BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0045.p (294 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,459,386 sequences; 5,307,515,862 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|NP_767189.1| bifunctional 5,10-methylene-tetrahydrofolate de... 513 e-143 ref|YP_575958.1| methylenetetrahydrofolate dehydrogenase (NADP+)... 496 e-138 ref|YP_001202485.1| bifunctional 5,10-methylene-tetrahydrofolate... 496 e-138 ref|YP_317099.1| tetrahydrofolate dehydrogenase/cyclohydrolase [... 494 e-138 ref|YP_001236470.1| bifunctional 5,10-methylene-tetrahydrofolate... 491 e-137 >ref|NP_767189.1| bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase [Bradyrhizobium japonicum USDA 110] sp|Q89WX9.1|FOLD_BRAJA RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase dbj|BAC45814.1| bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase [Bradyrhizobium japonicum USDA 110] Length = 294 Score = 513 bits (1321), Expect = e-143, Method: Compositional matrix adjust. Identities = 258/294 (87%), Positives = 273/294 (92%) Query: 1 MTARIIDGKAIAAELRARVADEVARVKRDHQLTPGLAVVLVGHDPASEVYVRSKHTQTQA 60 MTA+IIDGK IAA+LRARVADEVARVKR+H L PGLAVVLVG+DPASEVYVRSK TQTQA Sbjct: 1 MTAKIIDGKVIAADLRARVADEVARVKREHNLVPGLAVVLVGNDPASEVYVRSKGTQTQA 60 Query: 61 AGMASFEHKLPEDVSQADLLALIARLNRDPMVHGILVQLPLPKSLHTETIINAIDPAKDV 120 AGMASFEHKLP DVSQADLLA++A+LNRDP VHGILVQLPLPK L+TE +INAIDPAKDV Sbjct: 61 AGMASFEHKLPADVSQADLLAVVAKLNRDPAVHGILVQLPLPKGLNTEAVINAIDPAKDV 120 Query: 121 DGLHPNNAGRLAGGLAALSPCTPLGCIILTKSVHASLEGLNAIVIGRSNLVGRPLVQLLL 180 DGLHPNNAGRLAGG ALSPCTPLG IILTKSVH SLEGLNAIVIGRSNLVGRPLVQLLL Sbjct: 121 DGLHPNNAGRLAGGFEALSPCTPLGSIILTKSVHPSLEGLNAIVIGRSNLVGRPLVQLLL 180 Query: 181 NENATVTIAHSRSRDLPKLCAQADLVYAAVGRPEMVRGDWLKPGATVIDVGINRIPVPGG 240 NENATVTIAHSRSRDLP L +ADLVYAAVG+PEMVRGDWLKPGATVID+GI+RIP G Sbjct: 181 NENATVTIAHSRSRDLPGLVKRADLVYAAVGKPEMVRGDWLKPGATVIDIGISRIPKEDG 240 Query: 241 KPKLVGDVAFQEALNVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPAPAV 294 K +LVGDVA+QEAL VAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLP PAV Sbjct: 241 KTRLVGDVAYQEALGVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPKPAV 294 >ref|YP_575958.1| methylenetetrahydrofolate dehydrogenase (NADP+) [Nitrobacter hamburgensis X14] sp|Q1QQJ9.1|FOLD_NITHX RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase gb|ABE61498.1| 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [Nitrobacter hamburgensis X14] Length = 294 Score = 496 bits (1277), Expect = e-138, Method: Compositional matrix adjust. Identities = 251/294 (85%), Positives = 267/294 (90%) Query: 1 MTARIIDGKAIAAELRARVADEVARVKRDHQLTPGLAVVLVGHDPASEVYVRSKHTQTQA 60 MTA IIDGK IAA+LRARVA EVARVKRDH LTPGLAVVLVG DPASEVYVRSKH QTQA Sbjct: 1 MTASIIDGKVIAADLRARVAFEVARVKRDHGLTPGLAVVLVGSDPASEVYVRSKHKQTQA 60 Query: 61 AGMASFEHKLPEDVSQADLLALIARLNRDPMVHGILVQLPLPKSLHTETIINAIDPAKDV 120 AGMASFEH LP DV+Q DLLAL+ARLN DP VHGILVQLPLPK L TETI+ AIDPAKDV Sbjct: 61 AGMASFEHVLPADVAQPDLLALVARLNADPAVHGILVQLPLPKGLDTETIVAAIDPAKDV 120 Query: 121 DGLHPNNAGRLAGGLAALSPCTPLGCIILTKSVHASLEGLNAIVIGRSNLVGRPLVQLLL 180 DGLHP+NAGRLAGGL ALSPCTPLGCIILTKSVH+SLEG++AIVIGRSNLVGRPLVQLLL Sbjct: 121 DGLHPHNAGRLAGGLPALSPCTPLGCIILTKSVHSSLEGMDAIVIGRSNLVGRPLVQLLL 180 Query: 181 NENATVTIAHSRSRDLPKLCAQADLVYAAVGRPEMVRGDWLKPGATVIDVGINRIPVPGG 240 NENATVTIAHSRSR+LP+LC +ADLVYAAVG+ EMVRGDWLKPGATVIDVGI R P G Sbjct: 181 NENATVTIAHSRSRNLPELCRRADLVYAAVGKAEMVRGDWLKPGATVIDVGITRRPAADG 240 Query: 241 KPKLVGDVAFQEALNVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPAPAV 294 K +L+GDVAF EA+ VAGA+TPVPGGVGQMTVACLLVNTLRAACAI GLPAP V Sbjct: 241 KTRLIGDVAFDEAMEVAGAVTPVPGGVGQMTVACLLVNTLRAACAIKGLPAPGV 294 >ref|YP_001202485.1| bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase [Bradyrhizobium sp. ORS 278] sp|A4YK09.1|FOLD_BRASO RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase emb|CAL74235.1| bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase [Bradyrhizobium sp. ORS 278] Length = 294 Score = 496 bits (1276), Expect = e-138, Method: Compositional matrix adjust. Identities = 250/294 (85%), Positives = 270/294 (91%) Query: 1 MTARIIDGKAIAAELRARVADEVARVKRDHQLTPGLAVVLVGHDPASEVYVRSKHTQTQA 60 MTARIIDGK IAA+LRA+VA EV RVK D LTPGLAVVLVG+DPASEVYVRSKHTQTQA Sbjct: 1 MTARIIDGKIIAADLRAQVAREVERVKHDLGLTPGLAVVLVGNDPASEVYVRSKHTQTQA 60 Query: 61 AGMASFEHKLPEDVSQADLLALIARLNRDPMVHGILVQLPLPKSLHTETIINAIDPAKDV 120 AGMASFEHKLP DV+QA+LLALI++LN+DP VHGILVQLPLPK L TE +INAIDPAKDV Sbjct: 61 AGMASFEHKLPADVAQAELLALISKLNQDPSVHGILVQLPLPKGLDTEAVINAIDPAKDV 120 Query: 121 DGLHPNNAGRLAGGLAALSPCTPLGCIILTKSVHASLEGLNAIVIGRSNLVGRPLVQLLL 180 DGLHP+NAGRLAGG AL+PCTPLGCIIL+K+VHASLEG+NAIVIGRSNLVGRPLVQLLL Sbjct: 121 DGLHPHNAGRLAGGQPALAPCTPLGCIILSKTVHASLEGMNAIVIGRSNLVGRPLVQLLL 180 Query: 181 NENATVTIAHSRSRDLPKLCAQADLVYAAVGRPEMVRGDWLKPGATVIDVGINRIPVPGG 240 NENATVTIAHSRSRDLP L A+ADLVYAAVGRPEMV+ DW+KPGATVIDVGINRIP P G Sbjct: 181 NENATVTIAHSRSRDLPALTARADLVYAAVGRPEMVKRDWIKPGATVIDVGINRIPTPEG 240 Query: 241 KPKLVGDVAFQEALNVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPAPAV 294 K +LVGDVA+ E VAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLP P+V Sbjct: 241 KTRLVGDVAYAEVAEVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPKPSV 294 >ref|YP_317099.1| tetrahydrofolate dehydrogenase/cyclohydrolase [Nitrobacter winogradskyi Nb-255] sp|Q3SVE4.1|FOLD_NITWN RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase gb|ABA03747.1| 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [Nitrobacter winogradskyi Nb-255] Length = 294 Score = 494 bits (1273), Expect = e-138, Method: Compositional matrix adjust. Identities = 249/294 (84%), Positives = 266/294 (90%) Query: 1 MTARIIDGKAIAAELRARVADEVARVKRDHQLTPGLAVVLVGHDPASEVYVRSKHTQTQA 60 M A IIDGK IAA+LRARVA EV R+KRDH LTPGLAVVLVG+DPASEVYVR+KH QTQA Sbjct: 1 MAASIIDGKVIAADLRARVAGEVTRIKRDHGLTPGLAVVLVGNDPASEVYVRNKHKQTQA 60 Query: 61 AGMASFEHKLPEDVSQADLLALIARLNRDPMVHGILVQLPLPKSLHTETIINAIDPAKDV 120 AGMASFEH LP DV+QAD+LALIA LN DP VHGILVQLPLPK L TE II AIDPAKDV Sbjct: 61 AGMASFEHMLPADVAQADVLALIAELNADPAVHGILVQLPLPKGLDTEAIIAAIDPAKDV 120 Query: 121 DGLHPNNAGRLAGGLAALSPCTPLGCIILTKSVHASLEGLNAIVIGRSNLVGRPLVQLLL 180 DGLHP+NAGRLAGGL+ALSPCTPLGCIILTKSVHASLEGL+AIVIGRSNLVGRPLVQLLL Sbjct: 121 DGLHPHNAGRLAGGLSALSPCTPLGCIILTKSVHASLEGLDAIVIGRSNLVGRPLVQLLL 180 Query: 181 NENATVTIAHSRSRDLPKLCAQADLVYAAVGRPEMVRGDWLKPGATVIDVGINRIPVPGG 240 NENATVTIAHSRSR+LP+LC +ADLVYAAVGR EMVRGDWLKPGATVIDVGI R+P G Sbjct: 181 NENATVTIAHSRSRNLPELCRRADLVYAAVGRAEMVRGDWLKPGATVIDVGITRVPAAEG 240 Query: 241 KPKLVGDVAFQEALNVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPAPAV 294 K +L+GDVAF EA+ VAGA+TPVPGGVGQMTVACLLVNTLRAACAI GL AP V Sbjct: 241 KTRLIGDVAFDEAMQVAGAVTPVPGGVGQMTVACLLVNTLRAACAIEGLSAPGV 294 >ref|YP_001236470.1| bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase [Bradyrhizobium sp. BTAi1] sp|A5E8S0.1|FOLD_BRASB RecName: Full=Bifunctional protein FolD; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase gb|ABQ32564.1| 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [Bradyrhizobium sp. BTAi1] Length = 294 Score = 491 bits (1264), Expect = e-137, Method: Compositional matrix adjust. Identities = 248/294 (84%), Positives = 266/294 (90%) Query: 1 MTARIIDGKAIAAELRARVADEVARVKRDHQLTPGLAVVLVGHDPASEVYVRSKHTQTQA 60 MTARIIDGK IAA+LR +VA EV RVKRDH LTPGLAVVLVG+DPASEVYVRSKHTQTQA Sbjct: 1 MTARIIDGKVIAADLRGQVAREVERVKRDHGLTPGLAVVLVGNDPASEVYVRSKHTQTQA 60 Query: 61 AGMASFEHKLPEDVSQADLLALIARLNRDPMVHGILVQLPLPKSLHTETIINAIDPAKDV 120 AGMASFEHKLP DV+Q++LLALI +LN DP VHGILVQLPLPK L TE +INAIDPAKDV Sbjct: 61 AGMASFEHKLPADVAQSELLALIDKLNHDPSVHGILVQLPLPKGLETEIVINAIDPAKDV 120 Query: 121 DGLHPNNAGRLAGGLAALSPCTPLGCIILTKSVHASLEGLNAIVIGRSNLVGRPLVQLLL 180 DGLHP+NAGRL+GG AL+PCTPLGCIIL+K+VH SLEGLNAIVIGRSNLVGRPLVQLLL Sbjct: 121 DGLHPHNAGRLSGGQPALAPCTPLGCIILSKTVHPSLEGLNAIVIGRSNLVGRPLVQLLL 180 Query: 181 NENATVTIAHSRSRDLPKLCAQADLVYAAVGRPEMVRGDWLKPGATVIDVGINRIPVPGG 240 NENATVTIAHSRSRDL L A+ADLVYAAVGRPEMV+ DW+KPGATVIDVGINRIP G Sbjct: 181 NENATVTIAHSRSRDLAALTARADLVYAAVGRPEMVKRDWIKPGATVIDVGINRIPTAEG 240 Query: 241 KPKLVGDVAFQEALNVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPAPAV 294 K +LVGDVA+ E VAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLP PAV Sbjct: 241 KTRLVGDVAYAEVAEVAGAITPVPGGVGQMTVACLLVNTLRAACAIAGLPKPAV 294