BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0258.0006.p (269 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv1472 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase Mtu M... 144 3e-34 MT1518 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase MtC M... 144 3e-34 CC2575 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase Ccr C... 134 2e-31 PA4980 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase Pae P... 133 4e-31 ML1241 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase Mle M... 132 1e-30 >Rv1472 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase Mtu Mycobacterium tuberculosis H37Rv Length = 285 Score = 144 bits (362), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 101/268 (37%), Positives = 145/268 (54%), Gaps = 12/268 (4%) Query: 5 LLIEH-HDGVDWVTLNRPESLNALDPSLIDALNVYFQGLQRNRDTRVVVLKGAGANFCAG 63 +L+EH + +TLNRPE +N++ ++ L + + RVVVL GAG F G Sbjct: 20 VLVEHPRPEIAQITLNRPERMNSMAFDVMVPLKEALAQVSYDNSVRVVVLTGAGRGFSPG 79 Query: 64 LDLKHA--MARRGGQAEPPGVTEALDSQRRIADIVMLMRRAPQPIIALVQGAAAGGGFAL 121 D K A + P T AL S + D+++++RR QP+IA V G A GGG L Sbjct: 80 ADHKSAGVVPHVENLTRP---TYALRSMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCL 136 Query: 122 ALAADIRIAAKNARMNCAFIKLGLGGCDIGTSYFLPRLVGVSVASELILTGRFIHADRAL 181 ALAADIR+A+ +A A I GL ++G SY LPR +G S A E++LTGR + A+ A Sbjct: 137 ALAADIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAE 196 Query: 182 AVGMVSEVVEAAADLDAAANAYVEAMMMA--SPVGLRLSKECINMSVDAGSIEAVIAMED 239 +G+VS V LDA Y A MA S G+ L+K + +DA S+EA + E Sbjct: 197 RIGLVSRQVPDEQLLDA---CYAIAARMAGFSRPGIELTKRTLWSGLDAASLEAHMQAEG 253 Query: 240 RNQVLCS-RSEDFQEGIRAFLEKRKPVY 266 Q+ + +F+E + A E+R PV+ Sbjct: 254 LGQLFVRLLTANFEEAVAARAEQRAPVF 281 >MT1518 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase MtC Mycobacterium tuberculosis CDC1551 Length = 285 Score = 144 bits (362), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 101/268 (37%), Positives = 145/268 (54%), Gaps = 12/268 (4%) Query: 5 LLIEH-HDGVDWVTLNRPESLNALDPSLIDALNVYFQGLQRNRDTRVVVLKGAGANFCAG 63 +L+EH + +TLNRPE +N++ ++ L + + RVVVL GAG F G Sbjct: 20 VLVEHPRPEIAQITLNRPERMNSMAFDVMVPLKEALAQVSYDNSVRVVVLTGAGRGFSPG 79 Query: 64 LDLKHA--MARRGGQAEPPGVTEALDSQRRIADIVMLMRRAPQPIIALVQGAAAGGGFAL 121 D K A + P T AL S + D+++++RR QP+IA V G A GGG L Sbjct: 80 ADHKSAGVVPHVENLTRP---TYALRSMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCL 136 Query: 122 ALAADIRIAAKNARMNCAFIKLGLGGCDIGTSYFLPRLVGVSVASELILTGRFIHADRAL 181 ALAADIR+A+ +A A I GL ++G SY LPR +G S A E++LTGR + A+ A Sbjct: 137 ALAADIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAE 196 Query: 182 AVGMVSEVVEAAADLDAAANAYVEAMMMA--SPVGLRLSKECINMSVDAGSIEAVIAMED 239 +G+VS V LDA Y A MA S G+ L+K + +DA S+EA + E Sbjct: 197 RIGLVSRQVPDEQLLDA---CYAIAARMAGFSRPGIELTKRTLWSGLDAASLEAHMQAEG 253 Query: 240 RNQVLCS-RSEDFQEGIRAFLEKRKPVY 266 Q+ + +F+E + A E+R PV+ Sbjct: 254 LGQLFVRLLTANFEEAVAARAEQRAPVF 281 >CC2575 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase Ccr Caulobacter vibrioides Length = 265 Score = 134 bits (337), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 98/263 (37%), Positives = 138/263 (52%), Gaps = 5/263 (1%) Query: 5 LLIEHHDGVDWVTLNRPESLNALD-PSLIDALNVYFQGLQRNRDTRVVVLKGAGANFCAG 63 +L E + +TLNRP+++NAL P D + + + ++D R V+L GAG F AG Sbjct: 4 ILTEKRGHIAILTLNRPDAMNALGAPGDGDQVAAACEAINDDQDIRCVILTGAGKAFSAG 63 Query: 64 LDLKHAMARRGGQAEPPGVTEALDSQRRIADIVMLMRRAPQPIIALVQGAAAGGGFALAL 123 D+K AM R G GV ++ I IV + P IA V GAA G G +A Sbjct: 64 GDVK-AMKAREGAFGGNGVKVRDGYRKNIHRIVRAIYGLEVPSIAAVNGAAIGLGCDVAC 122 Query: 124 AADIRIAAKNARMNCAFIKLGLGGCDIGTSYFLPRLVGVSVASELILTGRFIHADRALAV 183 DIRIAA AR F+KLGL D G ++ +PR +G+S A+EL+ TG I A +A Sbjct: 123 MTDIRIAADTARFGVTFLKLGLIPGD-GGAWLMPRTIGMSRAAELLFTGDVIDAAKAAEW 181 Query: 184 GMVSEVVEAAADLDAAANAYVEAMMMASPVGLRLSKECINMSVDAGSIEAVIAMEDRNQV 243 G++S+ V A DL A A E + P LR++K + A S + ++ M Q Sbjct: 182 GLISKAVP-AGDLMGEALALAERIAQQPPHALRMAKSLLKHGQTA-SYDTLMEMSAAAQA 239 Query: 244 LCSRSEDFQEGIRAFLEKRKPVY 266 + +ED EG+ A LEKR PV+ Sbjct: 240 IAHHTEDHMEGVDAILEKRSPVF 262 >PA4980 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase Pae Pseudomonas aeruginosa Length = 263 Score = 133 bits (335), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 96/269 (35%), Positives = 131/269 (48%), Gaps = 12/269 (4%) Query: 3 QPLLIEHHDGVDWVTLNRPESLNALDPSLIDALNVYFQGLQRNRDTRVVVLKGAGANFCA 62 PL G+ W+ LNRP+ NALD ++AL+V +R+ R VVL G+G +FCA Sbjct: 5 SPLQTRVEAGIAWLVLNRPQQRNALDIPTLEALHVRLDACERDPAVRAVVLGGSGRSFCA 64 Query: 63 GLDL-KHAMARRGGQAEPPGVTEALDSQRRIADIVMLMRRAPQPIIALVQGAAAGGGFAL 121 G DL + A A G+ E G TEA + ++ + +P +A V G+A G G L Sbjct: 65 GADLAEWAAAEARGELESYGWTEAAHA------LMGRLHALDKPTVAAVNGSAVGAGMDL 118 Query: 122 ALAADIRIAAKNARMNCAFIKLGLGGC-DIGTSYFLPRLVGVSVASELILTGRFIHADRA 180 AL D RIAA +AR + G+ C D G S+ LPRL+G A L+ A+RA Sbjct: 119 ALCCDFRIAAASARFKAGYT--GMAYCPDAGASWHLPRLLGSEAAKRLLFLDEAWSAERA 176 Query: 181 LAVGMVSEVVEAAADLDAAANAYVEAMMMASPVGLRLSKECINMSVDAGSIEAVIAMEDR 240 L G+V EVV A L A A+ + +K + E + A E Sbjct: 177 LGAGLVGEVV-ADEHLVEAVGAFAARLASGPTFAFAQTKRLLRDGAGRSLAEQLRA-EQA 234 Query: 241 NQVLCSRSEDFQEGIRAFLEKRKPVYIRR 269 +LC RSED E +RA EKR P + R Sbjct: 235 AGLLCGRSEDAAEALRAVAEKRSPQFSGR 263 >ML1241 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase Mle Mycobacterium leprae Length = 294 Score = 132 bits (331), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 91/260 (35%), Positives = 137/260 (52%), Gaps = 11/260 (4%) Query: 13 VDWVTLNRPESLNALDPSLIDALNVYFQGLQRNRDTRVVVLKGAGANFCAGLDLKHA--M 70 V +TLNRP +N++ L+ +L + + + RVVVL GAG FC+G D K + Sbjct: 31 VALITLNRPGRMNSMALDLMKSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPV 90 Query: 71 ARRGGQAEPPGVTEALDSQRRIADIVMLMRRAPQPIIALVQGAAAGGGFALALAADIRIA 130 + G +P AL + + ++++ +RR QP+IA + G A GGG LALAAD+R+A Sbjct: 91 PQVEGLTQP---VRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVA 147 Query: 131 AKNARMNCAFIKLGLGGCDIGTSYFLPRLVGVSVASELILTGRFIHADRALAVGMVSEVV 190 + A A I GL ++G SY LPR VG S A E++L+GR + A+ A +G+VS V Sbjct: 148 STRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEEAEQIGLVSYRV 207 Query: 191 EAAADLDAAANAYVEAMMMA--SPVGLRLSKECINMSVDAGSIEAVIAMEDRNQVLCS-R 247 LD Y A MA S G L+K + +DA S++ + E Q+ + Sbjct: 208 SDDRLLD---TCYSIAARMATFSRSGTELTKRALWGGLDAASLDKHMQSESLAQLFIALH 264 Query: 248 SEDFQEGIRAFLEKRKPVYI 267 + +F+E EKR V + Sbjct: 265 TSNFEEAAAPCTEKRPTVLV 284