BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0249.0040.p (544 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC1818 Non COG 408 e-113 CC1799 Non COG 392 e-108 Rv1393c [P] COG2072 Predicted flavoprotein involved in K+ transp... 233 7e-61 MT1438 [P] COG2072 Predicted flavoprotein involved in K+ transpo... 233 7e-61 PA2097 [P] COG2072 Predicted flavoprotein involved in K+ transpo... 226 1e-58 >CC1818 Non COG Length = 543 Score = 408 bits (1048), Expect = e-113, Method: Compositional matrix adjust. Identities = 218/521 (41%), Positives = 298/521 (57%), Gaps = 6/521 (1%) Query: 20 IIIGAGLSGMYQLYRLRELGLSARVFEAGTGVGGTWYWNRYPGARFDSESYSYGYSFSKE 79 I++GAG GMY ++RLR+ GLS EAG VGGTWYWNRYPGAR D S Y Y+FS+ Sbjct: 19 IVVGAGFGGMYAIHRLRQEGLSVLGLEAGGDVGGTWYWNRYPGARCDVTSIDYSYAFSQA 78 Query: 80 LLEEWEWSEHFAGQPETLRYCNYVADKFDLRRDIQFESRVTSAIYQDDTRSWRITLESGA 139 + +EW WSE FA E L Y N+VAD+ DLR QF +RV + + D R W +T + G Sbjct: 79 IEQEWTWSEVFAAGSEILAYANFVADRLDLRSAYQFNTRVQTIAFDDARRVWTLTTDQGQ 138 Query: 140 QHACRFLITAIGPLSTPTLPRIEGRDDFRGQSFHTARWPKQKVDFTGKRVAVIGTGATGI 199 + LI A GPLS P I G D F+G+ + + +WP VDF+GKRV V+GTG++GI Sbjct: 139 RFEADNLIMATGPLSLPKPVDIPGADRFKGELYRSGKWPHHAVDFSGKRVGVVGTGSSGI 198 Query: 200 QTIQTIAGEVGHLTVFQRTANWAAPLHNGKIDAETQARIKAGYPEIFARCKETFACFVHT 259 Q + +A LTVFQRT ++ P+ N K+ + A++KA + A + TF V Sbjct: 199 QIVPVVAETCQSLTVFQRTPSFTLPMRNKKVSEDYAAQLKANMAGLRAAARTTFTGGVRP 258 Query: 260 PDPRGAFEVSEEEREAFYEKLYGEHGFGIWQGNFKDILIDRAANATISDFVARKIRERVR 319 R F + EER E+ + + + G F D+L + AAN ++DFV KI + V+ Sbjct: 259 LSTRPLFSIPVEERNELMEEAWAKGALQ-FLGLFSDLLTNAAANEIVADFVRDKISQTVK 317 Query: 320 DPKVAEMLIPKNHGFGTRRLPLETFYYEVYNRDNVELVDIKETPIERITPEGIRTTDKDY 379 DP AE L P+ + RR L+T YYE YN +V LVD E PI T G+RT+ ++ Sbjct: 318 DPVTAEALKPRGYPIYARRPCLDTQYYETYNLPHVSLVDCFEEPISAFTETGLRTSQREI 377 Query: 380 AFDIIIYATGFDAITGSFDKIDFRGAHGARLKEKWTHGPATYLGLMVDGFPNMMMLMGPH 439 A D+II ATG+DA+TG ID G G +L E W GP +YL L++ GFPN+ ++ GP+ Sbjct: 378 ALDVIIMATGYDALTGPMLAIDITGRDGLKLSEAWRDGPRSYLALLMHGFPNLFIIGGPN 437 Query: 440 --TALGNIPRSIEYSVDWVTGLIRFAQAKGLTFLDATPEGTADWTEHVKALGTGLLSNEV 497 + L N R E +VDWV I Q +GL ++AT E W++ V + L + Sbjct: 438 GPSILANYIRLDELNVDWVVDCILHMQREGLATVEATAEAQTRWSQTVGEIADRTLYVKA 497 Query: 498 DSWMTGINRNVEGKQTRIVARYSGSAPAYRARCDEVAAKGY 538 D+W TG N+EGK R ++G Y C VAA GY Sbjct: 498 DTWYTGT--NIEGKP-RGFFVFAGGLNRYAEICAGVAAAGY 535 >CC1799 Non COG Length = 556 Score = 392 bits (1006), Expect = e-108, Method: Compositional matrix adjust. Identities = 207/535 (38%), Positives = 298/535 (55%), Gaps = 6/535 (1%) Query: 6 QDNTAQTAALDYDVIIIGAGLSGMYQLYRLRELGLSARVFEAGTGVGGTWYWNRYPGARF 65 Q TA D ++IGAG GMY +++L +GLS + FEAG VGG WYWNRYPGAR Sbjct: 5 QQPTASQDPTRIDALVIGAGFGGMYAVHKLSGMGLSVQGFEAGGDVGGVWYWNRYPGARC 64 Query: 66 DSESYSYGYSFSKELLEEWEWSEHFAGQPETLRYCNYVADKFDLRRDIQFESRVTSAIYQ 125 D S Y YSFS ++ +EW WSE FA Q E L Y N+VAD+ DLRR FE+ VT A Y Sbjct: 65 DLMSLDYCYSFSPDIEQEWTWSEQFAAQSEILAYANFVADRLDLRRHFLFETWVTGAAYD 124 Query: 126 DDTRSWRITLESGAQHACRFLITAIGPLSTPTLPRIEGRDDFRGQSFHTARWPKQKVDFT 185 + WR+T++ G + + A GPLS P +G DDF+G+ A+WP V F Sbjct: 125 EAANVWRVTVDDGRVFEATYCVMASGPLSIPKGVPFDGADDFKGEILLAAKWPHTPVSFE 184 Query: 186 GKRVAVIGTGATGIQTIQTIAGEVGHLTVFQRTANWAAPLHNGKIDAETQARIKAGYPEI 245 GKRV ++GTG+TGIQ + +A G LTVFQRT ++ P+ N ++ + A +K Y I Sbjct: 185 GKRVGLVGTGSTGIQIVPEVAKTAGALTVFQRTPSFTLPMRNVTLEPDYVAELKRNYAGI 244 Query: 246 FARCKETFACFVHTPDPRGAFEVSEEEREAFYEKLYGEHGFGIWQGNFKDILIDRAANAT 305 + + V R F V+ E+R A E + G + G F D+L++ AN Sbjct: 245 RQVARNSPLGGVRPQSTRPFFSVTPEQRRALMEDSWARGGLS-FLGTFSDLLVNPEANEQ 303 Query: 306 ISDFVARKIRERVRDPKVAEMLIPKNHGFGTRRLPLETFYYEVYNRDNVELVDIKETPIE 365 +++FV KI E V DP AE L P+ + RR L+T YYE +N +V+L D E+PI Sbjct: 304 VAEFVRSKISEVVTDPVTAEKLKPRGYPIFARRPCLDTHYYETFNLPHVKLHDCLESPIV 363 Query: 366 RITPEGIRTTDKDYAFDIIIYATGFDAITGSFDKIDFRGAHGARLKEKWTHGPATYLGLM 425 +ITP G+ T + D++I+ATG+D +TG+ D G G +L++KW G ++LGLM Sbjct: 364 KITPAGLLTETGEVELDVLIFATGYDGLTGALLNFDVVGRGGLQLRDKWRDGAKSHLGLM 423 Query: 426 VDGFPNMMMLMGPH--TALGNIPRSIEYSVDWVTGLIRFAQAKGLTFLDATPEGTADWTE 483 + FPN+ ++ GP+ AL NI + ++DW+ I + +GL ++ T W + Sbjct: 424 IASFPNLFLVCGPNGPAALANIITLDQQNIDWIADAITHMRQEGLATIEPTEGAEQGWMD 483 Query: 484 HVKALGTGLLSNEVDSWMTGINRNVEGKQTRIVARYSGSAPAYRARCDEVAAKGY 538 V + L ++ ++W G N+ GK R ++ Y+G Y C A KGY Sbjct: 484 MVYGMAELTLVSKANTWYVG--GNISGK-PRGLSMYTGGFQRYSEACRLAAEKGY 535 >Rv1393c [P] COG2072 Predicted flavoprotein involved in K+ transport Mtu Mycobacterium tuberculosis H37Rv Length = 492 Score = 233 bits (595), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 162/477 (33%), Positives = 228/477 (47%), Gaps = 49/477 (10%) Query: 16 DYDVIIIGAGLSGMYQLYRLRELGLS-ARVFEAGTGVGGTWYWNRYPGARFDSESYSYGY 74 DY +I+GAG SG+ +L G S V EAG GVGGTW+WN YPG D S+SY + Sbjct: 4 DYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQF 63 Query: 75 SFSKELLEEWEWSEHFAGQPETLRYCNYVADKFDLRRDIQFESRVTSAIYQDDTRSWRIT 134 SF + WS +A E Y + DK+ +R I+ ++V +A + D+ WR+ Sbjct: 64 SFEQSR----HWSRTYAPGHELKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQ 119 Query: 135 LESGAQHACRFLITAIGPLSTPTLPRIEGRDDFRGQSFHTARWPKQKVDFTGKRVAVIGT 194 + G + RFLI+A G L+ P LP I+G D F G + HTARW + D TGKRV +IGT Sbjct: 120 TDPGGEITARFLISACGILTVPKLPDIDGVDSFEGVTMHTARWDHTQ-DLTGKRVGIIGT 178 Query: 195 GATGIQTIQTIAGEVGHLTVFQRTANWAAPLHNGKIDAETQARIKAGYPEIFARCKETFA 254 GA+ +Q I +A V HLTVFQRT W P + + T R P Sbjct: 179 GASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFD--VPLPTAVRWAMRIP----------- 225 Query: 255 CFVHTPDPRGAFEVSEEEREAFYEKLY--GEHGFGIWQGNFKDILIDRAANATISDFVAR 312 G V +AF E + H F ++ L +A R Sbjct: 226 ---------GGKAVHRLLSQAFVEATFPIAAHYFAVFP------LAKHMESAG-----RR 265 Query: 313 KIRERVRDPKVAEMLIPKNHGFGTRRLPLETFYYEVYNRDNVELVDIKETPIERITPEGI 372 +R++V DP V E L P+ + G +R Y +NRDNV LV PI++ITP + Sbjct: 266 YLRQQVHDPVVREQLTPR-YAVGCKRPGFHNTYLSTFNRDNVRLV---TEPIDKITPTAV 321 Query: 373 RTTD-KDYAFDIIIYATGFDAI-TGSFDKIDFRGAHGARLKEKW-THGPATYLGLMVDGF 429 TTD + D+++ ATGF + T S G GA L W H Y G+ V G+ Sbjct: 322 ATTDGASHEIDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPGY 381 Query: 430 PNMMMLMGPHTALGNIPRS-IEYSVDWVTGLIRFAQAKGLTFLDATPEGTADWTEHV 485 PN + GP+ +G+ + IE + ++ A+ G T ++ T E A + V Sbjct: 382 PNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGATRIEVTEEANARYFAEV 438 >MT1438 [P] COG2072 Predicted flavoprotein involved in K+ transport MtC Mycobacterium tuberculosis CDC1551 Length = 492 Score = 233 bits (595), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 162/477 (33%), Positives = 228/477 (47%), Gaps = 49/477 (10%) Query: 16 DYDVIIIGAGLSGMYQLYRLRELGLS-ARVFEAGTGVGGTWYWNRYPGARFDSESYSYGY 74 DY +I+GAG SG+ +L G S V EAG GVGGTW+WN YPG D S+SY + Sbjct: 4 DYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQF 63 Query: 75 SFSKELLEEWEWSEHFAGQPETLRYCNYVADKFDLRRDIQFESRVTSAIYQDDTRSWRIT 134 SF + WS +A E Y + DK+ +R I+ ++V +A + D+ WR+ Sbjct: 64 SFEQSR----HWSRTYAPGHELKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQ 119 Query: 135 LESGAQHACRFLITAIGPLSTPTLPRIEGRDDFRGQSFHTARWPKQKVDFTGKRVAVIGT 194 + G + RFLI+A G L+ P LP I+G D F G + HTARW + D TGKRV +IGT Sbjct: 120 TDPGGEITARFLISACGILTVPKLPDIDGVDSFEGVTMHTARWDHTQ-DLTGKRVGIIGT 178 Query: 195 GATGIQTIQTIAGEVGHLTVFQRTANWAAPLHNGKIDAETQARIKAGYPEIFARCKETFA 254 GA+ +Q I +A V HLTVFQRT W P + + T R P Sbjct: 179 GASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFD--VPLPTAVRWAMRIP----------- 225 Query: 255 CFVHTPDPRGAFEVSEEEREAFYEKLY--GEHGFGIWQGNFKDILIDRAANATISDFVAR 312 G V +AF E + H F ++ L +A R Sbjct: 226 ---------GGKAVHRLLSQAFVEATFPIAAHYFAVFP------LAKHMESAG-----RR 265 Query: 313 KIRERVRDPKVAEMLIPKNHGFGTRRLPLETFYYEVYNRDNVELVDIKETPIERITPEGI 372 +R++V DP V E L P+ + G +R Y +NRDNV LV PI++ITP + Sbjct: 266 YLRQQVHDPVVREQLTPR-YAVGCKRPGFHNTYLSTFNRDNVRLV---TEPIDKITPTAV 321 Query: 373 RTTD-KDYAFDIIIYATGFDAI-TGSFDKIDFRGAHGARLKEKW-THGPATYLGLMVDGF 429 TTD + D+++ ATGF + T S G GA L W H Y G+ V G+ Sbjct: 322 ATTDGASHEIDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPGY 381 Query: 430 PNMMMLMGPHTALGNIPRS-IEYSVDWVTGLIRFAQAKGLTFLDATPEGTADWTEHV 485 PN + GP+ +G+ + IE + ++ A+ G T ++ T E A + V Sbjct: 382 PNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGATRIEVTEEANARYFAEV 438 >PA2097 [P] COG2072 Predicted flavoprotein involved in K+ transport Pae Pseudomonas aeruginosa Length = 491 Score = 226 bits (576), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 159/487 (32%), Positives = 237/487 (48%), Gaps = 48/487 (9%) Query: 19 VIIIGAGLSGMYQLYRLRELGLSA-RVFEAGTGVGGTWYWNRYPGARFDSESYSYGYSFS 77 V+++GAG +G+ RLR+ G+ V E VGG W NRYPGA D S+ Y +SF Sbjct: 13 VLVVGAGFAGLGLAIRLRQAGIDDYLVLEKAADVGGCWRENRYPGAACDVPSHLYSFSFE 72 Query: 78 KELLEEWEWSEHFAGQPETLRYCNYVADKFDLRRDIQFESRVTSAIYQDDTRSWRITLES 137 + +WS FA Q E L Y + ADK+ LR I+F V A + + W++ Sbjct: 73 PKA----DWSRKFAPQAEILDYLRHCADKYRLREKIRFHCEVEEARFDAGSGEWQVRCAD 128 Query: 138 GAQHACRFLITAIGPLSTPTLPRIEGRDDFRGQSFHTARWPKQKVDFTGKRVAVIGTGAT 197 G R L+ A G LS P LPR+ G + F+G +FH+A W +V+ GKRVAVIGTGA+ Sbjct: 129 GQTLRARALVCATGQLSRPLLPRLPGLERFQGPAFHSANW-DAEVELAGKRVAVIGTGAS 187 Query: 198 GIQTIQTIAGEVGHLTVFQRTANWAAPLHNGKIDAETQARIKAGYPEIFARCKETFACFV 257 IQ + IA +V L++FQR+A + + + A+ + R+KA +P ++ Sbjct: 188 AIQFVPRIAPQVQRLSLFQRSAPYVIAKPD-RTYADWERRLKARWP------------WL 234 Query: 258 HTPDPRGAFEVSEEEREAFYEKLYGEHGFGIWQGNFKDILIDRAANATISDFVARKIRER 317 D RG + E R F + K + + R + + Sbjct: 235 QRLD-RGLKYLHHESRML---------AFATFPALMKVMRLS----------FHRHLHRQ 274 Query: 318 VRDPKVAEMLIPKNHGFGTRRLPLETFYYEVYNRDNVELVDIKETPIERITPEGIRTTD- 376 + DP++ L+P ++ G +R+ + YY R NVELVD T I +T + + D Sbjct: 275 IADPQLRARLVP-DYPLGCKRILISNDYYPALARSNVELVD---TGIREVTEDAVVGRDG 330 Query: 377 KDYAFDIIIYATGFDAITGSFDKIDFRGAHGARLKEKWTHGPATYLGLMVDGFPNMMMLM 436 + + D II+ TGF A T + G G L++ W G Y G+ V GFPN+ +L Sbjct: 331 RRHEVDAIIFGTGF-AATEFLAPMRILGLDGRDLRQAWADGAEAYKGISVSGFPNLFILY 389 Query: 437 GPHTALGN--IPRSIEYSVDWVTGLIRFAQAKGLTFLDATPEGTADWTEHV-KALGTGLL 493 GP+T LG+ I +E +V G +R Q +GL +LD PE + V + L + Sbjct: 390 GPNTNLGHNSIVYMLESQFPYVLGCLRQLQEQGLRYLDVKPEVQRRFNLEVQQGLRHTVW 449 Query: 494 SNEVDSW 500 DSW Sbjct: 450 ERGCDSW 456