317 bits (812), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 152/291 (52%), Positives = 201/291 (69%), Gaps = 2/291 (0%) Query: 1 MTLDLDEGEFHIGDPNSLWAGTSLYKLYGEAYTPWEWHKAIFDRAQELGIIIFSTPFDDT 60 +TLD+D EF I LW G +LY+LY EA+TP+EWH AIF+RA++ G+ IFS+PFD+T Sbjct: 67 ITLDVDRPEFKIH--GGLWDGRTLYELYEEAHTPFEWHAAIFERARQRGVTIFSSPFDET 124 Query: 61 AVDFLDDLNVPCYKIASFENTDLPLIRRVAATGKPVIISTGMATVAELEDTVNAARQAGC 120 AVD LD L P +KIASFE DLPLI+ AA GKP+IISTGMA + E++ ++ A AG Sbjct: 125 AVDLLDSLGAPAFKIASFEAVDLPLIKYAAAKGKPLIISTGMANLTEMQTALDTALSAGA 184 Query: 121 TDLILLKCTSTYPATAKNTNILTIPHMRQLFNCEIGLSDHTMGVGVSVASVALGATVIEK 180 ++LL C S+YPAT + N+ T+P M F C IGLSDHT G SVA+V+LGA +EK Sbjct: 185 PGVLLLHCVSSYPATFADANVRTVPDMAARFGCPIGLSDHTPGTAASVAAVSLGACAVEK 244 Query: 181 HFTLSRADGGVDSAFSMEPAEMAQLVLETERAWEALGRVSYGPTEAEKKSLQYRRTLYVV 240 HFTL+RADGG D+AFS+EPAE LV +T+ AW ALGR Y +E SL +RR+LYV Sbjct: 245 HFTLARADGGPDAAFSLEPAEFKALVDDTKNAWAALGRAHYDVLGSEATSLLFRRSLYVT 304 Query: 241 KDMSAGDLLSSDNVRAIRPGSGLQTKHLPQILGKAVKSAVKRGTPVSWDLI 291 D+ AG+ L+ NVR++RPG+GL L ++L + RG P+ W ++ Sbjct: 305 ADVKAGEPLTRANVRSVRPGNGLPPADLDKVLAGKATRDLARGEPLDWSMV 355 >HP0178 [M] COG2089 Sialic acid synthase Hpy Helicobacter pylori 26695 Length = 340 Score = 228 bits (581), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 117/291 (40%), Positives = 180/291 (61%), Gaps = 5/291 (1%) Query: 1 MTLDLDEGEFHIGDPNSLWAGTSLYKLYGEAYTPWEWHKAIFDRAQELGIIIFSTPFDDT 60 MTL+ E F I +LW +LY+LY +A TP EWH +F+ A++L + IFS+PF Sbjct: 47 MTLNSKEDPFIIQ--GTLWDKENLYELYQKASTPLEWHAELFELARKLDLGIFSSPFSSQ 104 Query: 61 AVDFLDDLNVPCYKIASFENTDLPLIRRVAATGKPVIISTGMATVAELEDTVNAARQAGC 120 A++ L+ LN P YKIASFE DL LI + A T KP+I+S+G+AT EL+D ++ R+ Sbjct: 105 ALELLESLNCPMYKIASFEIVDLDLIEKAARTQKPIILSSGIATHTELQDAISLCRRVNN 164 Query: 121 TDLILLKCTSTYPATAKNTNILTIPHMRQLFNCEIGLSDHTMGVGVSVASVALGATVIEK 180 D+ LLKC S YP+ ++ N+L++ + ++F + GLSDHT+G + + LGA++IEK Sbjct: 165 FDITLLKCVSAYPSKIEDANLLSMVKLGEIFGVKFGLSDHTIGSLCPILATTLGASMIEK 224 Query: 181 HFTLSRADGGVDSAFSMEPAEMAQLVLETERAWEALGRVS--YGPTEAEKKSLQYRRTLY 238 HF L+++ DSAFSM+ +V +++ ALG P EK+ + R+L+ Sbjct: 225 HFILNKSLQTPDSAFSMDFNGFKSMVEAIKQSVLALGEEEPRINPKTLEKRRF-FARSLF 283 Query: 239 VVKDMSAGDLLSSDNVRAIRPGSGLQTKHLPQILGKAVKSAVKRGTPVSWD 289 V+KD+ G+ L+ +N++A+RP GL K +ILG+ +K TP+S D Sbjct: 284 VIKDIQKGEALTENNIKALRPNLGLHPKFYKEILGQKASKFLKANTPLSAD 334 >jhp0166 [M] COG2089 Sialic acid synthase jHp Helicobacter pylori J99 Length = 340 Score = 224 bits (571), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 118/291 (40%), Positives = 179/291 (61%), Gaps = 5/291 (1%) Query: 1 MTLDLDEGEFHIGDPNSLWAGTSLYKLYGEAYTPWEWHKAIFDRAQELGIIIFSTPFDDT 60 MTLD E F I +LW +LY LY +A TP EWH +F+ A++L + IFS+PF Sbjct: 47 MTLDSKEDPFIIQ--GTLWDKENLYGLYQKASTPLEWHAELFELAKKLDLGIFSSPFSSK 104 Query: 61 AVDFLDDLNVPCYKIASFENTDLPLIRRVAATGKPVIISTGMATVAELEDTVNAARQAGC 120 A++ L+ L+ P YKIASFE DL LI + A T KP+I+S+G+AT AEL+D ++ R Sbjct: 105 ALELLESLDCPMYKIASFEIVDLDLIEKAARTQKPIILSSGIATHAELQDAISLCRGVNN 164 Query: 121 TDLILLKCTSTYPATAKNTNILTIPHMRQLFNCEIGLSDHTMGVGVSVASVALGATVIEK 180 D+ LLKC S YP+ ++ ++L++ + + F + GLSDHT+G + + LGA++IEK Sbjct: 165 FDITLLKCVSAYPSKIEDAHLLSMVKLGETFGVKFGLSDHTIGSLCPILATTLGASMIEK 224 Query: 181 HFTLSRADGGVDSAFSMEPAEMAQLVLETERAWEALGRV--SYGPTEAEKKSLQYRRTLY 238 HF L+++ DSAFSM+ +V +++ ALG P E++ + R+L+ Sbjct: 225 HFILNKSLQTPDSAFSMDFNGFKSMVGAIKQSVLALGEEEPKINPKTLEERRF-FARSLF 283 Query: 239 VVKDMSAGDLLSSDNVRAIRPGSGLQTKHLPQILGKAVKSAVKRGTPVSWD 289 V+KD+ G+ L+SDN++A+RP GL K +ILG+ +K TP+S D Sbjct: 284 VIKDIQKGEALTSDNIKALRPNLGLHPKFYKEILGQKASKFLKANTPLSAD 334 >Cj1317 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni Length = 343 Score = 218 bits (556), Expect = 9e-57, Method: Compositional matrix adjust. Identities = 115/283 (40%), Positives = 161/283 (56%), Gaps = 2/283 (0%) Query: 1 MTLDLDEGEFHIGDPNSLWAGTSLYKLYGEAYTPWEWHKAIFDRAQELGIIIFSTPFDDT 60 +TL+ D+ +F I LW LY+LY A TP+EWH IF+ AQ GI+ FS+PF Sbjct: 54 LTLNSDKEDFII--KGGLWDKRKLYELYESAKTPYEWHSQIFETAQNEGILCFSSPFAKE 111 Query: 61 AVDFLDDLNVPCYKIASFENTDLPLIRRVAATGKPVIISTGMATVAELEDTVNAARQAGC 120 V+FL + YKIASFE D +R +A KP I+STG+AT EL ++ Sbjct: 112 DVEFLKRFDPIAYKIASFEANDENFVRLIAKEKKPTIVSTGIATEEELFKICEIFKEEKN 171 Query: 121 TDLILLKCTSTYPATAKNTNILTIPHMRQLFNCEIGLSDHTMGVGVSVASVALGATVIEK 180 DL+ LKCTSTYP ++ N+ I +++ FN E+GLSDH+ G V +VALGA VIEK Sbjct: 172 PDLVFLKCTSTYPTAIEDMNLKGIVSLKEKFNVEVGLSDHSFGFLAPVMAVALGARVIEK 231 Query: 181 HFTLSRADGGVDSAFSMEPAEMAQLVLETERAWEALGRVSYGPTEAEKKSLQYRRTLYVV 240 HF L ++ DS FS++ E +V +A ALG E K+ + R+LY Sbjct: 232 HFMLDKSIESEDSKFSLDFDEFKAMVDAVRQAESALGDGKLDLDEKVLKNRVFARSLYAS 291 Query: 241 KDMSAGDLLSSDNVRAIRPGSGLQTKHLPQILGKAVKSAVKRG 283 KD+ G++ S +NV+++RP GL K ++LGK +K G Sbjct: 292 KDIKKGEMFSEENVKSVRPSFGLHPKFYQELLGKKASKDIKFG 334