BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0251.0022.p (327 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value yjhH [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuramina... 142 1e-33 CC1195 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneurami... 142 1e-33 PA0223 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneurami... 140 4e-33 STM3532 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuram... 139 8e-33 PA1254 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneurami... 134 3e-31 >yjhH [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase Eco Escherichia coli K12 Length = 319 Score = 142 bits (358), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 85/275 (30%), Positives = 139/275 (50%), Gaps = 10/275 (3%) Query: 25 MTKFRGVFPYLPTPLRSDGTVNGPALRAICDDLIKAGVHGLAALGSTGEYAYLNADARAD 84 M KF G+ P + + DGT++ A+R + D LI GV GL LG+ GE++ +N R Sbjct: 19 MKKFSGIIPPVSSTFHRDGTLDKKAMREVADFLINKGVDGLFYLGTGGEFSQMNTAQRMA 78 Query: 85 VVRHTADATQGRVPVIAGVAATTTREAIRQARRCKELGADCILLVLESYFPLDERQIESY 144 + GRVPV+ GV + +T EA++ A+ + GAD I+ + Y+ + R ++ Y Sbjct: 79 LAEEAVTIVDGRVPVLIGVGSPSTDEAVKLAQHAQAYGADGIVAINPYYWKVAPRNLDDY 138 Query: 145 FRAVADSVALPLLIYTNPQFQKTDLSIDVIERLA-NHPQIQYVKDASNNTGRLLSIMNRC 203 ++ +A SV LP+++Y P DL+ + + RLA + I +KD ++ G L +++N Sbjct: 139 YQQIARSVTLPVILYNFPDLTGQDLTPETVTRLALQNENIVGIKDTIDSVGHLRTMINTV 198 Query: 204 ----PQLGIFAASSHVPVAVMMLGGLGWMAGPACILPRTSVRLYDLSVAGRWEEAAALQR 259 P +F + M+LGG G + A P SV +Y G AA L + Sbjct: 199 KSVRPSFSVFCGYDDHLLNTMLLGGDGAITASANFAPELSVGIYRAWREGDLATAATLNK 258 Query: 260 RLWRVNEVFA-RFNLAACIKYGLGLQGYDVGLPAE 293 +L ++ ++A + IKY + VGLP E Sbjct: 259 KLLQLPAIYALETPFVSLIKYSMQC----VGLPVE 289 >CC1195 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase Ccr Caulobacter vibrioides Length = 294 Score = 142 bits (358), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 91/270 (33%), Positives = 136/270 (50%), Gaps = 5/270 (1%) Query: 26 TKFRGVFPYLPTPLRSDGTVNGPALRAICDDLIKAGVHGLAALGSTGEYAYLNADARADV 85 + F+GV P L TP R DG V+ A A+ + I GVHGL +G+TGE + L+ + V Sbjct: 4 SHFKGVIPALVTPFR-DGEVDEKAFVALVERQIAGGVHGLVPVGTTGETSTLSHEEHRRV 62 Query: 86 VRHTADATQGRVPVIAGVAATTTREAIRQARRCKELGADCILLVLESYFPLDERQIESYF 145 V T GRVPVIAG + +T EAI AR K +GAD L+V Y + + ++ Sbjct: 63 VELCVKTTAGRVPVIAGAGSNSTDEAIELARHAKTVGADACLVVTPYYNRPSQEGMYQHY 122 Query: 146 RAVADSVALPLLIYTNPQFQKTDLSIDVIERLANHPQIQYVKDASNNTGRLLSIMNRC-P 204 +A+ D+V LP+ +Y P D+S D +ERLA P I +KDA+ + R+ C P Sbjct: 123 KAINDAVELPIFVYNVPGRTGVDISNDTLERLAKLPNIVGIKDATGDLTRISFQRLMCGP 182 Query: 205 QLGIFAASSHVPVAVMMLGGLGWMAGPACILPRTSVRLYDLSVAGRWEEAAALQRRLWRV 264 + + + + M GG G ++ + + P + + G WE+ Q RL R+ Sbjct: 183 EWVMLSGDDPTALGYMAHGGHGVISVTSNVAPDACSAFMNACMQGEWEKGLYWQDRLVRL 242 Query: 265 NEVFARFNLAACIKYG---LGLQGYDVGLP 291 ++ + A K+ LGL DV LP Sbjct: 243 HKALFLDSSPAPTKFAMAQLGLCTEDVRLP 272 >PA0223 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase Pae Pseudomonas aeruginosa Length = 293 Score = 140 bits (353), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 87/291 (29%), Positives = 149/291 (51%), Gaps = 8/291 (2%) Query: 28 FRGVFPYLPTPLRSDGTVNGPALRAICDDLIKAGVHGLAALGSTGEYAYLNADARADVVR 87 G+ Y TP +DG ++ PAL + LI GVH +A LGSTGE AYL+ +VV Sbjct: 5 IHGIIGYTITPFAADGGLDLPALGRSIERLIDGGVHAIAPLGSTGEGAYLSDPEWDEVVD 64 Query: 88 HTADATQGRVPVIAGVAATTTREAIRQARRCKELGADCILLVLESYFPLDERQIESYFRA 147 T RVP I V+ TT + +R+A+ + LGA+ ++++ SY+ L+E ++ ++RA Sbjct: 65 FTLKTVAHRVPTIVSVSDLTTAKTVRRAQFAESLGAEAVMVLPISYWKLNEAEVFQHYRA 124 Query: 148 VADSVALPLLIYTNPQFQKTDLSIDVIERLANH-PQIQYVKDASNNTGRLLSIM----NR 202 V +++ +P+++Y NP D+S+++I R+ + VK+++ + R+ + R Sbjct: 125 VGEAIGVPVMLYNNPGTSGIDMSVELILRIVREVDNVTMVKESTGDIQRMHKLRLLGEGR 184 Query: 203 CPQLGIFAASSHVPVAVMMLGGLGWMAGPACILPRTSVRLYDLSVAGRWEEAAALQRRLW 262 P + + + + + G GW + ++P + +LY + G E+A AL R Sbjct: 185 VP---FYNGCNPLALEAFVAGAKGWCSAAPNLIPTLNGQLYQAVLDGDLEKARALFYRQL 241 Query: 263 RVNEVFARFNLAACIKYGLGLQGYDVGLPAEPQSPLSEAAGAEVSDILKEF 313 + + R L IK GLGL G +VG P P L + +L+E Sbjct: 242 PLLDFILRRGLPTTIKAGLGLSGLEVGAPRLPVQALDTEGCRYLQGLLEEL 292 >STM3532 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase Sty Salmonella typhimurium LT2 Length = 301 Score = 139 bits (350), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 84/297 (28%), Positives = 147/297 (49%), Gaps = 7/297 (2%) Query: 25 MTKFRGVFPYLPTPLRSDGTVNGPALRAICDDLIKAGVHGLAALGSTGEYAYLNADARAD 84 +TKF GVFP +PT + + G ++ + + D LI + V+G+ LGS GE+ ++ R + Sbjct: 4 ITKFHGVFPPVPTIVNAQGELDKVGMATLLDHLIASKVNGVLLLGSGGEFCHMTNALRLE 63 Query: 85 VVRHTADATQGRVPVIAGVAATTTREAIRQARRCKELGADCILLVLESYFPLDERQIESY 144 R+PV+ G+++T+T+E I + L D +L++ Y L + I + Sbjct: 64 TAEFCVRHINRRIPVLLGISSTSTQEVIEYGQHADRLEVDAVLVLNPYYARLTDEYIYHH 123 Query: 145 FRAVADSVALPLLIYTNPQFQKTDLSIDVIERLA-NHPQIQYVKDASNNTGRLLSIMNRC 203 F+ VA+++ P+++Y P DLS+D+I RLA +HP I +KD +N + I+N Sbjct: 124 FKTVANNIKSPVILYNFPALTGQDLSVDLITRLAQDHPNIIGIKDTVDNISHIREIINNV 183 Query: 204 ----PQLGIFAASSHVPVAVMMLGGLGWMAGPACILPRTSVRLYDLSVAGRWEEAAALQR 259 P IF+ + ++LGG G + A P+ + +Y +E LQR Sbjct: 184 RPVRPDFVIFSGYDEYMMDTLILGGNGGIPATANFAPQLTCGIYRAWCEKEYETMFGLQR 243 Query: 260 RLWRVNEVFARFN-LAACIKYGLGLQGYDVGLPAEPQS-PLSEAAGAEVSDILKEFG 314 RL ++ +++ + IK + L G D+ P P +E + + IL+ G Sbjct: 244 RLSALSTIYSLDSPFFGIIKKAIQLSGVDISTHVMPPVLPANEEHISNLKQILQRAG 300 >PA1254 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase Pae Pseudomonas aeruginosa Length = 305 Score = 134 bits (337), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 85/287 (29%), Positives = 143/287 (49%), Gaps = 1/287 (0%) Query: 27 KFRGVFPYLPTPLRSDGTVNGPALRAICDDLIKAGVHGLAALGSTGEYAYLNADARADVV 86 + GVFP + T +D +VN + +L++ GV GL GS GE L + + V Sbjct: 6 NWSGVFPAVTTQFNADFSVNLEETHTVISNLVRDGVSGLVVCGSVGENTSLTIEEKMAVT 65 Query: 87 RHTADATQGRVPVIAGVAATTTREAIRQARRCKELGADCILLVLESYFPLDERQIESYFR 146 DA+ GRVPVI G+A T+ A + A+ + +G D I+++ + + +FR Sbjct: 66 EVAKDASGGRVPVICGIAEFTSAGAAKVAKAVERVGVDGIMVMPALVYSSKPHETAEHFR 125 Query: 147 AVADSVALPLLIYTNPQFQKTDLSIDVIERLANHPQIQYVKDASNNTGRLLSIMNRCPQL 206 +VA LP+++Y NP + D++ D++ LA+ I KD+S +T R + + N+ + Sbjct: 126 SVASGTDLPVMVYNNPPIYRNDVTPDILVSLADCENIVCFKDSSGDTRRFIDVRNQVGER 185 Query: 207 GI-FAASSHVPVAVMMLGGLGWMAGPACILPRTSVRLYDLSVAGRWEEAAALQRRLWRVN 265 I FA V + + +G GW++G + + P+ ++ L+ AGR+ EA + L + Sbjct: 186 FILFAGLDDVVLESVAVGAQGWISGMSNVFPKEGETIFRLARAGRFAEAMPIYEWLMPIL 245 Query: 266 EVFARFNLAACIKYGLGLQGYDVGLPAEPQSPLSEAAGAEVSDILKE 312 + AR +L CIK L G L P+ L A V I+ + Sbjct: 246 HLDARPDLVQCIKLCEQLAGRGSALTRPPRLALRGADREHVERIMAK 292