BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0039.0003.p (602 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_103057.1| chloride channel protein [Mesorhizobium loti MA... 884 0.0 ref|YP_004612134.1| Cl- channel voltage-gated family protein [Me... 861 0.0 ref|YP_004142380.1| Cl- channel voltage-gated family protein [Me... 854 0.0 ref|YP_001631931.1| putative chloride channel protein [Bordetell... 617 e-174 ref|YP_003979071.1| voltage gated chloride channel family protei... 597 e-168 >ref|NP_103057.1| chloride channel protein [Mesorhizobium loti MAFF303099] dbj|BAB48843.1| chloride channel protein [Mesorhizobium loti MAFF303099] Length = 612 Score = 884 bits (2285), Expect = 0.0, Method: Compositional matrix adjust. Identities = 455/594 (76%), Positives = 516/594 (86%), Gaps = 1/594 (0%) Query: 7 KSSASAKTSAKIGDKASHLLSDFTTDPRVVVISAIAVFVSAAGVLAGAGLLQLIKLATNI 66 + A+A+ A + SHL SDFTTD RV+ I+ IAV V+ AG+ AG LL+LI+LATNI Sbjct: 5 RDPAAARKPAMKPSENSHL-SDFTTDARVLTIATIAVVVATAGLFAGIALLKLIRLATNI 63 Query: 67 AYFGQFSFADLKLQDSPLGLWTVLVPVAGSLIIGLMARFGSEKIRGHGIPEAIEAILLGR 126 AYFGQF+ A+LKLQD+PLGL V+VPV G+LIIGLMAR+GSEKIRGHGIPEAIEAILLGR Sbjct: 64 AYFGQFTLAELKLQDTPLGLAAVVVPVIGALIIGLMARYGSEKIRGHGIPEAIEAILLGR 123 Query: 127 SRLDPKVAILKPLSSAVSIGTGGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAG 186 SRL KVAILKPLSSA+SIG+GGPFGAEGPIIMTGGAIGSLIA+MLPVSDNERKTLLVAG Sbjct: 124 SRLGAKVAILKPLSSAISIGSGGPFGAEGPIIMTGGAIGSLIAKMLPVSDNERKTLLVAG 183 Query: 187 AAAGMTTVFGTPIAAIMLAVELLLFEWTPRSFIPVTVAAVVAAVGRTFLHMPAPLFPFTG 246 AAAGMTTVFGTPIAAIMLAVELLLFEWTPRSFIPV VAA++A V RT LH+P P+FPF G Sbjct: 184 AAAGMTTVFGTPIAAIMLAVELLLFEWTPRSFIPVAVAAIIAEVERTALHLPGPIFPFQG 243 Query: 247 GVDISVLQLGAWMLIGILSGLLSGVLTQLVYGCEDVFLKLPIHWMWWPLIGGLVVGLGGL 306 G+ +S LG W+L+GI +GLLSG+LTQ+VY CED F KLPIHWMWWP+IGGLVVG+GGL Sbjct: 244 GMAVSFTGLGGWVLVGICAGLLSGLLTQMVYACEDAFQKLPIHWMWWPMIGGLVVGIGGL 303 Query: 307 MEPQALGVGYDNLASMLSGDVVLKAALLLLVVKAVIWSVALGSGTSGGVLAPLLIMGGAM 366 +EP+ALGVGYDN+A ML G V AALLLLV+KA+IWSVALGSGTSGGVLAPLLIMGGAM Sbjct: 304 IEPRALGVGYDNIADMLDGRTVATAALLLLVIKAIIWSVALGSGTSGGVLAPLLIMGGAM 363 Query: 367 GTALSGYLPAASPGFWALLAMAATMGGTMRSPLTATFFAVELTGNTHVLLPLIAACGTAH 426 G L+G LPAA PGFWALLAM+ATMGGTMR+PLTATFFAVELTGNTHVL+PLIAAC AH Sbjct: 364 GAVLAGILPAADPGFWALLAMSATMGGTMRAPLTATFFAVELTGNTHVLVPLIAACAAAH 423 Query: 427 GVTVLLMRRSILTEKVARRGHHLVREYRVDPFALTRVRDVMTKAVETVADTMTLHGAAAF 486 VTVLLM+RSILTEK+ARRGHHLVREYRVDPFALTRVR+VMT VE+V TMTLHGAAAF Sbjct: 424 AVTVLLMKRSILTEKIARRGHHLVREYRVDPFALTRVREVMTAQVESVPATMTLHGAAAF 483 Query: 487 LTNPKTAHPSFPVVDANHNVLGVIDPPSVLRWRRAGKHRTATLKQLLAGSKITVAYPDEY 546 LT P+T HPSFPV+D N VLG+IDPP++LRWRRAGKHRT L LLAGSK+T+AYPDEY Sbjct: 484 LTAPETRHPSFPVIDENRRVLGLIDPPAILRWRRAGKHRTTRLSDLLAGSKVTLAYPDEY 543 Query: 547 LDRLADRLMQVNVSHLPVISREDQRLVGYIGWKDLMRVRARLQAEETQKTAFFG 600 L+ L+D+L+ NVSHLPV++RE +LVGY GWKDLMRVR+R QAEE + G Sbjct: 544 LEGLSDKLLMANVSHLPVVTRESLQLVGYAGWKDLMRVRSRKQAEERDHSTLLG 597 >ref|YP_004612134.1| Cl- channel voltage-gated family protein [Mesorhizobium opportunistum WSM2075] gb|AEH88040.1| Cl- channel voltage-gated family protein [Mesorhizobium opportunistum WSM2075] Length = 600 Score = 861 bits (2225), Expect = 0.0, Method: Compositional matrix adjust. Identities = 453/575 (78%), Positives = 515/575 (89%) Query: 26 LSDFTTDPRVVVISAIAVFVSAAGVLAGAGLLQLIKLATNIAYFGQFSFADLKLQDSPLG 85 L DFTTD RV++++AIAV V+ AG+ AG LL+LI+LATNIAYFGQFS ADLKLQD+PLG Sbjct: 11 LRDFTTDARVLLVAAIAVVVATAGLFAGIVLLKLIRLATNIAYFGQFSLADLKLQDTPLG 70 Query: 86 LWTVLVPVAGSLIIGLMARFGSEKIRGHGIPEAIEAILLGRSRLDPKVAILKPLSSAVSI 145 L VLVPV G+LIIGLMAR+GSEKIRGHGIPEAIEAILLGRS+LD KVAILKPLSSA+SI Sbjct: 71 LAAVLVPVVGALIIGLMARYGSEKIRGHGIPEAIEAILLGRSKLDAKVAILKPLSSAISI 130 Query: 146 GTGGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGAAAGMTTVFGTPIAAIMLA 205 G+GGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGAAAGMTTVFGTPIAAIMLA Sbjct: 131 GSGGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGAAAGMTTVFGTPIAAIMLA 190 Query: 206 VELLLFEWTPRSFIPVTVAAVVAAVGRTFLHMPAPLFPFTGGVDISVLQLGAWMLIGILS 265 VELLLFEWTPRSFIPV VAA++A V RT LH+P P+FPF GG+ +S LG W+L+GI + Sbjct: 191 VELLLFEWTPRSFIPVAVAAIIAEVERTLLHLPGPIFPFEGGMAVSFTGLGGWVLVGICA 250 Query: 266 GLLSGVLTQLVYGCEDVFLKLPIHWMWWPLIGGLVVGLGGLMEPQALGVGYDNLASMLSG 325 GLLSG+LTQ+VY CED F KLPIHWMWWP+IGGLVVG+GGL+EP+ALGVGYDN++ ML+G Sbjct: 251 GLLSGLLTQMVYACEDAFQKLPIHWMWWPMIGGLVVGIGGLIEPRALGVGYDNISDMLNG 310 Query: 326 DVVLKAALLLLVVKAVIWSVALGSGTSGGVLAPLLIMGGAMGTALSGYLPAASPGFWALL 385 + AALLLLVVKA+IWSVALGSGTSGGVLAPLLIMGGAMG L+G+LPAA PGFWALL Sbjct: 311 HTLATAALLLLVVKAIIWSVALGSGTSGGVLAPLLIMGGAMGAVLAGFLPAADPGFWALL 370 Query: 386 AMAATMGGTMRSPLTATFFAVELTGNTHVLLPLIAACGTAHGVTVLLMRRSILTEKVARR 445 AMAATMGGTMR+PLTATFFAVELTGNTHVL+PLIAAC AH VTVLLM+RSILTEK+ARR Sbjct: 371 AMAATMGGTMRAPLTATFFAVELTGNTHVLVPLIAACAAAHAVTVLLMKRSILTEKIARR 430 Query: 446 GHHLVREYRVDPFALTRVRDVMTKAVETVADTMTLHGAAAFLTNPKTAHPSFPVVDANHN 505 GHHLVREYRVDPFALTRVR+VMT VE+V TMTLHGAAAFLT P+T HPSFPV+D N + Sbjct: 431 GHHLVREYRVDPFALTRVREVMTTQVESVPATMTLHGAAAFLTAPETRHPSFPVIDENGH 490 Query: 506 VLGVIDPPSVLRWRRAGKHRTATLKQLLAGSKITVAYPDEYLDRLADRLMQVNVSHLPVI 565 VLG+IDPP++LRWRRAG HRT TL LLAGSK+T+AYPDEYL+ L+D+L+ NVSHLPV+ Sbjct: 491 VLGLIDPPAILRWRRAGTHRTTTLGALLAGSKVTLAYPDEYLEGLSDKLLTANVSHLPVV 550 Query: 566 SREDQRLVGYIGWKDLMRVRARLQAEETQKTAFFG 600 +RE +LVGY+GWKDLMRVR+R QAEE +++ G Sbjct: 551 TREGLQLVGYVGWKDLMRVRSRKQAEERERSTLLG 585 >ref|YP_004142380.1| Cl- channel voltage-gated family protein [Mesorhizobium ciceri biovar biserrulae WSM1271] gb|ADV12330.1| Cl- channel voltage-gated family protein [Mesorhizobium ciceri biovar biserrulae WSM1271] Length = 600 Score = 854 bits (2207), Expect = 0.0, Method: Compositional matrix adjust. Identities = 451/575 (78%), Positives = 510/575 (88%) Query: 26 LSDFTTDPRVVVISAIAVFVSAAGVLAGAGLLQLIKLATNIAYFGQFSFADLKLQDSPLG 85 L DFTTDPRV++++AIAV V+ AG+ AG LL+LI+LATNIAYFGQFS ADLKL+++PLG Sbjct: 11 LRDFTTDPRVLLVAAIAVVVATAGLFAGIALLKLIRLATNIAYFGQFSLADLKLENTPLG 70 Query: 86 LWTVLVPVAGSLIIGLMARFGSEKIRGHGIPEAIEAILLGRSRLDPKVAILKPLSSAVSI 145 L VLVPV G+LIIGLMAR+GSEKIRGHGIPEAIEAILLGRS+LD KVAILKPLSSA+SI Sbjct: 71 LAAVLVPVIGALIIGLMARYGSEKIRGHGIPEAIEAILLGRSKLDAKVAILKPLSSAISI 130 Query: 146 GTGGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGAAAGMTTVFGTPIAAIMLA 205 G+GGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGAAAGMTTVFGTPIAAIMLA Sbjct: 131 GSGGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGAAAGMTTVFGTPIAAIMLA 190 Query: 206 VELLLFEWTPRSFIPVTVAAVVAAVGRTFLHMPAPLFPFTGGVDISVLQLGAWMLIGILS 265 VELLLFEWTPRSFIPV VAAV+A V RT LH+P P+FPF GG+++S + L W+ IG+ + Sbjct: 191 VELLLFEWTPRSFIPVAVAAVIAEVERTMLHLPGPIFPFQGGMEVSFVGLAGWVAIGVCA 250 Query: 266 GLLSGVLTQLVYGCEDVFLKLPIHWMWWPLIGGLVVGLGGLMEPQALGVGYDNLASMLSG 325 GLLSG+LTQ+VY CED F KLPIHWMWWP++GGLVVG+GGL+EP ALGVGYDN+ ML G Sbjct: 251 GLLSGLLTQMVYACEDGFQKLPIHWMWWPMLGGLVVGIGGLIEPHALGVGYDNITDMLDG 310 Query: 326 DVVLKAALLLLVVKAVIWSVALGSGTSGGVLAPLLIMGGAMGTALSGYLPAASPGFWALL 385 V AALLLLVVKA+IWSVALGSGTSGGVLAPLLIMGGAMG L+G LPAA PGFWALL Sbjct: 311 RTVATAALLLLVVKAIIWSVALGSGTSGGVLAPLLIMGGAMGAVLAGVLPAADPGFWALL 370 Query: 386 AMAATMGGTMRSPLTATFFAVELTGNTHVLLPLIAACGTAHGVTVLLMRRSILTEKVARR 445 AMAATMGGTMR+PLTATFFAVELTGNTH+L+PLIAAC AH VTVLLM+RSILTEK+ARR Sbjct: 371 AMAATMGGTMRAPLTATFFAVELTGNTHMLVPLIAACAAAHAVTVLLMKRSILTEKIARR 430 Query: 446 GHHLVREYRVDPFALTRVRDVMTKAVETVADTMTLHGAAAFLTNPKTAHPSFPVVDANHN 505 GHHLVREYRVDPFALTRVR+VMT VE+V TMTLHGAAAFLT P+T HPSFPVVD N Sbjct: 431 GHHLVREYRVDPFALTRVREVMTSQVESVPATMTLHGAAAFLTAPETRHPSFPVVDENGQ 490 Query: 506 VLGVIDPPSVLRWRRAGKHRTATLKQLLAGSKITVAYPDEYLDRLADRLMQVNVSHLPVI 565 VLG+IDPP++LRWRRAG HRT TL LLAGSK+T+AYPDEYL+ L+D+L+ NVSHLPV+ Sbjct: 491 VLGLIDPPAILRWRRAGTHRTTTLGALLAGSKVTLAYPDEYLEGLSDKLLMANVSHLPVV 550 Query: 566 SREDQRLVGYIGWKDLMRVRARLQAEETQKTAFFG 600 +RE LVGY+GWKDLMRVR+R QAEE +++ G Sbjct: 551 TREGSLLVGYVGWKDLMRVRSRKQAEERERSTLLG 585 >ref|YP_001631931.1| putative chloride channel protein [Bordetella petrii DSM 12804] emb|CAP43663.1| putative chloride channel protein [Bordetella petrii] Length = 617 Score = 617 bits (1591), Expect = e-174, Method: Compositional matrix adjust. Identities = 363/595 (61%), Positives = 440/595 (73%), Gaps = 8/595 (1%) Query: 8 SSASAKTSAKIGDKASHLLSDFTTDPRVVVISAIAVFVSAAGVLAGAGLLQLIKLATNIA 67 SSA +SA++GD FTTD RV+++ +AV V AGV A LL+LI L TN+A Sbjct: 21 SSARPPSSARLGD--------FTTDRRVLLLMCMAVLVGLAGVGAAWVLLRLIALCTNLA 72 Query: 68 YFGQFSFADLKLQDSPLGLWTVLVPVAGSLIIGLMARFGSEKIRGHGIPEAIEAILLGRS 127 Y+G+FSF +L + + LG V VPV G +IIG MAR+GSEKIRGHGIPEA+EAIL+G+S Sbjct: 73 YYGRFSFENLPIAGNTLGWAAVAVPVVGCIIIGFMARYGSEKIRGHGIPEAMEAILIGKS 132 Query: 128 RLDPKVAILKPLSSAVSIGTGGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGA 187 R+ PKVA+LKPLSSAVSIGTGGPFGAEGPIIMTGGAIGSL+AQM+ +S +ERKTLLVAGA Sbjct: 133 RIQPKVAVLKPLSSAVSIGTGGPFGAEGPIIMTGGAIGSLLAQMVHMSSSERKTLLVAGA 192 Query: 188 AAGMTTVFGTPIAAIMLAVELLLFEWTPRSFIPVTVAAVVAAVGRTFLHMPAPLFPFTGG 247 AAGMT VFGTP+AAI+LAVELLLFEW PRSF+PV VAAVVAA R L AP+FP++G Sbjct: 193 AAGMTAVFGTPVAAILLAVELLLFEWKPRSFLPVAVAAVVAAAARPLLFDAAPIFPYSGV 252 Query: 248 VDISVLQLGAWMLIGILSGLLSGVLTQLVYGCEDVFLKLPIHWMWWPLIGGLVVGLGGLM 307 S+ + AW +GI++GL SGVLT LVY ED+F KLPIHWMWWP IGGLV+GLGGL+ Sbjct: 253 GQPSLHHVVAWAAVGIMAGLGSGVLTALVYAAEDLFEKLPIHWMWWPAIGGLVIGLGGLI 312 Query: 308 EPQALGVGYDNLASMLSGDVVLKAALLLLVVKAVIWSVALGSGTSGGVLAPLLIMGGAMG 367 EP ALGVGYDN+ +L+G + L+A LLLLVVK VIWSVALGSGTSGGVLAPLLI GGA+G Sbjct: 313 EPAALGVGYDNIIDLLAGKLALQAVLLLLVVKVVIWSVALGSGTSGGVLAPLLIFGGALG 372 Query: 368 TALSGYLPAASPGFWALLAMAATMGGTMRSPLTATFFAVELTGNTHVLLPLIAACGTAHG 427 + LP A PGFWALL MAA MGGTMR+PLTAT FAVELTGN VLLP++ AC A+G Sbjct: 373 ALATPALPHADPGFWALLGMAAMMGGTMRAPLTATLFAVELTGNFSVLLPVLTACAFAYG 432 Query: 428 VTVLLMRRSILTEKVARRGHHLVREYRVDPFALTRVRDVMTKAVETVADTMTLHGAAAFL 487 +TVLL++RSILTEK+ARRGHH+ REY VDPF L RV VMT VET+ +M + A A Sbjct: 433 LTVLLLKRSILTEKIARRGHHITREYHVDPFDLVRVSAVMTTKVETLPASMRVADAVAHF 492 Query: 488 TNPKTAHPSFPVVDANHNVLGVIDPPSVLRWRRAGKHRTATLKQLLAGSKITVAYPDEYL 547 T + H S+PVVD V+G I L W + L +++A ++ V YPDE Sbjct: 493 TTAERRHTSYPVVDGQGVVVGEITRADSLAWTLEDEDNARLLGEMVAHRELFVGYPDELA 552 Query: 548 DRLADRLMQVNVSHLPVISREDQRLVGYIGWKDLMRVRARLQAEETQKTAFFGAR 602 + ADR+ V LP++ R RLVG +G KDL+RVRA +E ++TA+F R Sbjct: 553 SQAADRMALTGVGRLPIVERATGRLVGLVGRKDLLRVRAGRLRDERERTAYFRWR 607 >ref|YP_003979071.1| voltage gated chloride channel family protein 1 [Achromobacter xylosoxidans A8] gb|ADP16356.1| voltage gated chloride channel family protein 1 [Achromobacter xylosoxidans A8] Length = 595 Score = 597 bits (1538), Expect = e-168, Method: Compositional matrix adjust. Identities = 343/592 (57%), Positives = 431/592 (72%), Gaps = 8/592 (1%) Query: 8 SSASAKTSAKIGDKASHLLSDFTTDPRVVVISAIAVFVSAAGVLAGAGLLQLIKLATNIA 67 +S+SA+ + ++GD FTTD RVV++ +A+ V A V A LL+LI L TN+A Sbjct: 4 TSSSARAALRLGD--------FTTDKRVVLLMGLAIPVGLASVAAAWALLRLIALCTNLA 55 Query: 68 YFGQFSFADLKLQDSPLGLWTVLVPVAGSLIIGLMARFGSEKIRGHGIPEAIEAILLGRS 127 Y QFSF D + LGL +V +PV G LIIGLMAR+GSEKIRGHGIPEA+EAIL+G+S Sbjct: 56 YHHQFSFEDQPITTGHLGLASVAIPVVGCLIIGLMARYGSEKIRGHGIPEAMEAILIGKS 115 Query: 128 RLDPKVAILKPLSSAVSIGTGGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGA 187 R+ PKVA+LKP+SSA+SIGTGGPFGAEGPIIMTGGAIGSL+AQ + + D ERKTLLVAGA Sbjct: 116 RIQPKVAVLKPVSSAISIGTGGPFGAEGPIIMTGGAIGSLLAQTIHLDDGERKTLLVAGA 175 Query: 188 AAGMTTVFGTPIAAIMLAVELLLFEWTPRSFIPVTVAAVVAAVGRTFLHMPAPLFPFTGG 247 AAGMT +F TP+AA++LAVELLLFEW PRSF+PV +AA+VAA R F+ P+F + G Sbjct: 176 AAGMTAIFATPLAAVLLAVELLLFEWKPRSFLPVAMAALVAAATRAFVLDAGPIFAYAGA 235 Query: 248 VDISVLQLGAWMLIGILSGLLSGVLTQLVYGCEDVFLKLPIHWMWWPLIGGLVVGLGGLM 307 + + L A ++G+L+GL SGVLT +VY ED+F KLP+HWMWWP GGLV+G+GGL+ Sbjct: 236 LSFTPAHLLACAVVGVLAGLGSGVLTSMVYTAEDLFEKLPLHWMWWPAFGGLVIGIGGLI 295 Query: 308 EPQALGVGYDNLASMLSGDVVLKAALLLLVVKAVIWSVALGSGTSGGVLAPLLIMGGAMG 367 EP ALGVGYDN+ +L+GD+ +A LLLLVVK +IWSVALGSGTSGGVLAPLLI GGA+G Sbjct: 296 EPAALGVGYDNIRHLLAGDLAFQAVLLLLVVKVIIWSVALGSGTSGGVLAPLLIFGGALG 355 Query: 368 TALSGYLPAASPGFWALLAMAATMGGTMRSPLTATFFAVELTGNTHVLLPLIAACGTAHG 427 + LP A+PGFWALL MAA MGGTMR+PLTAT FAVELTG+ LLP++AAC A+G Sbjct: 356 ALATPLLPQAAPGFWALLGMAAMMGGTMRAPLTATLFAVELTGDMGALLPVLAACVFAYG 415 Query: 428 VTVLLMRRSILTEKVARRGHHLVREYRVDPFALTRVRDVMTKAVETVADTMTLHGAAAFL 487 VTVLL++RSILTEK+ARRGHH+ REYRVDPF L RV VMT VET+ T+ A A Sbjct: 416 VTVLLLKRSILTEKIARRGHHISREYRVDPFDLLRVSQVMTTPVETLPADWTVAQAIAHF 475 Query: 488 TNPKTAHPSFPVVDANHNVLGVIDPPSVLRWRRAGKHRTATLKQLLAGSKITVAYPDEYL 547 T + H S+PV+DA V+G + L W + TL L G + +P+E Sbjct: 476 TTAQPVHTSYPVLDAQGVVVGEVTRADTLAWAIDDEQTGRTLGDALQGRDLVYGHPEELA 535 Query: 548 DRLADRLMQVNVSHLPVISREDQRLVGYIGWKDLMRVRARLQAEETQKTAFF 599 ++ADR+ +P++ R + RLVG +G KDL R RAR EE+Q+ A+F Sbjct: 536 SQIADRMALTGAGRVPILDRVNGRLVGIVGRKDLFRSRARRLREESQRNAYF 587