BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0218.0033.p (339 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|YP_001926589.1| adenylate/guanylate cyclase [Methylobacteriu... 187 3e-45 ref|YP_001927947.1| adenylate/guanylate cyclase [Methylobacteriu... 182 8e-44 ref|YP_001642216.1| adenylyl cyclase class-3/4/guanylyl cyclase ... 181 2e-43 ref|YP_004548352.1| adenylate/guanylate cyclase [Sinorhizobium m... 181 2e-43 ref|YP_003071236.1| transmembrane adenylate/guanylate cyclase [M... 181 2e-43 >ref|YP_001926589.1| adenylate/guanylate cyclase [Methylobacterium populi BJ001] gb|ACB82054.1| putative adenylate/guanylate cyclase [Methylobacterium populi BJ001] Length = 384 Score = 187 bits (474), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 124/337 (36%), Positives = 174/337 (51%), Gaps = 14/337 (4%) Query: 5 VTPVIVLAMFGLLVGGLFRYAFDESDEASVSNYVRSALDGAALTVIVWATHLYLSARGGW 64 +T +V A FG L G LF D ++ + G L VI + L+L+ Sbjct: 10 MTMAVVSAAFGALHGLLF------GDGPKLAGVLYGT--GVGLLVIAYERGLFLAGYSRR 61 Query: 65 LRRQSLIVELIGRSVILAVTVAAAAIVLEVVLYGHGLEAKWMRETF---LKIIGVGLLLS 121 LR+ + + L + + +A + + ++ G+ K E L I L +S Sbjct: 62 LRQLPTLAYFAAAEISLVLVIVSAMSLTGLTIWALGIADKPFLEAVTPKLSTIPFALAVS 121 Query: 122 IPITTIYELVRMIGGHTLLGIVLGRYRQPVREERVLLFLDLVGSTTLAESMGELRVQELL 181 I + + +IG T +LGRY +PV EERV LFLDL GSTT AE G+L QELL Sbjct: 122 ALIVAVLRVRDLIGSETFTSFILGRYHRPVSEERVFLFLDLAGSTTYAERHGDLAAQELL 181 Query: 182 TRFFFDIDEPIVSHGGEVHAYVGDEVIVTWPANADGRSRRYLDCVFAIEDRLAKGADQYR 241 F I EP+ + G++ YVGD+VIV+WP R + CVFAI L D +R Sbjct: 182 KAVFAAIAEPVRRYRGQIDDYVGDQVIVSWPLARGIEQSRCVACVFAIRRILEDDRDAWR 241 Query: 242 KEFGVVPAFRAGMHAGPVVIAECGDSRRQIAYFGDSVNVTARLQAHCKEASRPLLVSGDL 301 F +VP RA +H G VV AE G R +IAYFGD +N TARL+ C+E R +L+S + Sbjct: 242 ARFALVPELRAALHGGSVVTAEVGVDRHKIAYFGDVMNATARLEGLCRETGRGVLISDAI 301 Query: 302 LRLLP--PDRDLVVEPLGSTQLRGRAASIDIFCVARR 336 L LP PD + E LG +LRGR+ ++ + +A R Sbjct: 302 LARLPALPD-GIEAEALGGYRLRGRSETMAVHALAER 337 >ref|YP_001927947.1| adenylate/guanylate cyclase [Methylobacterium populi BJ001] gb|ACB83412.1| adenylate/guanylate cyclase [Methylobacterium populi BJ001] Length = 355 Score = 182 bits (461), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 94/229 (41%), Positives = 137/229 (59%), Gaps = 3/229 (1%) Query: 109 TFLKIIGVGLLLSIPITTIYELVRMIGGHTLLGIVLGRYRQPVREERVLLFLDLVGSTTL 168 T +++ L +S + + + +IGG + ++GRY +PV EER+ LFLD+VGST Sbjct: 110 TTPRVLAYALAVSALLVFVIRMRDLIGGEVFINFLVGRYHRPVEEERIFLFLDVVGSTAF 169 Query: 169 AESMGELRVQELLTRFFFDIDEPIVSHGGEVHAYVGDEVIVTWPANADGRSRRYLDCVFA 228 AE+ G+LR QE L+ F + EP+ G Y+GD ++TWP + R ++C+FA Sbjct: 170 AETHGDLRAQEYLSAVFATLAEPVRRFYGSTDDYIGDLAMITWPMERGLKDARCVECLFA 229 Query: 229 IEDRLAKGADQYRKEFGVVPAFRAGMHAGPVVIAECGDSRRQIAYFGDSVNVTARLQAHC 288 + +R+ AD + FG VP RAG+H GPVV AE G R +IAYFGD+VNV AR++A C Sbjct: 230 VRERIEAEADAWEARFGTVPRLRAGLHGGPVVTAEVGVDRHKIAYFGDAVNVVARVEALC 289 Query: 289 KEASRPLLVSGDLLRLLP--PDRDLVVEPLGSTQLRGRAASIDIFCVAR 335 + L+S DLL LP P+ +VV PLG+ LRGR + + + R Sbjct: 290 RPLGVDTLISEDLLARLPRLPE-GVVVRPLGTHALRGRGQPLSVATLER 337 >ref|YP_001642216.1| adenylyl cyclase class-3/4/guanylyl cyclase [Methylobacterium extorquens PA1] gb|ABY33145.1| adenylyl cyclase class-3/4/guanylyl cyclase [Methylobacterium extorquens PA1] Length = 355 Score = 181 bits (459), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 93/230 (40%), Positives = 138/230 (60%), Gaps = 3/230 (1%) Query: 109 TFLKIIGVGLLLSIPITTIYELVRMIGGHTLLGIVLGRYRQPVREERVLLFLDLVGSTTL 168 T +++ L +S + + + +IGG + ++GRY +PV EER+ LFLD+VGST Sbjct: 110 TTPRVLAYALAVSALLVFVIRMRDLIGGEVFINFLVGRYHRPVEEERIFLFLDVVGSTAF 169 Query: 169 AESMGELRVQELLTRFFFDIDEPIVSHGGEVHAYVGDEVIVTWPANADGRSRRYLDCVFA 228 AE+ G+LR QE L+ F + EP+ G Y+GD ++TWP + R ++C+FA Sbjct: 170 AETHGDLRAQEYLSAVFATLAEPVRRFYGSTDDYIGDLAMITWPMERGLKDARCVECLFA 229 Query: 229 IEDRLAKGADQYRKEFGVVPAFRAGMHAGPVVIAECGDSRRQIAYFGDSVNVTARLQAHC 288 + +R+ A+ + FG VP RAG+H GPVV AE G R +IAYFGD+VNV AR++A C Sbjct: 230 VRERIEAEAEGWEARFGTVPRLRAGLHGGPVVTAEVGVDRHKIAYFGDAVNVVARVEALC 289 Query: 289 KEASRPLLVSGDLLRLLP--PDRDLVVEPLGSTQLRGRAASIDIFCVARR 336 + L+S DLL+ LP P+ +VV PLG+ LRGR + + + R Sbjct: 290 RPLGVDTLISEDLLKRLPRLPE-GVVVRPLGTHALRGRGQPLAVATLERN 338 >ref|YP_004548352.1| adenylate/guanylate cyclase [Sinorhizobium meliloti AK83] gb|AEG52738.1| adenylate/guanylate cyclase [Sinorhizobium meliloti AK83] Length = 363 Score = 181 bits (459), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 98/262 (37%), Positives = 152/262 (58%), Gaps = 15/262 (5%) Query: 79 VILAVTVAAAAIVLEVVLYGHGLEAKWMRET-------FLKIIGVGLLLSIPITTIYELV 131 + + V AAA ++L V A MRE+ L ++ L S PI + + Sbjct: 81 IFVNVGYAAAGLLLHV--------AGVMRESRTDAMLPSLNVLVYALATSGPIIFVLRVR 132 Query: 132 RMIGGHTLLGIVLGRYRQPVREERVLLFLDLVGSTTLAESMGELRVQELLTRFFFDIDEP 191 ++G L ++ GRYR+PV+EERV LF+DL GST+LAE G+LR+QE L + F + +P Sbjct: 133 ELLGRDVFLSLLTGRYRKPVQEERVFLFIDLAGSTSLAERFGDLRMQEYLGKLFAAMADP 192 Query: 192 IVSHGGEVHAYVGDEVIVTWPANADGRSRRYLDCVFAIEDRLAKGADQYRKEFGVVPAFR 251 ++ +GG + YVGD ++TWP + + CVF I +++ A ++RK++G VP R Sbjct: 193 VLRYGGSIDDYVGDAAVITWPYDRAVADAACIRCVFDILEQIEADAHRWRKDYGEVPRLR 252 Query: 252 AGMHAGPVVIAECGDSRRQIAYFGDSVNVTARLQAHCKEASRPLLVSGDLLRLLPPDRDL 311 A +H G +V AE G + +I YFGD+VN TARL+ C+ +R +L+S DLLR L P + Sbjct: 253 AALHGGTIVAAEIGVDKHKITYFGDTVNTTARLEGLCRTLNRQVLISADLLRRLRPPVFV 312 Query: 312 VVEPLGSTQLRGRAASIDIFCV 333 E LG +++GR + + + Sbjct: 313 RAEDLGEHEVKGRGQKLAVLSL 334 >ref|YP_003071236.1| transmembrane adenylate/guanylate cyclase [Methylobacterium extorquens DM4] emb|CAX27432.1| putative transmembrane adenylate/guanylate cyclase [Methylobacterium extorquens DM4] Length = 412 Score = 181 bits (459), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 93/229 (40%), Positives = 138/229 (60%), Gaps = 3/229 (1%) Query: 109 TFLKIIGVGLLLSIPITTIYELVRMIGGHTLLGIVLGRYRQPVREERVLLFLDLVGSTTL 168 T +++ L +S + + + +IGG + ++GRY +PV EER+ LFLD+VGST Sbjct: 167 TTPRVLAYALAVSALLVFVIRMRDLIGGEVFINFLVGRYHRPVEEERIFLFLDVVGSTAF 226 Query: 169 AESMGELRVQELLTRFFFDIDEPIVSHGGEVHAYVGDEVIVTWPANADGRSRRYLDCVFA 228 AE+ G+LR QE L+ F + EP+ G Y+GD ++TWP + R ++C+FA Sbjct: 227 AETHGDLRAQEYLSAVFATLAEPVRRFYGSTDDYIGDLAMITWPMERGLKDARCVECLFA 286 Query: 229 IEDRLAKGADQYRKEFGVVPAFRAGMHAGPVVIAECGDSRRQIAYFGDSVNVTARLQAHC 288 + +R+ A+ + FG VP RAG+H GPVV AE G R +IAYFGD+VNV AR++A C Sbjct: 287 VRERIEAEAEGWEARFGTVPRLRAGLHGGPVVTAEVGVDRHKIAYFGDAVNVVARVEALC 346 Query: 289 KEASRPLLVSGDLLRLLP--PDRDLVVEPLGSTQLRGRAASIDIFCVAR 335 + L+S DLL+ LP P+ +VV PLG+ LRGR + + + R Sbjct: 347 RPLGVDTLISEDLLKRLPRLPE-GVVVRPLGTHALRGRGQPLSVATLER 394