BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0259.0021.p (370 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMc01169 [E] COG0686 Alanine dehydrogenase Sme Sinorhizobium mel... 562 e-160 mll9089 [E] COG0686 Alanine dehydrogenase Mlo Mesorhizobium loti 523 e-148 mll0362 [E] COG0686 Alanine dehydrogenase Mlo Mesorhizobium loti 508 e-144 CC3574 Non COG 468 e-131 VC1905 [E] COG0686 Alanine dehydrogenase Vch Vibrio cholerae 425 e-119 >SMc01169 [E] COG0686 Alanine dehydrogenase Sme Sinorhizobium meliloti Length = 372 Score = 562 bits (1449), Expect = e-160, Method: Compositional matrix adjust. Identities = 265/359 (73%), Positives = 319/359 (88%) Query: 1 MKVGVPKEIKAHEYRVGLTPGAVREYVAAGHRVMIEANAGAGIGATDDDYRAAGATILDS 60 M+VG PKEIK HEYRVGLTPG+VREYVA GH V++E AGAGIGA DD YRAAGA I+ + Sbjct: 1 MRVGCPKEIKNHEYRVGLTPGSVREYVAHGHEVIVETKAGAGIGADDDSYRAAGARIVPT 60 Query: 61 AGEVFASSEMIVKVKEPQPSEWSQLRESQILFTYLHLAPDPEQAKGLLKSGCTAIAYETV 120 A EVF ++MIVKVKEPQPSEW+QLRE QIL+TYLHLAPDPEQ +GLLKSG TA+AYETV Sbjct: 61 AREVFEKADMIVKVKEPQPSEWAQLREGQILYTYLHLAPDPEQTQGLLKSGVTAVAYETV 120 Query: 121 TDAHGGLPLLAPMSEVAGRLAIEAAGSALKRSAGGRGLLIGGVPGVQPARIVVIGGGVVG 180 TD GGLPLLAPMSEVAGRLAI+A ++L+++ GGRG+L+GGVPGV PA++ +IGGGVVG Sbjct: 121 TDERGGLPLLAPMSEVAGRLAIQAGATSLQKANGGRGILLGGVPGVLPAKVAIIGGGVVG 180 Query: 181 THAARMAVGLGAEVTIIDRSIPRLRELDELFEGRVRTRFSTIESLEEEVFAADVVIGAVL 240 HAA+MA GLGA+V+I+DRS+PRLR+LD++F GRV TR+STI++LEEEVF+AD+VIGAVL Sbjct: 181 LHAAKMAAGLGADVSILDRSLPRLRQLDDIFNGRVHTRYSTIDALEEEVFSADMVIGAVL 240 Query: 241 VPGASAPKLVRRSMLSSMRKRAVIVDVAIDQGGCFETSHPTTHADPTYEVDGIIHYCVAN 300 +PGA+APKLV R MLS+M+K AVIVDVAIDQGGCFETSH TTH++PTYEV+GI+HYCVAN Sbjct: 241 IPGAAAPKLVTREMLSAMKKGAVIVDVAIDQGGCFETSHATTHSEPTYEVEGIVHYCVAN 300 Query: 301 MPGAVPLTSSQALNNATLPFGLALANKGFSAVLDNPHLRAGLNVHRGRLTYKAVAESLG 359 MPGAVP+TS+ ALNNATL +GL LA++G A+ ++ HLRAGLNVHRGR+T AVAE+LG Sbjct: 301 MPGAVPITSAHALNNATLQYGLQLADRGLKAIAEDRHLRAGLNVHRGRVTNAAVAEALG 359 >mll9089 [E] COG0686 Alanine dehydrogenase Mlo Mesorhizobium loti Length = 371 Score = 523 bits (1346), Expect = e-148, Method: Compositional matrix adjust. Identities = 266/359 (74%), Positives = 316/359 (88%) Query: 1 MKVGVPKEIKAHEYRVGLTPGAVREYVAAGHRVMIEANAGAGIGATDDDYRAAGATILDS 60 M+VG PKEIK HEYRVGLTPG+VREYVA GH V++E AGAGIGA D+ YRAAGATI + Sbjct: 1 MRVGCPKEIKNHEYRVGLTPGSVREYVAHGHEVLVETGAGAGIGADDNAYRAAGATIAKT 60 Query: 61 AGEVFASSEMIVKVKEPQPSEWSQLRESQILFTYLHLAPDPEQAKGLLKSGCTAIAYETV 120 A +VFA S+MIVKVKEPQP+EW QLR+ QIL+TYLHLAPDPEQ KGLL SG TAIAYETV Sbjct: 61 AADVFAKSDMIVKVKEPQPNEWVQLRDGQILYTYLHLAPDPEQTKGLLASGVTAIAYETV 120 Query: 121 TDAHGGLPLLAPMSEVAGRLAIEAAGSALKRSAGGRGLLIGGVPGVQPARIVVIGGGVVG 180 TD GGLPLLAPMSEVAGRL+I+A +AL+++ GGRG+L+GGVPGV P ++ V+GGGVVG Sbjct: 121 TDDRGGLPLLAPMSEVAGRLSIQAGATALQKANGGRGVLLGGVPGVLPGKVTVLGGGVVG 180 Query: 181 THAARMAVGLGAEVTIIDRSIPRLRELDELFEGRVRTRFSTIESLEEEVFAADVVIGAVL 240 HAARMA GLGA+VTIIDRSIPRLR+LD+LF GRV TR+ST+E+LEEE F+AD+V+GAVL Sbjct: 181 LHAARMAAGLGADVTIIDRSIPRLRQLDDLFAGRVHTRYSTVEALEEECFSADIVVGAVL 240 Query: 241 VPGASAPKLVRRSMLSSMRKRAVIVDVAIDQGGCFETSHPTTHADPTYEVDGIIHYCVAN 300 +PGA+APKLV R MLS M+K +V+VDVAIDQGGCFETSH TTHA+PTYEVDG+IHYCVAN Sbjct: 241 IPGAAAPKLVTREMLSGMKKGSVLVDVAIDQGGCFETSHATTHAEPTYEVDGVIHYCVAN 300 Query: 301 MPGAVPLTSSQALNNATLPFGLALANKGFSAVLDNPHLRAGLNVHRGRLTYKAVAESLG 359 MPGAVP+TS+ ALNNATL +GL LA+KG A++D+ HLR GLNVH+G++T +AVAE+LG Sbjct: 301 MPGAVPVTSAHALNNATLHYGLQLADKGLKALVDDHHLRNGLNVHKGKITNRAVAEALG 359 >mll0362 [E] COG0686 Alanine dehydrogenase Mlo Mesorhizobium loti Length = 371 Score = 508 bits (1308), Expect = e-144, Method: Compositional matrix adjust. Identities = 267/359 (74%), Positives = 317/359 (88%) Query: 1 MKVGVPKEIKAHEYRVGLTPGAVREYVAAGHRVMIEANAGAGIGATDDDYRAAGATILDS 60 M+VG PKEIK HEYRVGLTPG+VREYVA GH V++EA AGAGIGA D+ YRAAGATI + Sbjct: 1 MRVGCPKEIKNHEYRVGLTPGSVREYVAHGHEVLVEAGAGAGIGADDNAYRAAGATIAKT 60 Query: 61 AGEVFASSEMIVKVKEPQPSEWSQLRESQILFTYLHLAPDPEQAKGLLKSGCTAIAYETV 120 A +VFA S+MIVKVKEPQP+EW QLR+ QIL+TYLHLAPDPEQ KGLL SG TAIAYETV Sbjct: 61 AADVFAKSDMIVKVKEPQPNEWVQLRDGQILYTYLHLAPDPEQTKGLLASGVTAIAYETV 120 Query: 121 TDAHGGLPLLAPMSEVAGRLAIEAAGSALKRSAGGRGLLIGGVPGVQPARIVVIGGGVVG 180 TD GGLPLLAPMSEVAGRL+I+A +AL+++ GGRG+L+GGVPGV P ++ V+GGGVVG Sbjct: 121 TDDRGGLPLLAPMSEVAGRLSIQAGATALQKANGGRGVLLGGVPGVLPGKVTVLGGGVVG 180 Query: 181 THAARMAVGLGAEVTIIDRSIPRLRELDELFEGRVRTRFSTIESLEEEVFAADVVIGAVL 240 HAARMA GLGA+VTIIDRSIPRLR+LD+LF GRV TR+ST+E+LEEE F+AD+V+GAVL Sbjct: 181 LHAARMAAGLGADVTIIDRSIPRLRQLDDLFAGRVHTRYSTVEALEEECFSADIVVGAVL 240 Query: 241 VPGASAPKLVRRSMLSSMRKRAVIVDVAIDQGGCFETSHPTTHADPTYEVDGIIHYCVAN 300 +PGA+APKLV R MLS M+K +V+VDVAIDQGGCFETSH TTHA+PTYEVDG+IHYCVAN Sbjct: 241 IPGAAAPKLVTREMLSGMKKGSVLVDVAIDQGGCFETSHATTHAEPTYEVDGVIHYCVAN 300 Query: 301 MPGAVPLTSSQALNNATLPFGLALANKGFSAVLDNPHLRAGLNVHRGRLTYKAVAESLG 359 MPGAVP+TS+ ALNNATL +GL LA+KG A++D+ HLR GLNVH+G++T +AVAE+LG Sbjct: 301 MPGAVPVTSAHALNNATLHYGLQLADKGLKALVDDHHLRNGLNVHKGKITNRAVAEALG 359 >CC3574 Non COG Length = 370 Score = 468 bits (1203), Expect = e-131, Method: Compositional matrix adjust. Identities = 240/359 (66%), Positives = 285/359 (79%) Query: 1 MKVGVPKEIKAHEYRVGLTPGAVREYVAAGHRVMIEANAGAGIGATDDDYRAAGATILDS 60 M+VGVP EIK E+RVGLTP AVREYV GH V++++ AG G G DD Y AGA+I+ Sbjct: 1 MRVGVPSEIKPGEHRVGLTPTAVREYVGHGHTVIVQSGAGLGAGYADDVYVKAGASIVAD 60 Query: 61 AGEVFASSEMIVKVKEPQPSEWSQLRESQILFTYLHLAPDPEQAKGLLKSGCTAIAYETV 120 A VFA ++MIVKVKEPQ EW +L ILFTYLHLAPDP Q +GLLKSGC AIAYETV Sbjct: 61 ADAVFAGADMIVKVKEPQKVEWEKLEPRHILFTYLHLAPDPAQTEGLLKSGCAAIAYETV 120 Query: 121 TDAHGGLPLLAPMSEVAGRLAIEAAGSALKRSAGGRGLLIGGVPGVQPARIVVIGGGVVG 180 TDA GGLPLLAPMSEVAGR+A+ +A L + GG GLL+ GVPGV PAR+ V+GGGVVG Sbjct: 121 TDAKGGLPLLAPMSEVAGRIAVFSAAETLLKHNGGMGLLLSGVPGVPPARVAVLGGGVVG 180 Query: 181 THAARMAVGLGAEVTIIDRSIPRLRELDELFEGRVRTRFSTIESLEEEVFAADVVIGAVL 240 ++AARMA GLGAEV +++RSIPR+RELD+L++GR+ TR+ST ++EEE+ ADVVIGAVL Sbjct: 181 SNAARMAAGLGAEVVVLERSIPRMRELDDLYQGRILTRYSTFGAVEEEILKADVVIGAVL 240 Query: 241 VPGASAPKLVRRSMLSSMRKRAVIVDVAIDQGGCFETSHPTTHADPTYEVDGIIHYCVAN 300 GA+APKLVRR L M+ +V+VDV+IDQGGCFETS PTTHA PTY VDG++HYCVAN Sbjct: 241 TAGAAAPKLVRREHLKQMKPGSVLVDVSIDQGGCFETSKPTTHAQPTYTVDGVVHYCVAN 300 Query: 301 MPGAVPLTSSQALNNATLPFGLALANKGFSAVLDNPHLRAGLNVHRGRLTYKAVAESLG 359 MPGA P TSS+AL NATLPFGLALA+KG A+ N HL GLNV G LT+ AVAE+LG Sbjct: 301 MPGAAPRTSSEALGNATLPFGLALADKGLDALKANAHLARGLNVLNGELTHPAVAEALG 359 >VC1905 [E] COG0686 Alanine dehydrogenase Vch Vibrio cholerae Length = 374 Score = 425 bits (1093), Expect = e-119, Method: Compositional matrix adjust. Identities = 227/363 (62%), Positives = 286/363 (78%), Gaps = 1/363 (0%) Query: 1 MKVGVPKEIKAHEYRVGLTPGAVREYVAAGHRVMIEANAGAGIGATDDDYRAAGATILDS 60 M +GVPKEIK HEYRVG+ P +VRE V+ GH+V +E NAG+GIG +DDDY A GA+IL + Sbjct: 1 MIIGVPKEIKNHEYRVGMIPASVRELVSHGHQVYVETNAGSGIGFSDDDYIAVGASILPT 60 Query: 61 AGEVFASSEMIVKVKEPQPSEWSQLRESQILFTYLHLAPDPEQAKGLLKSGCTAIAYETV 120 A +VFA +EMIVKVKEPQ E + L+E QILFTYLHLAPD Q + L+KS IAYETV Sbjct: 61 AADVFAKAEMIVKVKEPQAIERAMLKEGQILFTYLHLAPDFPQTEELIKSKAVCIAYETV 120 Query: 121 TDAHGGLPLLAPMSEVAGRLAIEAAGSALKRSAGGRGLLIGGVPGVQPARIVVIGGGVVG 180 TD G LPLLAPMSEVAGR++I+A L++S GG GLL+GGVPGV PA++VV+GGGVVG Sbjct: 121 TDNMGRLPLLAPMSEVAGRMSIQAGAQTLEKSRGGSGLLLGGVPGVAPAKVVVLGGGVVG 180 Query: 181 THAARMAVGLGAEVTIIDRSIPRLRELDELFEGRVRTRFSTIESLEEEVFAADVVIGAVL 240 +AARMA+GL A+VTI+DR+I LR+LDE F+GR +ST +++E+ V AD+VIGAVL Sbjct: 181 ANAARMAIGLRADVTILDRNIDTLRKLDEEFQGRANVVYSTADAIEKYVLEADLVIGAVL 240 Query: 241 VPGASAPKLVRRSMLSSMRKRAVIVDVAIDQGGCFETSHPTTHADPTYEVDGIIHYCVAN 300 +PGA+APKLV + + M+ + +VDVAIDQGGCFETSHPTTHA+PTY VD ++HYCVAN Sbjct: 241 IPGAAAPKLVTQQHIKRMKPGSAVVDVAIDQGGCFETSHPTTHAEPTYIVDDVVHYCVAN 300 Query: 301 MPGAVPLTSSQALNNATLPFGLALANKGFS-AVLDNPHLRAGLNVHRGRLTYKAVAESLG 359 MPGAV TS+ ALNNATLP+ + LANKG+ A+L++ GLNV G++TYK VAE+ G Sbjct: 301 MPGAVARTSTFALNNATLPYIVKLANKGYQKALLEDAGFLKGLNVIHGKVTYKEVAENFG 360 Query: 360 LPF 362 L + Sbjct: 361 LDY 363