BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0095.p (271 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0381 [H] COG2022 Uncharacterized enzyme of thiazole biosynthes... 381 e-106 XF0783 [H] COG2022 Uncharacterized enzyme of thiazole biosynthes... 368 e-102 CC1880 Non COG 317 1e-86 aq_2178 [H] COG2022 Uncharacterized enzyme of thiazole biosynthe... 298 7e-81 BS_yjbT [H] COG2022 Uncharacterized enzyme of thiazole biosynthe... 259 5e-69 >PA0381 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Pae Pseudomonas aeruginosa Length = 265 Score = 381 bits (979), Expect = e-106, Method: Compositional matrix adjust. Identities = 186/261 (71%), Positives = 222/261 (85%) Query: 10 ALTADAGLTIAGKTYNSRLLVGSGKYKDLDETRLATEASGADIITVAIRRVNIGQDPNAP 69 A + D IAG+TY SRLLVG+GKYKDLDETR A EASGA+I+TVA+RR NIGQ+P+ P Sbjct: 4 ASSTDTPFVIAGRTYGSRLLVGTGKYKDLDETRRAIEASGAEIVTVAVRRTNIGQNPDEP 63 Query: 70 SLLDVVPPSRYTILPNTAGCYNAEDAVYTLQLARELLNGHKLVKLEVLGDEKTLFPNMPE 129 +LLDV+PP RYTILPNTAGCY+A +AV T +LARELL+GH LVKLEVL D+KTLFPN+ E Sbjct: 64 NLLDVIPPDRYTILPNTAGCYDAVEAVRTCRLARELLDGHNLVKLEVLADQKTLFPNVVE 123 Query: 130 TLKAADTLVKDGFDVMVYCSDDPIQARMLEDIGVVAVMPLASLIGSGMGILNPWNLSLII 189 TLKAA+ LVKDGFDVMVY SDDPI AR L +IG +AVMPLA LIGSG+GI NP+NL +I+ Sbjct: 124 TLKAAEQLVKDGFDVMVYTSDDPIIARQLAEIGCIAVMPLAGLIGSGLGICNPYNLRIIL 183 Query: 190 EQSRIPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPVRMARAMKLAVEAGREAF 249 E++++PVLVDAGVGTASDAAIAMELGC+ VLMNTAIA A+DPV MA AMK A+ AGR A+ Sbjct: 184 EEAKVPVLVDAGVGTASDAAIAMELGCEAVLMNTAIAHAKDPVMMAEAMKHAIVAGRLAY 243 Query: 250 LAGRVPKRFAASPSSPMAGRV 270 LAGR+P++ AS SSP+ G + Sbjct: 244 LAGRMPRKLYASASSPLDGLI 264 >XF0783 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Xfa Xylella fastidiosa 9a5c Length = 275 Score = 368 bits (944), Expect = e-102, Method: Compositional matrix adjust. Identities = 181/254 (71%), Positives = 218/254 (85%) Query: 17 LTIAGKTYNSRLLVGSGKYKDLDETRLATEASGADIITVAIRRVNIGQDPNAPSLLDVVP 76 L IAG Y+SRLL G+GK+KDLDETRLATEA+G+ I+TVAIRRVNIGQDP+ P+LL+V+ Sbjct: 21 LVIAGIVYSSRLLTGTGKFKDLDETRLATEAAGSQIVTVAIRRVNIGQDPHQPNLLNVLS 80 Query: 77 PSRYTILPNTAGCYNAEDAVYTLQLARELLNGHKLVKLEVLGDEKTLFPNMPETLKAADT 136 P RYTILPNTAGCY AEDAV T +LARELL+GH+L KLEVLGD+KTL+P++ +TLKAA+ Sbjct: 81 PDRYTILPNTAGCYTAEDAVRTCRLARELLDGHRLTKLEVLGDKKTLYPDVVQTLKAAEQ 140 Query: 137 LVKDGFDVMVYCSDDPIQARMLEDIGVVAVMPLASLIGSGMGILNPWNLSLIIEQSRIPV 196 LV + F VMVY SDDPI A+ LE+IG VAVMPLA+ IGSG+G+ N +NL IIE +++P+ Sbjct: 141 LVAEDFQVMVYTSDDPILAKRLEEIGCVAVMPLAAPIGSGLGVQNRYNLLEIIENAQVPI 200 Query: 197 LVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPVRMARAMKLAVEAGREAFLAGRVPK 256 +VDAGVGTASDAAIAMELGCD VLMNTAIAGARDPV MA AM+ AVEAGREAFLAGR+P+ Sbjct: 201 IVDAGVGTASDAAIAMELGCDAVLMNTAIAGARDPVLMASAMRKAVEAGREAFLAGRIPR 260 Query: 257 RFAASPSSPMAGRV 270 + A+ SSP+ G V Sbjct: 261 KRYAAASSPVEGLV 274 >CC1880 Non COG Length = 269 Score = 317 bits (813), Expect = 1e-86, Method: Compositional matrix adjust. Identities = 169/271 (62%), Positives = 209/271 (77%), Gaps = 5/271 (1%) Query: 3 MNMNDAP-ALTADAG--LTIAGKTYNSRLLVGSGKYKDLDETRLATEASGADIITVAIRR 59 MN + P ++TAD+ T+AG+T+ SRL+VG+GKYKD A A+GA+I+TVA+RR Sbjct: 1 MNAHVTPDSVTADSDETWTVAGRTFRSRLIVGTGKYKDYATNAAAARAAGAEIVTVAVRR 60 Query: 60 VNIGQDPNAPSLLDVVPPSRYTILPNTAGCYNAEDAVYTLQLARELLNGHKLVKLEVLGD 119 VN+ DP+ P L+D V P+ +T LPNTAGC+ EDAV TL+LARE G LVKLEVL D Sbjct: 61 VNL-TDPSQPLLVDYVKPTEFTYLPNTAGCFTGEDAVRTLRLAREA-GGWDLVKLEVLSD 118 Query: 120 EKTLFPNMPETLKAADTLVKDGFDVMVYCSDDPIQARMLEDIGVVAVMPLASLIGSGMGI 179 KTLFP+M ETL++ LV DGF VMVYCSDDP+ AR LE+ G VA+MPL + IGSG+GI Sbjct: 119 PKTLFPDMEETLRSLKLLVADGFQVMVYCSDDPVYARKLEEAGAVAIMPLGAPIGSGLGI 178 Query: 180 LNPWNLSLIIEQSRIPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPVRMARAMK 239 N NL +IIE +++PVLVDAGVGTASDAAI MELGCD +LMNTAIA A+DP+RMA+AMK Sbjct: 179 QNRVNLRIIIENAKVPVLVDAGVGTASDAAIGMELGCDAILMNTAIAEAKDPIRMAKAMK 238 Query: 240 LAVEAGREAFLAGRVPKRFAASPSSPMAGRV 270 AV AGREA+LAGR+ KR A PSSP+AG + Sbjct: 239 HAVIAGREAYLAGRMQKRLYADPSSPLAGLI 269 >aq_2178 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Aae Aquifex aeolicus Length = 267 Score = 298 bits (764), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 153/264 (57%), Positives = 190/264 (71%), Gaps = 2/264 (0%) Query: 5 MNDAPALTADAGLTIAGKTYNSRLLVGSGKYKDLDETRLATEASGADIITVAIRRVNIGQ 64 M D L D L IAG+ + SRL++GSGK+KD +T+ EASGA+IITVA+RRVNI Sbjct: 1 MQDWEKLLQDDYLEIAGRKFKSRLIIGSGKFKDFQQTKEVLEASGAEIITVAVRRVNI-T 59 Query: 65 DPNAPSLLDVVPPSRYTILPNTAGCYNAEDAVYTLQLARELLNGHKLVKLEVLGDEKTLF 124 DP +LLD + P +Y ILPNTAGCY AE+A+ T +ARE G VKLEV+GD+KTL Sbjct: 60 DPTKENLLDYIDPKKYLILPNTAGCYTAEEAIKTAMMAREA-TGINWVKLEVIGDQKTLL 118 Query: 125 PNMPETLKAADTLVKDGFDVMVYCSDDPIQARMLEDIGVVAVMPLASLIGSGMGILNPWN 184 P+M ET KAA LVK+GF V+ Y DDP+ A+ EDIG AVMPLA+ IGSG+G+ NP+N Sbjct: 119 PDMEETYKAAKVLVKEGFVVLPYIFDDPVFAKKFEDIGCAAVMPLAAPIGSGLGLQNPYN 178 Query: 185 LSLIIEQSRIPVLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPVRMARAMKLAVEA 244 L I E +PV+VDAG+G+A+D MELG DGVL NTA+A A+DP++MA AMK A A Sbjct: 179 LIFIKEAVSVPVIVDAGIGSATDIPPVMELGVDGVLTNTALAEAKDPIKMAVAMKYATIA 238 Query: 245 GREAFLAGRVPKRFAASPSSPMAG 268 GR A+LAGR+PKR A PSSP G Sbjct: 239 GRLAYLAGRMPKRTYAVPSSPTKG 262 >BS_yjbT [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis Bsu Bacillus subtilis Length = 256 Score = 259 bits (661), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 136/253 (53%), Positives = 188/253 (74%), Gaps = 4/253 (1%) Query: 17 LTIAGKTYNSRLLVGSGKYKDLDETRLATEASGADIITVAIRRVNIGQDPNAPSLLDVVP 76 LTI GK++ SRLL+G+GKY D + A S +DI+T A+RR+NI + + P+ L+ + Sbjct: 4 LTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAVRRMNI-FEASQPNFLEQLD 62 Query: 77 PSRYTILPNTAGCYNAEDAVYTLQLARELLNG-HKLVKLEVLGDEKTLFPNMPETLKAAD 135 S+YT+LPNTAG AE+AV +LA+ +G ++K+EV+G ++L P+ ETLKA++ Sbjct: 63 LSKYTLLPNTAGASTAEEAVRIARLAKA--SGLCDMIKVEVIGCSRSLLPDPVETLKASE 120 Query: 136 TLVKDGFDVMVYCSDDPIQARMLEDIGVVAVMPLASLIGSGMGILNPWNLSLIIEQSRIP 195 L+++GF V+ Y SDD + AR LE++GV A+MP AS IGSG GILNP NLS IIEQ+++P Sbjct: 121 QLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGSGQGILNPLNLSFIIEQAKVP 180 Query: 196 VLVDAGVGTASDAAIAMELGCDGVLMNTAIAGARDPVRMARAMKLAVEAGREAFLAGRVP 255 V+VDAG+G+ DAA AMELG DGVL+NTA++GA DPV+MARAMKLAVEAGR ++ AGR+P Sbjct: 181 VIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVKMARAMKLAVEAGRLSYEAGRIP 240 Query: 256 KRFAASPSSPMAG 268 + + SSP G Sbjct: 241 LKQYGTASSPGEG 253